Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

Hepatology

Volumn 56, Issue 4, 2012, Pages 1499-1508

  Chen, Wei Dong ^a,b   Fu, Xianghui ^a   Dong, Bingning ^c   Wang, Yan Dong ^a,d   Shiah, Steven ^a   Moore, David D ^c   Huang, Wendong ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b HENAN UNIVERSITY   (China)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d Northeastern Ohio Medical University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS[2 (3,5 DICHLOROPYRIDYLOXY)] BENZENE; BENZENE DERIVATIVE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME; CYTOCHROME P450 2B10; CYTOCHROME P450 2C37; HISTONE; HISTONE 3 LYSINE 4; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE JMJD2D; MEMBRANE PROTEIN; RNA; TRANSCRIPTIONAL COACTIVATOR ACTIVATING SIGNAL COINTEGRATOR 2; UNCLASSIFIED DRUG; ZOXAZOLAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DRUG METABOLISM; EPIGENETIC MEMORY; EPIGENETICS; GENE EXPRESSION; GENE LOCUS; LIVER CELL; LIVER METABOLISM; MALE; MEMORY; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SENSITIVITY ANALYSIS; TRIMETHYLATION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION; HEPATOCYTES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PYRIDINES; RANDOM ALLOCATION; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA; SENSITIVITY AND SPECIFICITY;

EID: 84867185582     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25766     Document Type: Article

References (27)

1. Gallou-Kabani C, Vige A, Junien C. Lifelong circadian and epigenetic drifts in metabolic syndrome. Epigenetics 2007; 2: 137-146.
2. Pornthanakasem W, Kongruttanachok N, Phuangphairoj C, Suyarnsestakorn C, Sanghangthum T, Oonsiri S, et al. LINE-1 methylation status of endogenous DNA double-strand breaks. Nucleic Acids Res 2008; 36: 3667-3675.
3. Bateson P, Barker D, Clutton-Brock T, Deb D, D'Udine B, Foley RA, et al. Developmental plasticity and human health. Nature 2004; 430: 419-421.
4. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008; 359: 61-73.
5. Gluckman PD, Hanson MA, Low FM. The role of developmental plasticity and epigenetics in human health. Birth Defects Res C Embryo Today 2011; 93: 12-18.
6. Fagiolini M, Jensen CL, Champagne FA. Epigenetic influences on brain development and plasticity. Curr Opin Neurobiol 2009; 19: 207-212.
7. Hochberg Z, Feil R, Constancia M, Fraga M, Junien C, Carel JC, et al. Child health, developmental plasticity, and epigenetic programming. Endocr Rev 2011; 32: 159-224.
8. Martin-Subero JI, Esteller M. Profiling epigenetic alterations in disease. Adv Exp Med Biol 2011; 711: 162-177.
9. Hitchler MJ, Domann FE. Metabolic defects provide a spark for the epigenetic switch in cancer. Free Radic Biol Med 2009; 47: 115-127.
10. Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 2000; 407: 920-923.
11. di Masi A, De Marinis E, Ascenzi P, Marino M. Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects. Mol Aspects Med 2009; 30: 297-343.
12. Qatanani M, Moore DD. CAR, the continuously advancing receptor, in drug metabolism and disease. Curr Drug Metab 2005; 6: 329-339.
13. Baskin-Bey ES, Huang W, Ishimura N, Isomoto H, Bronk SF, Braley K, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. HEPATOLOGY 2006; 44: 252-262.
14. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, et al. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A 2003; 100: 4150-4155.
15. Zhang J, Huang W, Chua SS, Wei P, Moore DD. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 2002; 298: 422-424.
16. Huang W, Zhang J, Chua SS, Qatanani M, Han Y, Granata R, et al. Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci U S A 2003; 100: 4156-4161.
17. Huang W, Zhang J, Moore DD. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest 2004; 113: 137-143.
18. Lempiainen H, Muller A, Brasa S, Teo SS, Roloff TC, Morawiec L, et al. Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice. PLoS One 2011; 6: e18216.
19. Wang YD, Chen WD, Wang M, Yu D, Forman BM, Huang W. Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. HEPATOLOGY 2008; 48: 1632-1643.
20. Wang YD, Yang F, Chen WD, Huang X, Lai L, Forman BM, et al. Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. Mol Endocrinol 2008; 22: 1622-1632.
21. Wang YD, Chen WD, Yu D, Forman BM, Huang W. The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) in mice. HEPATOLOGY 2011; 54: 1421-1432.
22. Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, et al. Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 2000; 406: 435-439.
23. Choi E, Lee S, Yeom SY, Kim GH, Lee JW, Kim SW. Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor. Mol Endocrinol 2005; 19: 1711-1719.
24. Lee J, Kim DH, Lee S, Yang QH, Lee DK, Lee SK, et al. A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A 2009; 106: 8513-8518.
25. Blanco-Bose WE, Murphy MJ, Ehninger A, Offner S, Dubey C, Huang W, et al. C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. HEPATOLOGY 2008; 48: 1302-1311.
26. Kim DH, Lee J, Lee B, Lee JW. ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity. Mol Endocrinol 2009; 23: 1556-1562.
27. Shin S, Janknecht R. Diversity within the JMJD2 histone demethylase family. Biochem Biophys Res Commun 2007; 353: 973-977.