Dose of phenobarbital and age of treatment at early life are two key factors for the persistent induction of cytochrome P450 enzymes in adult mouse liver

Drug Metabolism and Disposition

Volumn 43, Issue 12, 2015, Pages 1938-1945

  Tien, Yun Chen ^a   Liu, Ke ^b   Pope, Chad ^a   Wang, Pengcheng ^b   Ma, Xiaochao ^b   Zhong, Xiao Bo ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 2B10; CYTOCHROME P450 2C; CYTOCHROME P450 2C29; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; MESSENGER RNA; PHENOBARBITAL; UNCLASSIFIED DRUG;

ADULT; AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; IN VIVO STUDY; LIVER; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; LIVER MICROSOME; METABOLISM; NEWBORN; PHYSIOLOGY;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FEMALE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; PHENOBARBITAL;

EID: 84949033626     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.066316     Document Type: Article

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