Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation

FASEB Journal

Volumn 29, Issue 11, 2015, Pages 4641-4653

  Grevengoed, Trisha J ^a   Cooper, Daniel E ^a   Young, Pamela A ^a   Ellis, Jessica M ^a   Coleman, Rosalind A ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

ATP synthase; B oxidation; Glucose metabolism; Heart metabolism; Lipid metabolism

Indexed keywords

ACYL COA SYNTHETASE 1; ADENOSINE DIPHOSPHATE; LONG CHAIN FATTY ACID COENZYME A LIGASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3B; OXYGEN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RAPAMYCIN; UNCLASSIFIED DRUG; ACSL1 PROTEIN, MOUSE; COENZYME A LIGASE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; BREATHING RATE; CELL DAMAGE; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FATTY ACID OXIDATION; FEMALE; GENE EXPRESSION; GROWTH INHIBITION; HEART; HEART MITOCHONDRION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN; ANIMAL; CARDIAC MUSCLE; DEFICIENCY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; AUTOPHAGY; COENZYME A LIGASES; MICE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MULTIPROTEIN COMPLEXES; MYOCARDIUM; OXYGEN CONSUMPTION; PROTON-TRANSLOCATING ATPASES; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84948823352     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-272732     Document Type: Article

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