-
1
-
-
84867027478
-
The determination and interpretation of the therapeutic index in drug development
-
Muller, P. Y., and Milton, M. N. (2012) The determination and interpretation of the therapeutic index in drug development. Nat. Rev. Drug Discov. 11, 751-761
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 751-761
-
-
Muller, P.Y.1
Milton, M.N.2
-
3
-
-
40449086665
-
Dose translation from animal to human studies revisited
-
Reagan-Shaw, S., Nihal, M., and Ahmad, N. (2008) Dose translation from animal to human studies revisited. FASEB J. 22, 659-661
-
(2008)
FASEB J.
, vol.22
, pp. 659-661
-
-
Reagan-Shaw, S.1
Nihal, M.2
Ahmad, N.3
-
5
-
-
0035015115
-
Body surface area as a determinant of pharmacokinetics and drug dosing
-
Sawyer, M., and Ratain, M. J. (2001) Body surface area as a determinant of pharmacokinetics and drug dosing. Invest. New Drugs 19, 171-177
-
(2001)
Invest. New Drugs
, vol.19
, pp. 171-177
-
-
Sawyer, M.1
Ratain, M.J.2
-
6
-
-
0037156937
-
How to calculate the dose of chemotherapy
-
Gurney, H. (2002) How to calculate the dose of chemotherapy. Br. J. Cancer 86, 1297-1302
-
(2002)
Br. J. Cancer
, vol.86
, pp. 1297-1302
-
-
Gurney, H.1
-
7
-
-
0037132703
-
Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. J
-
Baker, S. D., Verweij, J., Rowinsky, E. K., Donehower, R. C, Schellens, J. H., Grochow, L. B., and Sparreboom, A (2002) Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. J. Natl. Cancer Inst. 94, 1883-1888
-
(2002)
Natl. Cancer Inst.
, vol.94
, pp. 1883-1888
-
-
Baker, S.D.1
Verweij, J.2
Rowinsky, E.K.3
Donehower, R.C.4
Schellens, J.H.5
Grochow, L.B.6
Sparreboom, A.7
-
8
-
-
33846115223
-
Chemotherapy dosing part I: Scientific basis for current practice and use of body surface area
-
Kaestner, S. A., and Sewell, G. J. (2007) Chemotherapy dosing part I: scientific basis for current practice and use of body surface area. Clin. Oncol. (R Coll Radiol) 19, 23-37
-
(2007)
Clin. Oncol. (R Coll Radiol)
, vol.19
, pp. 23-37
-
-
Kaestner, S.A.1
Sewell, G.J.2
-
9
-
-
77950930742
-
Of mice and humans: Are they the same-Implications in cancer translational research
-
De Jong, M., and Maina, T. (2010) Of mice and humans: are they the same-Implications in cancer translational research. J. Nucl. Med. 51, 501-504
-
(2010)
J. Nucl. Med.
, vol.51
, pp. 501-504
-
-
De Jong, M.1
Maina, T.2
-
10
-
-
70449172754
-
Quantitative laws in metabolism and growth
-
Von Bertalanffy, L. (1957) Quantitative laws in metabolism and growth. Q. Rev. Biol. 32, 217-231
-
(1957)
Q. Rev. Biol.
, vol.32
, pp. 217-231
-
-
Von Bertalanffy, L.1
-
11
-
-
84957355538
-
Body size and metabolic rate
-
Kleiber, M. (1947) Body size and metabolic rate. Physiol. Rev. 27, 511-541
-
(1947)
Physiol. Rev.
, vol.27
, pp. 511-541
-
-
Kleiber, M.1
-
12
-
-
84930819284
-
A sceptics view: "Kleiber's Law" or the "3/4 Rule" is neither a law nor a rule but rather an empirical approximation
-
Hulbert, A. (2014) A sceptics view: "Kleiber's Law" or the "3/4 Rule" is neither a law nor a rule but rather an empirical approximation. Systems 2, 186-202
-
(2014)
Systems
, vol.2
, pp. 186-202
-
-
Hulbert, A.1
-
13
-
-
18944396944
-
Allometric scaling of mammalian metabolism
-
White, C. R., and Seymour, R S. (2005) Allometric scaling of mammalian metabolism. J. Exp. Biol. 208, 1611-1619
-
(2005)
J. Exp. Biol.
, vol.208
, pp. 1611-1619
-
-
White, C.R.1
Seymour, R.S.2
-
14
-
-
35349016814
-
Application of allometric principles for the prediction of pharmacokinetics in human and veterinary drug development
-
Mahmood, I. (2007) Application of allometric principles for the prediction of pharmacokinetics in human and veterinary drug development. Adv. Drug Deliv. Rev. 59, 1177-1192
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, pp. 1177-1192
-
-
Mahmood, I.1
-
15
-
-
0014818006
-
Energy metabolism, body size, and problems of scaling
-
Schmidt-Nielsen, K. (1970) Energy metabolism, body size, and problems of scaling. Fed. Proc. 29, 1524-1532
-
(1970)
Fed. Proc.
, vol.29
, pp. 1524-1532
-
-
Schmidt-Nielsen, K.1
-
16
-
-
0001341126
-
Uber den einfluss der korpergrosse auf stoffund kraftwechsel
-
Rubner, M. (1883) Uber den einfluss der korpergrosse auf stoffund kraftwechsel. Zeit. Biol. 19, 536-562
-
(1883)
Zeit. Biol.
, vol.19
, pp. 536-562
-
-
Rubner, M.1
-
17
-
-
0001146529
-
The use of body surface area as a criterion of drug dosage in cancer chemotherapy
-
Pinkel, D. (1958) The use of body surface area as a criterion of drug dosage in cancer chemotherapy. Cancer Res. 18, 853-856
-
(1958)
Cancer Res.
, vol.18
, pp. 853-856
-
-
Pinkel, D.1
-
18
-
-
0343396016
-
The blood volume of mammals as determined by experiments upon rabbits, guinea pigs, and mice and its relationship to the body weight and to the surface area expressed as a formula
-
Dreyer, G., and Ray, W. (1910) The Blood Volume of Mammals as Determined by Experiments upon Rabbits, Guinea Pigs, and Mice and Its Relationship to the Body Weight and to the Surface Area Expressed as a Formula. Phil. Trans. Royal Soc. London, s. B. 201, 133-60
-
(1910)
Phil. Trans. Royal Soc. London, S. B.
, vol.201
, pp. 133-160
-
-
Dreyer, G.1
Ray, W.2
-
19
-
-
33444464475
-
Further experiments upon the blood volume of mammals and its relation to the surface area of the body
-
Dreyer, G., and Ray, W. (1912) Further Experiments upon the Blood Volume of Mammals and Its Relation to the Surface Area of the Body. Phil. Trans. Royal Soc. London, s. B. 202, 191-212
-
(1912)
Phil. Trans. Royal Soc. London, S. B.
, vol.202
, pp. 191-212
-
-
Dreyer, G.1
Ray, W.2
-
20
-
-
0000664818
-
Body size and metabolism
-
Kleiber, M. (1932) Body size and metabolism. Hilgardia 6, 315-353
-
(1932)
Hilgardia
, vol.6
, pp. 315-353
-
-
Kleiber, M.1
-
22
-
-
67549090108
-
Blood collection techniques in exotic small mammals
-
Joslin, J. O. (2009) Blood collection techniques in exotic small mammals. J. Exot. Pet Med. 18, 117-139
-
(2009)
J. Exot. Pet Med.
, vol.18
, pp. 117-139
-
-
Joslin, J.O.1
-
24
-
-
0036800873
-
Novel phenotypes identified by plasma biochemical screening in the mouse
-
Hough, T. A., Nolan, P. M., Tsipouri, V., Toye, A. A., Gray, I. C, Goldsworthy, M., Moir, L., Cox, R D., Clements, S., Glenister, P. H., Wood, J., Selley, R. L., Strivens, M. A., Vizor, L., McCormack, S. L., Peters, J., Fisher, E. M., Spurr, N., Rastan, S., Martin, J. E., Brown, S. D., and Hunter, A J. (2002) Novel phenotypes identified by plasma biochemical screening in the mouse. Mamm. Genome 13, 595-602
-
(2002)
Mamm. Genome
, vol.13
, pp. 595-602
-
-
Hough, T.A.1
Nolan, P.M.2
Tsipouri, V.3
Toye, A.A.4
Gray, I.C.5
Goldsworthy, M.6
Moir, L.7
Cox, R.D.8
Clements, S.9
Glenister, P.H.10
Wood, J.11
Selley, R.L.12
Strivens, M.A.13
Vizor, L.14
McCormack, S.L.15
Peters, J.16
Fisher, E.M.17
Spurr, N.18
Rastan, S.19
Martin, J.E.20
Brown, S.D.21
Hunter, A.J.22
more..
-
25
-
-
69549096109
-
Reference values for serum proteins of common laboratory rodent strains
-
Zaias, J., Mineau, M., Cray, C, Yoon, D., and Altman, N. H. (2009) Reference values for serum proteins of common laboratory rodent strains. J. Am. Assoc. Lab. Anim. Sci. 48, 387-390
-
(2009)
J. Am. Assoc. Lab. Anim. Sci.
, vol.48
, pp. 387-390
-
-
Zaias, J.1
Mineau, M.2
Cray, C.3
Yoon, D.4
Altman, N.H.5
-
26
-
-
84859838638
-
Serum albumin and globulin
-
Walker, H. K., Hall, W. D., and Hurst, J. W., eds., Butterworths, Boston
-
Busher, J. T. (1990) Serum albumin and globulin. In Clinical Methods: The History, Physical, and Laboratory Examinations (Walker, H. K., Hall, W. D., and Hurst, J. W., eds.), pp. 497-499, Butterworths, Boston
-
(1990)
Clinical Methods: The History, Physical, and Laboratory Examinations
, pp. 497-499
-
-
Busher, J.T.1
-
27
-
-
84867047842
-
Of mice and men: Divergence of gene expression patterns in kidney
-
Cheval, L., Pierrat, F., Rajerison, R., Piquemal, D., and Doucet, A. (2012) Of mice and men: divergence of gene expression patterns in kidney. PLoS ONE 7, e46876
-
(2012)
PLoS ONE
, vol.7
, pp. e46876
-
-
Cheval, L.1
Pierrat, F.2
Rajerison, R.3
Piquemal, D.4
Doucet, A.5
-
28
-
-
3042603447
-
Kidney mass and relative medullary thickness of rodents in relation to habitat, body size, and phylogeny
-
Al-Kahtani, M. A., Zuleta, C., Caviedes-Vidal, E., and Garland, T., Jr. (2004) Kidney mass and relative medullary thickness of rodents in relation to habitat, body size, and phylogeny. Physiol. Biochem. Zool. 77, 346-365
-
(2004)
Physiol. Biochem. Zool.
, vol.77
, pp. 346-365
-
-
Al-Kahtani, M.A.1
Zuleta, C.2
Caviedes-Vidal, E.3
Garland, T.4
-
29
-
-
0032428485
-
Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics
-
Lin, J. H. (1998) Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics. Drug Metab. Dispos. 26, 1202-1212
-
(1998)
Drug Metab. Dispos.
, vol.26
, pp. 1202-1212
-
-
Lin, J.H.1
-
30
-
-
0020963903
-
Physiologically based pharmacokinetic modeling: Principles and applications
-
Gerlowski, L. E., and Jain, R. K. (1983) Physiologically based pharmacokinetic modeling: principles and applications. J. Pharm. Sci. 72, 1103-1127
-
(1983)
J. Pharm. Sci.
, vol.72
, pp. 1103-1127
-
-
Gerlowski, L.E.1
Jain, R.K.2
-
32
-
-
84866334428
-
Preclinical profile and characterization of the hepatitis C virus NS3 protease inhibitor asunaprevir (BMS-650032)
-
McPhee, F., Sheaffer, A K., Friborg, J., Hernandez, D., Falk, P., Zhai, G., Levine, S., Chaniewski, S., Yu, F., Barry, D., Chen, C, Lee, M. S., Mosure, K, Sun, L. Q., Sinz, M., Meanwell, N A, Colonno, R J., Knipe, J., and Scola, P. (2012) Preclinical profile and characterization of the hepatitis C virus NS3 protease inhibitor asunaprevir (BMS-650032). Antimicrob. Agents Chemother. 56, 5387-5396
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5387-5396
-
-
McPhee, F.1
Sheaffer, A.K.2
Friborg, J.3
Hernandez, D.4
Falk, P.5
Zhai, G.6
Levine, S.7
Chaniewski, S.8
Yu, F.9
Barry, D.10
Chen, C.11
Lee, M.S.12
Mosure, K.13
Sun, L.Q.14
Sinz, M.15
Meanwell, N.A.16
Colonno, R.J.17
Knipe, J.18
Scola, P.19
-
33
-
-
80052574523
-
Serotonin signaling is associated with lower amyloid-/3 levels and plaques in transgenic mice and humans
-
Cirrito, J. R., Disabato, B. M., Restivo, J. L., Verges, D. K., Goebel, W. D., Sathyan, A., Hayreh, D., D'Angelo, G., Benzinger, T., Yoon, H., Kim, J., Morris, J. C, Mintun, M. A., and Sheline, Y I. (2011) Serotonin signaling is associated with lower amyloid-/3 levels and plaques in transgenic mice and humans. Proc. Natl. Acad. Sci. USA 108, 14968-14973
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 14968-14973
-
-
Cirrito, J.R.1
Disabato, B.M.2
Restivo, J.L.3
Verges, D.K.4
Goebel, W.D.5
Sathyan, A.6
Hayreh, D.7
D'Angelo, G.8
Benzinger, T.9
Yoon, H.10
Kim, J.11
Morris, J.C.12
Mintun, M.A.13
Sheline, Y.I.14
-
34
-
-
84908178935
-
The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation
-
DiGiandomenico, A., Veach, R. A., Zienkiewicz, J., Moore, D. J., Wylezinski, L. S., Hutchens, M. A., and Hawiger, J. (2014) The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation. PLoS ONE 9, e110183
-
(2014)
PLoS ONE
, vol.9
, pp. e110183
-
-
Di Giandomenico, A.1
Veach, R.A.2
Zienkiewicz, J.3
Moore, D.J.4
Wylezinski, L.S.5
Hutchens, M.A.6
Hawiger, J.7
-
35
-
-
58149189408
-
Antibodymediated delivery of interleukin-2 to the stroma of breast cancer strongly enhances the potency of chemotherapy
-
Marlind, J., Kaspar, M., Trachsel, E., Sommavilla, R., Hindle, S., Bacci, C., Giovannoni, L., and Neri, D. (2008) Antibodymediated delivery of interleukin-2 to the stroma of breast cancer strongly enhances the potency of chemotherapy. Clin. Cancer Res. 14, 6515-6524
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6515-6524
-
-
Marlind, J.1
Kaspar, M.2
Trachsel, E.3
Sommavilla, R.4
Hindle, S.5
Bacci, C.6
Giovannoni, L.7
Neri, D.8
-
36
-
-
33748416499
-
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
-
Suntharalingam, G., Perry, M. R., Ward, S., Brett, S. J., Castello-Cortes, A, Brunner, M. D., and Panoskaltsis, N. (2006) Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl. J. Med. 355, 1018-1028
-
(2006)
N Engl. J. Med.
, vol.355
, pp. 1018-1028
-
-
Suntharalingam, G.1
Perry, M.R.2
Ward, S.3
Brett, S.J.4
Castello-Cortes, A.5
Brunner, M.D.6
Panoskaltsis, N.7
-
37
-
-
34548324267
-
The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials
-
Marchetti, S., and Schellens, J. H. (2007) The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials. Br. J. Cancer 97, 577-581
-
(2007)
Br. J. Cancer
, vol.97
, pp. 577-581
-
-
Marchetti, S.1
Schellens, J.H.2
-
38
-
-
84892960440
-
Lost in translation: Animal models and clinical trials in cancer treatment
-
Mak, I. W., Evaniew, N., and Ghert, M. (2014) Lost in translation: animal models and clinical trials in cancer treatment. Am. J. Transl. Res. 6, 114-118
-
(2014)
Am. J. Transl. Res.
, vol.6
, pp. 114-118
-
-
Mak, I.W.1
Evaniew, N.2
Ghert, M.3
-
39
-
-
0031938243
-
Comparative pharmacokinetics of deramciclane in rat, dog, rabbit and man after the administration of a single oral dose of 3 mg kg
-
Klebovich, I., Kanerva, H., Bojti, E., Urtti, A., and Drabant, S. (1998) Comparative pharmacokinetics of deramciclane in rat, dog, rabbit and man after the administration of a single oral dose of 3 mg kg. Pharm. Pharmacol. Commun. 4, 129-136
-
(1998)
Pharm. Pharmacol. Commun.
, vol.4
, pp. 129-136
-
-
Klebovich, I.1
Kanerva, H.2
Bojti, E.3
Urtti, A.4
Drabant, S.5
-
40
-
-
33847338002
-
Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100
-
Yu, R. Z., Kim, T. W., Hong, A., Watanabe, T. A., Gaus, H. J., and Geary, R. S. (2007) Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100. Drug Metab. Dispos. 35, 460-468
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 460-468
-
-
Yu, R.Z.1
Kim, T.W.2
Hong, A.3
Watanabe, T.A.4
Gaus, H.J.5
Geary, R.S.6
-
41
-
-
0032955949
-
The pharmacokinetic principles behind scaling from preclinical results to phase I protocols
-
Mahmood, I., and Balian, J. D. (1999) The pharmacokinetic principles behind scaling from preclinical results to phase I protocols. Clin. Pharmacokinet. 36, 1-11
-
(1999)
Clin. Pharmacokinet.
, vol.36
, pp. 1-11
-
-
Mahmood, I.1
Balian, J.D.2
-
42
-
-
0017100591
-
Problems in extrapolating toxicity data for laboratory animals to man
-
Dixon, R. L. (1976) Problems in extrapolating toxicity data for laboratory animals to man. Environ. Health Perspect. 13, 43-50
-
(1976)
Environ. Health Perspect.
, vol.13
, pp. 43-50
-
-
Dixon, R.L.1
-
43
-
-
0014709310
-
The evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man
-
Schein, P. S., Davis, R. D., Carter, S., Newman, J., Schein, D. R., and Rall, D. P. (1970) The evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man. Clin. Pharmacol. Ther. 11, 3-40
-
(1970)
Clin. Pharmacol. Ther.
, vol.11
, pp. 3-40
-
-
Schein, P.S.1
Davis, R.D.2
Carter, S.3
Newman, J.4
Schein, D.R.5
Rall, D.P.6
-
44
-
-
33746903600
-
Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model
-
Cao, X., Gibbs, S. T., Fang, L., Miller, H. A, Landowski, C. P., Shin, H. C, Lennernas, H., Zhong, Y., Amidon, G. L., Yu, L. X., and Sun, D. (2006) Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharm. Res. 23, 1675-1686
-
(2006)
Pharm. Res.
, vol.23
, pp. 1675-1686
-
-
Cao, X.1
Gibbs, S.T.2
Fang, L.3
Miller, H.A.4
Landowski, C.P.5
Shin, H.C.6
Lennernas, H.7
Zhong, Y.8
Amidon, G.L.9
Yu, L.X.10
Sun, D.11
-
45
-
-
34748925493
-
Prediction of human pharma-cokinetics using physiologically based modeling: A retrospective analysis of 26 clinically tested drugs
-
De Buck, S. S., Sinha, V. K, Fenu, L. A, Nijsen, M. J., Mackie, C. E., and Gilissen, R A (2007) Prediction of human pharma-cokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs. Drug Metab. Dispos. 35, 1766-1780
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 1766-1780
-
-
De Buck, S.S.1
Sinha, V.K.2
Fenu, L.A.3
Nijsen, M.J.4
Mackie, C.E.5
Gilissen, R.A.6
-
47
-
-
33344471951
-
Comments on "a mathematical description of the functionality of correction factors used in allometry for predicting human drug clearance"
-
Mahmood, I. (2006) Comments on "a mathematical description of the functionality of correction factors used in allometry for predicting human drug clearance". Drug Metab. Dispos. 34, 507-509
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 507-509
-
-
Mahmood, I.1
-
48
-
-
84862620957
-
Models of physiology and physiologically based models in clinical pharmacology
-
Atkinson, A J., Jr., and Smith, B. P. (2012) Models of physiology and physiologically based models in clinical pharmacology. Clin. Pharmacol. Ther. 92, 3-6
-
(2012)
Clin. Pharmacol. Ther.
, vol.92
, pp. 3-6
-
-
Atkinson, A.J.1
Smith, B.P.2
-
49
-
-
77449086999
-
Compartmental analysis and its manifold applications to pharmacokinetics
-
Rescigno, A. (2010) Compartmental analysis and its manifold applications to pharmacokinetics. AAPSJ. 12, 61-72
-
(2010)
AAPSJ.
, vol.12
, pp. 61-72
-
-
Rescigno, A.1
-
50
-
-
15244344542
-
Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man
-
Parrott, N., Jones, H., Paquereau, N., and Lave, T. (2005) Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man. Basic Clin. Pharmacol. Toxicol. 96, 193-199
-
(2005)
Basic Clin. Pharmacol. Toxicol.
, vol.96
, pp. 193-199
-
-
Parrott, N.1
Jones, H.2
Paquereau, N.3
Lave, T.4
-
51
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur, J. A, Pearson, K J., Price, N. L., Jamieson, H. A, Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K, Pistell, P. J., Poosala, S., Becker, K G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K W., Spencer, R G., Lakatta, E. G., Le Couteur, D., Shaw, R J., Navas, P., Puigserver, P., Ingram, D. K, De Cabo, R, and Sinclair, D. A (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
Le Couteur, D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
De Cabo, R.26
Sinclair, D.A.27
more..
-
52
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge, M., Argmann, C, Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P., and Auwerx, J. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127, 1109-1122
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
53
-
-
10044243554
-
Resveratrol-associated renal toxicity
-
Crowell, J. A., Korytko, P. J., Morrissey, R. L., Booth, T. D., and Levine, B. S. (2004) Resveratrol-associated renal toxicity. Toxicol. Sci. 82, 614-619
-
(2004)
Toxicol. Sci.
, vol.82
, pp. 614-619
-
-
Crowell, J.A.1
Korytko, P.J.2
Morrissey, R.L.3
Booth, T.D.4
Levine, B.S.5
-
54
-
-
80054853722
-
Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity
-
Johnson, W. D., Morrissey, R. L., Usborne, A. L., Kapetanovic, I., Crowell, J. A., Muzzio, M., and McCormick, D. L. (2011) Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity. Food Chem. Toxicol. 49, 3319-3327
-
(2011)
Food Chem. Toxicol.
, vol.49
, pp. 3319-3327
-
-
Johnson, W.D.1
Morrissey, R.L.2
Usborne, A.L.3
Kapetanovic, I.4
Crowell, J.A.5
Muzzio, M.6
McCormick, D.L.7
-
55
-
-
0036667553
-
Inhibition of cancer growth by resveratrol is related to its low bioavailability
-
Asensi, M., Medina, I., Ortega, A., Carretero, J., Baño, M. C., Obrador, E., and Estrela, J. M. (2002) Inhibition of cancer growth by resveratrol is related to its low bioavailability. Free Radic. Biol. Med. 33, 387-398
-
(2002)
Free Radic. Biol. Med.
, vol.33
, pp. 387-398
-
-
Asensi, M.1
Medina, I.2
Ortega, A.3
Carretero, J.4
Baño, M.C.5
Obrador, E.6
Estrela, J.M.7
-
56
-
-
67649999248
-
Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers
-
Almeida, L., Vaz-da-Silva, M., Falcão, A., Soares, E., Costa, R., Loureiro, A. I., Fernandes-Lopes, C., Rocha, J. F., Nunes, T., Wright, L., and Soares-da-Silva, P. (2009) Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol. Nutr. Food Res. 53(Suppl 1), S7-S15
-
(2009)
Mol. Nutr. Food Res.
, vol.53
, pp. S7-S15
-
-
Almeida, L.1
Vaz-Da-Silva, M.2
Falcão, A.3
Soares, E.4
Costa, R.5
Loureiro, A.I.6
Fernandes-Lopes, C.7
Rocha, J.F.8
Nunes, T.9
Wright, L.10
Soares-Da-Silva, P.11
-
57
-
-
34250901592
-
Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
-
Boocock, D. J., Faust, G. E. S., Patel, K. R., Schinas, A. M., Brown, V. A., Ducharme, M. P., Booth, T. D., Crowell, J. A., Perloff, M., Gescher, A. J., Steward, W. P., and Brenner, D. E. (2007) Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol. Biomarkers Prev. 16, 1246-1252
-
(2007)
Cancer Epidemiol. Biomarkers Prev.
, vol.16
, pp. 1246-1252
-
-
Boocock, D.J.1
Faust, G.E.S.2
Patel, K.R.3
Schinas, A.M.4
Brown, V.A.5
Ducharme, M.P.6
Booth, T.D.7
Crowell, J.A.8
Perloff, M.9
Gescher, A.J.10
Steward, W.P.11
Brenner, D.E.12
-
58
-
-
9444296057
-
High absorption but very low bioavailability of oral resveratrol in humans
-
Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., Jr., and Walle, U. K. (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos. 32, 1377-1382
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 1377-1382
-
-
Walle, T.1
Hsieh, F.2
De Legge, M.H.3
Oatis, J.E.4
Walle, U.K.5
-
59
-
-
0037248470
-
Absorption of three wine-related polyphenols in three different matrices by healthy subjects
-
Goldberg, D. M., Yan, J., and Soleas, G. J. (2003) Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin. Biochem. 36, 79-87
-
(2003)
Clin. Biochem.
, vol.36
, pp. 79-87
-
-
Goldberg, D.M.1
Yan, J.2
Soleas, G.J.3
-
60
-
-
1242336775
-
Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice
-
Meng, X., Maliakal, P., Lu, H., Lee, M. J., and Yang, C. S. (2004) Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J. Agric. Food Chem. 52, 935-942
-
(2004)
J. Agric. Food Chem.
, vol.52
, pp. 935-942
-
-
Meng, X.1
Maliakal, P.2
Lu, H.3
Lee, M.J.4
Yang, C.S.5
-
61
-
-
0036082463
-
Metabolism and disposition of resveratrol in rats: Extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model
-
Marier, J. F., Vachon, P., Gritsas, A., Zhang, J., Moreau, J. P., and Ducharme, M. P. (2002) Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J. Pharmacol. Exp. Ther. 302, 369-373
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.302
, pp. 369-373
-
-
Marier, J.F.1
Vachon, P.2
Gritsas, A.3
Zhang, J.4
Moreau, J.P.5
Ducharme, M.P.6
-
62
-
-
20344364428
-
Metabolism and bioavailability of trans-resveratrol
-
Wenzel, E., and Somoza, V. (2005) Metabolism and bioavailability of trans-resveratrol. Mol. Nutr. Food Res. 49, 472-481
-
(2005)
Mol. Nutr. Food Res.
, vol.49
, pp. 472-481
-
-
Wenzel, E.1
Somoza, V.2
-
63
-
-
53849145999
-
The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol
-
Das, S., Lin, H. S., Ho, P. C., and Ng, K. Y. (2008) The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm. Res. 25, 2593-2600
-
(2008)
Pharm. Res.
, vol.25
, pp. 2593-2600
-
-
Das, S.1
Lin, H.S.2
Ho, P.C.3
Ng, K.Y.4
-
64
-
-
79959910572
-
Population pharmacokinetic modeling of trans-resveratrol and its glucuronide and sulfate conjugates after oral and intravenous administration in rats
-
Colom, H., Alfaras, I., Maijó, M., Juan, M. E., and Planas, J. M. (2011) Population pharmacokinetic modeling of trans-resveratrol and its glucuronide and sulfate conjugates after oral and intravenous administration in rats. Pharm. Res. 28, 1606-1621
-
(2011)
Pharm. Res.
, vol.28
, pp. 1606-1621
-
-
Colom, H.1
Alfaras, I.2
Maijó, M.3
Juan, M.E.4
Planas, J.M.5
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