Vasorelaxing and antihypertensive effects of 7,8-dihydroxyflavone

American Journal of Hypertension

Volumn 27, Issue 5, 2014, Pages 750-760

  Huai, Ruituo ^a,b   Han, Xiaohua ^a   Wang, Bingxiang ^a   Li, Chunlin ^a   Niu, Yawen ^a   Li, Ran ^a   Qu, Zhiqiang ^a  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b SHANDONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

7,8 dihydroxyflavone; antihypertensive; aorta; blood pressure; hypertension; vasorelaxant.

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 7,8 DIHYDROXYFLAVONE; ANTIHYPERTENSIVE AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHENYLEPHRINE; TROPOMYOSIN; 6,7-DIHYDROXYFLAVONE; CYCLIC GMP; FLAVONE DERIVATIVE; NOS3 PROTEIN, RAT; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CALCIUM SIGNALING; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; MUSCLE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PHOSPHORYLATION; SPONTANEOUSLY HYPERTENSIVE RAT; THORACIC AORTA; VASCULAR ENDOTHELIUM;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA, THORACIC; CALCIUM SIGNALING; CELLS, CULTURED; CYCLIC GMP; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FLAVONES; HYPERTENSION; INJECTIONS, INTRAVENOUS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; RATS, INBRED SHR; VASODILATION; VASODILATOR AGENTS;

EID: 84898874034     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hpt220     Document Type: Article

References (33)

1. Jang S W, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wilson WD, Xiao G, Blanchi B, Sun YE, Ye K. A selective TrkB agonist with potent neurotrophic activities by 7, 8-dihydroxyfavone. Proc Natl Acad Sci USA 2010; 107:2687-2692.
2. Devi L, Ohno M. 7, 8-dihydroxyfavone, a small-molecule TrkB agonist, reverses memory defcits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2012; 37:434-444.
3. Spencer JP. Te impact of fruit favonoids on memory and cognition. Br J Nutr 2010; 104:S40-S47.
4. Cazorla M, Premont J, Mann A, Girard N, Kellendonk C, Rognan D. Identifcation of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest 2011; 121:1846-1857.
5. Donovan MJ, Miranda RC, Kraemer R, McCafrey TA, Tessarollo L, Mahadeo D, Sharif S, Kaplan DR, Tsoulfas P, Parada L, Toran-Allerand CD, Hajjar D P, Hempstead BL. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol 1995; 147:309-324.
6. Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibanez CF, Rafi S, Hempstead BL. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 2000; 127:4531-4540.
7. Nicolle E, Souard F, Faure P, Boumendjel A. Flavonoids as promising lead compounds in type 2 diabetes mellitus: molecules of interest and structure-activity relationship. CurrMed Chem 2011; 18:2661-2672.
8. Liu HL, Jiang WB, Xie MX. Flavonoids: recent advances as anticancer drugs. Recent Pat Anti-Canc 2010; 5:152-164.
9. Gutierrez-Merino C, Lopez-Sanchez C, Lagoa R, Samhan-Arias AK, Bueno C, Garcia-Martinez V. Neuroprotective actions of favonoids. CurrMed Chem 2011; 18:1195-1212.
10. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2009; 2:270-278.
11. Heiss C, Keen CL, Kelm M. Flavanols and cardiovascular disease prevention. Eur Heart J 2010; 31:2583-U2532.
12. Schewe T, Stefen Y, Sies H. How do dietary favanols improve vascular function? A position paper. Arch Biochem Biophys 2008; 476:102-106.
13. Schini-Kerth VB, Auger C, Kim JH, Etienne-Selloum N, Chataigneau T. Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pfug Arch Eur J Phy 2010; 459:853-862.
14. Schini-Kerth VB, Auger C, Etienne-Selloum N, Chataigneau T. Polyphenol-induced endothelium-dependent relaxations: role of NO and EDHF. Adv Pharmacol 2010; 60:133-175.
15. Santhanam AV, Smith LA, Katusic ZS. Brain-derived neurotrophic factor stimulates production of prostacyclin in cerebral arteries. Stroke 2010; 41:350-356.
16. Benito S, Lopez D, Saiz M P, Buxaderas S, Sanchez J, Puig-Parellada P, Mitjavila MT. A favonoid-rich diet increases nitric oxide production in rat aorta. Br J Pharmacol 2002; 135:910-916.
17. Diebolt M, Bucher B, Andriantsitohaina R. Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression. Hypertension 2001; 38:159-165.
18. Loscalzo J, Welch G. Nitric oxide and its role in the cardiovascular system. Prog Cardiovasc Dis 1995; 38:87-104.
19. Kojda G, Laursen JB, Ramasamy S, Kent JD, Kurz S, Burchfeld J, Shesely EG, Harrison DG. Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: contributions of NOS isoforms to blood pressure and heart rate control. Cardiovasc Res 1999; 42:206-213.
20. Searles CD. Transcriptional and posttranscriptional regulation of endothe-lial nitric oxide synthase expression. Am J Physiol 2006; 291:C803-C816.
21. Morgado M, Cairrao E, Santos-Silva AJ, Verde I. Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle. Cell Mol Life Sci 2012; 69:247-266.
22. Prieto D. Physiological regulation of penile arteries and veins. Int J Impot Res 2008; 20:17-29.
23. Ko EA, Han J, Jung ID, Park WS. Physiological roles of K+ channels in vascular smooth muscle cells. J Smooth Muscle Res 2008; 44:65-81.
24. Gupta VK, You Y, Li JC, Klistorner A, Graham SL. Protective efects of 7, 8-dihydroxyfavone on retinal ganglion and RGC-5 cells against exci-totoxic and oxidative stress. J Mol Neurosci 2013; 49:96-104.
25. English AW, Liu K, Nicolini JM, Mulligan AM, Ye K. Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves. Proc Natl Acad Sci USA 2013; 110:16217-16222.
26. Yu Q, Chang Q, Liu X, Wang Y, Li H, Gong S, Ye K, Lin X. Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists. J Neurosci 2013; 33:13042-13052.
27. Andero R, Daviu N, Escorihuela RM, Nadal R, Armario A. 7, 8-dihy-droxyfavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Hippocampus 2012; 22:399-408.
28. Bollen E, Vanmierlo T, Akkerman S, Wouters C, Steinbusch HM, Prickaerts J. 7, 8-Dihydroxyfavone improves memory consolidation processes in rats and mice. Behav Brain Res 2013; 257C:8-12.
29. Liu X, Chan CB, Qi Q, Xiao G, Luo HR, He X, Ye K. Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7, 8-dihydroxyfavone active in mouse models of depression. J Med Chem 2012; 55:8524-8537.
30. Lincoln TM, Dey N, Sellak H. Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression. J Appl Physiol 2001; 91:1421-1430.
31. Van Hove CE, Van der Donckt C, Herman AG, Bult H, Fransen P. Vasodilator efcacy of nitric oxide depends on mechanisms of intracellular calcium mobilization in mouse aortic smooth muscle cells. Br J Pharmacol 2009; 158:920-930.
32. Linder AE, McCluskey L P, Cole KR 3rd, Lanning KM, Webb RC. Dynamic association of nitric oxide downstream signaling molecules with endothelial caveolin-1 in rat aorta. J Pharmacol Exp Terap 2005; 314:9-15.
33. Dornas WC, Silva ME. Animal models for the study of arterial hypertension. J Biosci 2011; 36:731-737.