Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients

Blood

Volumn 118, Issue 12, 2011, Pages 3273-3279

  Curti, Antonio ^a   Ruggeri, Loredana ^b   D'Addio, Alessandra ^c   Bontadini, Andrea ^a   Dan, Elisa ^a   Motta, Maria Rosa ^a   Trabanelli, Sara ^a   Giudice, Valeria ^a   Urbani, Elena ^b   Martinelli, Giovanni ^a   Paolini, Stefania ^a   Fruet, Fiorenza ^a   Isidori, Alessandro ^d   Parisi, Sarah ^a   Bandini, Giuseppe ^a   Baccarani, Michele ^a   Velardi, Andrea ^b   Lemoli, Roberto M ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c CREMONA HOSPITAL   (Italy)

^d SAN SALVATORE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD56 ANTIGEN; CYCLOPHOSPHAMIDE; FLUDARABINE; INTERLEUKIN 2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ADOPTIVE TRANSFER; ADULT; AGED; ALLOIMMUNITY; ARTICLE; BONE MARROW; CELL CLONE; CELL TRANSFER; CLINICAL ARTICLE; DONOR SELECTION; FEMALE; GERIATRIC PATIENT; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HIGH RISK POPULATION; HUMAN; INFUSION; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; MALE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; SAFETY; STEM CELL TRANSPLANTATION;

EID: 80053208226     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-01-329508     Document Type: Article

References (19)

1. Löwenberg B, Downing JR, Burnett A. Acute myeloid leukemia. N Engl J Med. 1999;341(14):1051-1062. (Pubitemid 29451802)
2. Farag SS, Caligiuri MA. Human natural killer cell development and biology. Blood Rev. 2006;20(3):123-137. (Pubitemid 43786166)
3. Waldhauer I, Steinle A. NK cells and cancer immunosurveillance. Oncogene. 2008;27(45):5932-5943.
4. Höglund P, Brodin P. Current perspectives of natural killer cell education by MHC class I molecules. Nat Rev Immunol. 2010;10(10):724-734.
5. Moretta L, Moretta A. Killer immunoglobulin-like receptors. Curr Opin Immunol. 2004;16(5):626-633. (Pubitemid 39165891)
6. Moretta A, Locatelli F, Moretta L. Human NK cells: from HLA class I-specific killer Ig-like receptors to the therapy of acute leukemias. Immunol Rev. 2008;224:58-69.
7. Ruggeri L, Capanni M, Casucci M, et al. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood. 1999;94(1):333-339. (Pubitemid 29300166)
8. Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002;295(5562):2097-2100. (Pubitemid 34229476)
9. Ruggeri L, Mancusi A, Capanni M, et al. Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value. Blood. 2007;110(1):433-440. (Pubitemid 47026866)
10. Pende D, Marcenaro S, Falco M, et al. Antileukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and re-definition of inhibitory KIR specificity. Blood. 2008;113(13):3119-3129.
11. Willemze R, Rodrigues CA, Labopin M, et al. KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia. Leukemia. 2009;23(3):492-500.
12. Miller JS, Soignier Y, Panoskaltsis-Mortari A, et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood. 2005;105(8):3051-3057.
13. Shi J, Tricot G, Szmania S, et al. Infusion of haplo-identical killer immunoglobulin-like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation. Br J Haematol. 2008;143(5):641-653.
14. Rubnitz JE, Inaba H, Ribeiro RC, et al. NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J Clin Oncol. 2010;28(6):955-959.
15. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2008.
16. Bontadini A, Testi M, Cuccia MC, et al. Distribution of killer cell immunoglobulin-like receptors genes in the Italian Caucasian population. J Transl Med. 2006;4:44-52.
17. Kristt D, Gesundheit B, Stein J, et al. Quantitative monitoring of multi-donor chimerism: A systematic, validated framework for routine analysis. Bone Marrow Transplant. 2010;45(1):137-147.
18. Isidori A, Motta MR, Tani M, et al. Positive selection and transplantation of autologous highly purified CD133(+) stem cells in resistant/relapsed chronic lymphocytic leukemia patients results in rapid hematopoietic reconstitution without an adequate leukemic cell purging. Biol Blood Marrow Transplant. 2007;13(10):1224-1232. (Pubitemid 47413021)
19. Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 2002;298(5594):850-854. (Pubitemid 35231542)