Manganese increases high mannose glycoform on monoclonal antibody expressed in CHO when glucose is absent or limiting: Implications for use of alternate sugars

Biotechnology Progress

Volumn 31, Issue 2, 2015, Pages 460-467

  Surve, Tanaya ^a   Gadgil, Mugdha ^a  

^a CSIR National Chemical Laboratory   (India)

Author keywords

CHO; Fructose; Galactose; Glucose; Glycosylation; High mannose glycan; Manganese

Indexed keywords

FRUCTOSE; GLYCOSYLATION; MANGANESE; MONOCLONAL ANTIBODIES; POLYSACCHARIDES;

BASAL MEDIUM; EFFECT OF MN; GALACTOSE; GALACTOSYLATION; GLUCOSE AVAILABILITY; HIGH-MANNOSE GLYCAN; LOW CONCENTRATIONS; SMALL REDUCTION;

GLUCOSE;

CULTURE MEDIUM; HEXOSE; MANGANESE; MANNOSE; MONOCLONAL ANTIBODY;

ANIMAL; BIOTECHNOLOGY; CHEMISTRY; CHO CELL LINE; CRICETULUS; CULTURE MEDIUM; DRUG EFFECTS; GLYCOSYLATION; HAMSTER; METABOLISM;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; GLYCOSYLATION; HEXOSES; MANGANESE; MANNOSE;

EID: 84928175300     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.2029     Document Type: Article

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