Gene-cellular interactions of nanomaterials: Genotoxicity to genomics

Nanotoxicology: Characterization, Dosing and Health Effects

Volumn , Issue , 2007, Pages 173-196

  Cunningham, Mary Jane ^a  

^a HOUSTON ADVANCED RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84949091927     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (178)

1. Roco MC. National Nanotechnology Initiative-Past, Present, Future. In Handbook on Nanoscience, Engineering and Technology. 2nd ed. NY: Taylor and Francis, 2007.
2. Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005; 113: 823-39.
3. Hoet PHM, Brueske-Hohlfeld I, Salata OV. Nanoparticles-known and unknown health risks. J Nanobiotechnol 2004; 2: 12.
4. Salata OV. Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2004; 2: 3.
5. Jortner J, Rao CNR. Nanostructured advanced materials. Perspectives and directions. Pure Appl Chem 2002; 74: 1491-506.
6. Oberdorster G. Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 2001; 74: 1-8.
7. Donaldson K, Stone V, Clouter A, et al. Ultrafine particles. Occup Environ Med 2001; 58: 211-6.
8. Kang YJ. New understanding in cardiotoxicity. Curr Opin Drug Discov Develop 2003; 6: 110-6.
9. Delfino RJ, Sioutas C, Malik S. Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ Health Perspect 2005; 113: 934-46.
10. Samet JH, Dominici F, Curriero FC, et al. Fine particulate air pollutions and mortality in 20 U. cities, 1987-1994. New Eng J Med 2000; 343: 1742-9.
11. Dickey JH. Part VII. Air pollution: overview of sources and health effects. Dis Mon 2000; 46: 566-89.
12. Antonini JM, Afshari AA, Stone S, et al. Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals. J Occup Environ Health 2006; 3: 194-203.
13. Miller RW. How environmental hazards in childhood have been discovered: carcinogens, teratogens, neurotoxicants, and others. Pediatrics 2004; 113 (Suppl 4): 945-51.
14. Daniel LN, Mao Y, Saffiotti U. Oxidative DNA damage by crystalline silica. Free Radic Biol Med 1993; 14: 463-72.
15. Shi X, Castranova V, Halliwell B, et al. Reactive oxygen species and silicainduced carcinogenesis. J Toxicol Environ Health B Crit Rev 1998; 1: 181-97.
16. Vallyathan, V, Shi X. The role of oxygen free radicals in occupational and environmental lung diseases. EnvironHealth Perspect 1997; 105(Suppl 1): 165-77.
17. Karch J, Birringer R, Gleiter H. Ceramics ductile at low temperature. Nature 1987; 330: 556-8.
18. Dey A, De S, De A, et al. Giant dielectric constant in titania nanoparticles embedded in conducting polymer matrix. J Nanosci Nanotechnol 2006; 6: 1427-36.
19. Fan Z, Lu JG. Zinc oxide nanostructures: synthesis and properties. J Nanosci Nanotechnol 2005; 5: 1561-73.
20. Thess A, Lee R, Nikolaev P, et al. Crystalline ropes of metallic carbon nanotubes. Science 1996; 273: 483-7.
21. Ayutsede J, Gandhi M, Sugigara S, et al. Carbon nanotube reinforced Bombyx mori silk nanofibers by the electrospinning process. Biomacromolecules 2006; 7: 208-14.
22. Durkop T, Getty SA, Cobas E, et al. Extraordinary mobility in semiconducting carbon nanotubes. Nano Lett 2004; 4: 35-9.
23. Durkop T, Cobas E, Fuhrer MS. High-mobility semiconducting nanotubes. AIP Conf Proc 2003; 685: 524-7.
24. McEuen PL, Fuhrer MS, Park H. Single-walled carbon nanotube electronics. IEEE Trans Nanotechnol 2002; 1: 78-85.
25. Prasher R. Predicting the thermal resistance of nanosized constrictions. Nano Lett 2005; 5: 2155-9.
26. Li SD, Peng Z, Kong LX, et al. Thermal degradation kinetics and morphology of natural rubber/silica nanocomposites. J Nanosci Nanotechnol 2006; 6: 541-6.
27. Zhang WX, Wang CB, Lien HL. Treatment of chlorinated organic contaminants with nanoscale bimetallic particles. Catal Today 1998; 40: 387-95.
28. Chan WCW, Maxwell DJ, Gao X, et al. Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol 2002; 13: 40-6.
29. Alivisatos AP. Semiconductor clusters, nanocrystals and quantum dots. Science 1996; 271: 933-7.
30. Jaiswal JK, Mattoussi H, Mauro JM, et al. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat Biotechnol 2003; 21: 47-51.
31. Michalet X, Pinaud FF, Bentolila LA, et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 2005; 307: 538-44.
32. Bo XZ, Tassi NG, Lee CY, et al. Pentacene-carbon nanotubes: semiconducting assemblies for thin-film transistor applications. Appl Phys Lett 2005; 87: 203510.
33. Ebron VH, Yang Z, Seyer JD, et al. Fuel-powered artificial muscles. Science 2006; 311: 1580-3.
34. Collins PG, Avouris P. Nanotubes for electronics. Sci Am 2000; 283: 62-9.
35. Lam CW, James JT, McCluskey R, et al. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 2004; 77: 126-34.
36. Warheit DB, Laurence BR, Reed KL, et al. Comparative pulmonary toxicity assessment of single wall carbon nanotubes in rats. Toxicol Sci 2004; 77: 117-25.
37. Oberdorster E. Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ Health Perspect 2004; 112: 1058-62.
38. Chrisp CE, Fisher GL. Mutagenicity of airborne particles. Mutat Res 1980; 76: 143-64.
39. Schins RP. Mechanisms of genotoxicity of particles and fibers. Inhal Toxicol 2002; 14: 57-78.
40. Claxton LD, Matthews PP, Warren, SH. The genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity. Mutat Res 2004; 567: 347-99.
41. Borm, PJA. Toxicity and occupational health hazards of coal fly ash (CFA). A review of data and comparison to coal mine dust. Ann Occup Hyg 1997; 41: 659-76.
42. Knaapen AM, Borm PJA, Albrecht C, et al. Inhaled particles and lung cancer. Part A: Mechanisms. Int J Cancer 2004; 109: 799-809.
43. Cimino MC. Comparative overview of current international strategies and guidelines for genetic toxicology testing for regulatory purposes. Environ Mol Mutagen 2006; 47: 362-90.
44. Hoel DG, Haseman JK, Hogan MD, et al. The impact of toxicity on carcinogenicity studies: implications for risk assessment.Carcinogenesis 1988; 9: 2045-52.
45. Tennant RW, Elwell MR, Spalding JW, et al. Evidence that toxic injury is not always associated with induction of chemical carcinogenesis. Mol Carcinogen 1991; 4: 420-40.
46. Yamasaki, H, Ashby, J, Bignami, M, et al. Nongenotoxic carcinogens: development of detection methods based on mechanisms: a European project. Mutat Res 1996; 353: 47-63.
47. IARC Monographs on the evaluation of carcinogenic risks to humans. IARC Monograph Series, vol. 68, Silica, Some Silicates, Coal Dust and Para-Aramid Fibrils. Lyon, France: International Agency for Research on Cancer1997; 41: 242.
48. Zhong BZ, Whong WZ, Ong TM. Detection of mineral-dust-induced DNA damage in two mammalian cell lines using the alkaline single cell gel/comet assay. Mutat Res 1997; 393: 181-7.
49. Johnston CJ, Driscoll KE, Finkelstein JN, et al. Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol Sci 2000; 56: 405-13.
50. Ashikaga T, Wada M, Kobayashi H, et al. Effect of photocatalytic activity of TiO2 on plasmid DNA. Mutat Res 2000; 466: 1-7.
51. Zhang Q, Kusaka Y, Zhu X, et al. Comparative toxicity of standard nickel and ultrafine nickel in lung after intratrachael instillation. J Occup Health 2003; 45: 23-30.
52. Wilson MR, Lightbody JH, Donaldson K, et al. Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicol Appl Pharmacol 2002; 184: 172-9.
53. Gilmour PS, Ziesenis A, Morrison ER, et al. Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles. Toxicol Appl Pharmacol 2004; 195: 35-44.
54. Donaldson K, Beswick PH, Gilmour PS. Free radical activity associated with the surface of particles: a unifying factor in determining biological activity? Toxicol Lett 1996; 88: 293-8.
55. Fisher GL, Chrisp CE, Raabe, OG. Physical factors affecting the mutagenicity of fly ash from a coal-fired power plant. Science 1979; 204: 879-81.
56. Johnston CJ, Finkelstein JN, Mercer P, et al. Pulmonary effects induced by ultrafine PTFE particles. Toxicol Appl Pharmacol 2000; 168: 208-15.
57. Antonini JM, Lewis AB, Roberts JR, et al. Pulmonary effects of welding fumes: review of worker and experimental animal studies. Am J Ind Med 2003; 43: 350-60.
58. Hedenstedt A, Jenssen D, Lidesten BM, et al. Mutagenicity of fume particles from stainless steel welding. Scand J Work Environ Health 1977; 3: 203-11.
59. Maxild J, Andersen M, Kiel P. Mutagenicity of fume particles from metal arc welding on stainless steel in the Salmonella/microsome test. Mutat Res 1978; 56: 235-43.
60. Dalal NS, Suryan MM, Vallyathan V, et al. Detection of reactive free radicals in fresh coal mine dust and their implication for pulmonary injury. Ann Occup Hyg 1989; 33: 79-84.
61. Mumford JL, Lewtas J. Mutagenicity and cytotoxicity of coal fly ash from fluidized-bed and conventional combustion. J Toxicol Environ Health 1982; 10: 565-86.
62. Keane MJ, Xing SG, Harrison JC, et al. Genotoxicity of diesel-exhaust particles dispersed in simulated pulmonary surfactant. Mutat Res 1991; 260: 233-8.
63. Daniel LN, Mao Y, Wang TCL, et al. DNA strand breakage, thymine glycol production, and hydroxyl radical generation induced by different samples of crystalline silica in vitro. Environ Res 1995; 71: 60-73.
64. Ball JC, Straccia AM, Young WC, et al. The formation of reactive oxygen species catalyzed by neutral, aqueous extracts of NIST ambient particulate matter and diesel engine particles. J Air Waste Manag Assoc 2000; 50: 1897-903.
65. Long JF, Waldman WJ, Kristovich R, et al. Comparison of ultrastructural cytotoxic effects of carbon and carbon/iron particulates on human monocytederived macrophages. Environ Health Perspect 2005; 113: 170-4.
66. Bond JA, Johnson NF, Snipes MB, et al. DNA adduct formation in rat alveolar type II cells: cells potentially at risk for inhaled diesel exhaust. Environ Mol Mutagen 1990; 16: 64-9.
67. King LC, Kohan MJ, Austin AC, et al. Evaluation of the release of mutagens from diesel particles in the presence of physiological fluids. Environ Mutagen 1981; 3: 109-21.
68. Humfrey CDN, Levy LS, Faux SP. Potential carcinogenicity of foundry fumes: a comparative in vivo-in vitro study. Food Chem Toxicol 1996; 34: 1103-11.
69. Kleinjans JCS, Janssen YMW, van Agen B, et al. Genotoxicity of coal fly ash, assessed in vitro in Salmonella typhimurium and human lymphocytes, and in vivo in an occupationally exposed population. Mutat Res 1989; 224: 127-34.
70. Karlsson HL, Nygren J, Moller L. Genotoxicity of airborne particulate matter: the role of cell-particle interaction and of substances with adductforming and oxidizing capacity. Mutat Res 2004; 565: 1-10.
71. Englen MD, Taylor SM, Laegreid WW, et al. The effects of different silicas on arachidonic acid metabolism in alveolar macrophages. Exp Lung Res 1990; 16: 691-709.
72. Barrett EG, Johnston C, Oberdorster G, et al. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-α. Am J Physiol Lung Cell Mol Physiol 1998; 275(6 Pt 1): L1110-9.
73. Driscoll KE, Howard BW, Carter JM, et al. Alpha-quartz-induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure. Am J Pathol 1996; 149: 1627-1637.
74. Ishihara Y, Kyono H, Kohyama N, et al. Acute biological effects of intratracheally instilled titanium dioxide whiskers compared with nonfibrous titanium dioxide and amosite in rats. Inhal Toxicol 1999; 11: 131-49.
75. MacNee W, Donaldson K. Mechanism of lung injury caused by PM10 and ultrafine particles with special reference to COPD. Eur Respir J 2003; 21(Suppl 40): 47s-51s.
76. Moussa F, Chretien P, Dubois P, et al. The influence of C60 powders on cultured human leukocytes. Fullerene Sci Technol 1995; 3: 333-42.
77. Baierl T, Drosselmeyer E, Seidel A, et al. Comparison of immunological effects of fullerene C60 and raw soot from fullerene production on alveolar macrophages and macrophage like cells in vitro. Exp Toxicol Pathol 1996; 48: 508-11.
78. Nakajima N, Nishi C, Li FM, et al. Photo-induced cytotoxicity of watersoluble fullerene. Fullerene Sci Technol 1996; 4: 1-19.
79. Tsuchiya T, Oguri I, Yamakoshi YN, et al. Novel harmful effects of [60] fullerene on mouse embryos in vitro and in vivo. FEBS Lett 1996; 393: 139-45.
80. Moussa F, Chretien P, Pressac M, et al. Preliminary study of the influence of cubic C60 on cultured human monocytes: lack of interleukin-1b secretion. Fullerene Sci Technol 1997; 5: 503-10.
81. Sakai A, Yamakoshi Y, Miyata N. Visible light irradiation of 60 fullerene causes killing and initiation of transformation of BALB/3T3 cells. Fullerene Sci Technol 1999; 7: 743-56.
82. Fumelli C, Marconi A, Salvioli S, et al. Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis. J Invest Dermatol 2000; 115: 835-41.
83. Babynin EV, Nuretdinov IA, Gubskaia VP, et al. Study of mutagenic activity of fullerene and some of its derivatives using Hisþ reversions of Salmonella typhimurium as an example. Genetika 2002; 38: 453-7.
84. Cusan C, Da Ros T, Spalluto G, et al. A new multi-charged C60 derivative: synthesis and biological properties. Eur J Org Chem 2002; 17: 2928-34.
85. Rancan F, Rosan S, Boehm F, et al. Cytotoxicity and photocytotoxicity of a dendritic C60 mono-adduct and a malonic acid C60 tris-adduct on Jurkat cells. J Photochem Photobiol B 2002; 67: 157-62.
86. Yang XL, Fan CH, Zhu HS. Photo-induced cytotoxicity of malonic acid [C60] fullerene derivatives and its mechanism. Toxicol In Vitro 2002; 16: 41-6.
87. Mikata Y, Takagi S, Tanahashi M, et al. Detection of 1270nm emission from singlet oxygen and photocytotoxic property of sugar-pendant (60) fullerenes. Bioorg Med Chem Lett 2003; 13: 3289-92.
88. Bosi S, Feruglio L, Da Ros T, et al. Hemolytic effects of water-soluble fullerene derivatives. J Med Chem 2004; 47: 6711-5.
89. Burlaka AP, Sidorik YP, Prylutska SV, et al. Catalytic system of the reactive oxygen species on the C60 fullerene basis. Exp Oncol 2004; 26: 326-7.
90. Jia G, Wang H, Yan, L, et al. Cytotoxicity of carbon nanomaterials: singlewall nanotube, multi-wall nanotube and fullerene. Environ Sci Technol 2005; 39: 1378-83.
91. Lyon DY, Fortner JD, Sayes CM, et al. Bacterial cell association and antimicrobial activity of a C60 water suspension. Environ Toxicol Chem 2005; 24: 2757-62.
92. Sayes CM, Gobin AM, Ausman KD, et al. Nano-C60 cytotoxicity is due to lipid peroxidation. Biomaterials 2005; 26: 7587-95.
93. Rancan F, Helmreich M, Molich A, et al. Fullerene-pyropheophorbide a complexes as sensitizer for photodynamic therapy: uptake and photoinduced cytotoxicity on Jurkat cells. J Photochem Photobiol B 2005; 80: 1-7.
94. Fiorito S, Serafino A, Andreola F, et al. Effects of fullerenes and singlewall carbon nanotubes on murine and human macrophages. Carbon 2006; 44: 1100-5.
95. Isakovic A, Markovic Z, Todorovic-Markovic B, et al. Distinct cytotoxic mechanisms of pristine versus hydroxylated fullerene. Toxicol Sci 2006; 91: 173-83.
96. Rouse JG, Yang J, Barron AR, et al. Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes. Toxicol In Vitro 2006; 20: 1313-20.
97. Xiao L, Takada H, Gan XH, et al. The water-soluble fullerene derivative ‘Radical Sponge®’ exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes. Bioorg Med Chem Lett 2006; 16: 1590-5.
98. Yamawaki H, Iwai N. Cytotoxicity of water-soluble fullerene in vascular endothelial cells. Am J Physiol Cell Physiol 2006; 290: C1495-502.
99. Lesniak W, Bielinska AU, Sun K, et al. Silver/dendrimer nanocomposites as biomarkers: fabrication, characterization, in vitro toxicity, and intracellular detection. Nano Lett 2005; 5: 2123-130.
100. Derfus A, Chan, WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2004; 4: 11-8.
101. Chen F, Gerion D. Fluorescent CdSe/ZnS nanocrystal-peptide conjugates for long-term, nontoxic imaging and nuclear targeting in living cells. Nano Lett4: 1827-32.
102. Hoshino A, Hanaki KI, Suzuki K, et al. Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body. Biochem Biophys Res Commun 2004a; 314: 46-53.
103. Hoshino A, Fujioka K, Oku T, et al. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 2004b; 4: 2163-9.
104. Kirchner C, Liedl T, Kudera S, et al. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 2005; 5: 331-8.
105. Lovric J, Bazzi HS, Cuie, Y, et al. Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. JMol Med 2005; 83: 377-85.
106. Shiohara A, Hoshino A, Hanaki KI, et al. On the cytotoxicity caused by quantum dots. Microbiol Immunol 2004; 48: 669-75.
107. Isobe H, Tanaka T, Maeda R, et al. Preparation, purification, characterization, and cytotoxicity assessment of water-soluble, transition-metal-free carbon nanotube aggregates. Angew Chem Int Ed Engl 2006; 45: 6676-80.
108. Zhang, Q, Kusaka Y, Sato, K, et al. Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: role of free radicals. J Toxicol Environ Health A 1998; 53: 423-38.
109. Gupta AK, Berry C, Gupta M, et al. Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis. IEEE Trans Nanobiosci 2003; 2: 255-61.
110. Goodman CM, McCusker CD, Yilmaz T, et al. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconj Chem 2004; 15: 897-900.
111. Braydich-Stolle L, Hussain S, Schlager JJ, et al. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 2005; 88: 412-9.
112. Cheng FY, Su CH, Yang YS, et al. Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications. Biomaterials 2005; 26: 729-38.
113. Gupta AK, Gupta M. Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. Biomaterials 2005; 26: 1565-73.
114. Hussain SM, Hess KL, Gearhart JM, et al. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 2005; 19: 975-83.
115. Lu ZX, Zhang ZL, Zhang MX, et al. Core/shell quantum dot-photosensitized nano-TiO2 films: fabrication and application to the damage of cells and DNA. J Phys Chem B 2005; 109: 22663-6.
116. Petri-Fink A, Chastellain, M, Juillerat-Jeanneret L, et al. Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells. Biomaterials 2005; 26: 2685-94.
117. Shukla R, Bansal V, Chaudhary M, et al. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 2005; 21: 10644-54.
118. Auffan M, Decome L, Rose J, et al. In vitro interactions between DMSAcoated maghemite nanoparticles and human fibroblasts: a physicochemical and cyto-genotoxical study. Environ Sci Technol 2006; 40: 4367-73.
119. Dufour EK, Kumaravel T, Nohynek GJ, et al. Clastogenicity, photoclastogenicity or pseudo-photo-clastogenicity: genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells. Mutat Res 2006; 607: 215-24.
120. Hussain SM, Javorina AK, Schrand AM, et al. The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion. Toxicol Sci 2006; 92: 456-63.
121. Qi L, Xu Z, Chen M. In vitro and in vivo suppression of hepatocellularcarcinoma growth by chitosan nanoparticles. Eur J Cancer 2007; 43: 184-93.
122. Sayes CM, Wahi R, Kurian PA, et al. Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol Sci 2006; 92: 174-85.
123. Wang B, Feng WY, Wang TC, et al. Acute toxicity of nano-and micro-scale zinc powder in healthy adult mice. Toxicol Lett 2006; 161: 115-23.
124. Warheit DB, Webb TR, Sayes CM, et al. Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area. Toxicol Sci 2006; 91: 227-36.
125. Ameller T, Marsaud V, Legrand P, et al. Pure antiestrogen RU 58668-loaded nanospheres: morphology, cell activity and toxicity studies. Eur J Pharmaceut Sci 2004; 21: 361-70.
126. De S, Miller DW, Robinson DH. Effect of particle size of nanospheres and microspheres on the cellular-association and cytotoxicity of paclitaxel in 4T1 cells. Pharmaceut Res 2005; 22: 766-75.
127. Park EK, Lee SB, Lee YM. Preparation and characterization of methoxy poly (ethylene glycol)/poly(ε-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs. Biomaterials 2005; 26: 1053-61.
128. Shvedova AA, Castranova V, Kisin ER, et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A 2003; 66: 1909-26.
129. Kam NWS, Jessop TC, Wender PA, et al. Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into mammalian cells. J Am Chem Soc 2004; 126: 6850-1.
130. PantarottoD, Briand JP, PratoM, et al. Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem Commun (Camb) 2004a; (01): 16-7.
131. Pantarotto D, Singh R, McCarthy D, et al. Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew Chem Int Ed Engl 2004b; 43: 5242-6.
132. Bianco A, Hoebeke J, Kostarelos K, et al. Carbon nanotubes: on the road to deliver. Curr Drug Deliv 2005a; 2: 253-9.
133. Bianco A, Hoebeke J, Godefroy S, et al. Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties. J Am Chem Soc 2005b; 127: 58-9.
134. Cunningham MJ, Magnuson SR, Falduto MT, et al. Gene expression profiling of nanoscale materials using a systems biology approach. Toxicol Sci 2005; 84: 9.
135. Cui D, Tian F, Ozkan CS, et al. Effect of single wall carbon nanotubes on human HEK293 cells. Toxicol Lett 2005; 155: 73-85.
136. Ding L, Stilwell J, Zhang T, et al. Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast. Nano Lett 2005; 5: 2448-64.
137. Manna SK, Sarkar S, Barr J, et al. Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kB in human keratinocytes. Nano Lett 2005; 5: 1676-84.
138. Monteiro-Riviere NA, Inman AO, Wang YY, et al. Surfactant effects on carbon nanotube interactions with human keratinocytes. Nanomed: Nanotechnol Biol Med 2005a; 1: 293-9.
139. Monteiro-Riviere NA, Nemanich RJ, Inman, AO, et al. Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicol Lett 2005b; 155: 377-84.
140. Muller J, Huaux F, Moreau N, et al. Respiratory toxicity of multi-wall carbon nanotubes. Toxicol Appl Pharmacol 2005; 207: 221-31.
141. Murr LE, Garza KM, Soto KF, et al. Cytotoxicity assessment of some carbon nanotubes and related carbon nanoparticle aggregates and the implications for anthropogenic carbon nanotube aggregates in the environment. Int J Environ Res Public Health 2005; 2: 31-42.
142. Shvedova AA, Kisin ER, Mercer R, et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 2005; 289: L698-708.
143. Bottini M, Bruckner S, Nika K, et al. Multi-walled carbon nanotube induce T lymphocyte apoptosis. Toxicol Lett 2006; 160: 121-6.
144. Dumortier H, Lacotte S, Pastorin G, et al. Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. Nano Lett 2006; 6: 1522-8.
145. Magrez A, Kasas S, Salicio V, et al. Cellular toxicity of carbon-based nanomaterials. Nano Lett 2006; 6: 1121-5.
146. Nimmagadda A, Thurston K, Nollert MU, et al. Chemical modification of SWNT alters in vitro cell-SWNT interactions. J Biomed Mater Res A 2006; 76: 614-25.
147. Sayes CM, Liang F, Hudson JL, et al. Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol Lett 2006; 161: 135-42.
148. Tian F, Cui D, Schwarz H, et al. Cytotoxicity of single-wall carbon nanotubes on human fibroblasts. Toxicol In Vitro 2006; 20: 1202-12.
149. Worle-Knirsch JM, Pulskamp K, Krug, HF. Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett 2006; 6: 1261-8.
150. Zanello LP, Zhao B, Hu H, et al. Bone cell proliferation on carbon nanotubes. Nano Lett 2006; 6: 562-7.
151. Zhu Y, Zhao Q, Li Y, et al. The interaction and toxicity of multi-walled carbon nanotubes with Stylonychia mytilus. J Nanosci Nanotechnol 2006; 6: 1357-64.
152. Pulskamp K, Diabate S, Krug HF. Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett 2007; 168: 58-74.
153. Wick P, Manser P, Limbach LK, et al. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett 2007; 168: 121-31.
154. Zakharenko LP, Zakharov IK, Lunegov SN, et al. [Demonstration of the absence of genotoxicity of fullerene C60 using the somatic mosaic method]. Dokl Akad Naut 1994; 335: 261-2.
155. Sera N, Tokiwa H, Miyata N. Mutagenicity of the fullerene C60-generated singlet oxygen dependent formation of lipid peroxides. Carcinogenesis 1996; 17: 2163-9.
156. Zakharenko LP, Zakharov IK, Vasiuniana EA, et al. [Determination of the genotoxicity of fullerene C60 and fullerol using the method of somatic mosaics on cells of Drosophila melanogaster wing and SOS-chromotest]. Genetika 1997; 33: 405-9.
157. Lin AMY, Chyi, BY, Wang SD, et al. Carboxyfullerene prevents iron-induced oxidative stress in rat brain. J Neurochem 1999; 72: 1634-40.
158. Kamat JP, Devasagayam TPA, Priyadarsini KI, et al. Reactive oxygen species mediated membrane damage induced by fullerene derivatives and its possible biological implications. Toxicology 2000; 155: 55-61.
159. Mori T, Takada H, Ito S, et al. Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology 2006; 225: 48-54.
160. Xia T, Kovochich M, Brant J, et al. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 2006; 6: 1794-807.
161. Green M, Howman E. Semiconductor quantum dots and free radical induced DNA nicking. Chem Commun (Camb) 2005; (01): 121-3.
162. Ye L, Su Q, Zhou XD, et al. [Genotoxicity of a new NanoHA-PA66 root filling material in vitro]. Hua Xi Kou Qiang Yi Xue Za Zhi 2004; 22: 93-5.
163. Kim JS, Yoon TJ, Yu KN, et al. Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol Sci 2006; 89: 338-47.
164. Henry TB, Menn FM, Wilgus J, et al. Gene expression changes in zebrafish after exposure to aqueous C60 nanoparticles generated by different methods. Abstract presented at Overcoming Obstacles to Effective Research Design in Nanotoxicology, Boston, MA, April24-25, 2006.
165. Cunningham MJ. Genomics and proteomics: the new millennium of drug development and discovery. J Pharmacol Toxicol Meth 2000; 44: 291-300.
166. Cunningham MJ, Dat DD. Microarrays-fabricating. In: Fuchs J, Podda M, eds. Encyclopedia of Diagnostic Genomics and Proteomics. New York: Marcel Dekker, 2005: 819-23.
167. Cunningham MJ, Shah M. Toxicogenomics. In: Gad SC, ed. Handbook of Pharmaceutical Biotechnology. New Jersey: John Wiley & Sons, in press.
168. Sato H, Sagai M, Suzuki KT, et al. Identification, by cDNA microarray, of A-raf and proliferating cell nuclear antigen as genes induced in rat lung by exposure to diesel exhaust. Res Commun Mol Pathol Pharmacol 1999; 105: 77-89.
169. Koike E, Hirano S, Shimojo N, et al. cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles. Toxicol Sci 2002; 67: 241-6.
170. Wiethoff AJ, Reed KL, Webb TR, et al. Assessing the role of neutrophil apoptosis in the resolution of particle-induced pulmonary inflammation. Inhal Toxicol 2003; 15: 1231-46.
171. Wise H, Balharry D, Reynolds LJ, et al. Conventional and toxicogenomic assessment of the acute pulmonary damage induced by the instillation of Cardiff PM10 into the rat lung. Sci Total Environ 2006; 360: 60-7.
172. Kim HJ, Ishidou E, Kitagawa E, et al. A yeast DNA microarray for the evaluation of toxicity in environmental water containing burned ash. Environ Monitor Assess 2004; 92: 253-72.
173. Verheyen GR, Nuijten JM, Van Hummelen P, et al. Microarray analysis of the effect of diesel exhaust particles on in vitro cultured macrophages. Toxicol In Vitro 2004; 18: 377-91.
174. Yanagisawa R, Takano H, Inoue KI, et al. Complementary DNA microarray analysis in acute lung injury induced by lipopolysaccharide and diesel exhaust particles. Exp Biol Med 2004; 229: 1081-7.
175. Koike E, Hirano S, Furuyama A, et al. cDNA microarray analysis of rat alveolar epithelial cells following exposure to organic extract of diesel exhaust particles. Toxicol Appl Pharmacol 2004; 201: 178-85.
176. Yamawaki H, Iwai N. Mechanisms underlying nano-sized air-pollutionmediated progression of atherosclerosis: carbon black causes cytotoxic injury/inflammation and inhibits cell growth in vascular endothelial cells. Circ J 2006; 70: 129-40.
177. Ding L, Stilwell J, Zhang T, et al. Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast. Nano Lett 2005; 5: 2448-64.
178. Cui D, Tian F, Ozkan CS, et al. Effect of single wall carbon nanotubes on human HEK293 cells. Toxicol Lett 2005; 155: 73-85.