메뉴 건너뛰기




Volumn 31, Issue 11, 2015, Pages 1531-1542

Advances in CRISPR/Cas9-mediated gene editing

Author keywords

CRISPR Cas9 system; Gene editing; Off target effect; Single guide RNA

Indexed keywords

DNA; RNA;

EID: 84949501101     PISSN: 10003061     EISSN: None     Source Type: Journal    
DOI: 10.13345/j.cjb.140589     Document Type: Review
Times cited : (10)

References (72)
  • 1
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thompsson KR, Capecchi MR. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell, 1987, 51(3): 503-512.
    • (1987) Cell , vol.51 , Issue.3 , pp. 503-512
    • Thompsson, K.R.1    Capecchi, M.R.2
  • 2
    • 84879264708 scopus 로고    scopus 로고
    • ZFN, TALEN, and CRISPR/Cas based methods for genome engineering
    • Thomas G, Charles A, Carlos F. ZFN, TALEN, and CRISPR/Cas based methods for genome engineering. Trends Biotechnol, 2013, 31(7): 397-405.
    • (2013) Trends Biotechnol , vol.31 , Issue.7 , pp. 397-405
    • Thomas, G.1    Charles, A.2    Carlos, F.3
  • 3
    • 84874608929 scopus 로고    scopus 로고
    • RNA-guided editing of bacterial genomes using CRISPR-Cas systems
    • Jiang W, Bikard D, Cox D. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol, 2013, 31(3): 233-239.
    • (2013) Nat Biotechnol , vol.31 , Issue.3 , pp. 233-239
    • Jiang, W.1    Bikard, D.2    Cox, D.3
  • 4
    • 84876575031 scopus 로고    scopus 로고
    • Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
    • James E, Julie EN, Prashant M. Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res, 2013, 41(7): 4336-4343.
    • (2013) Nucleic Acids Res , vol.41 , Issue.7 , pp. 4336-4343
    • James, E.1    Julie, E.N.2    Prashant, M.3
  • 5
    • 84881475586 scopus 로고    scopus 로고
    • Heritable genome editing in C. elegans via a CRISPR-Cas9 system
    • Friedland AE, Tzur YB, Esvelt KM, et al. Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat Methods, 2013, 10(8): 741-743.
    • (2013) Nat Methods , vol.10 , Issue.8 , pp. 741-743
    • Friedland, A.E.1    Tzur, Y.B.2    Esvelt, K.M.3
  • 6
    • 84892437994 scopus 로고    scopus 로고
    • Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system
    • Andrew RB, Charlotte T, Chris PP. Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Rep, 2013, 4(1): 220-228.
    • (2013) Cell Rep , vol.4 , Issue.1 , pp. 220-228
    • Andrew, R.B.1    Charlotte, T.2    Chris, P.P.3
  • 7
    • 84876409836 scopus 로고    scopus 로고
    • Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos
    • Chang N, Sun C, Gao L. Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res, 2013, 23(4): 465-472.
    • (2013) Cell Res , vol.23 , Issue.4 , pp. 465-472
    • Chang, N.1    Sun, C.2    Gao, L.3
  • 8
    • 84882788354 scopus 로고    scopus 로고
    • Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
    • Jao LE, Wente SR, Chen W. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci USA, 2013, 110(34): 13904-13909.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.34 , pp. 13904-13909
    • Jao, L.E.1    Wente, S.R.2    Chen, W.3
  • 9
    • 84877103949 scopus 로고    scopus 로고
    • Generation of gene-modified mice via Cas9/RNA-mediated gene targeting
    • Shen B, Zhang J, Wu H. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res, 2013, 23(5): 720-723.
    • (2013) Cell Res , vol.23 , Issue.5 , pp. 720-723
    • Shen, B.1    Zhang, J.2    Wu, H.3
  • 10
    • 84883779087 scopus 로고    scopus 로고
    • Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
    • Wei L, Fei T, Tianda L, et al. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat Biotechnol, 2013, 31(8): 684-686.
    • (2013) Nat Biotechnol , vol.31 , Issue.8 , pp. 684-686
    • Wei, L.1    Fei, T.2    Tianda, L.3
  • 11
    • 84885181396 scopus 로고    scopus 로고
    • Efficient genome editing in plants using a CRISPR/Cas system
    • Feng ZY, Zhang BT, Ding WN. Efficient genome editing in plants using a CRISPR/Cas system. Cell Res, 2013, 23(10): 1229-1232.
    • (2013) Cell Res , vol.23 , Issue.10 , pp. 1229-1232
    • Feng, Z.Y.1    Zhang, B.T.2    Ding, W.N.3
  • 12
    • 84894321885 scopus 로고    scopus 로고
    • Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system
    • Liang Z, Zhang K, Chen KL, et al. Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system. J Genet Genomics, 2014, 41(2): 63-68.
    • (2014) J Genet Genomics , vol.41 , Issue.2 , pp. 63-68
    • Liang, Z.1    Zhang, K.2    Chen, K.L.3
  • 13
    • 85042815594 scopus 로고    scopus 로고
    • Targeted genome modification of crop plants using a CRISPR-Cas system
    • Shan QW, Wang Y, Li J, et al. Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol, 2013, 31(8): 686-688.
    • (2013) Nat Biotechnol , vol.31 , Issue.8 , pp. 686-688
    • Shan, Q.W.1    Wang, Y.2    Li, J.3
  • 14
    • 84873734105 scopus 로고    scopus 로고
    • RNA-guided human genome engineering via Cas9
    • Mali P, Yang L, Esvelt KM, et al. RNA-guided human genome engineering via Cas9. Science, 2013, 339(6121): 823-826.
    • (2013) Science , vol.339 , Issue.6121 , pp. 823-826
    • Mali, P.1    Yang, L.2    Esvelt, K.M.3
  • 15
    • 0023600057 scopus 로고
    • Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli and identification of the gene product
    • Ishino Y, Shinagawa H, Makino K. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli and identification of the gene product. J Bacteriol, 1987, 169(12): 5429-5433.
    • (1987) J Bacteriol , vol.169 , Issue.12 , pp. 5429-5433
    • Ishino, Y.1    Shinagawa, H.2    Makino, K.3
  • 16
    • 33748096466 scopus 로고    scopus 로고
    • A putative viral defence mechanism in archaeal cells
    • Lillestøl R, Redder P, Garrett RA. A putative viral defence mechanism in archaeal cells. Archaea, 2006, 2(1): 59-72.
    • (2006) Archaea , vol.2 , Issue.1 , pp. 59-72
    • Lillestøl, R.1    Redder, P.2    Garrett, R.A.3
  • 17
    • 0036692993 scopus 로고    scopus 로고
    • Bacteriophage-resistance systems in dairy starter strains, molecular analysis to application
    • Coffey A, Ross RP. Bacteriophage-resistance systems in dairy starter strains, molecular analysis to application. Anton Leeuw, 2002, 82(1): 303-321.
    • (2002) Anton Leeuw , vol.82 , Issue.1 , pp. 303-321
    • Coffey, A.1    Ross, R.P.2
  • 18
    • 0036267740 scopus 로고    scopus 로고
    • Identification of genes that are associated with DNA repeats in prokaryotes
    • Jansen R, Embden JD, Gaastra W. Identification of genes that are associated with DNA repeats in prokaryotes. Mol Microbiol, 2002, 43(6): 1565-1575.
    • (2002) Mol Microbiol , vol.43 , Issue.6 , pp. 1565-1575
    • Jansen, R.1    Embden, J.D.2    Gaastra, W.3
  • 19
    • 34250662138 scopus 로고    scopus 로고
    • The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats
    • Grissa I, Vergnaud G, Pourcel C. The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats. BMC Bioinformatics, 2007, 8(1): 172-181.
    • (2007) BMC Bioinformatics , vol.8 , Issue.1 , pp. 172-181
    • Grissa, I.1    Vergnaud, G.2    Pourcel, C.3
  • 20
    • 77953633943 scopus 로고    scopus 로고
    • The discovery of zinc fingers and their applications in gene regulation and genome manipulation
    • Klug A. The discovery of zinc fingers and their applications in gene regulation and genome manipulation. Q Rev Biophys, 2010, 79: 213-231.
    • (2010) Q Rev Biophys , vol.79 , pp. 213-231
    • Klug, A.1
  • 21
    • 72149110399 scopus 로고    scopus 로고
    • Breaking the code of DNA binding specificity of TAL-type III effectors
    • Boch J, Scholze H, Schornack S. Breaking the code of DNA binding specificity of TAL-type III effectors. Science, 2009, 326(5959): 1509-1512.
    • (2009) Science , vol.326 , Issue.5959 , pp. 1509-1512
    • Boch, J.1    Scholze, H.2    Schornack, S.3
  • 22
    • 23844505202 scopus 로고    scopus 로고
    • Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extra-chromosomal origin
    • Bolotin A, Quinquis B, Sorokin A. Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extra-chromosomal origin. Microbiology, 2005, 151(8): 2551-2561.
    • (2005) Microbiology , vol.151 , Issue.8 , pp. 2551-2561
    • Bolotin, A.1    Quinquis, B.2    Sorokin, A.3
  • 23
    • 16444385662 scopus 로고    scopus 로고
    • Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
    • Mojica FJ, Diez VC, Garcia MJ. Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J Mol Evol, 2005, 60(2): 174-182.
    • (2005) J Mol Evol , vol.60 , Issue.2 , pp. 174-182
    • Mojica, F.J.1    Diez, V.C.2    Garcia, M.J.3
  • 24
    • 34047118522 scopus 로고    scopus 로고
    • CRISPR provides acquired resistance against viruses in prokaryotes
    • Barrangou R, Fremaux C, Deveau H. CRISPR provides acquired resistance against viruses in prokaryotes. Science, 2007, 315(5819): 1709-1712.
    • (2007) Science , vol.315 , Issue.5819 , pp. 1709-1712
    • Barrangou, R.1    Fremaux, C.2    Deveau, H.3
  • 25
    • 57849137502 scopus 로고    scopus 로고
    • CRISPR interference limits horizontal gene transfer in Staphylococci by targeting DNA
    • Marraffini LA, Sontheimer EJ. CRISPR interference limits horizontal gene transfer in Staphylococci by targeting DNA. Science, 2008, 322(5909): 1843-1845.
    • (2008) Science , vol.322 , Issue.5909 , pp. 1843-1845
    • Marraffini, L.A.1    Sontheimer, E.J.2
  • 26
    • 0036267740 scopus 로고    scopus 로고
    • Identification of genes that are associated with DNA repeats in prokaryotes
    • Jansen R, Embden JD, Gaastra W. Identification of genes that are associated with DNA repeats in prokaryotes. Mol Microbiol, 2002, 43(6): 1565-1575.
    • (2002) Mol Microbiol , vol.43 , Issue.6 , pp. 1565-1575
    • Jansen, R.1    Embden, J.D.2    Gaastra, W.3
  • 27
    • 35748974534 scopus 로고    scopus 로고
    • Evolutionary conservation of sequence and secondary structures in CRISPR repeats
    • Kunin V, Sorek R, Hugenholtz P. Evolutionary conservation of sequence and secondary structures in CRISPR repeats. Genome Biol, 2007, 8(4): R61.
    • (2007) Genome Biol , vol.8 , Issue.4 , pp. R61
    • Kunin, V.1    Sorek, R.2    Hugenholtz, P.3
  • 28
    • 15844390228 scopus 로고    scopus 로고
    • CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
    • Pouecel C, Salvignol G, Vergnaud G. CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Microbiology, 2005, 151(3): 653-663.
    • (2005) Microbiology , vol.151 , Issue.3 , pp. 653-663
    • Pouecel, C.1    Salvignol, G.2    Vergnaud, G.3
  • 29
    • 0029166294 scopus 로고
    • Long stretches of short tandem repeats are present in the largest replicons of the Archaea Halofera mediterranei and Halofera volcanii and could be involved in replicon partitioning
    • Mojica FJ, Ferrer C, Juez G. Long stretches of short tandem repeats are present in the largest replicons of the Archaea Halofera mediterranei and Halofera volcanii and could be involved in replicon partitioning. Mol Microbiol, 1995, 17(1): 85-93.
    • (1995) Mol Microbiol , vol.17 , Issue.1 , pp. 85-93
    • Mojica, F.J.1    Ferrer, C.2    Juez, G.3
  • 30
    • 58349087246 scopus 로고    scopus 로고
    • Germ warfare in a microbial matcommunity: CRISPR provide insights into the co-evolution of host and viral genomes
    • Heidelberg JF, Nelson WC, Schoenfeld T. Germ warfare in a microbial matcommunity: CRISPR provide insights into the co-evolution of host and viral genomes. PLoS ONE, 2009, 4(1): e4169.
    • (2009) PLoS ONE , vol.4 , Issue.1 , pp. e4169
    • Heidelberg, J.F.1    Nelson, W.C.2    Schoenfeld, T.3
  • 31
    • 49649114086 scopus 로고    scopus 로고
    • Small CRISPR RNAs guide antiviral defense in prokaryotes
    • Brouns SJ, Jore MM, Lundgren M. Small CRISPR RNAs guide antiviral defense in prokaryotes. Science, 2008, 321(5891): 960-964.
    • (2008) Science , vol.321 , Issue.5891 , pp. 960-964
    • Brouns, S.J.1    Jore, M.M.2    Lundgren, M.3
  • 32
    • 78149261827 scopus 로고    scopus 로고
    • The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
    • Garneau JE, Dupuis M, Villion M. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature, 2010, 468(7320): 67-71.
    • (2010) Nature , vol.468 , Issue.7320 , pp. 67-71
    • Garneau, J.E.1    Dupuis, M.2    Villion, M.3
  • 33
    • 34248400310 scopus 로고    scopus 로고
    • A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
    • Haft DH, Selengut J, Mongodin EF, et al. A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. PLoS Comput Biol, 2005, 1(6): 474-483.
    • (2005) PLoS Comput Biol , vol.1 , Issue.6 , pp. 474-483
    • Haft, D.H.1    Selengut, J.2    Mongodin, E.F.3
  • 34
    • 79956157571 scopus 로고    scopus 로고
    • Evolution and classification of the CRISPR-Cas systems
    • Makarova KS, Haft DH, Barrangou R. Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol, 2011, 9(6): 467-477.
    • (2011) Nat Rev Microbiol , vol.9 , Issue.6 , pp. 467-477
    • Makarova, K.S.1    Haft, D.H.2    Barrangou, R.3
  • 35
    • 79960554003 scopus 로고    scopus 로고
    • Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
    • Makarova KS, Aravind L, Wolf YI, et al. Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Biol Direct, 2011, 6(38): 1-27.
    • (2011) Biol Direct , vol.6 , Issue.38 , pp. 1-27
    • Makarova, K.S.1    Aravind, L.2    Wolf, Y.I.3
  • 36
    • 79958848350 scopus 로고    scopus 로고
    • Recognition and maturation of effector RNAs in a CRISPR interference pathway
    • Gesner EM, Schellenberg MJ, Garside EL. Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat Struct Mol Biol, 2011, 18(6): 688-692.
    • (2011) Nat Struct Mol Biol , vol.18 , Issue.6 , pp. 688-692
    • Gesner, E.M.1    Schellenberg, M.J.2    Garside, E.L.3
  • 37
    • 79958825675 scopus 로고    scopus 로고
    • An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3
    • Sashital DG, Jinek M, Doudns JA. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nat Struct Molr Biol, 2011, 18(6): 680-687.
    • (2011) Nat Struct Molr Biol , vol.18 , Issue.6 , pp. 680-687
    • Sashital, D.G.1    Jinek, M.2    Doudns, J.A.3
  • 38
    • 79251598240 scopus 로고    scopus 로고
    • The structure of the CRISPR-associated protein Cas3 provides insight into the regulation of the CRISPR/Cas system
    • Lintner NG, Frankel KA, Tsutakawa SE. The structure of the CRISPR-associated protein Cas3 provides insight into the regulation of the CRISPR/Cas system. J Mol Biol, 2011, 405(4): 939-955.
    • (2011) J Mol Biol , vol.405 , Issue.4 , pp. 939-955
    • Lintner, N.G.1    Frankel, K.A.2    Tsutakawa, S.E.3
  • 39
    • 79953250082 scopus 로고    scopus 로고
    • CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
    • Deltcheva E, Chylinski K, Sharma CM. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature, 2011, 471(7340): 602-607.
    • (2011) Nature , vol.471 , Issue.7340 , pp. 602-607
    • Deltcheva, E.1    Chylinski, K.2    Sharma, C.M.3
  • 40
    • 84895871173 scopus 로고    scopus 로고
    • DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
    • Sternberg SH, Redding S, Jinek M, et al. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature, 2014, 507(7490): 62-67.
    • (2014) Nature , vol.507 , Issue.7490 , pp. 62-67
    • Sternberg, S.H.1    Redding, S.2    Jinek, M.3
  • 41
    • 49649120271 scopus 로고    scopus 로고
    • A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats
    • Beloglazova N, Brown G, Zimmerman MD. A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. J Biochem, 2008, 283(29): 20361-20371.
    • (2008) J Biochem , vol.283 , Issue.29 , pp. 20361-20371
    • Beloglazova, N.1    Brown, G.2    Zimmerman, M.D.3
  • 42
    • 67149084593 scopus 로고    scopus 로고
    • Analysis of CRISPR system function in plant pathogen Xanthomonas oryzae
    • Semenova E, Nagornykh M, Pyatnitskiy M. Analysis of CRISPR system function in plant pathogen Xanthomonas oryzae. FEMS Microbiol Lett, 2009, 296(1): 110-116.
    • (2009) FEMS Microbiol Lett , vol.296 , Issue.1 , pp. 110-116
    • Semenova, E.1    Nagornykh, M.2    Pyatnitskiy, M.3
  • 43
    • 84872034396 scopus 로고    scopus 로고
    • The double-edged sword of CRISPR-Cas systems
    • Villion M, Moineau S. The double-edged sword of CRISPR-Cas systems. Cell Res, 2013, 23(1): 15-17.
    • (2013) Cell Res , vol.23 , Issue.1 , pp. 15-17
    • Villion, M.1    Moineau, S.2
  • 44
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • Jinek M, Chylinski K, Fonfara I. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science, 2012, 337(6096): 816-821.
    • (2012) Science , vol.337 , Issue.6096 , pp. 816-821
    • Jinek, M.1    Chylinski, K.2    Fonfara, I.3
  • 45
    • 84887104139 scopus 로고    scopus 로고
    • Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
    • Kevin ME, Prashant M, Jonathan LB. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods, 2013, 10(11): 1116-1121.
    • (2013) Nat Methods , vol.10 , Issue.11 , pp. 1116-1121
    • Kevin, M.E.1    Prashant, M.2    Jonathan, L.B.3
  • 46
    • 84884663630 scopus 로고    scopus 로고
    • Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
    • Hou Z, Zhang Y, Propson NE. Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci USA, 2013, 110(39): 15644-15649.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.39 , pp. 15644-15649
    • Hou, Z.1    Zhang, Y.2    Propson, N.E.3
  • 48
    • 84884165315 scopus 로고    scopus 로고
    • DNA targeting specificity of RNA-guided Cas9 nucleases
    • Patrick DH, David A, Joshua AW, et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol, 2013, 31(9): 827-832.
    • (2013) Nat Biotechnol , vol.31 , Issue.9 , pp. 827-832
    • Patrick, D.H.1    David, A.2    Joshua, A.W.3
  • 49
    • 84874617789 scopus 로고    scopus 로고
    • Efficient genome editing in zebrafish using a CRISPR-Cas system
    • Hwang WY, Fu Y, Reyon D, et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol, 2013, 31(3): 227-229.
    • (2013) Nat Biotechnol , vol.31 , Issue.3 , pp. 227-229
    • Hwang, W.Y.1    Fu, Y.2    Reyon, D.3
  • 50
    • 84892765883 scopus 로고    scopus 로고
    • Genome-scale CRISPR-Cas9 knockout screening in human cells
    • Shalem O, Sanjana NE, Hartenian E. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science, 2014, 343(6166): 84-87.
    • (2014) Science , vol.343 , Issue.6166 , pp. 84-87
    • Shalem, O.1    Sanjana, N.E.2    Hartenian, E.3
  • 51
    • 84892749369 scopus 로고    scopus 로고
    • Genetic screens in human cells using the CRISPR/Cas9 system
    • Wang T, Wei JJ, Sabatini DM. Genetic screens in human cells using the CRISPR/Cas9 system. Science, 2014, 343(6166): 80-84.
    • (2014) Science , vol.343 , Issue.6166 , pp. 80-84
    • Wang, T.1    Wei, J.J.2    Sabatini, D.M.3
  • 52
    • 84903975411 scopus 로고    scopus 로고
    • Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/Cas9
    • Shen B, Brown KM, Lee TD. Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/Cas9. MBio, 2014, 5(3): e01114.
    • (2014) MBio , vol.5 , Issue.3
    • Shen, B.1    Brown, K.M.2    Lee, T.D.3
  • 53
    • 84892771868 scopus 로고    scopus 로고
    • Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis
    • Guo X, Zhang T, Hu Z. Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development, 2014, 141(3): 707-714.
    • (2014) Development , vol.141 , Issue.3 , pp. 707-714
    • Guo, X.1    Zhang, T.2    Hu, Z.3
  • 54
    • 84894081986 scopus 로고    scopus 로고
    • Generation of gene modified cynomolgus monkey via Cas9/RNA mediated gene targeting in one-cell embryos
    • Niu Y, Shen B, Cui YQ. Generation of gene modified cynomolgus monkey via Cas9/RNA mediated gene targeting in one-cell embryos. Cell, 2014, 156(4): 836-843.
    • (2014) Cell , vol.156 , Issue.4 , pp. 836-843
    • Niu, Y.1    Shen, B.2    Cui, Y.Q.3
  • 55
    • 84897594300 scopus 로고    scopus 로고
    • One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
    • Hai T, Teng F, Guo RF, et al. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res, 2014, 24(3): 372-375.
    • (2014) Cell Res , vol.24 , Issue.3 , pp. 372-375
    • Hai, T.1    Teng, F.2    Guo, R.F.3
  • 56
    • 84921521153 scopus 로고    scopus 로고
    • CRISPR/Cas9 nuclease-mediated gene knock-in in bovine-induced pluripotent cells
    • Heo YT, Quan X, Xu YN, et al. CRISPR/Cas9 nuclease-mediated gene knock-in in bovine-induced pluripotent cells. Stem Cells Dev, 2015, 24(3): 393-402.
    • (2015) Stem Cells Dev , vol.24 , Issue.3 , pp. 393-402
    • Heo, Y.T.1    Quan, X.2    Xu, Y.N.3
  • 57
    • 84921556331 scopus 로고    scopus 로고
    • One-step generation of myostatin gene knockout sheep via the CRISPR/Cas9 system
    • Han HB, Ma YH, Wang T, et al. One-step generation of myostatin gene knockout sheep via the CRISPR/Cas9 system. Front Agr Sci Eng, 2014, 1(1): 2-5.
    • (2014) Front Agr Sci Eng , vol.1 , Issue.1 , pp. 2-5
    • Han, H.B.1    Ma, Y.H.2    Wang, T.3
  • 58
    • 84883785822 scopus 로고    scopus 로고
    • Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9
    • Li JF, Norville JE, Aach J, et al. Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol, 2013, 31(8): 688-691.
    • (2013) Nat Biotechnol , vol.31 , Issue.8 , pp. 688-691
    • Li, J.F.1    Norville, J.E.2    Aach, J.3
  • 59
    • 33745577150 scopus 로고    scopus 로고
    • A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
    • Clop A, Marcq F, Takeda H. A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nat Genet, 2006, 38(7): 813-818.
    • (2006) Nat Genet , vol.38 , Issue.7 , pp. 813-818
    • Clop, A.1    Marcq, F.2    Takeda, H.3
  • 60
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang H, Yang H, Shivalila CS. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell, 2013, 153(4): 910-918.
    • (2013) Cell , vol.153 , Issue.4 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3
  • 61
    • 84890050551 scopus 로고    scopus 로고
    • Correction of a genetic disease in mouse via use of CRISPR-Cas9
    • Wu Y, Liang D, Wang YH. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell, 2013, 13(6): 659-662.
    • (2013) Cell Stem Cell , vol.13 , Issue.6 , pp. 659-662
    • Wu, Y.1    Liang, D.2    Wang, Y.H.3
  • 62
    • 84890033064 scopus 로고    scopus 로고
    • Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
    • Schwank G, Koo BK, Sasselli V, et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell, 2013, 13(6): 653-658.
    • (2013) Cell Stem Cell , vol.13 , Issue.6 , pp. 653-658
    • Schwank, G.1    Koo, B.K.2    Sasselli, V.3
  • 63
    • 84877782955 scopus 로고    scopus 로고
    • A CRISPR-CAS system mediates bacterial innate immune evasion and virulence
    • Sampson TR, Saroj SD, Llewellyn AC. A CRISPR-CAS system mediates bacterial innate immune evasion and virulence. Nature, 2013, 497(7448): 254-257.
    • (2013) Nature , vol.497 , Issue.7448 , pp. 254-257
    • Sampson, T.R.1    Saroj, S.D.2    Llewellyn, A.C.3
  • 64
    • 84949523640 scopus 로고    scopus 로고
    • CRISPR technology leaps from lab to industry
    • Helen S. CRISPR technology leaps from lab to industry. J Nematol, 2014, 46(2): 130-260.
    • (2014) J Nematol , vol.46 , Issue.2 , pp. 130-260
    • Helen, S.1
  • 65
    • 84880570576 scopus 로고    scopus 로고
    • High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
    • Fu Y, Foden JA, Khayter C. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol, 2013, 31(9): 822-826.
    • (2013) Nat Biotechnol , vol.31 , Issue.9 , pp. 822-826
    • Fu, Y.1    Foden, J.A.2    Khayter, C.3
  • 66
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong L, Ran FA, Cox D, et al. Multiplex genome engineering using CRISPR/Cas systems. Science, 2013, 339(6121): 819-823.
    • (2013) Science , vol.339 , Issue.6121 , pp. 819-823
    • Cong, L.1    Ran, F.A.2    Cox, D.3
  • 67
    • 84903545084 scopus 로고    scopus 로고
    • Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
    • Cem K, Sevki A, Ritambhara S, et al. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease. Nat Biotechnol, 2014, 32(7): 677-683.
    • (2014) Nat Biotechnol , vol.32 , Issue.7 , pp. 677-683
    • Cem, K.1    Sevki, A.2    Ritambhara, S.3
  • 68
    • 84884155038 scopus 로고    scopus 로고
    • High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
    • Vikram P, Steven L, John PG, et al. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat Biotechnol, 2013, 31(9): 839-843.
    • (2013) Nat Biotechnol , vol.31 , Issue.9 , pp. 839-843
    • Vikram, P.1    Steven, L.2    John, P.G.3
  • 69
    • 84884288934 scopus 로고    scopus 로고
    • Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
    • Ran FA, Hsu PD, Lin CY, et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell, 2013, 154(6): 1380-1389.
    • (2013) Cell , vol.154 , Issue.6 , pp. 1380-1389
    • Ran, F.A.1    Hsu, P.D.2    Lin, C.Y.3
  • 70
    • 84874687019 scopus 로고    scopus 로고
    • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    • Qi LS, Larson MH, Gilbert LA, et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell, 2013, 152(5): 1173-1183.
    • (2013) Cell , vol.152 , Issue.5 , pp. 1173-1183
    • Qi, L.S.1    Larson, M.H.2    Gilbert, L.A.3
  • 71
    • 84893157352 scopus 로고    scopus 로고
    • Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
    • Martin J, Fuguo J, David WT, et al. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science, 2014, 43(6176): 1247997.
    • (2014) Science , vol.43 , Issue.6176
    • Martin, J.1    Fuguo, J.2    David, W.T.3
  • 72
    • 84913568580 scopus 로고    scopus 로고
    • Programmable RNA recognition and cleavage by CRISPR/Cas9
    • O'Connell MR, Oakes BL, Sternberg SH, et al. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature, 2014, 516(7530): 263-266.
    • (2014) Nature , vol.516 , Issue.7530 , pp. 263-266
    • O'Connell, M.R.1    Oakes, B.L.2    Sternberg, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.