Disruption of IP3R2-mediated Ca2+ signaling pathway in astrocytes ameliorates neuronal death and brain damage while reducing behavioral deficits after focal ischemic stroke

Cell Calcium

Volumn 58, Issue 6, 2015, Pages 565-576

  Li, Hailong ^a,b   Xie, Yicheng ^a,b   Zhang, Nannan ^a   Yu, Yang ^b   Zhang, Qiao ^b   Ding, Shinghua ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Astrocytic Ca2+ signaling; Behavioral tests; Infarction; Ischemic stroke; Neuronal death; Photothrombosis; Reactive astrogliosis; Two photon imaging

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; NEURON SPECIFIC NUCLEAR PROTEIN; PROTEIN S100B; VESICULAR GLUTAMATE TRANSPORTER 1; CALCIUM; IP3R2 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BEHAVIOR DISORDER; BRAIN DAMAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; CALCIUM SIGNALING; CELL DENSITY; CONTROLLED STUDY; CYTOARCHITECTURE; FEMALE; FUNCTIONAL DISEASE; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANIMAL BEHAVIOR; BRAIN; BRAIN INJURY; CELL DEATH; CEREBROVASCULAR ACCIDENT; CYTOLOGY; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; PHYSIOLOGY;

ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; BRAIN; BRAIN INJURIES; CALCIUM; CALCIUM SIGNALING; CELL DEATH; DISEASE MODELS, ANIMAL; FEMALE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MALE; MICE; MICE, KNOCKOUT; NEURONS; STROKE;

EID: 84947866178     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2015.09.004     Document Type: Article

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