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Volumn 341, Issue 1, 1999, Pages 28-37

Shattuck lecture - Medical and societal consequences of the human genome project

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

EID: 0033168459     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199907013410106     Document Type: Review
Times cited : (665)

References (45)
  • 1
    • 0003748389 scopus 로고
    • Washington, D.C.: National Academy Press
    • National Research Council Committee on Mapping and Sequencing the Human Genome. Mapping and sequencing the human genome. Washington, D.C.: National Academy Press, 1988.
    • (1988) Mapping and Sequencing the Human Genome
  • 4
    • 0027942568 scopus 로고
    • A comprehensive human linkage map with centimorgan density
    • Murray JC, Buetow KH, Weber JL, et al. A comprehensive human linkage map with centimorgan density. Science 1994;265:2049-54.
    • (1994) Science , vol.265 , pp. 2049-2054
    • Murray, J.C.1    Buetow, K.H.2    Weber, J.L.3
  • 5
    • 0032561502 scopus 로고    scopus 로고
    • A physical map of 30,000 human genes
    • Deloukas P, Schuler GD, Gyapay G, et al. A physical map of 30,000 human genes. Science 1998;282:744-6.
    • (1998) Science , vol.282 , pp. 744-746
    • Deloukas, P.1    Schuler, G.D.2    Gyapay, G.3
  • 6
    • 0027433148 scopus 로고
    • A new five-year plan for the U.S. Human genome project
    • Collins FS, Galas D. A new five-year plan for the U.S. Human Genome Project. Science 1993;262:43-6.
    • (1993) Science , vol.262 , pp. 43-46
    • Collins, F.S.1    Galas, D.2
  • 7
    • 0031589946 scopus 로고    scopus 로고
    • The yeast genome directory
    • The yeast genome directory. Nature 1997;387:Suppl:5.
    • (1997) Nature , vol.387 , Issue.SUPPL. , pp. 5
  • 8
    • 15444350252 scopus 로고    scopus 로고
    • The complete genome sequence of Escherichia coli K-12
    • Blattner FR, Plunkett G III, Bloch CA, et al. The complete genome sequence of Escherichia coli K-12. Science 1997;277:1453-74.
    • (1997) Science , vol.277 , pp. 1453-1474
    • Blattner, F.R.1    Plunkett G. III2    Bloch, C.A.3
  • 9
    • 0026849567 scopus 로고
    • Positional cloning: Let's not call it reverse anymore
    • Collins FS. Positional cloning: let's not call it reverse anymore. Nat Genet 1992;1:3-6.
    • (1992) Nat Genet , vol.1 , pp. 3-6
    • Collins, F.S.1
  • 10
    • 0028907339 scopus 로고
    • Positional cloning moves from perditional to traditional
    • Erratum, Nat Genet 1995;11:104
    • Idem. Positional cloning moves from perditional to traditional. Nat Genet 1995;9:347-50. [Erratum, Nat Genet 1995;11:104.]
    • (1995) Nat Genet , vol.9 , pp. 347-350
    • Collins, F.S.1
  • 11
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-7.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 12
    • 0031951197 scopus 로고    scopus 로고
    • A susceptibility locus for Parkinson's disease maps to chromosome 2p13
    • Gasser T, Muller-Myhsok B, Wszolek ZK, et al. A susceptibility locus for Parkinson's disease maps to chromosome 2p13. Nat Genet 1998;18: 262-5.
    • (1998) Nat Genet , vol.18 , pp. 262-265
    • Gasser, T.1    Muller-Myhsok, B.2    Wszolek, Z.K.3
  • 13
    • 0032231463 scopus 로고    scopus 로고
    • Autosomal recessive juvenile parkinsonism maps to 6q25.2-q27 in four ethnic groups: Detailed genetic mapping of the linked region
    • Jones AC, Yamamura Y, Almasy L, et al. Autosomal recessive juvenile parkinsonism maps to 6q25.2-q27 in four ethnic groups: detailed genetic mapping of the linked region. Am J Hum Genet 1998;63:80-7.
    • (1998) Am J Hum Genet , vol.63 , pp. 80-87
    • Jones, A.C.1    Yamamura, Y.2    Almasy, L.3
  • 14
    • 0032190090 scopus 로고    scopus 로고
    • The ubiquitin pathway in Parkinson's disease
    • Leroy E, Boyer R, Auburger G, et al. The ubiquitin pathway in Parkinson's disease. Nature 1998;395:451-2.
    • (1998) Nature , vol.395 , pp. 451-452
    • Leroy, E.1    Boyer, R.2    Auburger, G.3
  • 15
    • 0027489773 scopus 로고
    • Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
    • Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 1993;90:11282-6.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11282-11286
    • Ueda, K.1    Fukushima, H.2    Masliah, E.3
  • 16
    • 0032496881 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Gene discovery and its implications for population-based screening
    • Burke W, Thomson E, Khoury MJ, et al. Hereditary hemochromatosis: gene discovery and its implications for population-based screening. JAMA 1998;280:172-8.
    • (1998) JAMA , vol.280 , pp. 172-178
    • Burke, W.1    Thomson, E.2    Khoury, M.J.3
  • 17
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996; 13:399-408.
    • (1996) Nat Genet , vol.13 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 18
    • 0028113345 scopus 로고
    • A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
    • Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 226:66-71.
    • (1994) Science , vol.226 , pp. 66-71
    • Miki, Y.1    Swensen, J.2    Shattuck-Eidens, D.3
  • 19
    • 0006713602 scopus 로고
    • Identification of the breast cancer susceptibility gene BRCA2
    • Erratum, Nature 1996;379:749
    • Wooster R, Bignell G, Lancaster J, et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 1995;378:789-92. [Erratum, Nature 1996;379:749.]
    • (1995) Nature , vol.378 , pp. 789-792
    • Wooster, R.1    Bignell, G.2    Lancaster, J.3
  • 20
    • 10544236911 scopus 로고    scopus 로고
    • Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY 1)
    • Yamagata K, Furuta H, Oda O, et al. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY 1). Nature 1996;384:458-60.
    • (1996) Nature , vol.384 , pp. 458-460
    • Yamagata, K.1    Furuta, H.2    Oda, O.3
  • 21
    • 0027472126 scopus 로고
    • Familial hyperglycemia due to mutations in glucokinase: Definition of a subtype of diabetes mellitus
    • Froguel P, Zouali H, Vionnet N, et al. Familial hyperglycemia due to mutations in glucokinase: definition of a subtype of diabetes mellitus. N Engl J Med 1993;328:697-702.
    • (1993) N Engl J Med , vol.328 , pp. 697-702
    • Froguel, P.1    Zouali, H.2    Vionnet, N.3
  • 22
    • 10544249874 scopus 로고    scopus 로고
    • Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
    • Yamagata K, Oda N, Kaisaki PJ, et al. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature 1996;384:455-8.
    • (1996) Nature , vol.384 , pp. 455-458
    • Yamagata, K.1    Oda, N.2    Kaisaki, P.J.3
  • 23
    • 0027742295 scopus 로고
    • The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
    • Erratum, Cell 1994;77:167
    • Fishel R, Lescoe MK, Rao MR, et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 1993;75:1027-38. [Erratum, Cell 1994;77:167]
    • (1993) Cell , vol.75 , pp. 1027-1038
    • Fishel, R.1    Lescoe, M.K.2    Rao, M.R.3
  • 24
    • 0027145633 scopus 로고
    • Mutations of a muts homolog in hereditary nonpolyposis colorectal cancer
    • Leach FS, Nicolaides NC, Papadopoulos N, et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993;75:1215-25.
    • (1993) Cell , vol.75 , pp. 1215-1225
    • Leach, F.S.1    Nicolaides, N.C.2    Papadopoulos, N.3
  • 25
    • 0028350601 scopus 로고
    • Mutation of a mutL homolog in hereditary colon cancer
    • Papadopoulos N, Nicolaides NC, Wei YF, et al. Mutation of a mutL homolog in hereditary colon cancer. Science 1994;263:1625-9.
    • (1994) Science , vol.263 , pp. 1625-1629
    • Papadopoulos, N.1    Nicolaides, N.C.2    Wei, Y.F.3
  • 26
    • 0031984056 scopus 로고    scopus 로고
    • DNA variation and the future of human genetics
    • Schafer AJ, Hawkins JR. DNA variation and the future of human genetics. Nat Biotechnol 1998;16:33-9.
    • (1998) Nat Biotechnol , vol.16 , pp. 33-39
    • Schafer, A.J.1    Hawkins, J.R.2
  • 27
    • 0030688004 scopus 로고    scopus 로고
    • Variations on a theme: Cataloging human DNA sequence variation
    • Collins FS, Guyer MS, Charkravarti A. Variations on a theme: cataloging human DNA sequence variation. Science 1997;278:1580-1.
    • (1997) Science , vol.278 , pp. 1580-1581
    • Collins, F.S.1    Guyer, M.S.2    Charkravarti, A.3
  • 28
    • 0032524383 scopus 로고    scopus 로고
    • Large-scale identification, mapping and gcnotyping of single-nucleotide polymorphisms in the human genome
    • Wang DG, Fan J-B, Siao C-J, et al. Large-scale identification, mapping and gcnotyping of single-nucleotide polymorphisms in the human genome. Science 1998;280:1077-82.
    • (1998) Science , vol.280 , pp. 1077-1082
    • Wang, D.G.1    Fan, J.-B.2    Siao, C.-J.3
  • 29
    • 0029829670 scopus 로고    scopus 로고
    • Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis
    • Hacia JG, Brody LC, Chee MS, Fodor SP, Collins FS. Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis. Nat Genet 1996;14:441-7.
    • (1996) Nat Genet , vol.14 , pp. 441-447
    • Hacia, J.G.1    Brody, L.C.2    Chee, M.S.3    Fodor, S.P.4    Collins, F.S.5
  • 30
    • 0029852580 scopus 로고    scopus 로고
    • Use of a cDNA microarray to analyse gene expression patterns in human cancer
    • DeRisi J, Penland L, Brown PO, et al. Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet 1996;14:457-60.
    • (1996) Nat Genet , vol.14 , pp. 457-460
    • DeRisi, J.1    Penland, L.2    Brown, P.O.3
  • 31
    • 0031895247 scopus 로고    scopus 로고
    • Evolutionary sequence comparisons using high-density oligonucleotide arrays
    • Hacia JG, Makalowski W, Edgemon K, et al. Evolutionary sequence comparisons using high-density oligonucleotide arrays. Nat Genet 1998; 18:155-8.
    • (1998) Nat Genet , vol.18 , pp. 155-158
    • Hacia, J.G.1    Makalowski, W.2    Edgemon, K.3
  • 32
    • 0032555671 scopus 로고    scopus 로고
    • Direct allelic variation scanning of the yeast genome
    • Winzeler EA, Richards DR, Conway AR, et al. Direct allelic variation scanning of the yeast genome. Science 1998;281:1194-7
    • (1998) Science , vol.281 , pp. 1194-1197
    • Winzeler, E.A.1    Richards, D.R.2    Conway, A.R.3
  • 33
    • 0031822837 scopus 로고    scopus 로고
    • Tissue microarrays for high-throughput molecular profiling of tumor specimens
    • Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998; 4:844-7.
    • (1998) Nat Med , vol.4 , pp. 844-847
    • Kononen, J.1    Bubendorf, L.2    Kallioniemi, A.3
  • 34
    • 0007691164 scopus 로고
    • Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease
    • Poirier J, Delisle M-C, Quirion R, et al. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. Proc Natl Acad Sci U S A 1995;92:12260-4.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 12260-12264
    • Poirier, J.1    Delisle, M.-C.2    Quirion, R.3
  • 35
    • 0032495541 scopus 로고    scopus 로고
    • The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis
    • Kuivenhoven JA, Jukema JW, Zwinderman AH, et al. The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. N Engl J Med 1998;338:86-93.
    • (1998) N Engl J Med , vol.338 , pp. 86-93
    • Kuivenhoven, J.A.1    Jukema, J.W.2    Zwinderman, A.H.3
  • 36
    • 0032543748 scopus 로고    scopus 로고
    • High risk of cerebral-vein thrombosis in carriers of a prothrombin gene mutation and in users of oral contraceptives
    • Martinelli I, Sacchi E, Landi G, Taioli E, Duca F, Mannucci PM. High risk of cerebral-vein thrombosis in carriers of a prothrombin gene mutation and in users of oral contraceptives. N Engl J Med 1998;338:1793-7.
    • (1998) N Engl J Med , vol.338 , pp. 1793-1797
    • Martinelli, I.1    Sacchi, E.2    Landi, G.3    Taioli, E.4    Duca, F.5    Mannucci, P.M.6
  • 37
    • 0344685020 scopus 로고    scopus 로고
    • Washington, D.C.: Pharmaceutical Research and Manufacturers of America
    • New medicines in development: biotechnology 1998. Washington, D.C.: Pharmaceutical Research and Manufacturers of America, 1998:35.
    • (1998) New Medicines in Development: Biotechnology 1998 , pp. 35
  • 38
    • 0031889082 scopus 로고    scopus 로고
    • A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: Partial restoration of nasal epithelial CFTR function
    • Rubenstein RC, Zeitlin PL. A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function. Am J Respir Crit Care Med 1998;157:484-90.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 484-490
    • Rubenstein, R.C.1    Zeitlin, P.L.2
  • 40
    • 0031003216 scopus 로고    scopus 로고
    • Genetic information and the workplace: Legislative approaches and policy challenges
    • Rothenberg K, Fuller B, Rothstein M, et al. Genetic information and the workplace: legislative approaches and policy challenges. Science 1997; 275:1755-7.
    • (1997) Science , vol.275 , pp. 1755-1757
    • Rothenberg, K.1    Fuller, B.2    Rothstein, M.3
  • 41
    • 0344253486 scopus 로고
    • Washington, D.C.: Equal Employment Opportunity Commission, March 15
    • Compliance manual. Section 902. Washington, D.C.: Equal Employment Opportunity Commission, March 15, 1995.
    • (1995) Compliance Manual. Section 902
  • 45
    • 0008234999 scopus 로고
    • Chauvinism in medicine
    • Osler W. Chauvinism in medicine. Montreal Med J 1902;31:684-99.
    • (1902) Montreal Med J , vol.31 , pp. 684-699
    • Osler, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.