Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with il-2 exvivo expansion

Journal of Immunotherapy

Volumn 33, Issue 7, 2010, Pages 684-696

  Xing, Dongxia ^a   Ramsay, Alan G ^b   Gribben, John G ^b   Decker, William K ^a   Burks, Jared K ^a   Munsell, Mark ^c   Li, Sufang ^a   Robinson, Simon N ^a   Yang, Hong ^a   Steiner, David ^a   Shah, Nina ^a   McMannis, John D ^a   Champlin, Richard E ^a   Hosing, Chitra ^a   Zweidler Mckay, Patrick A ^a   Shpall, Elizabeth J ^a   Bollard, Catherine M ^d  

^a Departments of Stem Cell Transplantation and Cellular Therapy   (United States)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d CENTER FOR CELL AND GENE THERAPY   (United States)

Author keywords

CD2; cord blood; immunologic synapse; LFA 1; natural killer cell

Indexed keywords

CD2 ANTIGEN; F ACTIN; INTEGRIN; INTERLEUKIN 2; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PERFORIN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVITY; CELL EXPANSION; CELL FUNCTION; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; LEUKEMIA CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC POTENTIAL; TARGET CELL; UMBILICAL CORD BLOOD;

ACTINS; ANIMALS; ANTIGENS, CD2; CELL PROLIFERATION; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; FETAL BLOOD; HUMANS; IMMUNOLOGICAL SYNAPSES; IMMUNOTHERAPY, ADOPTIVE; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; INTERLEUKIN-2; KILLER CELLS, NATURAL; LEUKEMIA, MYELOID, ACUTE; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, KNOCKOUT; MICE, SCID; PERFORIN; RECEPTOR AGGREGATION;

EID: 77955172722     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3181e475e9     Document Type: Article

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