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Volumn 144, Issue , 2016, Pages 103-112

7,8-Dihydroxyflavone inhibits adipocyte differentiation via antioxidant activity and induces apoptosis in 3T3-L1 preadipocyte cells

Author keywords

7,8 Dihydroxyflavone; Adipocyte; Anti obesity; Antioxidant; Differentiation

Indexed keywords

2,7 DICHLOROFLUORESCEIN DIACETATE; 7,8 DIHYDROXYFLAVONE; CATALASE; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; FAT DROPLET; FLUORESCEIN DIACETATE; FLUORESCEIN ISOTHIOCYANATE; HEME OXYGENASE 1; LIPOCORTIN 5; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OIL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; 6,7-DIHYDROXYFLAVONE; ANTIOBESITY AGENT; ANTIOXIDANT; FLAVONE DERIVATIVE; SCAVENGER;

EID: 84948981232     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.11.028     Document Type: Article
Times cited : (40)

References (60)
  • 1
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • P.G. Kopelman Obesity as a medical problem Nature 404 2000 635 645
    • (2000) Nature , vol.404 , pp. 635-645
    • Kopelman, P.G.1
  • 2
    • 0031821520 scopus 로고    scopus 로고
    • Understanding adipocyte differentiation
    • F.G. Gresgoire, C.M. Smas, and H.S. Sul Understanding adipocyte differentiation Physiol. Rev. 78 1998 783 809
    • (1998) Physiol. Rev. , vol.78 , pp. 783-809
    • Gresgoire, F.G.1    Smas, C.M.2    Sul, H.S.3
  • 3
    • 84864335937 scopus 로고    scopus 로고
    • Adipose tissue and adipocyte differentiation: Molecular and cellular aspects and tissue engineering applications
    • R. Reis, F. Chiellini, University of Oulu Oulu
    • S.M. Niemela, J.R. Sarkanen, and N. Ashammakhi Adipose tissue and adipocyte differentiation: molecular and cellular aspects and tissue engineering applications N. Ashammakhi, R. Reis, F. Chiellini, Topics in Tissue Engineering 2008 University of Oulu Oulu 1 26
    • (2008) Topics in Tissue Engineering , pp. 1-26
    • Niemela, S.M.1    Sarkanen, J.R.2    Ashammakhi, N.3
  • 6
    • 14544298335 scopus 로고    scopus 로고
    • The role of MAPKs in adipocyte differentiation and obesity
    • F. Bost, M. Aouadi, L. Caron, and B. Binetruy The role of MAPKs in adipocyte differentiation and obesity Biochimie 87 2005 51 56
    • (2005) Biochimie , vol.87 , pp. 51-56
    • Bost, F.1    Aouadi, M.2    Caron, L.3    Binetruy, B.4
  • 7
    • 80054993459 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases and reactive oxygen species: How can ROS activate MAPK pathways?
    • Y. Son, Y.K. Cheong, N.H. Kim, H.T. Chung, D.G. Kang, and H.O. Pae Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways? J. Signal. Transduct. 2011 2011 1 6
    • (2011) J. Signal. Transduct. , vol.2011 , pp. 1-6
    • Son, Y.1    Cheong, Y.K.2    Kim, N.H.3    Chung, H.T.4    Kang, D.G.5    Pae, H.O.6
  • 8
    • 51449123847 scopus 로고    scopus 로고
    • Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells
    • M. Sekiya, A. Hiraishi, M. Touyama, and K. Sakamoto Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells Biochem. Biophys. Res. Commun. 375 2008 602 607
    • (2008) Biochem. Biophys. Res. Commun. , vol.375 , pp. 602-607
    • Sekiya, M.1    Hiraishi, A.2    Touyama, M.3    Sakamoto, K.4
  • 9
    • 67449091887 scopus 로고    scopus 로고
    • Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion
    • H. Lee, Y.J. Lee, H. Choi, E.H. Ko, and J.W. Kim Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion J. Biol. Chem. 284 2009 10601 10609
    • (2009) J. Biol. Chem. , vol.284 , pp. 10601-10609
    • Lee, H.1    Lee, Y.J.2    Choi, H.3    Ko, E.H.4    Kim, J.W.5
  • 10
    • 33646764163 scopus 로고    scopus 로고
    • Association of anti-obesity activity of N-acetylcysteine with metallothionein-II down-regulation
    • J.R. Kim, H.H. Ryu, H.J. Chung, J.H. Lee, S.W. Kim, W.H. Kwun, and et al. Association of anti-obesity activity of N-acetylcysteine with metallothionein-II down-regulation Exp. Mol. Med. 38 2006 162 172
    • (2006) Exp. Mol. Med. , vol.38 , pp. 162-172
    • Kim, J.R.1    Ryu, H.H.2    Chung, H.J.3    Lee, J.H.4    Kim, S.W.5    Kwun, W.H.6
  • 11
    • 84859243058 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate suppresses adipocyte differentiation through the MEK/ERK and PI3K/Akt pathways
    • H. Kim, and K. Sakamoto (-)-Epigallocatechin gallate suppresses adipocyte differentiation through the MEK/ERK and PI3K/Akt pathways Cell Biol. Int. 36 2012 147 153
    • (2012) Cell Biol. Int. , vol.36 , pp. 147-153
    • Kim, H.1    Sakamoto, K.2
  • 12
    • 0029030529 scopus 로고
    • Antioxidant potential of intermediates in phenylpropanoid metabolism in higher plants
    • C. Castelluccio, G. Paganga, N. Melikian, G.P. Bolwell, J. Pridham, J. Sampson, and et al. Antioxidant potential of intermediates in phenylpropanoid metabolism in higher plants FEBS Lett. 368 1995 188 192
    • (1995) FEBS Lett. , vol.368 , pp. 188-192
    • Castelluccio, C.1    Paganga, G.2    Melikian, N.3    Bolwell, G.P.4    Pridham, J.5    Sampson, J.6
  • 13
    • 0033771548 scopus 로고    scopus 로고
    • Antioxidant effects of polyphenols in chocolate on low-density lipoprotein both in vitro and ex vivo
    • R. Hirano, N. Osakabe, A. Iwamoto, A. Matsumoto, M. Natsume, T. Takizawa, and et al. Antioxidant effects of polyphenols in chocolate on low-density lipoprotein both in vitro and ex vivo J. Nutr. Sci. Vitaminol. 46 2000 199 204
    • (2000) J. Nutr. Sci. Vitaminol. , vol.46 , pp. 199-204
    • Hirano, R.1    Osakabe, N.2    Iwamoto, A.3    Matsumoto, A.4    Natsume, M.5    Takizawa, T.6
  • 15
    • 0027504187 scopus 로고
    • Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study
    • M.G. Hertog, E.J. Feskens, P.C. Hollman, M.B. Katan, and D. Kromhout Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study Lancet 342 1993 1007 1011
    • (1993) Lancet , vol.342 , pp. 1007-1011
    • Hertog, M.G.1    Feskens, E.J.2    Hollman, P.C.3    Katan, M.B.4    Kromhout, D.5
  • 18
    • 84860498875 scopus 로고    scopus 로고
    • 7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-kappaB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells
    • H.Y. Park, G.Y. Kim, J.W. Hyun, H.J. Hwang, N.D. Kim, B.W. Kim, and et al. 7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-kappaB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells Int. J. Mol. Med. 29 2012 1146 1152
    • (2012) Int. J. Mol. Med. , vol.29 , pp. 1146-1152
    • Park, H.Y.1    Kim, G.Y.2    Hyun, J.W.3    Hwang, H.J.4    Kim, N.D.5    Kim, B.W.6
  • 19
    • 84898874034 scopus 로고    scopus 로고
    • Vasorelaxing and antihypertensive effects of 7,8-dihydroxyflavone
    • R. Huai, X. Han, B. Wang, C. Li, Y. Niu, R. Li, and et al. Vasorelaxing and antihypertensive effects of 7,8-dihydroxyflavone Am. J. Hypertens. 27 2014 750 760
    • (2014) Am. J. Hypertens. , vol.27 , pp. 750-760
    • Huai, R.1    Han, X.2    Wang, B.3    Li, C.4    Niu, Y.5    Li, R.6
  • 20
    • 84899529353 scopus 로고    scopus 로고
    • 7,8-Dihydroxyflavone protects human keratinocytes against oxidative stress-induced cell damage via the ERK and PI3K/Akt-mediated Nrf2/HO-1 signaling pathways
    • M.J. Ryu, K.A. Kang, M.J. Piao, K.C. Kim, J. Zheng, C.W. Yao, and et al. 7,8-Dihydroxyflavone protects human keratinocytes against oxidative stress-induced cell damage via the ERK and PI3K/Akt-mediated Nrf2/HO-1 signaling pathways Int. J. Mol. Med. 33 2014 964 970
    • (2014) Int. J. Mol. Med. , vol.33 , pp. 964-970
    • Ryu, M.J.1    Kang, K.A.2    Piao, M.J.3    Kim, K.C.4    Zheng, J.5    Yao, C.W.6
  • 21
    • 84888235110 scopus 로고    scopus 로고
    • Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity
    • X. Han, S. Zhu, B. Wang, L. Chen, R. Li, W. Yao, and et al. Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity Neurochem. Int. 64 2014 18 23
    • (2014) Neurochem. Int. , vol.64 , pp. 18-23
    • Han, X.1    Zhu, S.2    Wang, B.3    Chen, L.4    Li, R.5    Yao, W.6
  • 22
    • 79960082531 scopus 로고    scopus 로고
    • Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity
    • J. Chen, K.W. Chua, C.C. Chua, H. Yu, A. Pei, B.H. Chua, and et al. Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity Neurosci. Lett. 499 2011 181 185
    • (2011) Neurosci. Lett. , vol.499 , pp. 181-185
    • Chen, J.1    Chua, K.W.2    Chua, C.C.3    Yu, H.4    Pei, A.5    Chua, B.H.6
  • 23
    • 60749102990 scopus 로고    scopus 로고
    • Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity
    • R. Zhang, K.A. Kang, M.J. Piao, D.O. Ko, Z.H. Wang, W.Y. Chang, and et al. Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity Biol. Pharm. Bull. 32 2009 166 171
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 166-171
    • Zhang, R.1    Kang, K.A.2    Piao, M.J.3    Ko, D.O.4    Wang, Z.H.5    Chang, W.Y.6
  • 25
    • 84859739268 scopus 로고    scopus 로고
    • Protocol for effective differentiation of 3T3-L1 cells to adipocytes
    • K. Zebish, V. Voigt, M. Wabitsch, and M. Brandsh Protocol for effective differentiation of 3T3-L1 cells to adipocytes Anal. Biochem. 425 2012 88 90
    • (2012) Anal. Biochem. , vol.425 , pp. 88-90
    • Zebish, K.1    Voigt, V.2    Wabitsch, M.3    Brandsh, M.4
  • 26
    • 0032086769 scopus 로고    scopus 로고
    • HPLC method for evaluation of the free radical-scavenging activity of food by using 1,1-diphenyl-2-picrylhydrazyl
    • G. Yamaguchi, H. Takamura, T. Matoba, and J. Terao HPLC method for evaluation of the free radical-scavenging activity of food by using 1,1-diphenyl-2-picrylhydrazyl Biosci. Biotechnol. Biochem. 62 1998 1201 1204
    • (1998) Biosci. Biotechnol. Biochem. , vol.62 , pp. 1201-1204
    • Yamaguchi, G.1    Takamura, H.2    Matoba, T.3    Terao, J.4
  • 27
    • 0034535853 scopus 로고    scopus 로고
    • Adipocyte differentiation and gene expression
    • J.M. Ntambi, and Y.C. Kim Adipocyte differentiation and gene expression J. Nutr. 130 2000 3122S 3126S
    • (2000) J. Nutr. , vol.130 , pp. 3122S-3126S
    • Ntambi, J.M.1    Kim, Y.C.2
  • 28
    • 67449091887 scopus 로고    scopus 로고
    • Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion
    • H. Lee, Y.J. Lee, and H. Choi Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion J. Biol. Chem. 284 2009 10601 10609
    • (2009) J. Biol. Chem. , vol.284 , pp. 10601-10609
    • Lee, H.1    Lee, Y.J.2    Choi, H.3
  • 29
    • 27744455616 scopus 로고    scopus 로고
    • Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase
    • J.T. Hwang, I.J. Park, Y.K. Lee, S.K. Lee, H.W. Baik, J. Ha, and et al. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase Biochem. Biophys. Res. Commun. 338 2005 694 699
    • (2005) Biochem. Biophys. Res. Commun. , vol.338 , pp. 694-699
    • Hwang, J.T.1    Park, I.J.2    Lee, Y.K.3    Lee, S.K.4    Baik, H.W.5    Ha, J.6
  • 30
    • 80052903790 scopus 로고    scopus 로고
    • Cyanidin-3-O-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes
    • B. Scazzocchio, R. Vari, C. Filesi, M. D'Archivo, C. Santangelo, C. Giovannini, and et al. Cyanidin-3-O-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes Diabetes 60 2011 2234 2244
    • (2011) Diabetes , vol.60 , pp. 2234-2244
    • Scazzocchio, B.1    Vari, R.2    Filesi, C.3    D'Archivo, M.4    Santangelo, C.5    Giovannini, C.6
  • 31
    • 84907189181 scopus 로고    scopus 로고
    • Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells
    • J. Singh, and P. Kakkar Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells Phytomedicine 21 2014 1733 1741
    • (2014) Phytomedicine , vol.21 , pp. 1733-1741
    • Singh, J.1    Kakkar, P.2
  • 32
    • 77951154576 scopus 로고    scopus 로고
    • Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight
    • D.H. Kim, S.C. Woods, and R.J. Seeley Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight Diabetes 59 2010 907 915
    • (2010) Diabetes , vol.59 , pp. 907-915
    • Kim, D.H.1    Woods, S.C.2    Seeley, R.J.3
  • 33
    • 23744496757 scopus 로고    scopus 로고
    • Adipose development: From stem cell to adipocyte
    • T.C. Otto, and M.D. Lane Adipose development: from stem cell to adipocyte Crit. Rev. Biochem. Mol. Biol. 40 2005 229 242
    • (2005) Crit. Rev. Biochem. Mol. Biol. , vol.40 , pp. 229-242
    • Otto, T.C.1    Lane, M.D.2
  • 34
    • 0029083111 scopus 로고
    • Control of adipocyte differentiation
    • M. Cynthia, and H.S. Sul Control of adipocyte differentiation Biochem. J. 309 1995 697 710
    • (1995) Biochem. J. , vol.309 , pp. 697-710
    • Cynthia, M.1    Sul, H.S.2
  • 35
    • 0032885388 scopus 로고    scopus 로고
    • Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
    • W.C. Earnshaw, L.M. Martins, and S.H. Kaufmann Mammalian caspases: structure, activation, substrates, and functions during apoptosis Annu. Rev. Biochem. 68 1999 383 424
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 383-424
    • Earnshaw, W.C.1    Martins, L.M.2    Kaufmann, S.H.3
  • 36
    • 80051668693 scopus 로고    scopus 로고
    • Apoptosis: Why and how does it occur in biology?
    • E. Ulukaya, C. Acilan, and Y. Yilmaz Apoptosis: why and how does it occur in biology? Cell. Biolchem. Funct. 29 2011 468 480
    • (2011) Cell. Biolchem. Funct. , vol.29 , pp. 468-480
    • Ulukaya, E.1    Acilan, C.2    Yilmaz, Y.3
  • 38
    • 0017239088 scopus 로고
    • Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells
    • H. Green, and O. Kehinde Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells Cell 7 1976 105 113
    • (1976) Cell , vol.7 , pp. 105-113
    • Green, H.1    Kehinde, O.2
  • 39
    • 33748942837 scopus 로고    scopus 로고
    • Transcriptional control of adipocyte formation
    • S.R. Farmer Transcriptional control of adipocyte formation Cell Metab. 4 2006 263 273
    • (2006) Cell Metab. , vol.4 , pp. 263-273
    • Farmer, S.R.1
  • 40
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • P. Tontonoz, E. Hu, and B.M. Spiegelman Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor Cell 79 1994 1147 1156
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 42
    • 42649130051 scopus 로고    scopus 로고
    • Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin
    • J.Y. Yang, M.A. Della-Fera, S. Rayalam, S. Ambati, D.L. Hartzell, H.J. Park, and et al. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin Life Sci. 82 2008 1032 1039
    • (2008) Life Sci. , vol.82 , pp. 1032-1039
    • Yang, J.Y.1    Della-Fera, M.A.2    Rayalam, S.3    Ambati, S.4    Hartzell, D.L.5    Park, H.J.6
  • 44
    • 80053108880 scopus 로고    scopus 로고
    • Production of reactive oxygen species and changes in antioxidant enzymes activities during differentiation of 3T3-L1
    • O.K. Lee, Y.I. Kwon, H.D. Hong, C.S. Park, B.Y. Lee, and Y.C. Kim Production of reactive oxygen species and changes in antioxidant enzymes activities during differentiation of 3T3-L1 J. Korean Soc. Appl. Bi. 52 2009 70 75
    • (2009) J. Korean Soc. Appl. Bi. , vol.52 , pp. 70-75
    • Lee, O.K.1    Kwon, Y.I.2    Hong, H.D.3    Park, C.S.4    Lee, B.Y.5    Kim, Y.C.6
  • 45
    • 0042818386 scopus 로고    scopus 로고
    • Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways
    • K.J. Cho, H.E. Moon, H. Moini, L. Packer, D.Y. Yoon, and A.S. Chung Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways J. Biol. Chem. 278 2003 34823 34833
    • (2003) J. Biol. Chem. , vol.278 , pp. 34823-34833
    • Cho, K.J.1    Moon, H.E.2    Moini, H.3    Packer, L.4    Yoon, D.Y.5    Chung, A.S.6
  • 46
    • 3142677140 scopus 로고    scopus 로고
    • Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
    • M.S. Kim, J.Y. Park, C. Namkoong, P.G. Jang, J.W. Ryu, H.S. Song, and et al. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase Nat. Med. 10 2004 727 733
    • (2004) Nat. Med. , vol.10 , pp. 727-733
    • Kim, M.S.1    Park, J.Y.2    Namkoong, C.3    Jang, P.G.4    Ryu, J.W.5    Song, H.S.6
  • 47
    • 0036804710 scopus 로고    scopus 로고
    • Free radicals, antioxidants, and nutrition
    • Y.Z. Fang, S. Yang, and G. Wu Free radicals, antioxidants, and nutrition Nutrition 18 2002 872 879
    • (2002) Nutrition , vol.18 , pp. 872-879
    • Fang, Y.Z.1    Yang, S.2    Wu, G.3
  • 48
    • 0033973712 scopus 로고    scopus 로고
    • The heme synthesis and degradation pathway: Role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties
    • S.W. Ryter, and R.M. Tyrrell The heme synthesis and degradation pathway: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties Free Radic. Biol. Med. 28 2000 289 309
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 289-309
    • Ryter, S.W.1    Tyrrell, R.M.2
  • 50
    • 0029875833 scopus 로고    scopus 로고
    • High glucose induces antioxidant enzymes in human endothelial cells in culture. Evidence linking hyperglycemia and oxidative stress
    • A. Ceriello, P. dello Russo, P. Amstad, and P. Cerutti High glucose induces antioxidant enzymes in human endothelial cells in culture. Evidence linking hyperglycemia and oxidative stress Diabetes 45 1996 471 477
    • (1996) Diabetes , vol.45 , pp. 471-477
    • Ceriello, A.1    Dello Russo, P.2    Amstad, P.3    Cerutti, P.4
  • 52
    • 0037195843 scopus 로고    scopus 로고
    • Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα gene expression during the differentiation of 3T3-L1 preadipocytes
    • D. Prusty, B.H. Park, K.E. Davis, and S.R. Farmer Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα gene expression during the differentiation of 3T3-L1 preadipocytes J. Biol. Chem. 277 2002 46226 46232
    • (2002) J. Biol. Chem. , vol.277 , pp. 46226-46232
    • Prusty, D.1    Park, B.H.2    Davis, K.E.3    Farmer, S.R.4
  • 53
    • 17944363488 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins β and -δ In preadipocytes
    • N. Belmonte, B.W. Phillips, F. Massiera, P. Villageois, B. Wdziekonski, P. Saint-Marc, and et al. Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins β and -δ in preadipocytes Mol. Endocrinol. 15 2001 2037 2049
    • (2001) Mol. Endocrinol. , vol.15 , pp. 2037-2049
    • Belmonte, N.1    Phillips, B.W.2    Massiera, F.3    Villageois, P.4    Wdziekonski, B.5    Saint-Marc, P.6
  • 54
    • 0033610788 scopus 로고    scopus 로고
    • Specific inhibitors of p38 mitogen-activated protein kinase block 3T3- L1 adipogenesis
    • J.A. Engelman, M.P. Lisanti, and P.E. Scherer Specific inhibitors of p38 mitogen-activated protein kinase block 3T3- L1 adipogenesis J. Biol. Chem. 273 1998 32111 32120
    • (1998) J. Biol. Chem. , vol.273 , pp. 32111-32120
    • Engelman, J.A.1    Lisanti, M.P.2    Scherer, P.E.3
  • 55
    • 0037323398 scopus 로고    scopus 로고
    • Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor γ during bone morphogenetic protein 2-induced adipogenesis
    • K. Hata, R. Nishimura, F. Ikeda, K. Yamashita, T. Matsubara, T. Nokubi, and et al. Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor γ during bone morphogenetic protein 2-induced adipogenesis Mol. Biol. Cell 14 2003 545 555
    • (2003) Mol. Biol. Cell , vol.14 , pp. 545-555
    • Hata, K.1    Nishimura, R.2    Ikeda, F.3    Yamashita, K.4    Matsubara, T.5    Nokubi, T.6
  • 56
    • 19944433322 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
    • F. Bost, M. Aouadi, L. Caron, P. Even, N. Belmonte, M. Prot, and et al. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis Diabetes 54 2005 402 411
    • (2005) Diabetes , vol.54 , pp. 402-411
    • Bost, F.1    Aouadi, M.2    Caron, L.3    Even, P.4    Belmonte, N.5    Prot, M.6
  • 57
    • 84924980688 scopus 로고    scopus 로고
    • Activation of muscular TrkB by its small molecular agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice
    • C.B. Chan, M.C.L. Tse, X. Liu, S. Zhang, R. Schmidt, R. Otten, and et al. Activation of muscular TrkB by its small molecular agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice Chem. Biol. 22 2015 355 368
    • (2015) Chem. Biol. , vol.22 , pp. 355-368
    • Chan, C.B.1    Tse, M.C.L.2    Liu, X.3    Zhang, S.4    Schmidt, R.5    Otten, R.6
  • 58
    • 0026517080 scopus 로고
    • Enhancement of adipocyte differentiation by an insulin-sensitizing agent
    • R.F. Kletzien, S.D. Clarke, and R.G. Ulrich Enhancement of adipocyte differentiation by an insulin-sensitizing agent Mol. Pharm. 41 2 1992 393 398
    • (1992) Mol. Pharm. , vol.41 , Issue.2 , pp. 393-398
    • Kletzien, R.F.1    Clarke, S.D.2    Ulrich, R.G.3
  • 59
    • 84856059838 scopus 로고    scopus 로고
    • 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease
    • L. Devi, and M. Ohno 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease Neuropsychopharmacology 37 2012 434 444
    • (2012) Neuropsychopharmacology , vol.37 , pp. 434-444
    • Devi, L.1    Ohno, M.2
  • 60
    • 84913586296 scopus 로고    scopus 로고
    • Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling
    • C.H. Wu, T.H. Hung, C.C. Chen, C.H. Ke, C.Y. Lee, P.Y. Wang, and et al. Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling PLoS One 9 11 2014 e113397
    • (2014) PLoS One , vol.9 , Issue.11
    • Wu, C.H.1    Hung, T.H.2    Chen, C.C.3    Ke, C.H.4    Lee, C.Y.5    Wang, P.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.