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Volumn 36, Issue 6, 2015, Pages 809-822

Personalized Critical Care Medicine: How Far Away Are We?

Author keywords

ARDS; biomarkers; critical care; genetics; personalized medicine; pharmacogenomics; sepsis

Indexed keywords

BIOLOGICAL MARKER;

EID: 84947939730     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0035-1564852     Document Type: Article
Times cited : (11)

References (140)
  • 1
    • 0033168459 scopus 로고    scopus 로고
    • Shattuck lecture--medical and societal consequences of the Human Genome Project
    • Collins F. S. Shattuck lecture--medical and societal consequences of the Human Genome Project. N Engl J Med: 1999; 341 1 28 37
    • (1999) N Engl J Med , vol.341 , Issue.1 , pp. 28-37
    • Collins, F.S.1
  • 2
    • 0037288767 scopus 로고    scopus 로고
    • Systems biology: Integrating technology, biology, and computation
    • Hood L. Systems biology: integrating technology, biology, and computation. Mech Ageing Dev: 2003; 124 1 9 16
    • (2003) Mech Ageing Dev , vol.124 , Issue.1 , pp. 9-16
    • Hood, L.1
  • 3
    • 79952431304 scopus 로고    scopus 로고
    • Predictive, personalized, preventive, participatory (P4) cancer medicine
    • Hood L., Friend S. H. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol: 2011; 8 3 184 187
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.3 , pp. 184-187
    • Hood, L.1    Friend, S.H.2
  • 4
    • 84922895251 scopus 로고    scopus 로고
    • Personalized respiratory medicine: Exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014
    • Agustí A., Antó J. M., Auffray C., et al. Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014. Am J Respir Crit Care Med: 2015; 191 4 391 401
    • (2015) Am J Respir Crit Care Med , vol.191 , Issue.4 , pp. 391-401
    • Agustí, A.1    Antó, J.M.2    Auffray, C.3
  • 5
    • 78650367080 scopus 로고    scopus 로고
    • Critical care normality: Individualized versus protocolized care
    • Wendon J. Critical care normality: individualized versus protocolized care. Crit Care Med: 2010; 38 (10, Suppl): S590 S599
    • (2010) Crit Care Med , vol.38 , Issue.10 , pp. S590-S599
    • Wendon, J.1
  • 6
    • 84884586767 scopus 로고    scopus 로고
    • The Surviving Sepsis Campaign's revised sepsis bundles
    • Barochia A. V., Cui X., Eichacker P. Q. The Surviving Sepsis Campaign's revised sepsis bundles. Curr Infect Dis Rep: 2013; 15 5 385 393
    • (2013) Curr Infect Dis Rep , vol.15 , Issue.5 , pp. 385-393
    • Barochia, A.V.1    Cui, X.2    Eichacker, P.Q.3
  • 7
    • 84865853084 scopus 로고    scopus 로고
    • Personalized medicine: Is it a pharmacogenetic mirage?
    • Shah R. R., Shah D. R. Personalized medicine: is it a pharmacogenetic mirage? Br J Clin Pharmacol: 2012; 74 4 698 721
    • (2012) Br J Clin Pharmacol , vol.74 , Issue.4 , pp. 698-721
    • Shah, R.R.1    Shah, D.R.2
  • 8
    • 77954827460 scopus 로고    scopus 로고
    • The path to personalized medicine
    • Hamburg M. A., Collins F. S. The path to personalized medicine. N Engl J Med: 2010; 363 4 301 304
    • (2010) N Engl J Med , vol.363 , Issue.4 , pp. 301-304
    • Hamburg, M.A.1    Collins, F.S.2
  • 9
    • 84907152444 scopus 로고    scopus 로고
    • Pharmacogenomics in the intensive care unit: Focus on potential implications for clinical practice
    • Allen J. M., Gelot S. Pharmacogenomics in the intensive care unit: focus on potential implications for clinical practice. Recent Pat Biotechnol: 2014; 8 2 116 122
    • (2014) Recent Pat Biotechnol , vol.8 , Issue.2 , pp. 116-122
    • Allen, J.M.1    Gelot, S.2
  • 10
    • 0347135822 scopus 로고    scopus 로고
    • Challenges of implementing pharmacogenetics in the critical care environment
    • Freeman B. D., McLeod H. L. Challenges of implementing pharmacogenetics in the critical care environment. Nat Rev Drug Discov: 2004; 3 1 88 93
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.1 , pp. 88-93
    • Freeman, B.D.1    McLeod, H.L.2
  • 11
    • 22044433685 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 (CYP2C9) and Vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity
    • Bodin L., Verstuyft C., Tregouet D. A., et al. Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. Blood: 2005; 106 1 135 140
    • (2005) Blood , vol.106 , Issue.1 , pp. 135-140
    • Bodin, L.1    Verstuyft, C.2    Tregouet, D.A.3
  • 12
    • 0006390275 scopus 로고
    • Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase
    • McGuire M. C., Nogueira C. P., Bartels C. F., et al. Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase. Proc Natl Acad Sci U S A: 1989; 86 3 953 957
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.3 , pp. 953-957
    • McGuire, M.C.1    Nogueira, C.P.2    Bartels, C.F.3
  • 13
    • 0038127232 scopus 로고    scopus 로고
    • Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population
    • Hamdy S. I., Hiratsuka M., Narahara K., et al. Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population. Br J Clin Pharmacol: 2003; 55 6 560 569
    • (2003) Br J Clin Pharmacol , vol.55 , Issue.6 , pp. 560-569
    • Hamdy, S.I.1    Hiratsuka, M.2    Narahara, K.3
  • 14
    • 84889762983 scopus 로고    scopus 로고
    • Pharmacogenetics and coumarin dosing--recalibrating expectations
    • Zineh I., Pacanowski M., Woodcock J. Pharmacogenetics and coumarin dosing--recalibrating expectations. N Engl J Med: 2013; 369 24 2273 2275
    • (2013) N Engl J Med , vol.369 , Issue.24 , pp. 2273-2275
    • Zineh, I.1    Pacanowski, M.2    Woodcock, J.3
  • 15
    • 84889824971 scopus 로고    scopus 로고
    • A pharmacogenetic versus a clinical algorithm for warfarin dosing
    • COAG Investigators
    • Kimmel S. E., French B., Kasner S. E., et al. COAG Investigators. A pharmacogenetic versus a clinical algorithm for warfarin dosing. N Engl J Med: 2013; 369 24 2283 2293
    • (2013) N Engl J Med , vol.369 , Issue.24 , pp. 2283-2293
    • Kimmel, S.E.1    French, B.2    Kasner, S.E.3
  • 16
    • 84889873119 scopus 로고    scopus 로고
    • A randomized trial of genotype-guided dosing of warfarin
    • EU-PACT Group
    • Pirmohamed M., Burnside G., Eriksson N., et al. EU-PACT Group. A randomized trial of genotype-guided dosing of warfarin. N Engl J Med: 2013; 369 24 2294 2303
    • (2013) N Engl J Med , vol.369 , Issue.24 , pp. 2294-2303
    • Pirmohamed, M.1    Burnside, G.2    Eriksson, N.3
  • 18
    • 80053207197 scopus 로고    scopus 로고
    • A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study
    • Choi L., Caffo B. S., Kohli U., et al. A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study. J Pharmacokinet Pharmacodyn: 2011; 38 5 613 636
    • (2011) J Pharmacokinet Pharmacodyn , vol.38 , Issue.5 , pp. 613-636
    • Choi, L.1    Caffo, B.S.2    Kohli, U.3
  • 19
    • 84864198770 scopus 로고    scopus 로고
    • CYP2A6 genetic variation and dexmedetomidine disposition
    • Kohli U., Pandharipande P., Muszkat M., et al. CYP2A6 genetic variation and dexmedetomidine disposition. Eur J Clin Pharmacol: 2012; 68 6 937 942
    • (2012) Eur J Clin Pharmacol , vol.68 , Issue.6 , pp. 937-942
    • Kohli, U.1    Pandharipande, P.2    Muszkat, M.3
  • 20
    • 74749090954 scopus 로고    scopus 로고
    • Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception
    • Kohli U., Muszkat M., Sofowora G. G., et al. Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception. Eur J Pain: 2010; 14 2 154 159
    • (2010) Eur J Pain , vol.14 , Issue.2 , pp. 154-159
    • Kohli, U.1    Muszkat, M.2    Sofowora, G.G.3
  • 21
    • 38549107556 scopus 로고    scopus 로고
    • Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine
    • Kurnik D., Muszkat M., Sofowora G. G., et al. Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine. Hypertension: 2008; 51 2 406 411
    • (2008) Hypertension , vol.51 , Issue.2 , pp. 406-411
    • Kurnik, D.1    Muszkat, M.2    Sofowora, G.G.3
  • 22
    • 79959697897 scopus 로고    scopus 로고
    • Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine
    • Kurnik D., Muszkat M., Li C., et al. Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine. Circ Cardiovasc Genet: 2011; 4 2 179 187
    • (2011) Circ Cardiovasc Genet , vol.4 , Issue.2 , pp. 179-187
    • Kurnik, D.1    Muszkat, M.2    Li, C.3
  • 23
    • 80052483095 scopus 로고    scopus 로고
    • The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery
    • Yaʇar S., Yava͆ S., Karahalil B. The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery. Mol Biol Rep: 2011; 38 5 3383 3389
    • (2011) Mol Biol Rep , vol.38 , Issue.5 , pp. 3383-3389
    • Yaʇar, S.1    Yava͆, S.2    Karahalil, B.3
  • 24
    • 20644459848 scopus 로고    scopus 로고
    • Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response
    • Muszkat M., Sofowora G. G., Xie H. G., Wood A. J., Stein C. M. Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response. Pharmacogenet Genomics: 2005; 15 1 23 28
    • (2005) Pharmacogenet Genomics , vol.15 , Issue.1 , pp. 23-28
    • Muszkat, M.1    Sofowora, G.G.2    Xie, H.G.3    Wood, A.J.4    Stein, C.M.5
  • 25
    • 84873339299 scopus 로고    scopus 로고
    • Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012
    • Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup
    • Dellinger R. P., Levy M. M., Rhodes A., et al. Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med: 2013; 41 2 580 637
    • (2013) Crit Care Med , vol.41 , Issue.2 , pp. 580-637
    • Dellinger, R.P.1    Levy, M.M.2    Rhodes, A.3
  • 26
    • 84904759579 scopus 로고    scopus 로고
    • Serious adverse events associated with vasopressin and norepinephrine infusion in septic shock
    • Anantasit N., Boyd J. H., Walley K. R., Russell J. A. Serious adverse events associated with vasopressin and norepinephrine infusion in septic shock. Crit Care Med: 2014; 42 8 1812 1820
    • (2014) Crit Care Med , vol.42 , Issue.8 , pp. 1812-1820
    • Anantasit, N.1    Boyd, J.H.2    Walley, K.R.3    Russell, J.A.4
  • 27
    • 84880869654 scopus 로고    scopus 로고
    • Personalized medicine in sepsis: The coming of age
    • Christaki E. Personalized medicine in sepsis: the coming of age. Expert Rev Anti Infect Ther: 2013; 11 7 645 647
    • (2013) Expert Rev Anti Infect Ther , vol.11 , Issue.7 , pp. 645-647
    • Christaki, E.1
  • 28
    • 84867157650 scopus 로고    scopus 로고
    • New approaches to sepsis: Molecular diagnostics and biomarkers
    • Reinhart K., Bauer M., Riedemann N. C., Hartog C. S. New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev: 2012; 25 4 609 634
    • (2012) Clin Microbiol Rev , vol.25 , Issue.4 , pp. 609-634
    • Reinhart, K.1    Bauer, M.2    Riedemann, N.C.3    Hartog, C.S.4
  • 29
    • 79953014845 scopus 로고    scopus 로고
    • Physiologic parameters as biomarkers: What can we learn from physiologic variables and variation?
    • Ferrer R., Artigas A. Physiologic parameters as biomarkers: what can we learn from physiologic variables and variation? Crit Care Clin: 2011; 27 2 229 240
    • (2011) Crit Care Clin , vol.27 , Issue.2 , pp. 229-240
    • Ferrer, R.1    Artigas, A.2
  • 30
    • 56249128276 scopus 로고    scopus 로고
    • Mechanical ventilation guided by esophageal pressure in acute lung injury
    • Talmor D., Sarge T., Malhotra A., et al. Mechanical ventilation guided by esophageal pressure in acute lung injury. N Engl J Med: 2008; 359 20 2095 2104
    • (2008) N Engl J Med , vol.359 , Issue.20 , pp. 2095-2104
    • Talmor, D.1    Sarge, T.2    Malhotra, A.3
  • 31
    • 84862523834 scopus 로고    scopus 로고
    • ECMO criteria for influenza A (H1N1)-associated ARDS: Role of transpulmonary pressure
    • Grasso S., Terragni P., Birocco A., et al. ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure. Intensive Care Med: 2012; 38 3 395 403
    • (2012) Intensive Care Med , vol.38 , Issue.3 , pp. 395-403
    • Grasso, S.1    Terragni, P.2    Birocco, A.3
  • 32
    • 84897394892 scopus 로고    scopus 로고
    • Model-based setting of inspiratory pressure and respiratory rate in pressure-controlled ventilation
    • Schranz C., Becher T., Schädler D., Weiler N., Möller K. Model-based setting of inspiratory pressure and respiratory rate in pressure-controlled ventilation. Physiol Meas: 2014; 35 3 383 397
    • (2014) Physiol Meas , vol.35 , Issue.3 , pp. 383-397
    • Schranz, C.1    Becher, T.2    Schädler, D.3    Weiler, N.4    Möller, K.5
  • 33
    • 84867311277 scopus 로고    scopus 로고
    • Goal-directed mechanical ventilation: Are we aiming at the right goals? A proposal for an alternative approach aiming at optimal lung compliance, guided by esophageal pressure in acute respiratory failure
    • Soroksky A., Esquinas A. Goal-directed mechanical ventilation: are we aiming at the right goals? A proposal for an alternative approach aiming at optimal lung compliance, guided by esophageal pressure in acute respiratory failure. Crit Care Res Pract: 2012; 2012 12 597932
    • (2012) Crit Care Res Pract , vol.2012 , Issue.12 , pp. 597932
    • Soroksky, A.1    Esquinas, A.2
  • 34
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group
    • Group B. DW.; Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther: 2001; 69 3 89 95
    • (2001) Clin Pharmacol Ther , vol.69 , Issue.3 , pp. 89-95
    • Group, B.D.1
  • 35
    • 84907271131 scopus 로고    scopus 로고
    • Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment
    • Sandquist M., Wong H. R. Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Rev Clin Immunol: 2014; 10 10 1349 1356
    • (2014) Expert Rev Clin Immunol , vol.10 , Issue.10 , pp. 1349-1356
    • Sandquist, M.1    Wong, H.R.2
  • 36
    • 84893793382 scopus 로고    scopus 로고
    • Predicting outcome in patients with sepsis: New biomarkers for old expectations
    • Charles P. E., Gibot S. Predicting outcome in patients with sepsis: new biomarkers for old expectations. Crit Care: 2014; 18 1 108
    • (2014) Crit Care , vol.18 , Issue.1 , pp. 108
    • Charles, P.E.1    Gibot, S.2
  • 37
    • 79953000353 scopus 로고    scopus 로고
    • Multimarker panels in sepsis
    • Casserly B., Read R., Levy M. M. Multimarker panels in sepsis. Crit Care Clin: 2011; 27 2 391 405
    • (2011) Crit Care Clin , vol.27 , Issue.2 , pp. 391-405
    • Casserly, B.1    Read, R.2    Levy, M.M.3
  • 38
    • 84922383256 scopus 로고    scopus 로고
    • 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
    • Konstantinides S. V. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J: 2014; 35 45 3145 3146
    • (2014) Eur Heart J , vol.35 , Issue.45 , pp. 3145-3146
    • Konstantinides, S.V.1
  • 39
    • 79955555188 scopus 로고    scopus 로고
    • Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: A scientific statement from the American Heart Association
    • American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; American Heart Association Council on Peripheral Vascular Disease; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology
    • Jaff M. R., McMurtry M. S., Archer S. L., et al. American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; American Heart Association Council on Peripheral Vascular Disease; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation: 2011; 123 16 1788 1830
    • (2011) Circulation , vol.123 , Issue.16 , pp. 1788-1830
    • Jaff, M.R.1    McMurtry, M.S.2    Archer, S.L.3
  • 40
    • 84878832957 scopus 로고    scopus 로고
    • Clinical utility of biomarkers of AKI in cardiac surgery and critical illness
    • Koyner J. L., Parikh C. R. Clinical utility of biomarkers of AKI in cardiac surgery and critical illness. Clin J Am Soc Nephrol: 2013; 8 6 1034 1042
    • (2013) Clin J Am Soc Nephrol , vol.8 , Issue.6 , pp. 1034-1042
    • Koyner, J.L.1    Parikh, C.R.2
  • 41
    • 84927788959 scopus 로고    scopus 로고
    • Diagnosis of acute kidney injury: Kidney Disease Improving Global Outcomes criteria and beyond
    • Ostermann M. Diagnosis of acute kidney injury: Kidney Disease Improving Global Outcomes criteria and beyond. Curr Opin Crit Care: 2014; 20 6 581 587
    • (2014) Curr Opin Crit Care , vol.20 , Issue.6 , pp. 581-587
    • Ostermann, M.1
  • 42
    • 84923346326 scopus 로고    scopus 로고
    • Biomarkers of AKI: A review of mechanistic relevance and potential therapeutic implications
    • Alge J. L., Arthur J. M. Biomarkers of AKI: a review of mechanistic relevance and potential therapeutic implications. Clin J Am Soc Nephrol: 2015; 10 1 147 155
    • (2015) Clin J Am Soc Nephrol , vol.10 , Issue.1 , pp. 147-155
    • Alge, J.L.1    Arthur, J.M.2
  • 43
    • 84878880571 scopus 로고    scopus 로고
    • Is there value in plasma cytokine measurements in patients with severe trauma and sepsis?
    • Gentile L. F., Cuenca A. G., Vanzant E. L., et al. Is there value in plasma cytokine measurements in patients with severe trauma and sepsis? Methods: 2013; 61 1 3 9
    • (2013) Methods , vol.61 , Issue.1 , pp. 3-9
    • Gentile, L.F.1    Cuenca, A.G.2    Vanzant, E.L.3
  • 44
    • 84924796432 scopus 로고    scopus 로고
    • Sepsis biomarkers. Value and limitations
    • Vincent J. L., Teixeira L. Sepsis biomarkers. Value and limitations. Am J Respir Crit Care Med: 2014; 190 10 1081 1082
    • (2014) Am J Respir Crit Care Med , vol.190 , Issue.10 , pp. 1081-1082
    • Vincent, J.L.1    Teixeira, L.2
  • 45
    • 77956628404 scopus 로고    scopus 로고
    • Sepsis biomarkers: A review
    • Pierrakos C., Vincent J. L. Sepsis biomarkers: a review. Crit Care: 2010; 14 1 R15
    • (2010) Crit Care , vol.14 , Issue.1 , pp. R15
    • Pierrakos, C.1    Vincent, J.L.2
  • 46
    • 84901689664 scopus 로고    scopus 로고
    • The beginning of personalized medicine in sepsis: Small steps to a bright future
    • Christaki E., Giamarellos-Bourboulis E. J. The beginning of personalized medicine in sepsis: small steps to a bright future. Clin Genet: 2014; 86 1 56 61
    • (2014) Clin Genet , vol.86 , Issue.1 , pp. 56-61
    • Christaki, E.1    Giamarellos-Bourboulis, E.J.2
  • 47
    • 0024451525 scopus 로고
    • Increased plasma levels of interleukin-6 in sepsis
    • Hack C. E., De Groot E. R., Felt-Bersma R. J., et al. Increased plasma levels of interleukin-6 in sepsis. Blood: 1989; 74 5 1704 1710
    • (1989) Blood , vol.74 , Issue.5 , pp. 1704-1710
    • Hack, C.E.1    De Groot, E.R.2    Felt-Bersma, R.J.3
  • 48
    • 0026575846 scopus 로고
    • Cytokine serum level during severe sepsis in human IL-6 as a marker of severity
    • Damas P., Ledoux D., Nys M., et al. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg: 1992; 215 4 356 362
    • (1992) Ann Surg , vol.215 , Issue.4 , pp. 356-362
    • Damas, P.1    Ledoux, D.2    Nys, M.3
  • 49
    • 0028129179 scopus 로고
    • Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis
    • Patel R. T., Deen K. I., Youngs D., Warwick J., Keighley M. R. Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis. Br J Surg: 1994; 81 9 1306 1308
    • (1994) Br J Surg , vol.81 , Issue.9 , pp. 1306-1308
    • Patel, R.T.1    Deen, K.I.2    Youngs, D.3    Warwick, J.4    Keighley, M.R.5
  • 50
    • 33745622134 scopus 로고    scopus 로고
    • Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis
    • Uzzan B., Cohen R., Nicolas P., Cucherat M., Perret G. Y. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med: 2006; 34 7 1996 2003
    • (2006) Crit Care Med , vol.34 , Issue.7 , pp. 1996-2003
    • Uzzan, B.1    Cohen, R.2    Nicolas, P.3    Cucherat, M.4    Perret, G.Y.5
  • 51
    • 84873528481 scopus 로고    scopus 로고
    • Biomarkers: What is their benefit in the identification of infection, severity assessment, and management of community-acquired pneumonia?
    • Upadhyay S., Niederman M. S. Biomarkers: what is their benefit in the identification of infection, severity assessment, and management of community-acquired pneumonia? Infect Dis Clin North Am: 2013; 27 1 19 31
    • (2013) Infect Dis Clin North Am , vol.27 , Issue.1 , pp. 19-31
    • Upadhyay, S.1    Niederman, M.S.2
  • 52
    • 77952273695 scopus 로고    scopus 로고
    • Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: A prospective cohort trial
    • ProHOSP Study Group
    • Müller F., Christ-Crain M., Bregenzer T., et al. ProHOSP Study Group. Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial. Chest: 2010; 138 1 121 129
    • (2010) Chest , vol.138 , Issue.1 , pp. 121-129
    • Müller, F.1    Christ-Crain, M.2    Bregenzer, T.3
  • 53
    • 27144436156 scopus 로고    scopus 로고
    • Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team pneumonia severity index
    • Masiá M., Gutiérrez F., Shum C., et al. Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team pneumonia severity index. Chest: 2005; 128 4 2223 2229
    • (2005) Chest , vol.128 , Issue.4 , pp. 2223-2229
    • Masiá, M.1    Gutiérrez, F.2    Shum, C.3
  • 54
    • 33745471090 scopus 로고    scopus 로고
    • Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: A randomized trial
    • Christ-Crain M., Stolz D., Bingisser R., et al. Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med: 2006; 174 1 84 93
    • (2006) Am J Respir Crit Care Med , vol.174 , Issue.1 , pp. 84-93
    • Christ-Crain, M.1    Stolz, D.2    Bingisser, R.3
  • 55
    • 70149088214 scopus 로고    scopus 로고
    • Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: The ProHOSP randomized controlled trial
    • ProHOSP Study Group
    • Schuetz P., Christ-Crain M., Thomann R., et al. ProHOSP Study Group. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA: 2009; 302 10 1059 1066
    • (2009) JAMA , vol.302 , Issue.10 , pp. 1059-1066
    • Schuetz, P.1    Christ-Crain, M.2    Thomann, R.3
  • 56
    • 84873044315 scopus 로고    scopus 로고
    • Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
    • Schuetz P., Müller B., Christ-Crain M., et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev: 2012; 9 CD007498
    • (2012) Cochrane Database Syst Rev , vol.9 , pp. CD007498
    • Schuetz, P.1    Müller, B.2    Christ-Crain, M.3
  • 57
    • 33847056146 scopus 로고    scopus 로고
    • Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: Systematic review and meta-analysis
    • Tang B. M., Eslick G. D., Craig J. C., McLean A. S. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis: 2007; 7 3 210 217
    • (2007) Lancet Infect Dis , vol.7 , Issue.3 , pp. 210-217
    • Tang, B.M.1    Eslick, G.D.2    Craig, J.C.3    McLean, A.S.4
  • 58
    • 84925366157 scopus 로고    scopus 로고
    • Procalcitonin algorithm in critically ill adults with undifferentiated infection or suspected sepsis. A randomized controlled trial
    • ProGUARD Study Investigators; ANZICS Clinical Trials Group
    • Shehabi Y., Sterba M., Garrett P. M., et al. ProGUARD Study Investigators; ANZICS Clinical Trials Group. Procalcitonin algorithm in critically ill adults with undifferentiated infection or suspected sepsis. A randomized controlled trial. Am J Respir Crit Care Med: 2014; 190 10 1102 1110
    • (2014) Am J Respir Crit Care Med , vol.190 , Issue.10 , pp. 1102-1110
    • Shehabi, Y.1    Sterba, M.2    Garrett, P.M.3
  • 59
    • 80051921479 scopus 로고    scopus 로고
    • Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial
    • Procalcitonin And Survival Study (PASS) Group
    • Jensen J. U., Hein L., Lundgren B., et al. Procalcitonin And Survival Study (PASS) Group. Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial. Crit Care Med: 2011; 39 9 2048 2058
    • (2011) Crit Care Med , vol.39 , Issue.9 , pp. 2048-2058
    • Jensen, J.U.1    Hein, L.2    Lundgren, B.3
  • 60
    • 84921341841 scopus 로고    scopus 로고
    • Role of presepsin for the evaluation of sepsis in the emergency department
    • Pizzolato E., Ulla M., Galluzzo C., et al. Role of presepsin for the evaluation of sepsis in the emergency department. Clin Chem Lab Med: 2014; 52 10 1395 1400
    • (2014) Clin Chem Lab Med , vol.52 , Issue.10 , pp. 1395-1400
    • Pizzolato, E.1    Ulla, M.2    Galluzzo, C.3
  • 61
    • 84922242867 scopus 로고    scopus 로고
    • Presepsin: Solving a soluble (CD14) problem in sepsis?
    • Ackland G. L., Prowle J. R. Presepsin: solving a soluble (CD14) problem in sepsis? Intensive Care Med: 2015; 41 2 351 353
    • (2015) Intensive Care Med , vol.41 , Issue.2 , pp. 351-353
    • Ackland, G.L.1    Prowle, J.R.2
  • 62
    • 84892152854 scopus 로고    scopus 로고
    • Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: Data from the Albumin Italian Outcome Sepsis trial
    • ALBIOS Study Investigators
    • Masson S., Caironi P., Spanuth E., et al. ALBIOS Study Investigators. Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care: 2014; 18 1 R6
    • (2014) Crit Care , vol.18 , Issue.1 , pp. R6
    • Masson, S.1    Caironi, P.2    Spanuth, E.3
  • 63
    • 84928153773 scopus 로고    scopus 로고
    • Presepsin in the prognosis of infectious diseases and diagnosis of infectious disseminated intravascular coagulation: A prospective, multicentre, observational study
    • Takahashi G., Shibata S., Ishikura H., et al. Presepsin in the prognosis of infectious diseases and diagnosis of infectious disseminated intravascular coagulation: a prospective, multicentre, observational study. Eur J Anaesthesiol: 2015; 32 3 199 206
    • (2015) Eur J Anaesthesiol , vol.32 , Issue.3 , pp. 199-206
    • Takahashi, G.1    Shibata, S.2    Ishikura, H.3
  • 64
    • 84908086516 scopus 로고    scopus 로고
    • Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment
    • Behnes M., Bertsch T., Lepiorz D., et al. Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment. Crit Care: 2014; 18 5 507
    • (2014) Crit Care , vol.18 , Issue.5 , pp. 507
    • Behnes, M.1    Bertsch, T.2    Lepiorz, D.3
  • 65
    • 84918543908 scopus 로고    scopus 로고
    • Circulating presepsin (soluble CD14 subtype) as a marker of host response in patients with severe sepsis or septic shock: Data from the multicenter, randomized ALBIOS trial
    • Masson S., Caironi P., Fanizza C., et al. Circulating presepsin (soluble CD14 subtype) as a marker of host response in patients with severe sepsis or septic shock: data from the multicenter, randomized ALBIOS trial. Intensive Care Med: 2015; 41 1 12 20
    • (2015) Intensive Care Med , vol.41 , Issue.1 , pp. 12-20
    • Masson, S.1    Caironi, P.2    Fanizza, C.3
  • 66
    • 34247328556 scopus 로고    scopus 로고
    • Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: A prospective study
    • Kofoed K., Andersen O., Kronborg G., et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care: 2007; 11 2 R38
    • (2007) Crit Care , vol.11 , Issue.2 , pp. R38
    • Kofoed, K.1    Andersen, O.2    Kronborg, G.3
  • 67
    • 59649123701 scopus 로고    scopus 로고
    • A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis
    • Shapiro N. I., Trzeciak S., Hollander J. E., et al. A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Crit Care Med: 2009; 37 1 96 104
    • (2009) Crit Care Med , vol.37 , Issue.1 , pp. 96-104
    • Shapiro, N.I.1    Trzeciak, S.2    Hollander, J.E.3
  • 68
    • 84863448198 scopus 로고    scopus 로고
    • Combination biomarkers to diagnose sepsis in the critically ill patient
    • Gibot S., Béné M. C., Noel R., et al. Combination biomarkers to diagnose sepsis in the critically ill patient. Am J Respir Crit Care Med: 2012; 186 1 65 71
    • (2012) Am J Respir Crit Care Med , vol.186 , Issue.1 , pp. 65-71
    • Gibot, S.1    Béné, M.C.2    Noel, R.3
  • 69
    • 84896595576 scopus 로고    scopus 로고
    • A multibiomarker-based outcome risk stratification model for adult septic shock
    • Wong H. R., Lindsell C. J., Pettilä V., et al. A multibiomarker-based outcome risk stratification model for adult septic shock. Crit Care Med: 2014; 42 4 781 789
    • (2014) Crit Care Med , vol.42 , Issue.4 , pp. 781-789
    • Wong, H.R.1    Lindsell, C.J.2    Pettilä, V.3
  • 70
    • 77957164205 scopus 로고    scopus 로고
    • Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: The influence of circulating adiponectin
    • Al-Attas O. S., Al-Daghri N. M., Alokail M. S., et al. Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin. Eur J Endocrinol: 2010; 163 4 601 607
    • (2010) Eur J Endocrinol , vol.163 , Issue.4 , pp. 601-607
    • Al-Attas, O.S.1    Al-Daghri, N.M.2    Alokail, M.S.3
  • 71
    • 0343893748 scopus 로고    scopus 로고
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
    • The Acute Respiratory Distress Syndrome Network Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med: 2000; 342 18 1301 1308
    • (2000) N Engl J Med , vol.342 , Issue.18 , pp. 1301-1308
  • 72
    • 79953021526 scopus 로고    scopus 로고
    • Biomarkers in acute lung injury: Insights into the pathogenesis of acute lung injury
    • Cross L. J., Matthay M. A. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin: 2011; 27 2 355 377
    • (2011) Crit Care Clin , vol.27 , Issue.2 , pp. 355-377
    • Cross, L.J.1    Matthay, M.A.2
  • 73
    • 79960121636 scopus 로고    scopus 로고
    • Biomarkers in acute lung injury--marking forward progress
    • Barnett N., Ware L. B. Biomarkers in acute lung injury--marking forward progress. Crit Care Clin: 2011; 27 3 661 683
    • (2011) Crit Care Clin , vol.27 , Issue.3 , pp. 661-683
    • Barnett, N.1    Ware, L.B.2
  • 74
    • 0030984313 scopus 로고    scopus 로고
    • Biological markers of acute lung injury: Prognostic and pathogenetic significance
    • Pittet J. F., Mackersie R. C., Martin T. R., Matthay M. A. Biological markers of acute lung injury: prognostic and pathogenetic significance. Am J Respir Crit Care Med: 1997; 155 4 1187 1205
    • (1997) Am J Respir Crit Care Med , vol.155 , Issue.4 , pp. 1187-1205
    • Pittet, J.F.1    Mackersie, R.C.2    Martin, T.R.3    Matthay, M.A.4
  • 75
    • 84895069834 scopus 로고    scopus 로고
    • Biomarkers in acute respiratory distress syndrome
    • Binnie A., Tsang J. L., dos Santos C. C. Biomarkers in acute respiratory distress syndrome. Curr Opin Crit Care: 2014; 20 1 47 55
    • (2014) Curr Opin Crit Care , vol.20 , Issue.1 , pp. 47-55
    • Binnie, A.1    Tsang, J.L.2    Dos Santos, C.C.3
  • 76
    • 84881581885 scopus 로고    scopus 로고
    • Biomarkers of ALI/ARDS: Pathogenesis, discovery, and relevance to clinical trials
    • Janz D. R., Ware L. B. Biomarkers of ALI/ARDS: pathogenesis, discovery, and relevance to clinical trials. Semin Respir Crit Care Med: 2013; 34 4 537 548
    • (2013) Semin Respir Crit Care Med , vol.34 , Issue.4 , pp. 537-548
    • Janz, D.R.1    Ware, L.B.2
  • 77
    • 0028267785 scopus 로고
    • The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination
    • Bernard G. R., Artigas A., Brigham K. L., et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med: 1994; 149 (3, Pt 1): 818 824
    • (1994) Am J Respir Crit Care Med , vol.149 , Issue.3 , pp. 818-824
    • Bernard, G.R.1    Artigas, A.2    Brigham, K.L.3
  • 78
    • 84862490519 scopus 로고    scopus 로고
    • Acute respiratory distress syndrome: The Berlin Definition
    • ARDS Definition Task Force
    • Ranieri V. M., Rubenfeld G. D., Thompson B. T., et al. ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin Definition. JAMA: 2012; 307 23 2526 2533
    • (2012) JAMA , vol.307 , Issue.23 , pp. 2526-2533
    • Ranieri, V.M.1    Rubenfeld, G.D.2    Thompson, B.T.3
  • 79
    • 68849093117 scopus 로고    scopus 로고
    • Plasma C-reactive protein levels are associated with improved outcome in ARDS
    • Bajwa E. K., Khan U. A., Januzzi J. L., Gong M. N., Thompson B. T., Christiani D. C. Plasma C-reactive protein levels are associated with improved outcome in ARDS. Chest: 2009; 136 2 471 480
    • (2009) Chest , vol.136 , Issue.2 , pp. 471-480
    • Bajwa, E.K.1    Khan, U.A.2    Januzzi, J.L.3    Gong, M.N.4    Thompson, B.T.5    Christiani, D.C.6
  • 80
    • 0034967219 scopus 로고    scopus 로고
    • Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis
    • Kolb M., Margetts P. J., Anthony D. C., Pitossi F., Gauldie J. Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest: 2001; 107 12 1529 1536
    • (2001) J Clin Invest , vol.107 , Issue.12 , pp. 1529-1536
    • Kolb, M.1    Margetts, P.J.2    Anthony, D.C.3    Pitossi, F.4    Gauldie, J.5
  • 81
    • 0029827881 scopus 로고    scopus 로고
    • Role of complement, chemokines, and regulatory cytokines in acute lung injury
    • Ward P. A. Role of complement, chemokines, and regulatory cytokines in acute lung injury. Ann N Y Acad Sci: 1996; 796 104 112
    • (1996) Ann N y Acad Sci , vol.796 , pp. 104-112
    • Ward, P.A.1
  • 83
    • 0034987933 scopus 로고    scopus 로고
    • Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism
    • Geiser T., Atabai K., Jarreau P. H., Ware L. B., Pugin J., Matthay M. A. Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism. Am J Respir Crit Care Med: 2001; 163 6 1384 1388
    • (2001) Am J Respir Crit Care Med , vol.163 , Issue.6 , pp. 1384-1388
    • Geiser, T.1    Atabai, K.2    Jarreau, P.H.3    Ware, L.B.4    Pugin, J.5    Matthay, M.A.6
  • 85
    • 0345436055 scopus 로고    scopus 로고
    • Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: A randomized controlled trial
    • Ranieri V. M., Suter P. M., Tortorella C., et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA: 1999; 282 1 54 61
    • (1999) JAMA , vol.282 , Issue.1 , pp. 54-61
    • Ranieri, V.M.1    Suter, P.M.2    Tortorella, C.3
  • 86
    • 0029892565 scopus 로고    scopus 로고
    • Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1
    • Pugin J., Ricou B., Steinberg K. P., Suter P. M., Martin T. R. Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1. Am J Respir Crit Care Med: 1996; 153 (6, Pt 1): 1850 1856
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.6 , pp. 1850-1856
    • Pugin, J.1    Ricou, B.2    Steinberg, K.P.3    Suter, P.M.4    Martin, T.R.5
  • 87
    • 0026787392 scopus 로고
    • High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis
    • Suter P. M., Suter S., Girardin E., Roux-Lombard P., Grau G. E., Dayer J. M. High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am Rev Respir Dis: 1992; 145 5 1016 1022
    • (1992) Am Rev Respir Dis , vol.145 , Issue.5 , pp. 1016-1022
    • Suter, P.M.1    Suter, S.2    Girardin, E.3    Roux-Lombard, P.4    Grau, G.E.5    Dayer, J.M.6
  • 88
    • 0028860550 scopus 로고
    • Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome
    • Meduri G. U., Kohler G., Headley S., Tolley E., Stentz F., Postlethwaite A. Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome. Chest: 1995; 108 5 1303 1314
    • (1995) Chest , vol.108 , Issue.5 , pp. 1303-1314
    • Meduri, G.U.1    Kohler, G.2    Headley, S.3    Tolley, E.4    Stentz, F.5    Postlethwaite, A.6
  • 89
    • 0028898380 scopus 로고
    • Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time
    • Meduri G. U., Headley S., Kohler G., et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest: 1995; 107 4 1062 1073
    • (1995) Chest , vol.107 , Issue.4 , pp. 1062-1073
    • Meduri, G.U.1    Headley, S.2    Kohler, G.3
  • 90
    • 33747712040 scopus 로고    scopus 로고
    • The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome
    • Bastarache J. A., Ware L. B., Bernard G. R. The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome. Semin Respir Crit Care Med: 2006; 27 4 365 376
    • (2006) Semin Respir Crit Care Med , vol.27 , Issue.4 , pp. 365-376
    • Bastarache, J.A.1    Ware, L.B.2    Bernard, G.R.3
  • 91
    • 76749100153 scopus 로고    scopus 로고
    • Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury
    • NHLBI ARDS Clinical Trials Network
    • Ware L. B., Koyama T., Billheimer D. D., et al. NHLBI ARDS Clinical Trials Network. Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest: 2010; 137 2 288 296
    • (2010) Chest , vol.137 , Issue.2 , pp. 288-296
    • Ware, L.B.1    Koyama, T.2    Billheimer, D.D.3
  • 92
    • 34547689307 scopus 로고    scopus 로고
    • Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome
    • National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network
    • Ware L. B., Matthay M. A., Parsons P. E., Thompson B. T., Januzzi J. L., Eisner M. D.; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med: 2007; 35 8 1821 1828
    • (2007) Crit Care Med , vol.35 , Issue.8 , pp. 1821-1828
    • Ware, L.B.1    Matthay, M.A.2    Parsons, P.E.3    Thompson, B.T.4    Januzzi, J.L.5    Eisner, M.D.6
  • 94
    • 0038805215 scopus 로고    scopus 로고
    • Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury
    • Prabhakaran P., Ware L. B., White K. E., Cross M. T., Matthay M. A., Olman M. A. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Am J Physiol Lung Cell Mol Physiol: 2003; 285 1 L20 L28
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285 , Issue.1 , pp. L20-L28
    • Prabhakaran, P.1    Ware, L.B.2    White, K.E.3    Cross, M.T.4    Matthay, M.A.5    Olman, M.A.6
  • 95
    • 84884213392 scopus 로고    scopus 로고
    • SuPAR and PAI-1 in critically ill, mechanically ventilated patients
    • FINNALI Study Group
    • Jalkanen V., Yang R., Linko R., et al. FINNALI Study Group. SuPAR and PAI-1 in critically ill, mechanically ventilated patients. Intensive Care Med: 2013; 39 3 489 496
    • (2013) Intensive Care Med , vol.39 , Issue.3 , pp. 489-496
    • Jalkanen, V.1    Yang, R.2    Linko, R.3
  • 96
  • 97
    • 84924854841 scopus 로고    scopus 로고
    • Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk
    • Wei Y., Wang Z., Su L., et al. Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk. Chest: 2015; 147 3 607 617
    • (2015) Chest , vol.147 , Issue.3 , pp. 607-617
    • Wei, Y.1    Wang, Z.2    Su, L.3
  • 98
    • 0031847251 scopus 로고    scopus 로고
    • Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance
    • Verghese G. M., McCormick-Shannon K., Mason R. J., Matthay M. A. Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Am J Respir Crit Care Med: 1998; 158 2 386 394
    • (1998) Am J Respir Crit Care Med , vol.158 , Issue.2 , pp. 386-394
    • Verghese, G.M.1    McCormick-Shannon, K.2    Mason, R.J.3    Matthay, M.A.4
  • 99
    • 0034898745 scopus 로고    scopus 로고
    • Vascular endothelial growth factor synthesis in the acute phase of experimental and clinical lung injury
    • Maitre B., Boussat S., Jean D., et al. Vascular endothelial growth factor synthesis in the acute phase of experimental and clinical lung injury. Eur Respir J: 2001; 18 1 100 106
    • (2001) Eur Respir J , vol.18 , Issue.1 , pp. 100-106
    • Maitre, B.1    Boussat, S.2    Jean, D.3
  • 100
    • 0035509116 scopus 로고    scopus 로고
    • Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome
    • Thickett D. R., Armstrong L., Christie S. J., Millar A. B. Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome. Am J Respir Crit Care Med: 2001; 164 9 1601 1605
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.9 , pp. 1601-1605
    • Thickett, D.R.1    Armstrong, L.2    Christie, S.J.3    Millar, A.B.4
  • 101
    • 21744449337 scopus 로고    scopus 로고
    • VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema
    • Ware L. B., Kaner R. J., Crystal R. G., et al. VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema. Eur Respir J: 2005; 26 1 101 105
    • (2005) Eur Respir J , vol.26 , Issue.1 , pp. 101-105
    • Ware, L.B.1    Kaner, R.J.2    Crystal, R.G.3
  • 102
    • 0037111186 scopus 로고    scopus 로고
    • A role for vascular endothelial growth factor in acute and resolving lung injury
    • Thickett D. R., Armstrong L., Millar A. B. A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med: 2002; 166 10 1332 1337
    • (2002) Am J Respir Crit Care Med , vol.166 , Issue.10 , pp. 1332-1337
    • Thickett, D.R.1    Armstrong, L.2    Millar, A.B.3
  • 103
    • 77956231365 scopus 로고    scopus 로고
    • Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients
    • Ong T., McClintock D. E., Kallet R. H., Ware L. B., Matthay M. A., Liu K. D. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med: 2010; 38 9 1845 1851
    • (2010) Crit Care Med , vol.38 , Issue.9 , pp. 1845-1851
    • Ong, T.1    McClintock, D.E.2    Kallet, R.H.3    Ware, L.B.4    Matthay, M.A.5    Liu, K.D.6
  • 104
    • 33750699301 scopus 로고    scopus 로고
    • Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death
    • Bhandari V., Choo-Wing R., Lee C. G., et al. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med: 2006; 12 11 1286 1293
    • (2006) Nat Med , vol.12 , Issue.11 , pp. 1286-1293
    • Bhandari, V.1    Choo-Wing, R.2    Lee, C.G.3
  • 105
    • 53649099512 scopus 로고    scopus 로고
    • Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients
    • van der Heijden M., van Nieuw Amerongen G. P., Koolwijk P., van Hinsbergh V. W., Groeneveld A. B. Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients. Thorax: 2008; 63 10 903 909
    • (2008) Thorax , vol.63 , Issue.10 , pp. 903-909
    • Van Der Heijden, M.1    Van Nieuw Amerongen, G.P.2    Koolwijk, P.3    Van Hinsbergh, V.W.4    Groeneveld, A.B.5
  • 106
    • 84875865632 scopus 로고    scopus 로고
    • Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients
    • Agrawal A., Matthay M. A., Kangelaris K. N., et al. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med: 2013; 187 7 736 742
    • (2013) Am J Respir Crit Care Med , vol.187 , Issue.7 , pp. 736-742
    • Agrawal, A.1    Matthay, M.A.2    Kangelaris, K.N.3
  • 107
    • 0025128163 scopus 로고
    • Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome
    • Rubin D. B., Wiener-Kronish J. P., Murray J. F., et al. Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. J Clin Invest: 1990; 86 2 474 480
    • (1990) J Clin Invest , vol.86 , Issue.2 , pp. 474-480
    • Rubin, D.B.1    Wiener-Kronish, J.P.2    Murray, J.F.3
  • 108
    • 0022643170 scopus 로고
    • Specific coagulation and fibrinolysis tests as biochemical markers in traumatic-induced adult respiratory distress syndrome
    • Modig J., Bagge L. Specific coagulation and fibrinolysis tests as biochemical markers in traumatic-induced adult respiratory distress syndrome. Resuscitation: 1986; 13 2 87 95
    • (1986) Resuscitation , vol.13 , Issue.2 , pp. 87-95
    • Modig, J.1    Bagge, L.2
  • 109
  • 110
    • 4644286455 scopus 로고    scopus 로고
    • Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury
    • Ware L. B., Eisner M. D., Thompson B. T., Parsons P. E., Matthay M. A. Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med: 2004; 170 7 766 772
    • (2004) Am J Respir Crit Care Med , vol.170 , Issue.7 , pp. 766-772
    • Ware, L.B.1    Eisner, M.D.2    Thompson, B.T.3    Parsons, P.E.4    Matthay, M.A.5
  • 111
    • 57149103758 scopus 로고    scopus 로고
    • RAGE: A biomarker for acute lung injury
    • Griffiths M. J., McAuley D. F. RAGE: a biomarker for acute lung injury. Thorax: 2008; 63 12 1034 1036
    • (2008) Thorax , vol.63 , Issue.12 , pp. 1034-1036
    • Griffiths, M.J.1    McAuley, D.F.2
  • 112
    • 67650069965 scopus 로고    scopus 로고
    • Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury
    • Su X., Looney M. R., Gupta N., Matthay M. A. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol: 2009; 297 1 L1 L5
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , Issue.1 , pp. L1-L5
    • Su, X.1    Looney, M.R.2    Gupta, N.3    Matthay, M.A.4
  • 113
    • 33646243227 scopus 로고    scopus 로고
    • Receptor for advanced glycation end-products is a marker of type i cell injury in acute lung injury
    • Uchida T., Shirasawa M., Ware L. B., et al. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med: 2006; 173 9 1008 1015
    • (2006) Am J Respir Crit Care Med , vol.173 , Issue.9 , pp. 1008-1015
    • Uchida, T.1    Shirasawa, M.2    Ware, L.B.3
  • 114
    • 77952280855 scopus 로고    scopus 로고
    • Acute lung injury in patients with traumatic injuries: Utility of a panel of biomarkers for diagnosis and pathogenesis
    • Fremont R. D., Koyama T., Calfee C. S., et al. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma: 2010; 68 5 1121 1127
    • (2010) J Trauma , vol.68 , Issue.5 , pp. 1121-1127
    • Fremont, R.D.1    Koyama, T.2    Calfee, C.S.3
  • 115
    • 49949086032 scopus 로고    scopus 로고
    • Prognostic value of plasma N-terminal probrain natriuretic peptide levels in the acute respiratory distress syndrome
    • Bajwa E. K., Januzzi J. L., Gong M. N., Thompson B. T., Christiani D. C. Prognostic value of plasma N-terminal probrain natriuretic peptide levels in the acute respiratory distress syndrome. Crit Care Med: 2008; 36 8 2322 2327
    • (2008) Crit Care Med , vol.36 , Issue.8 , pp. 2322-2327
    • Bajwa, E.K.1    Januzzi, J.L.2    Gong, M.N.3    Thompson, B.T.4    Christiani, D.C.5
  • 116
    • 39049137434 scopus 로고    scopus 로고
    • Biomarker evidence of myocardial cell injury is associated with mortality in acute respiratory distress syndrome
    • Bajwa E. K., Boyce P. D., Januzzi J. L., Gong M. N., Thompson B. T., Christiani D. C. Biomarker evidence of myocardial cell injury is associated with mortality in acute respiratory distress syndrome. Crit Care Med: 2007; 35 11 2484 2490
    • (2007) Crit Care Med , vol.35 , Issue.11 , pp. 2484-2490
    • Bajwa, E.K.1    Boyce, P.D.2    Januzzi, J.L.3    Gong, M.N.4    Thompson, B.T.5    Christiani, D.C.6
  • 117
    • 84863740364 scopus 로고    scopus 로고
    • Prognostic significance of elevated cardiac troponin-T levels in acute respiratory distress syndrome patients
    • Rivara M. B., Bajwa E. K., Januzzi J. L., Gong M. N., Thompson B. T., Christiani D. C. Prognostic significance of elevated cardiac troponin-T levels in acute respiratory distress syndrome patients. PLoS ONE: 2012; 7 7 e40515
    • (2012) PLoS ONE , vol.7 , Issue.7 , pp. e40515
    • Rivara, M.B.1    Bajwa, E.K.2    Januzzi, J.L.3    Gong, M.N.4    Thompson, B.T.5    Christiani, D.C.6
  • 118
    • 84887030946 scopus 로고    scopus 로고
    • Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome
    • National Heart, Lung and Blood Institute Acute Respiratory Distress Syndrome Network
    • Bajwa E. K., Volk J. A., Christiani D. C., et al. National Heart, Lung and Blood Institute Acute Respiratory Distress Syndrome Network. Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome. Crit Care Med: 2013; 41 11 2521 2531
    • (2013) Crit Care Med , vol.41 , Issue.11 , pp. 2521-2531
    • Bajwa, E.K.1    Volk, J.A.2    Christiani, D.C.3
  • 119
    • 84055190055 scopus 로고    scopus 로고
    • IGF1 and IGFBP3 in acute respiratory distress syndrome
    • Ahasic A. M., Zhai R., Su L., et al. IGF1 and IGFBP3 in acute respiratory distress syndrome. Eur J Endocrinol: 2012; 166 1 121 129
    • (2012) Eur J Endocrinol , vol.166 , Issue.1 , pp. 121-129
    • Ahasic, A.M.1    Zhai, R.2    Su, L.3
  • 120
    • 84886732783 scopus 로고    scopus 로고
    • Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome
    • Ware L. B., Koyama T., Zhao Z., et al. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care: 2013; 17 5 R253
    • (2013) Crit Care , vol.17 , Issue.5 , pp. R253
    • Ware, L.B.1    Koyama, T.2    Zhao, Z.3
  • 121
    • 79953202811 scopus 로고    scopus 로고
    • Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury
    • National Heart, Blood, and Lung Institute Acute Respiratory Distress Syndrome Network
    • Calfee C. S., Ware L. B., Glidden D. V., et al. National Heart, Blood, and Lung Institute Acute Respiratory Distress Syndrome Network. Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med: 2011; 39 4 711 717
    • (2011) Crit Care Med , vol.39 , Issue.4 , pp. 711-717
    • Calfee, C.S.1    Ware, L.B.2    Glidden, D.V.3
  • 122
    • 84905502770 scopus 로고    scopus 로고
    • Subphenotypes in acute respiratory distress syndrome: Latent class analysis of data from two randomised controlled trials
    • NHLBI ARDS Network
    • Calfee C. S., Delucchi K., Parsons P. E., Thompson B. T., Ware L. B., Matthay M. A.; NHLBI ARDS Network. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med: 2014; 2 8 611 620
    • (2014) Lancet Respir Med , vol.2 , Issue.8 , pp. 611-620
    • Calfee, C.S.1    Delucchi, K.2    Parsons, P.E.3    Thompson, B.T.4    Ware, L.B.5    Matthay, M.A.6
  • 123
    • 34447642160 scopus 로고    scopus 로고
    • Genetics and proteomics: Deciphering gene association studies in critical illness
    • Yende S., Kammerer C. M., Angus D. C. Genetics and proteomics: deciphering gene association studies in critical illness. Crit Care: 2006; 10 4 227
    • (2006) Crit Care , vol.10 , Issue.4 , pp. 227
    • Yende, S.1    Kammerer, C.M.2    Angus, D.C.3
  • 124
    • 33846116266 scopus 로고    scopus 로고
    • Wading into the genomic pool to unravel acute lung injury genetics
    • Meyer N. J., Garcia J. G. Wading into the genomic pool to unravel acute lung injury genetics. Proc Am Thorac Soc: 2007; 4 1 69 76
    • (2007) Proc Am Thorac Soc , vol.4 , Issue.1 , pp. 69-76
    • Meyer, N.J.1    Garcia, J.G.2
  • 125
    • 84920404115 scopus 로고    scopus 로고
    • Host genetics shapes adult sepsis survival
    • Flores C. Host genetics shapes adult sepsis survival. Lancet Respir Med: 2015; 3 1 7 8
    • (2015) Lancet Respir Med , vol.3 , Issue.1 , pp. 7-8
    • Flores, C.1
  • 126
    • 0023870774 scopus 로고
    • Genetic and environmental influences on premature death in adult adoptees
    • Sorensen T. I., Nielsen G. G., Andersen P. K., Teasdale T. W. Genetic and environmental influences on premature death in adult adoptees. N Engl J Med: 1988; 318 12 727 732
    • (1988) N Engl J Med , vol.318 , Issue.12 , pp. 727-732
    • Sorensen, T.I.1    Nielsen, G.G.2    Andersen, P.K.3    Teasdale, T.W.4
  • 127
    • 69849099496 scopus 로고    scopus 로고
    • Bench-to-bedside review: Association of genetic variation with sepsis
    • Sutherland A. M., Walley K. R. Bench-to-bedside review: association of genetic variation with sepsis. Crit Care: 2009; 13 2 210
    • (2009) Crit Care , vol.13 , Issue.2 , pp. 210
    • Sutherland, A.M.1    Walley, K.R.2
  • 128
    • 1242320032 scopus 로고    scopus 로고
    • Genomic polymorphisms in sepsis
    • Lin M. T., Albertson T. E. Genomic polymorphisms in sepsis. Crit Care Med: 2004; 32 2 569 579
    • (2004) Crit Care Med , vol.32 , Issue.2 , pp. 569-579
    • Lin, M.T.1    Albertson, T.E.2
  • 129
    • 84878249792 scopus 로고    scopus 로고
    • Beyond single-marker analyses: Mining whole genome scans for insights into treatment responses in severe sepsis
    • Man M., Close S. L., Shaw A. D., et al. Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. Pharmacogenomics J: 2013; 13 3 218 226
    • (2013) Pharmacogenomics J , vol.13 , Issue.3 , pp. 218-226
    • Man, M.1    Close, S.L.2    Shaw, A.D.3
  • 130
    • 84920376264 scopus 로고    scopus 로고
    • Genome-wide association study of survival from sepsis due to pneumonia: An observational cohort study
    • ESICM/ECCRN GenOSept Investigators
    • Rautanen A., Mills T. C., Gordon A. C., et al. ESICM/ECCRN GenOSept Investigators. Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med: 2015; 3 1 53 60
    • (2015) Lancet Respir Med , vol.3 , Issue.1 , pp. 53-60
    • Rautanen, A.1    Mills, T.C.2    Gordon, A.C.3
  • 131
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
    • Bernard G. R., Vincent J. L., Laterre P. F., et al. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med: 2001; 344 10 699 709
    • (2001) N Engl J Med , vol.344 , Issue.10 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 132
    • 70349239233 scopus 로고    scopus 로고
    • Identification of pediatric septic shock subclasses based on genome-wide expression profiling
    • Wong H. R., Cvijanovich N., Lin R., et al. Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med: 2009; 7 34
    • (2009) BMC Med , vol.7 , pp. 34
    • Wong, H.R.1    Cvijanovich, N.2    Lin, R.3
  • 133
    • 84922311029 scopus 로고    scopus 로고
    • Developing a clinically feasible personalized medicine approach to pediatric septic shock
    • Wong H. R., Cvijanovich N. Z., Anas N., et al. Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med: 2015; 191 3 309 315
    • (2015) Am J Respir Crit Care Med , vol.191 , Issue.3 , pp. 309-315
    • Wong, H.R.1    Cvijanovich, N.Z.2    Anas, N.3
  • 135
    • 84909632775 scopus 로고    scopus 로고
    • Beyond single-nucleotide polymorphisms: Genetics, genomics, and other 'omic approaches to acute respiratory distress syndrome
    • Meyer N. J. Beyond single-nucleotide polymorphisms: genetics, genomics, and other 'omic approaches to acute respiratory distress syndrome. Clin Chest Med: 2014; 35 4 673 684
    • (2014) Clin Chest Med , vol.35 , Issue.4 , pp. 673-684
    • Meyer, N.J.1
  • 136
    • 84882247154 scopus 로고    scopus 로고
    • Genetic heterogeneity and risk of acute respiratory distress syndrome
    • Meyer N. J., Christie J. D. Genetic heterogeneity and risk of acute respiratory distress syndrome. Semin Respir Crit Care Med: 2013; 34 4 459 474
    • (2013) Semin Respir Crit Care Med , vol.34 , Issue.4 , pp. 459-474
    • Meyer, N.J.1    Christie, J.D.2
  • 137
    • 66149183017 scopus 로고    scopus 로고
    • Recent advances in genetic predisposition to clinical acute lung injury
    • Gao L., Barnes K. C. Recent advances in genetic predisposition to clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol: 2009; 296 5 L713 L725
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296 , Issue.5 , pp. L713-L725
    • Gao, L.1    Barnes, K.C.2
  • 138
    • 84870301161 scopus 로고    scopus 로고
    • Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
    • Tejera P., Meyer N. J., Chen F., et al. Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. J Med Genet: 2012; 49 11 671 680
    • (2012) J Med Genet , vol.49 , Issue.11 , pp. 671-680
    • Tejera, P.1    Meyer, N.J.2    Chen, F.3
  • 139
    • 84856278890 scopus 로고    scopus 로고
    • Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma
    • Trauma ALI SNP Consortium (TASC) investigators
    • Christie J. D., Wurfel M. M., Feng R., et al. Trauma ALI SNP Consortium (TASC) investigators. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS ONE: 2012; 7 1 e28268
    • (2012) PLoS ONE , vol.7 , Issue.1 , pp. e28268
    • Christie, J.D.1    Wurfel, M.M.2    Feng, R.3
  • 140
    • 66149092331 scopus 로고    scopus 로고
    • Discovery of the gene signature for acute lung injury in patients with sepsis
    • Howrylak J. A., Dolinay T., Lucht L., et al. Discovery of the gene signature for acute lung injury in patients with sepsis. Physiol Genomics: 2009; 37 2 133 139
    • (2009) Physiol Genomics , vol.37 , Issue.2 , pp. 133-139
    • Howrylak, J.A.1    Dolinay, T.2    Lucht, L.3


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