Fatty acid utilization in the hypertrophied and failing heart: Molecular regulatory mechanisms

American Journal of the Medical Sciences

Volumn 318, Issue 1, 1999, Pages 36-42

  Barger, Philip M ^a   Kelly, Daniel P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Energy metabolism; Heart failure; Hypertrophy; Lipids; Mitochondria

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; TRANSCRIPTION FACTOR;

CONFERENCE PAPER; ENERGY METABOLISM; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GENE CONTROL; HEART FAILURE; HEART HYPERTROPHY; HEART MITOCHONDRION; HEART MUSCLE METABOLISM; HUMAN; NONHUMAN; TRANSCRIPTION REGULATION;

EID: 0033507201     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9629(15)40570-1     Document Type: Conference Paper

References (30)

1. Lompre AM, Schwartz K, Albis A, et al. Myosin isozymes redistribution in chronic heart overloading. Nature 1979;282: 105-7.
2. Nadal-Ginard B, Mahdavi V. Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches. J Clin Invest 1989;84: 1694-700.
3. Lattion AL, Michel JB, Arnauld E, et al. Myocardial recruitment during ANF mRNA increase with volume overload in the rat. Am J Physiol 1986;251:H890-6.
4. Buttrick PM, Kaplan M, Leinwand LA, et al. Alterations in gene expression in the rat heart after chronic pathological and physiological loads. J Mol Cell Cardiol 1994;26:61-7.
5. Bishop SP, Altschuld RA. Increased glycolytic metabolism in cardiac hypertrophy and congestive failure. Am J Physiol 1970;218:153-9.
6. Taegtmeyer H, Overturf ML. Effects of moderate hypertension on cardiac function and metabolism in the rabbit. Hypertension 1988;11:416-26.
7. Bing RJ. The metabolism of the heart. Harvey Lect 1955;50: 27-70.
8. Taegtmeyer H. Energy metabolism of the heart: from basic concepts to clinical applications. Curr Probl Cardiol 1994;19: 57-116.
9. Takeyama D, Kagaya Y, Yamane Y, et al. Effects of chronic right ventricular pressure overload on myocardial glucose and free fatty acid metabolism in the conscious rat. Cardiovasc Res 1995;29:763-7.
10. Massie BM, Schaefer S, Garcia J, et al. Myocardial high-energy phosphate and substrate metabolism in swine with moderate left ventricular hypertrophy. Circulation 1995;91: 1814-23.
11. Christe ME, Rodgers RL. Altered glucose and fatty acid oxidation in hearts of the spontaneously hypertensive rat. J Mol Cell Cardiol 1994;26:1371-5.
12. Wittels B, Spann JF Jr. Defective lipid metabolism in the failing heart. J Clin Invest 1968;47:1787-94.
13. Feinendegen LE, Henrich MM, Kuikka JT, et al. Myocardial lipid turnover in dilated cardiomyopathy: a dual in vivo tracer approach J Nucl Cardiol 1995;2:42-52.
14. Kelly DP, Strauss AW. Inherited cardiomyopathies. N Engl J Med 1993;330:913-9.
15. Kelly DP, Gordon JI, Alpers R, et al. The tissue-specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins: medium-chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase. J Biol Chem 1989;264:18921-5.
16. Nagao M, Parimoo B, Tanaka K. Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and α-subunit of electron transfer flavoprotein in rat. J Biol Chem 1993;268:24114-24.
17. McCune SA, Park S, Radin MJ, et al. The SHHF/Mcc-facp: a genetic model of congestive heart failure. In: Singal PK, Dixon IMC, Beamish RE, Dhalla NS, editors. Mechanisms of heart failure. Boston: Kluwer Academic Publishers; 1995. p. 91-106.
18. Sack MN, Rader TA, Park S, et al. Mitochondrial fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 1996;94:2837-42.
19. Rockman HA, Ono S, Ross RS, et al. Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl Acad Sci U S A 1994;91:2694-8.
20. Sack MN, Disch D, Rockman H, et al. A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci U S A 1997;94: 6438-43.
21. Disch DL, Rader TA, Cresci S, et al. Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: A role for nuclear receptors in cardiac and brown adipose expression. Mol Cell Biol 1996;16:4043-51.
22. Carter ME, Gulick TG, Moore DD, et al. A pleiotropic response element in the medium chain acyl-CoA dehydrogenase gene promoter mediates transcriptional regulation by members of the nuclear receptor transcription family and defines novel receptor DNA binding motifs. Mol Cell Biol 1994;14:4360-72.
23. Leone TC, Cresci S, Carter ME, et al. The human medium-chain acyl-CoA dehydrogenase (MCAD) gene promoter consists of a complex arrangement of nuclear receptor response elements and Sp1 binding sites. J Biol Chem 1995; 270:16308-14.
24. Gulick T, Cresci S, Caira T, et al. The peroxisome proliferator activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci U S A 1994;91:11012-6.
25. Karns LR, Kariya K, Simpson PC. M-CAT, CArG, and Sp1 elements required for αl-adrenergic induction of the skeletal alpha-actin promoter during cardiac myocyte hypertrophy. Transcriptional enhancer factor-1 and protein kinase C as conserved transducers of the fetal program in cardiac growth. J Biol Chem 1995;270:410-7.
26. Sadoshima J, Izumo S. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J 1993;12:1681-92.
27. +)-ATPase activity in rat cardiac hypertrophy. Expression of the neonatal forms. J Biol Chem 1986;261:185-9.
28. 2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat. Circ Res 1990;66:554-64.
29. Greaves P, Martin J, Michel MC, et al. Cardiac hypertrophy in the dog and rat induced by oxfenicine, an agent which modifies muscle metabolism. Arch Toxicol 1984;7:488-93.
30. Rupp H, Jacob R. Metabolically-modulated growth and phenotype of the rat. Eur Heart J 1992;13:56-61.