Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macrophages: A potential mechanism of immune escape

Cancer Letters

Volumn 317, Issue 1, 2012, Pages 99-105

  Chen, Cheng ^a   Qu, Qiu Xia ^a   Shen, Yu ^a   Mu, Chuan Yong ^a   Zhu, Yi Bei ^b   Zhang, Xue Guang ^a,b   Huang, Jian An ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

B7 H4; Lung cancer; Tumor associated macrophages

Indexed keywords

ONCOPROTEIN; V SET DOMAIN CONTAINING T CELL ACTIVATION INHIBITOR 1;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; FEMALE; GENETIC TRANSFORMATION; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; INTERFERON-GAMMA; INTERLEUKIN-10; LYMPHOCYTES, TUMOR-INFILTRATING; MACROPHAGES; MICE; MICE, INBRED C57BL; RNA, MESSENGER; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; TUMOR ESCAPE; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1;

EID: 84856356091     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.11.017     Document Type: Article

References (21)

1. J.B. Swann, M.J. Smyth. Immune surveillance of tumors, J. Clin. Invest. 117 (2007) 1137-1146.
2. Koukourakis M.I., Giatromanolaki A., Harris A.L., Sivridis E. Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res. 2006, 66:632-637.
3. Mahipal A., Terai M., Berd D., Chervoneva I., Patel K., Mastrangelo M.J., Sato T. Tumor-derived interleukin-10 as a prognostic factor in stage III patients undergoing adjuvant treatment with an autologous melanoma cell vaccine. Cancer Immunol. Immunother. 2011, 7:1039-1045.
4. Dong H., Chen L. B7-H1 pathway and its role in the evasion of tumor immunity. J. Mol. Med. 2003, 81:281-287.
5. Chavin G., Sheinin Y., Crispen P.L., Boorjian S.A., Roth T.J., Rangel L., Blute M.L., Sebo T.J., Tindall D.J., Kwon E.D., Karnes R.J. Expression of immunosuppresive B7-H3 ligand by hormone-treated prostate cancer tumors and metastases. Clin. Cancer Res. 2009, 15:2174-2180.
6. Reiman Jennifer M., Kmieciak Maciej, Manjili Masoud H., Knutson Keith L. Tumor immunoediting and immunosculpting pathways to cancer progression. Semin. Cancer Biol. 2007, 17:275-287.
7. Bui Jack D., Schreiber Robert D. Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?. Curr. Opin. Immunol. 2007, 19:203-208.
8. Sica G.L., Choi I.H., Zhu G., Tamada K., Wang S.D., Tamura H., Chapoval A.I., Flies D.B., Bajorath J., Chen L. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003, 18:849-861.
9. Kryczek I., Wei S., Zou L., Zhu G., Mottram P., Xu H., Chen L., Zou W. Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. J. Immunol. 2006, 177:40-44.
10. Mugler K.C., Singh M., Tringler B., Torkko K.C., Liu W., Papkoff J., Shroyer K.R. B7-h4 expression in a range of breast pathology: correlation with tumor T-cell infiltration. Appl. Immunohistochem. Mol. Morphol. 2007, 15:363-370.
11. Miyatake T., Tringler B., Liu W., Liu S.H., Papkoff J., Enomoto T., Torkko K.C., Dehn D.L., Swisher A., Shroyer K.R. B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. Gynecol. Oncol. 2007, 106:119-127.
12. Cheng L., Jiang J., Gao R., Wei S., Nan F., Li S., Kong B. B7-H4 expression promotes tumorigenesis in ovarian cancer. Int. J. Gynecol. Cancer 2009, 19:481-1486.
13. Sun Y., Wang Y., Zhao J., Gu M., Giscombe R., Lefvert A.K., Wang X. B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer 2006, 53:143-151.
14. Bunt S.K., Yang L., Sinha P., Clements V.K., Leips J., Ostrand Rosenberg S. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloidderived suppressor cells and limits tumor progression. Cancer Res. 2007, 67:10019-10026.
15. Karin M., Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 2005, 5:749-759.
16. Mantovani A., Schioppa T., Porta C., Allavena P. And Sica A: role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev. 2006, 25:315-322.
17. Antonio S., Alessandra S., Alberto M. Tumor-associated macrophages: a molecular perspective. Int. Immunopharmacol. 2002, 2:1045-1054.
18. Alberto M., Antonio S., Paola A., Cecilia G., Massimo L. Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum. Immunol. 2009, 70:325-330.
19. Adam W.M., Rita M., Young I. Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) produce CCL22 which selectively recruits regulatory T-cells (Tregs) to the tumor microenvironment. FASEB J. 2008, 22:1078-1079.
20. Heusinkveld M., van Steenwijk P.J., Goedemans R., Ramwadhdoebe T.H., Gorter A., Welters M.J., van Hall T., van der Burg S.H. M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. J. Immunol. 2011, 187:1157-1165.
21. Chen C., Qu Q.X., Shen Y., Lv Y.T., Zhu Y.B., Zhang X.G., Huang J.A. Overexpression of B7-H4 in tumor infiltrated dendritic cells. J. Immunoass. Immunoch. 2011, 32:353-364.