Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity

Circulation

Volumn 119, Issue 21, 2009, Pages 2818-2828

  Yan, Jie ^a   Young, Martin E ^b   Cui, Lei ^a   Lopaschuk, Gary D ^c   Liao, Ronglih ^a   Tian, Rong ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cardiomyopathy; Contractility; Fatty acids; Glucose; Metabolism

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FATTY ACID; GLUCOSE TRANSPORTER 1; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; 3 OXOACID COENZYME A TRANSFERASE; 3-KETOACID COA-TRANSFERASE; COENZYME A TRANSFERASE; GLUCOSE; HYBRID PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; REACTIVE OXYGEN METABOLITE; SLC2A1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; HEART DISEASE; LIPID DIET; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; CALCIUM SIGNALING; ENZYME SPECIFICITY; FAT INTAKE; GENE EXPRESSION REGULATION; GENETICS; HEART CONTRACTION; HEART MUSCLE; HEART MUSCLE CELL; LOW FAT DIET; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

ACETYL-COA CARBOXYLASE; ANIMALS; CALCIUM SIGNALING; COENZYME A-TRANSFERASES; DIET, FAT-RESTRICTED; DIETARY FATS; FATTY ACIDS; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; OBESITY; OXIDATION-REDUCTION; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY;

EID: 67649209841     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.832915     Document Type: Article

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