Genome-wide association study of survival from sepsis due to pneumonia: An observational cohort study

The Lancet Respiratory Medicine

Volumn 3, Issue 1, 2015, Pages 53-60

  Rautanen, Anna ^a   Mills, Tara C ^a   Gordon, Anthony C ^b   Hutton, Paula ^c   Steffens, Michael ⁱ   Nuamah, Rosamond ^d   Chiche, Jean Daniel ^e   Parks, Tom ^a   Chapman, Stephen J ^a   Davenport, Emma E ^a   Elliott, Katherine S ^a   Bion, Julian ^f   Lichtner, Peter ^g   Meitinger, Thomas ^g,h   Wienker, Thomas F ⁱ   Caulfield, Mark J ^d   Mein, Charles ^d   Bloos, Frank ^j   Bobek, Ilona ^k   Cotogni, Paolo ^l   Sramek, Vladimir ^m   Sarapuu, Silver ⁿ   Kobilay, Makbule ⁱ   Ranieri, V Marco ^l   Rello, Jordi ^o   Sirgo, Gonzalo ^p   Weiss, Yoram G ^q   Russwurm, Stefan ^j   Schneider, E Marion ^r   Reinhart, Konrad ^j   Holloway, Paul A H ^b   Knight, Julian C ^a   Garrard, Chris S ^c   Russell, James A ^s   Walley, Keith R ^s   Stüber, Frank ^t   Hill, Adrian V S ^a   Hinds, Charles J ^d   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e Hospital Cochin ^*  (France)

^f UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^g INSTITUTE OF EPIDEMIOLOGY   (Germany)

^h TECHNICAL UNIVERSITY OF MUNICH   (Germany)

ⁱ UNIVERSITY OF BONN   (Germany)

^j JENA UNIVERSITY HOSPITAL   (Germany)

^k National Health Centre   (Hungary)

^l UNIVERSITY OF TURIN   (Italy)

^m MASARYK UNIVERSITY   (Czech Republic)

ⁿ TARTU UNIVERSITY HOSPITAL   (Estonia)

^o UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^p HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^q HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^r UNIVERSITY HOSPITAL ULM   (Germany)

^s UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^t UNIVERSITY OF BERN   (Switzerland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; PROTEIN TYROSINE KINASE; GENETIC MARKER; PROTO-ONCOGENE PROTEIN C-FES-FPS;

ABDOMINAL INFECTION; ADULT; ARTICLE; CAUCASIAN; COHORT ANALYSIS; DRUG TARGETING; FEMALE; FER GENE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PNEUMONIA; RISK ASSESSMENT; RISK REDUCTION; SEPSIS; SEPTIC SHOCK; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL TIME; COMPLICATION; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MIDDLE AGED; STATISTICS AND NUMERICAL DATA; SURVIVAL ANALYSIS;

COHORT STUDIES; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; PNEUMONIA; PROTEIN-TYROSINE KINASES; SEPSIS; SURVIVAL ANALYSIS;

EID: 84920376264     PISSN: 22132600     EISSN: 22132619     Source Type: Journal    
DOI: 10.1016/S2213-2600(14)70290-5     Document Type: Article

References (42)

1. Kumar G, Kumar N, Taneja A, et al. Nationwide trends of severe sepsis in the 21st century (2000-2007). Chest 2011, 140:1223-1231.
2. Martin GS, Mannino DM, Eaton S, Moss M The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554.
3. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007, 35:1244-1250.
4. Gaieski DF, Edwards JM, Kallan MJ, Carr BG Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med 2013, 41:1167-1174.
5. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29:1303-1310.
6. Lagu T, Rothberg MB, Shieh MS, Pekow PS, Steingrub JS, Lindenauer PK Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med 2012, 40:754-761.
7. Adhikari NK, Fowler RA, Bhagwanjee S, Rubenfeld GD Critical care and the global burden of critical illness in adults. Lancet 2010, 376:1339-1346.
8. Quartin AA, Schein RM, Kett DH, Peduzzi PN Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. JAMA 1997, 277:1058-1063.
9. Storgaard M, Hallas J, Gahrn-Hansen B, Pedersen SS, Pedersen C, Lassen AT Short- and long-term mortality in patients with community-acquired severe sepsis and septic shock. Scand J Infect Dis 2013, 45:577-583.
10. Winters BD, Eberlein M, Leung J, Needham DM, Pronovost PJ, Sevransky JE Long-term mortality and quality of life in sepsis: a systematic review. Crit Care Med 2010, 38:1276-1283.
11. Angus DC, van der Poll T Severe sepsis and septic shock. N Engl J Med 2013, 369:840-851.
12. Visscher PM, Brown MA, McCarthy MI, Yang J Five years of GWAS discovery. Am J Hum Genet 2012, 90:7-24.
13. Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW Genetic and environmental influences on premature death in adult adoptees. N Engl J Med 1988, 318:727-732.
14. Cooke GS, Hill AV Genetics of susceptibility to human infectious disease. Nat Rev Genet 2001, 2:967-977.
15. Gingles NA, Alexander JE, Kadioglu A, et al. Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains. Infect Immun 2001, 69:426-434.
16. Chapman SJ, Hill AV Human genetic susceptibility to infectious disease. Nat Rev Genet 2012, 13:175-188.
17. Gordon AC, Lagan AL, Aganna E, et al. TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes Immun 2004, 5:631-640.
18. Stuber F, Udalova IA, Book M, et al. -308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J Inflamm 1995, 46:42-50.
19. Gordon AC, Waheed U, Hansen TK, et al. Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock 2006, 25:88-93.
20. Sutherland AM, Walley KR, Russell JA Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005, 33:638-644.
21. Bone RC, Sibbald WJ, Sprung CL, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1481-1483.
22. Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 2008, 358:877-887.
23. Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344:699-709.
24. Man M, Close SL, Shaw AD, et al. Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. Pharmacogenomics J 2013, 13:218-226.
25. Laterre PF, Garber G, Levy H, et al. Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS study. Crit Care Med 2005, 33:952-961.
26. Han B, Eskin E Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies. Am J Hum Genet 2011, 88:586-598.
27. Grambsch PM TT Proportional hazards tests and diagnostics based on weighted residuals. Biometrika Trust 1994, 81:515-526.
28. Wattanathum A, Manocha S, Groshaus H, Russell JA, Walley KR Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis. Chest 2005, 128:1690-1698.
29. Hao QL, Ferris DK, White G, Heisterkamp N, Groffen J Nuclear and cytoplasmic location of the FER tyrosine kinase. Mol Cell Biol 1991, 11:1180-1183.
30. Kim L, Wong TW Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. J Biol Chem 1998, 273:23542-23548.
31. Xu G, Craig AW, Greer P, et al. Continuous association of cadherin with beta-catenin requires the non-receptor tyrosine-kinase Fer. J Cell Sci 2004, 117:3207-3219.
32. Sangrar W, Gao Y, Scott M, Truesdell P, Greer PA Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion. Mol Cell Biol 2007, 27:6140-6152.
33. Craig AW, Greer PA Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol Cell Biol 2002, 22:6363-6374.
34. McCafferty DM, Craig AW, Senis YA, Greer PA Absence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxin. J Immunol 2002, 168:4930-4935.
35. Qi W, Ebbert KV, Craig AW, Greer PA, McCafferty DM Absence of Fer protein tyrosine kinase exacerbates endotoxin induced intestinal epithelial barrier dysfunction in vivo. Gut 2005, 54:1091-1097.
36. Khajah M, Andonegui G, Chan R, Craig AW, Greer PA, McCafferty DM Fer kinase limits neutrophil chemotaxis toward end target chemoattractants. J Immunol 2013, 190:2208-2216.
37. Kovach MA, Standiford TJ The function of neutrophils in sepsis. Curr Opin Infect Dis 2012, 25:321-327.
38. Mira JP, Cariou A, Grall F, et al. Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study. JAMA 1999, 282:561-568.
39. Clark MF, Baudouin SV A systematic review of the quality of genetic association studies in human sepsis. Intensive Care Med 2006, 32:1706-1712.
40. Davila S, Wright VJ, Khor CC, et al. Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet 2010, 42:772-776.
41. Christie JD, Wurfel MM, Feng R, et al. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One 2012, 7:e28268.
42. Frank AJ, Sheu CC, Zhao Y, et al. BCL2 genetic variants are associated with acute kidney injury in septic shock. Crit Care Med 2012, 40:2116-2123.