Chinese hamster ovary (CHO) host cell engineering to increase sialylation of recombinant therapeutic proteins by modulating sialyltransferase expression

Biotechnology Progress

Volumn 31, Issue 2, 2015, Pages 334-346

  Lin, Nan ^a   Mascarenhas, Joaquina ^a   Sealover, Natalie R ^a   George, Henry J ^a   Brooks, Jeanne ^a   Kayser, Kevin J ^a   Gau, Brian ^a   Yasa, Isil ^a   Azadi, Parastoo ^b   Archer Hartmann, Stephanie ^b  

^a Sigma Aldrich Co   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Chinese hamster ovary cells; Glycoengineering; Host cell engineering; St6gal1; 2,6 linked sialic acid

Indexed keywords

CARBOXYLIC ACIDS; CELL CULTURE; CELLS; GLYCOSYLATION; MASS SPECTROMETRY; RECOMBINANT PROTEINS;

CHINESE HAMSTER OVARY; CHINESE HAMSTER OVARY CELLS; COMBINATORIAL ENGINEERING; GLYCOENGINEERING; LINEAR ION TRAP MASS SPECTROMETRIES; RECOMBINANT GLYCOPROTEINS; SIALIC ACIDS; ST6GAL1;

CELL ENGINEERING;

CRICETULUS GRISEUS; SAMBUCUS NIGRA;

N ACETYLNEURAMINIC ACID; POLYSACCHARIDE; RECOMBINANT PROTEIN; SIALYLTRANSFERASE;

ANIMAL; CELL ENGINEERING; CHEMISTRY; CHO CELL LINE; CRICETULUS; HAMSTER; METABOLIC ENGINEERING; METABOLISM; PROCEDURES;

ANIMALS; CELL ENGINEERING; CHO CELLS; CRICETINAE; CRICETULUS; METABOLIC ENGINEERING; N-ACETYLNEURAMINIC ACID; POLYSACCHARIDES; RECOMBINANT PROTEINS; SIALYLTRANSFERASES;

EID: 84928208106     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.2038     Document Type: Article

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