-
1
-
-
0023646810
-
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
-
Thompsson KR, Capecchi MR. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell, 1987, 51(3): 503-512.
-
(1987)
Cell
, vol.51
, Issue.3
, pp. 503-512
-
-
Thompsson, K.R.1
Capecchi, M.R.2
-
2
-
-
84879264708
-
ZFN, TALEN, and CRISPR/Cas based methods for genome engineering
-
Thomas G, Charles A, Carlos F. ZFN, TALEN, and CRISPR/Cas based methods for genome engineering. Trends Biotechnol, 2013, 31(7): 397-405.
-
(2013)
Trends Biotechnol
, vol.31
, Issue.7
, pp. 397-405
-
-
Thomas, G.1
Charles, A.2
Carlos, F.3
-
3
-
-
84874608929
-
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
-
Jiang W, Bikard D, Cox D. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol, 2013, 31(3): 233-239.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.3
, pp. 233-239
-
-
Jiang, W.1
Bikard, D.2
Cox, D.3
-
4
-
-
84876575031
-
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
-
James E, Julie EN, Prashant M. Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res, 2013, 41(7): 4336-4343.
-
(2013)
Nucleic Acids Res
, vol.41
, Issue.7
, pp. 4336-4343
-
-
James, E.1
Julie, E.N.2
Prashant, M.3
-
5
-
-
84881475586
-
Heritable genome editing in C. elegans via a CRISPR-Cas9 system
-
Friedland AE, Tzur YB, Esvelt KM, et al. Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat Methods, 2013, 10(8): 741-743.
-
(2013)
Nat Methods
, vol.10
, Issue.8
, pp. 741-743
-
-
Friedland, A.E.1
Tzur, Y.B.2
Esvelt, K.M.3
-
6
-
-
84892437994
-
Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system
-
Andrew RB, Charlotte T, Chris PP. Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Rep, 2013, 4(1): 220-228.
-
(2013)
Cell Rep
, vol.4
, Issue.1
, pp. 220-228
-
-
Andrew, R.B.1
Charlotte, T.2
Chris, P.P.3
-
7
-
-
84876409836
-
Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos
-
Chang N, Sun C, Gao L. Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res, 2013, 23(4): 465-472.
-
(2013)
Cell Res
, vol.23
, Issue.4
, pp. 465-472
-
-
Chang, N.1
Sun, C.2
Gao, L.3
-
8
-
-
84882788354
-
Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
-
Jao LE, Wente SR, Chen W. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci USA, 2013, 110(34): 13904-13909.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.34
, pp. 13904-13909
-
-
Jao, L.E.1
Wente, S.R.2
Chen, W.3
-
9
-
-
84877103949
-
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting
-
Shen B, Zhang J, Wu H. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res, 2013, 23(5): 720-723.
-
(2013)
Cell Res
, vol.23
, Issue.5
, pp. 720-723
-
-
Shen, B.1
Zhang, J.2
Wu, H.3
-
10
-
-
84883779087
-
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
-
Wei L, Fei T, Tianda L, et al. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat Biotechnol, 2013, 31(8): 684-686.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.8
, pp. 684-686
-
-
Wei, L.1
Fei, T.2
Tianda, L.3
-
11
-
-
84885181396
-
Efficient genome editing in plants using a CRISPR/Cas system
-
Feng ZY, Zhang BT, Ding WN. Efficient genome editing in plants using a CRISPR/Cas system. Cell Res, 2013, 23(10): 1229-1232.
-
(2013)
Cell Res
, vol.23
, Issue.10
, pp. 1229-1232
-
-
Feng, Z.Y.1
Zhang, B.T.2
Ding, W.N.3
-
12
-
-
84894321885
-
Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system
-
Liang Z, Zhang K, Chen KL, et al. Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system. J Genet Genomics, 2014, 41(2): 63-68.
-
(2014)
J Genet Genomics
, vol.41
, Issue.2
, pp. 63-68
-
-
Liang, Z.1
Zhang, K.2
Chen, K.L.3
-
13
-
-
85042815594
-
Targeted genome modification of crop plants using a CRISPR-Cas system
-
Shan QW, Wang Y, Li J, et al. Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol, 2013, 31(8): 686-688.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.8
, pp. 686-688
-
-
Shan, Q.W.1
Wang, Y.2
Li, J.3
-
14
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali P, Yang L, Esvelt KM, et al. RNA-guided human genome engineering via Cas9. Science, 2013, 339(6121): 823-826.
-
(2013)
Science
, vol.339
, Issue.6121
, pp. 823-826
-
-
Mali, P.1
Yang, L.2
Esvelt, K.M.3
-
15
-
-
0023600057
-
Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli and identification of the gene product
-
Ishino Y, Shinagawa H, Makino K. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli and identification of the gene product. J Bacteriol, 1987, 169(12): 5429-5433.
-
(1987)
J Bacteriol
, vol.169
, Issue.12
, pp. 5429-5433
-
-
Ishino, Y.1
Shinagawa, H.2
Makino, K.3
-
16
-
-
33748096466
-
A putative viral defence mechanism in archaeal cells
-
Lillestøl R, Redder P, Garrett RA. A putative viral defence mechanism in archaeal cells. Archaea, 2006, 2(1): 59-72.
-
(2006)
Archaea
, vol.2
, Issue.1
, pp. 59-72
-
-
Lillestøl, R.1
Redder, P.2
Garrett, R.A.3
-
17
-
-
0036692993
-
Bacteriophage-resistance systems in dairy starter strains, molecular analysis to application
-
Coffey A, Ross RP. Bacteriophage-resistance systems in dairy starter strains, molecular analysis to application. Anton Leeuw, 2002, 82(1): 303-321.
-
(2002)
Anton Leeuw
, vol.82
, Issue.1
, pp. 303-321
-
-
Coffey, A.1
Ross, R.P.2
-
18
-
-
0036267740
-
Identification of genes that are associated with DNA repeats in prokaryotes
-
Jansen R, Embden JD, Gaastra W. Identification of genes that are associated with DNA repeats in prokaryotes. Mol Microbiol, 2002, 43(6): 1565-1575.
-
(2002)
Mol Microbiol
, vol.43
, Issue.6
, pp. 1565-1575
-
-
Jansen, R.1
Embden, J.D.2
Gaastra, W.3
-
19
-
-
34250662138
-
The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats
-
Grissa I, Vergnaud G, Pourcel C. The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats. BMC Bioinformatics, 2007, 8(1): 172-181.
-
(2007)
BMC Bioinformatics
, vol.8
, Issue.1
, pp. 172-181
-
-
Grissa, I.1
Vergnaud, G.2
Pourcel, C.3
-
20
-
-
77953633943
-
The discovery of zinc fingers and their applications in gene regulation and genome manipulation
-
Klug A. The discovery of zinc fingers and their applications in gene regulation and genome manipulation. Q Rev Biophys, 2010, 79: 213-231.
-
(2010)
Q Rev Biophys
, vol.79
, pp. 213-231
-
-
Klug, A.1
-
21
-
-
72149110399
-
Breaking the code of DNA binding specificity of TAL-type III effectors
-
Boch J, Scholze H, Schornack S. Breaking the code of DNA binding specificity of TAL-type III effectors. Science, 2009, 326(5959): 1509-1512.
-
(2009)
Science
, vol.326
, Issue.5959
, pp. 1509-1512
-
-
Boch, J.1
Scholze, H.2
Schornack, S.3
-
22
-
-
23844505202
-
Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extra-chromosomal origin
-
Bolotin A, Quinquis B, Sorokin A. Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extra-chromosomal origin. Microbiology, 2005, 151(8): 2551-2561.
-
(2005)
Microbiology
, vol.151
, Issue.8
, pp. 2551-2561
-
-
Bolotin, A.1
Quinquis, B.2
Sorokin, A.3
-
23
-
-
16444385662
-
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
-
Mojica FJ, Diez VC, Garcia MJ. Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J Mol Evol, 2005, 60(2): 174-182.
-
(2005)
J Mol Evol
, vol.60
, Issue.2
, pp. 174-182
-
-
Mojica, F.J.1
Diez, V.C.2
Garcia, M.J.3
-
24
-
-
34047118522
-
CRISPR provides acquired resistance against viruses in prokaryotes
-
Barrangou R, Fremaux C, Deveau H. CRISPR provides acquired resistance against viruses in prokaryotes. Science, 2007, 315(5819): 1709-1712.
-
(2007)
Science
, vol.315
, Issue.5819
, pp. 1709-1712
-
-
Barrangou, R.1
Fremaux, C.2
Deveau, H.3
-
25
-
-
57849137502
-
CRISPR interference limits horizontal gene transfer in Staphylococci by targeting DNA
-
Marraffini LA, Sontheimer EJ. CRISPR interference limits horizontal gene transfer in Staphylococci by targeting DNA. Science, 2008, 322(5909): 1843-1845.
-
(2008)
Science
, vol.322
, Issue.5909
, pp. 1843-1845
-
-
Marraffini, L.A.1
Sontheimer, E.J.2
-
26
-
-
0036267740
-
Identification of genes that are associated with DNA repeats in prokaryotes
-
Jansen R, Embden JD, Gaastra W. Identification of genes that are associated with DNA repeats in prokaryotes. Mol Microbiol, 2002, 43(6): 1565-1575.
-
(2002)
Mol Microbiol
, vol.43
, Issue.6
, pp. 1565-1575
-
-
Jansen, R.1
Embden, J.D.2
Gaastra, W.3
-
27
-
-
35748974534
-
Evolutionary conservation of sequence and secondary structures in CRISPR repeats
-
Kunin V, Sorek R, Hugenholtz P. Evolutionary conservation of sequence and secondary structures in CRISPR repeats. Genome Biol, 2007, 8(4): R61.
-
(2007)
Genome Biol
, vol.8
, Issue.4
, pp. R61
-
-
Kunin, V.1
Sorek, R.2
Hugenholtz, P.3
-
28
-
-
15844390228
-
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
-
Pouecel C, Salvignol G, Vergnaud G. CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Microbiology, 2005, 151(3): 653-663.
-
(2005)
Microbiology
, vol.151
, Issue.3
, pp. 653-663
-
-
Pouecel, C.1
Salvignol, G.2
Vergnaud, G.3
-
29
-
-
0029166294
-
Long stretches of short tandem repeats are present in the largest replicons of the Archaea Halofera mediterranei and Halofera volcanii and could be involved in replicon partitioning
-
Mojica FJ, Ferrer C, Juez G. Long stretches of short tandem repeats are present in the largest replicons of the Archaea Halofera mediterranei and Halofera volcanii and could be involved in replicon partitioning. Mol Microbiol, 1995, 17(1): 85-93.
-
(1995)
Mol Microbiol
, vol.17
, Issue.1
, pp. 85-93
-
-
Mojica, F.J.1
Ferrer, C.2
Juez, G.3
-
30
-
-
58349087246
-
Germ warfare in a microbial matcommunity: CRISPR provide insights into the co-evolution of host and viral genomes
-
Heidelberg JF, Nelson WC, Schoenfeld T. Germ warfare in a microbial matcommunity: CRISPR provide insights into the co-evolution of host and viral genomes. PLoS ONE, 2009, 4(1): e4169.
-
(2009)
PLoS ONE
, vol.4
, Issue.1
, pp. e4169
-
-
Heidelberg, J.F.1
Nelson, W.C.2
Schoenfeld, T.3
-
31
-
-
49649114086
-
Small CRISPR RNAs guide antiviral defense in prokaryotes
-
Brouns SJ, Jore MM, Lundgren M. Small CRISPR RNAs guide antiviral defense in prokaryotes. Science, 2008, 321(5891): 960-964.
-
(2008)
Science
, vol.321
, Issue.5891
, pp. 960-964
-
-
Brouns, S.J.1
Jore, M.M.2
Lundgren, M.3
-
32
-
-
78149261827
-
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
-
Garneau JE, Dupuis M, Villion M. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature, 2010, 468(7320): 67-71.
-
(2010)
Nature
, vol.468
, Issue.7320
, pp. 67-71
-
-
Garneau, J.E.1
Dupuis, M.2
Villion, M.3
-
33
-
-
34248400310
-
A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
-
Haft DH, Selengut J, Mongodin EF, et al. A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. PLoS Comput Biol, 2005, 1(6): 474-483.
-
(2005)
PLoS Comput Biol
, vol.1
, Issue.6
, pp. 474-483
-
-
Haft, D.H.1
Selengut, J.2
Mongodin, E.F.3
-
34
-
-
79956157571
-
Evolution and classification of the CRISPR-Cas systems
-
Makarova KS, Haft DH, Barrangou R. Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol, 2011, 9(6): 467-477.
-
(2011)
Nat Rev Microbiol
, vol.9
, Issue.6
, pp. 467-477
-
-
Makarova, K.S.1
Haft, D.H.2
Barrangou, R.3
-
35
-
-
79960554003
-
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
-
Makarova KS, Aravind L, Wolf YI, et al. Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Biol Direct, 2011, 6(38): 1-27.
-
(2011)
Biol Direct
, vol.6
, Issue.38
, pp. 1-27
-
-
Makarova, K.S.1
Aravind, L.2
Wolf, Y.I.3
-
36
-
-
79958848350
-
Recognition and maturation of effector RNAs in a CRISPR interference pathway
-
Gesner EM, Schellenberg MJ, Garside EL. Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat Struct Mol Biol, 2011, 18(6): 688-692.
-
(2011)
Nat Struct Mol Biol
, vol.18
, Issue.6
, pp. 688-692
-
-
Gesner, E.M.1
Schellenberg, M.J.2
Garside, E.L.3
-
37
-
-
79958825675
-
An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3
-
Sashital DG, Jinek M, Doudns JA. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nat Struct Molr Biol, 2011, 18(6): 680-687.
-
(2011)
Nat Struct Molr Biol
, vol.18
, Issue.6
, pp. 680-687
-
-
Sashital, D.G.1
Jinek, M.2
Doudns, J.A.3
-
38
-
-
79251598240
-
The structure of the CRISPR-associated protein Cas3 provides insight into the regulation of the CRISPR/Cas system
-
Lintner NG, Frankel KA, Tsutakawa SE. The structure of the CRISPR-associated protein Cas3 provides insight into the regulation of the CRISPR/Cas system. J Mol Biol, 2011, 405(4): 939-955.
-
(2011)
J Mol Biol
, vol.405
, Issue.4
, pp. 939-955
-
-
Lintner, N.G.1
Frankel, K.A.2
Tsutakawa, S.E.3
-
39
-
-
79953250082
-
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
-
Deltcheva E, Chylinski K, Sharma CM. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature, 2011, 471(7340): 602-607.
-
(2011)
Nature
, vol.471
, Issue.7340
, pp. 602-607
-
-
Deltcheva, E.1
Chylinski, K.2
Sharma, C.M.3
-
40
-
-
84895871173
-
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
-
Sternberg SH, Redding S, Jinek M, et al. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature, 2014, 507(7490): 62-67.
-
(2014)
Nature
, vol.507
, Issue.7490
, pp. 62-67
-
-
Sternberg, S.H.1
Redding, S.2
Jinek, M.3
-
41
-
-
49649120271
-
A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats
-
Beloglazova N, Brown G, Zimmerman MD. A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. J Biochem, 2008, 283(29): 20361-20371.
-
(2008)
J Biochem
, vol.283
, Issue.29
, pp. 20361-20371
-
-
Beloglazova, N.1
Brown, G.2
Zimmerman, M.D.3
-
42
-
-
67149084593
-
Analysis of CRISPR system function in plant pathogen Xanthomonas oryzae
-
Semenova E, Nagornykh M, Pyatnitskiy M. Analysis of CRISPR system function in plant pathogen Xanthomonas oryzae. FEMS Microbiol Lett, 2009, 296(1): 110-116.
-
(2009)
FEMS Microbiol Lett
, vol.296
, Issue.1
, pp. 110-116
-
-
Semenova, E.1
Nagornykh, M.2
Pyatnitskiy, M.3
-
43
-
-
84872034396
-
The double-edged sword of CRISPR-Cas systems
-
Villion M, Moineau S. The double-edged sword of CRISPR-Cas systems. Cell Res, 2013, 23(1): 15-17.
-
(2013)
Cell Res
, vol.23
, Issue.1
, pp. 15-17
-
-
Villion, M.1
Moineau, S.2
-
44
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek M, Chylinski K, Fonfara I. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science, 2012, 337(6096): 816-821.
-
(2012)
Science
, vol.337
, Issue.6096
, pp. 816-821
-
-
Jinek, M.1
Chylinski, K.2
Fonfara, I.3
-
45
-
-
84887104139
-
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
-
Kevin ME, Prashant M, Jonathan LB. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods, 2013, 10(11): 1116-1121.
-
(2013)
Nat Methods
, vol.10
, Issue.11
, pp. 1116-1121
-
-
Kevin, M.E.1
Prashant, M.2
Jonathan, L.B.3
-
46
-
-
84884663630
-
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
-
Hou Z, Zhang Y, Propson NE. Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci USA, 2013, 110(39): 15644-15649.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.39
, pp. 15644-15649
-
-
Hou, Z.1
Zhang, Y.2
Propson, N.E.3
-
48
-
-
84884165315
-
DNA targeting specificity of RNA-guided Cas9 nucleases
-
Patrick DH, David A, Joshua AW, et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol, 2013, 31(9): 827-832.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.9
, pp. 827-832
-
-
Patrick, D.H.1
David, A.2
Joshua, A.W.3
-
49
-
-
84874617789
-
Efficient genome editing in zebrafish using a CRISPR-Cas system
-
Hwang WY, Fu Y, Reyon D, et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol, 2013, 31(3): 227-229.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.3
, pp. 227-229
-
-
Hwang, W.Y.1
Fu, Y.2
Reyon, D.3
-
50
-
-
84892765883
-
Genome-scale CRISPR-Cas9 knockout screening in human cells
-
Shalem O, Sanjana NE, Hartenian E. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science, 2014, 343(6166): 84-87.
-
(2014)
Science
, vol.343
, Issue.6166
, pp. 84-87
-
-
Shalem, O.1
Sanjana, N.E.2
Hartenian, E.3
-
51
-
-
84892749369
-
Genetic screens in human cells using the CRISPR/Cas9 system
-
Wang T, Wei JJ, Sabatini DM. Genetic screens in human cells using the CRISPR/Cas9 system. Science, 2014, 343(6166): 80-84.
-
(2014)
Science
, vol.343
, Issue.6166
, pp. 80-84
-
-
Wang, T.1
Wei, J.J.2
Sabatini, D.M.3
-
52
-
-
84903975411
-
Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/Cas9
-
Shen B, Brown KM, Lee TD. Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/Cas9. MBio, 2014, 5(3): e01114.
-
(2014)
MBio
, vol.5
, Issue.3
-
-
Shen, B.1
Brown, K.M.2
Lee, T.D.3
-
53
-
-
84892771868
-
Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis
-
Guo X, Zhang T, Hu Z. Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development, 2014, 141(3): 707-714.
-
(2014)
Development
, vol.141
, Issue.3
, pp. 707-714
-
-
Guo, X.1
Zhang, T.2
Hu, Z.3
-
54
-
-
84894081986
-
Generation of gene modified cynomolgus monkey via Cas9/RNA mediated gene targeting in one-cell embryos
-
Niu Y, Shen B, Cui YQ. Generation of gene modified cynomolgus monkey via Cas9/RNA mediated gene targeting in one-cell embryos. Cell, 2014, 156(4): 836-843.
-
(2014)
Cell
, vol.156
, Issue.4
, pp. 836-843
-
-
Niu, Y.1
Shen, B.2
Cui, Y.Q.3
-
55
-
-
84897594300
-
One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
-
Hai T, Teng F, Guo RF, et al. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res, 2014, 24(3): 372-375.
-
(2014)
Cell Res
, vol.24
, Issue.3
, pp. 372-375
-
-
Hai, T.1
Teng, F.2
Guo, R.F.3
-
56
-
-
84921521153
-
CRISPR/Cas9 nuclease-mediated gene knock-in in bovine-induced pluripotent cells
-
Heo YT, Quan X, Xu YN, et al. CRISPR/Cas9 nuclease-mediated gene knock-in in bovine-induced pluripotent cells. Stem Cells Dev, 2015, 24(3): 393-402.
-
(2015)
Stem Cells Dev
, vol.24
, Issue.3
, pp. 393-402
-
-
Heo, Y.T.1
Quan, X.2
Xu, Y.N.3
-
57
-
-
84921556331
-
One-step generation of myostatin gene knockout sheep via the CRISPR/Cas9 system
-
Han HB, Ma YH, Wang T, et al. One-step generation of myostatin gene knockout sheep via the CRISPR/Cas9 system. Front Agr Sci Eng, 2014, 1(1): 2-5.
-
(2014)
Front Agr Sci Eng
, vol.1
, Issue.1
, pp. 2-5
-
-
Han, H.B.1
Ma, Y.H.2
Wang, T.3
-
58
-
-
84883785822
-
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9
-
Li JF, Norville JE, Aach J, et al. Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol, 2013, 31(8): 688-691.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.8
, pp. 688-691
-
-
Li, J.F.1
Norville, J.E.2
Aach, J.3
-
59
-
-
33745577150
-
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
-
Clop A, Marcq F, Takeda H. A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nat Genet, 2006, 38(7): 813-818.
-
(2006)
Nat Genet
, vol.38
, Issue.7
, pp. 813-818
-
-
Clop, A.1
Marcq, F.2
Takeda, H.3
-
60
-
-
84877707375
-
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
-
Wang H, Yang H, Shivalila CS. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell, 2013, 153(4): 910-918.
-
(2013)
Cell
, vol.153
, Issue.4
, pp. 910-918
-
-
Wang, H.1
Yang, H.2
Shivalila, C.S.3
-
61
-
-
84890050551
-
Correction of a genetic disease in mouse via use of CRISPR-Cas9
-
Wu Y, Liang D, Wang YH. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell, 2013, 13(6): 659-662.
-
(2013)
Cell Stem Cell
, vol.13
, Issue.6
, pp. 659-662
-
-
Wu, Y.1
Liang, D.2
Wang, Y.H.3
-
62
-
-
84890033064
-
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
-
Schwank G, Koo BK, Sasselli V, et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell, 2013, 13(6): 653-658.
-
(2013)
Cell Stem Cell
, vol.13
, Issue.6
, pp. 653-658
-
-
Schwank, G.1
Koo, B.K.2
Sasselli, V.3
-
63
-
-
84877782955
-
A CRISPR-CAS system mediates bacterial innate immune evasion and virulence
-
Sampson TR, Saroj SD, Llewellyn AC. A CRISPR-CAS system mediates bacterial innate immune evasion and virulence. Nature, 2013, 497(7448): 254-257.
-
(2013)
Nature
, vol.497
, Issue.7448
, pp. 254-257
-
-
Sampson, T.R.1
Saroj, S.D.2
Llewellyn, A.C.3
-
64
-
-
84949523640
-
CRISPR technology leaps from lab to industry
-
Helen S. CRISPR technology leaps from lab to industry. J Nematol, 2014, 46(2): 130-260.
-
(2014)
J Nematol
, vol.46
, Issue.2
, pp. 130-260
-
-
Helen, S.1
-
65
-
-
84880570576
-
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
-
Fu Y, Foden JA, Khayter C. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol, 2013, 31(9): 822-826.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.9
, pp. 822-826
-
-
Fu, Y.1
Foden, J.A.2
Khayter, C.3
-
66
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong L, Ran FA, Cox D, et al. Multiplex genome engineering using CRISPR/Cas systems. Science, 2013, 339(6121): 819-823.
-
(2013)
Science
, vol.339
, Issue.6121
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
-
67
-
-
84903545084
-
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
-
Cem K, Sevki A, Ritambhara S, et al. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease. Nat Biotechnol, 2014, 32(7): 677-683.
-
(2014)
Nat Biotechnol
, vol.32
, Issue.7
, pp. 677-683
-
-
Cem, K.1
Sevki, A.2
Ritambhara, S.3
-
68
-
-
84884155038
-
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
-
Vikram P, Steven L, John PG, et al. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat Biotechnol, 2013, 31(9): 839-843.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.9
, pp. 839-843
-
-
Vikram, P.1
Steven, L.2
John, P.G.3
-
69
-
-
84884288934
-
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
-
Ran FA, Hsu PD, Lin CY, et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell, 2013, 154(6): 1380-1389.
-
(2013)
Cell
, vol.154
, Issue.6
, pp. 1380-1389
-
-
Ran, F.A.1
Hsu, P.D.2
Lin, C.Y.3
-
70
-
-
84874687019
-
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
-
Qi LS, Larson MH, Gilbert LA, et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell, 2013, 152(5): 1173-1183.
-
(2013)
Cell
, vol.152
, Issue.5
, pp. 1173-1183
-
-
Qi, L.S.1
Larson, M.H.2
Gilbert, L.A.3
-
71
-
-
84893157352
-
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
-
Martin J, Fuguo J, David WT, et al. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science, 2014, 43(6176): 1247997.
-
(2014)
Science
, vol.43
, Issue.6176
-
-
Martin, J.1
Fuguo, J.2
David, W.T.3
-
72
-
-
84913568580
-
Programmable RNA recognition and cleavage by CRISPR/Cas9
-
O'Connell MR, Oakes BL, Sternberg SH, et al. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature, 2014, 516(7530): 263-266.
-
(2014)
Nature
, vol.516
, Issue.7530
, pp. 263-266
-
-
O'Connell, M.R.1
Oakes, B.L.2
Sternberg, S.H.3
|