Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart

Cardiovascular Research

Volumn 76, Issue 1, 2007, Pages 71-80

  Sharma, Saumya ^a   Guthrie, Patrick H ^a   Chan, Suzanne S ^a   Haq, Syed ^b   Taegtmeyer, Heinrich ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

Amino acids; Glucose; Growth substances; Insulin; Metabolism

Indexed keywords

ADENYLATE KINASE; CARBOHYDRATE; DEOXYGLUCOSE; GLUCOSE; HEXOSAMINE; INSULIN; INSULIN RECEPTOR KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PENTOSE PHOSPHATE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; GLUCOSE METABOLISM; GLYCOLYSIS; HEART; HEART DEVELOPMENT; HEART MUSCLE CELL; INHIBITION KINETICS; ISOLATED HEART; MALE; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELLS, CULTURED; GLUCOSE; GLYCOLYSIS; HEXOSAMINES; INSULIN; MALE; MYOCYTES, CARDIAC; PENTOSEPHOSPHATES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION;

EID: 34548418134     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2007.05.004     Document Type: Article

References (34)

1. Rohde J., Heitman J., and Cardenas M.E. The TOR kinases link nutrient sensing to cell growth. J Biol Chem 276 (2001) 9583-9586
2. Crespo J.L., and Hall M.N. Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol Mol Biol Rev 66 (2002) 579-591
3. Proud C.G. Role of mTOR signalling in the control of translation initiation and elongation by nutrients. Curr Top Microbiol Immunol 279 (2004) 215-244
4. Barbieri M., Bonafe M., Franceschi C., and Paolisso G. Insulin/igf-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab 285 (2003) E1064-E1071
5. Moule S.K., and Denton R.M. Multiple signaling pathways involved in the metabolic effects of insulin. Am J Cardiol 80 (1997) 41A-49A
6. Proud C.G. Regulation of mammalian translation factors by nutrients. Eur J Biochem 269 (2002) 5338-5349
7. Schmelzle T., and Hall M.N. TOR, a central controller of cell growth. Cell 103 2 (2000) 253-262
8. Shioi T., McMullen J.R., Tarnavski O., Converso K., Sherwood M.C., Manning W.J., et al. Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation 107 (2003) 1664-1670
9. Shioi T., McMullen J.R., Kang P.M., Douglas P.S., Obata T., Franke T.F., et al. Akt/protein kinase b promotes organ growth in transgenic mice. Mol Cell Biol 22 (2002) 2799-2809
10. Anthony J.C., Anthony T.G., Kimball S.R., Vary T.C., and Jefferson L.S. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eif4f formation. J Nutr 130 (2000) 139-145
11. Anthony J.C., Yoshizawa F., Anthony T.G., Vary T.C., Jefferson L.S., and Kimball S.R. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 130 (2000) 2413-2419
12. Vary T.C., Jefferson L.S., and Kimball S.R. Amino acid-induced stimulation of translation initiation in rat skeletal muscle. Am J Physiol 277 6 Pt 1 (1999) E1077-E1086
13. Kimball S.R., and Jefferson L.S. Control of protein synthesis by amino acid availability. Curr Opin Clin Nutr Metab Care 5 (2002) 43-45
14. Anthony T.G., Anthony J.C., Yoshizawa F., Kimball S.R., and Jefferson L.S. Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats. J Nutr 131 (2001) 1171-1176
15. Wang X., Campbell L.E., Miller C.M., and Proud C.G. Amino acid availability regulates p70 s6 kinase and multiple translation factors. Biochem J 334 (1998) 261-267
16. Taegtmeyer H., Hems R., and Krebs H.A. Utilization of energy-providing substrates in the isolated working rat heart. Biochem J 186 (1980) 701-711
17. Haq S., Choukroun G., Kang Z.B., Ranu H., Matsui T., Rosenzweig A., et al. Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J Cell Biol 151 (2000) 117-130
18. Depre C., Shipley G.L., Chen W., Han Q., Doenst T., Moore M.L., et al. Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med 4 (1998) 1269-1275
19. Razeghi P., Sharma S., Ying J., Li Y.P., Stepkowski S., Reid M.B., et al. Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation. Circulation 108 (2003) 2536-2541
20. McClain D.A. Hexosamines as mediators of nutrient sensing and regulation in diabetes. J Diabetes Complications 16 (2002) 72-80
21. Sakamoto K., and Goodyear L.J. Invited review: Intracellular signaling in contracting skeletal muscle. J Appl Physiol 93 (2002) 369-383
22. Cheng S.W., Fryer L.G., Carling D., and Shepherd P.R. Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem 279 (2004) 15719-15722
23. 3H]glucose overestimates glycolytic flux in isolated working rat heart: role of the pentose phosphate pathway. Am J Physiol Endocrinol Metab 280 (2001) E502-E508
24. Doiron B., Cuif M.H., Chen R., and Kahn A. Transcriptional glucose signaling through the glucose response element is mediated by the pentose phosphate pathway. J Biol Chem 271 (1996) 5321-5324
25. Rovetto M., Lamberton W., and Neely J. Mechanisms of glycolytic inhibition in ischemic rat heart. Circ Res 37 (1975) 742-751
26. Randle P.J., Garland P.B., Hales C.N., and Newsholme E.A. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 (1963) 785-789
27. Taegtmeyer H., McNulty P., and Young M.E. Adaptation and maladaptation of the heart in diabetes: Part I: general concepts. Circulation 105 (2002) 1727-1733
28. Belke D.D., Betuing S., Tuttle M.J., Graveleau C., Young M.E., Pham M., et al. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 109 (2002) 629-639
29. Taegtmeyer H., Roberts A.F., and Raine A.E. Energy metabolism in reperfused heart muscle: metabolic correlates to return of function. J Am Coll Cardiol 6 (1985) 864-870
30. Andreozzi F., D'Alessandris C., Federici M., Laratta E., Del Guerra S., Del Prato S., et al. Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on ser307 and ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in rin pancreatic beta-cells. Endocrinology 145 (2004) 2845-2857
31. Chan A.Y., Soltys C.L., Young M.E., Proud C.G., and Dyck J.R. Activation of amp-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J Biol Chem 279 (2004) 32771-32779
32. Towle H.C., Kaytor E.N., and Shih H.M. Regulation of the expression of lipogenic enzyme genes by carbohydrate. Annu Rev Nutr 17 (1997) 405-433
33. Lei B., Lionetti V., Young M.E., Chandler M.P., d'Agostino C., Kang E., et al. Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure. J Mol Cell Cardiol 36 (2004) 567-576
34. Nikolaidis L.A., Sturzu A., Stolarski C., Elahi D., Shen Y.T., and Shannon R.P. The development of myocardial insulin resistance in conscious dogs with advanced dilated cardiomyopathy. Cardiovasc Res 61 (2004) 297-306