Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells

Phytomedicine

Volumn 21, Issue 12, 2014, Pages 1733-1741

  Singh, Jyotsna ^a   Kakkar, Poonam ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Adipogenesis; Apoptosis; Lipolysis; Oroxylin A; Oroxylum indicum; PPAR

Indexed keywords

ADIPONECTIN; CYTOCHROME C; KAEMPFEROL; LIPID; MESSENGER RNA; MORIN; NARINGENIN; OROXYLIN A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BAX; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; 5,7-DIHYDROXY-6-METHOXY-2-PHENYLCHROMEN-4-ONE; FLAVONOID;

3T3 CELL LINE; ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CELL VIABILITY; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LIPID STORAGE; LIPOLYSIS; MOUSE; NONHUMAN; OROXYLUM; PROADIPOCYTE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; WESTERN BLOTTING; ANIMAL; BIGNONIACEAE; CHEMISTRY; DRUG EFFECTS; MEDICINAL PLANT;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; APOPTOSIS; BIGNONIACEAE; FLAVONOIDS; LIPOLYSIS; MICE; PLANTS, MEDICINAL;

EID: 84907189181     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.08.014     Document Type: Article

References (37)

1. C. Ando, N. Takahashi, S. Hirai, K. Nishimura, S. Lin, T. Uemura, T. Goto, R. Yu, J. Nakagami, S. Murakami, and T. Kawada Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation FEBS Lett. 583 2009 3649 3654
2. Y. Barak, M.C. Nelson, E.S. Ong, Y.Z. Jones, P. Ruiz-Lozano, and K.R. Chien PPARγ is required for placental, cardiac, and adipose tissue development Mol. Cell 4 1999 585 595
3. G. Carter, A. Apostolatos, R. Patel, A. Mathur, D. Cooper, and M. Murr Dysregulated alternative splicing pattern of PKC during differentiation of human pre-adipocytes represents distinct differences between lean and obese adipocytes ISRN Obes. 2013 9 Article ID 161345
4. M.H. Cha, I.C. Kim, B.H. Lee, and Y. Yoon Baicalein inhibits adipocyte differentiation by enhancing COX-2 expression J. Med. Food 9 2006 145 153
5. P. D'Mello, P. Shetgiri, and K. Darji Investigation and quantitation of phytoconstituents from Oroxylum indicum bark by GC - mass and HPLC techniques IJPBS 3 2012 237 242
6. P.M. D'Mello, K.K. Darji, and P.P. Shetgiri Evaluation of anti-obesity activity of various plant extracts Pharmacogn. J. 3 2011 56 59
7. Y. Gao, N. Lu, Y. Ling, Y. Chen, L. Wang, and Q. Zhao Oroxylin A inhibits angiogenesis through blocking vascular endothelial growth factor-induced KDR/Flk-1 phosphorylation J. Cancer Res. Clin. Oncol. 136 2010 667 675
8. C. Herold, H.O. Rennekampff, and S. Engeli Apoptotic pathways in adipose tissue Apoptosis 18 2013 911 916
9. R. Hu, N. Chen, J. Yao, Q. Zhao, F. Zhang, and Z.Y. Li The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors Anticancer Drugs 23 2012 651 658
10. S.J. Humphrey, G. Yang, P. Yang, D.J. Fazakerley, J. Stöckli, J.Y. Yang, and D.E. James Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2 Cell Metab. 17 2013 1009 1020
11. R.T. Hurt, C. Kulisek, L.A. Buchanan, and S.A. McClave The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists Gastroenterol. Hepatol. (N Y) 6 2010 780 792
12. S.A. Hussain, and B.H. Marouf Flavonoids as alternatives in treatment of type 2 diabetes mellitus AJMP 1 2013 031 036
13. S.J. Jeon, H. Bak, J. Seo, S.M. Han, S.H. Lee, and S.H. Han Oroxylin A induces BDNF expression on critical neurons through adenosine A2A receptor stimulation: a possible role in neuroprotection Biomol. Ther. (Seoul) 20 2012 27 35
14. S.I. Kang, H.S. Shin, H.C. Ko, and S.J. Kim Effects of sinensetin on lipid metabolism in mature 3T3-L1 adipocytes Phytother. Res. 27 2013 131 134
15. A. Kawahara, N. Haraguchi, H. Tsuchiya, Y. Ikeda, S. Hama, and K. Kogure Peroxisome proliferator-activated receptor γ (PPARγ)-independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907 Biol. Pharmaceut. Bull. 36 2013 1428 1434
16. D.H. Kim, S.C. Woods, and R.J. Seeley Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight Diabetes 59 2010 907 915
17. C. Lalou, A. Basak, P. Mishra, B.C. Mohanta, R. Banik, and B. Dinda Inhibition of tumor cells proliferation and migration by the flavonoid furin inhibitor isolated from Oroxylum indicum Curr. Med. Chem. 20 2013 583 591
18. J.M. Lehmann, L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPARγ) J. Biol. Chem. 270 1995 12953 12956
19. S. Lim, K. Soh, and U. Kuppusamy Effects of naringenin on lipogenesis, lipolysis and glucose uptake in rat adipocyte primary culture: a natural antidiabetic agent Internet J. Altern. Med. 5 2 2007 2007
20. C.E. Lowe, S. O'Rahilly, and J.J. Rochford Adipogenesis at a glance J. Cell Sci. 124 2011 2681 2686
21. Y. Niwano, F. Beppu, T. Shimada, R. Kyan, K. Yasura, and M. Tamaki Extensive screening of plant food stuffs in Okinawa, Japan with anti-obese activity on adipocytes in vitro Plant Food Hum. Nutr. 64 2009 6 10
22. M. Ono, and K. Fujimori Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells J. Agric. Food Chem. 59 2011 13346 13352
23. H.S. Park, S.H. Kim, Y.S. Kim, S.Y. Ryu, J.T. Hwang, H.J. Yang, G.H. Kim, D.Y. Kwon, and M.S. Kim Luteolin inhibits adipogenic differentiation by regulating PPARgamma activation Biofactors 35 2009 373 379
24. U.H. Park, J.C. Jeong, J.S. Jang, M.R. Sung, H. Youn, S.J. Lee, E.J. Kim, and S.J. Um Negative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cells Biol. Pharm. Bull. 35 2012 1525 1533
25. J.B. Prins, C.U. Niesler, C.M. Winterford, N.A. Bright, and K. Siddle Tumor necrosis factor-alpha induces apoptosis of human adipose cells Diabetes 46 1997 1939 1944
26. J.L. Ramírez-Zacarías, F. Castro-Muñozledo, and W. Kuri-Harcuch Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O Histochemistry 97 1992 493 497
27. S. Rayalam, M.A. Della-Fera, and C.A. Baile Phytochemicals and regulation of the adipocyte life cycle J. Nutr. Biochem. 19 2008 717 726
28. E.D. Rosen, P. Sarraf, A.E. Troy, G. Bradwin, K. Moore, and D.S. Milstone PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro Mol. Cell 4 1999 611 617
29. M. Ryden, E. Arvidsson, L. Blomqvist, L. Perbeck, and A. Dicker Targets for TNF-alpha-induced lipolysis in human adipocytes Biochem. Biophys. Res. Commun. 318 2004 168 175
30. J. Singh, and P. Kakkar Modulation of liver function, antioxidant responses, insulin resistance and glucose transport by Oroxylum indicum stem bark in STZ induced diabetic rats Food Chem. Toxicol. 62 2013 722 731
31. A. Sorisky, and A. Gagnon Clinical implications of adipose tissue remodelling: adipogenesis and apoptosis Can. J. Diabetes 26 2002 232 240
32. J.M. Stephens The fat controller: adipocyte development PLoS Biol. 10 2012 e1001436
33. A.K. Student, R.Y. Hsu, and M.D. Lane Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes J. Biol. Chem. 255 1980 4745 4750
34. P. Trayhurn Endocrine and signalling role of adipose tissue: new perspectives on fat Acta Physiol. Scand. 184 2005 285 293
35. Z. Wu, Y. Xie, N.L. Bucher, and S.R. Farmer Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis Genes Dev. 9 1995 2350 2363
36. Y. Xiao, T. Yuan, W. Yao, and K. Liao 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway FEBS J. 277 2010 687 696
37. M. Zou, N. Lu, C. Hu, W. Liu, Y. Sun, and X. Wang Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling Cell Signal. 24 2012 1722 1732