Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 28, 2013, Pages 11612-11617

  Kanemaru, Kazunori ^a   Kubota, Jun ^a   Sekiya, Hiroshi ^a   Hirose, Kenzo ^a   Okubo, Yohei ^a   Iino, Masamitsu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Calcium signal; Reactive astrocyte; Stab wound; Translational repressor

Indexed keywords

NERVE CELL ADHESION MOLECULE; PROTEIN DERIVATIVE; PUMILIO 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN INJURY; CONTROLLED STUDY; DOWN REGULATION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; UPREGULATION;

CALCIUM SIGNAL; REACTIVE ASTROCYTE; STAB WOUND; TRANSLATIONAL REPRESSOR;

ANIMALS; ASTROCYTES; BRAIN INJURIES; CADHERINS; CALCIUM; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; UP-REGULATION;

MUS;

EID: 84879920511     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300378110     Document Type: Article

References (36)

1. Haydon PG, Carmignoto G (2006) Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86(3):1009-1031. (Pubitemid 44033387)
2. Silver J, Miller JH (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5(2):146-156. (Pubitemid 38160289)
3. Sofroniew MV (2009) Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 32(12):638-647.
4. Robel S, Berninger B, Götz M (2011) The stem cell potential of glia: Lessons from reactive gliosis. Nat Rev Neurosci 12(2):88-104.
5. Cornell-Bell AH, Finkbeiner SM, Cooper MS, Smith SJ (1990) Glutamate induces calcium waves in cultured astrocytes: Long-range glial signaling. Science 247(4941):470-473.
6. Duffy S, MacVicar BA (1995) Adrenergic calcium signaling in astrocyte networks within the hippocampal slice. J Neurosci 15(8):5535-5550.
7. 2+ signaling evoked by sensory stimulation in vivo. Nat Neurosci 9(6):816-823.
8. Nimmerjahn A, Kirchhoff F, Kerr JN, Helmchen F (2004) Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nat Methods 1(1):31-37.
9. Holtzclaw LA, Pandhit S, Bare DJ, Mignery GA, Russell JT (2002) Astrocytes in adult rat brain express type 2 inositol 1,4,5-trisphosphate receptors. Glia 39(1):69-84.
10. 2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity. J Neurosci 28(19):4967-4973.
11. 3)-receptor type 2-deficient mice. Circ Res 96(12):1274-1281.
12. Bush TG, et al. (1999) Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 23(2):297-308. (Pubitemid 29315725)
13. Buffo A, et al. (2008) Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proc Natl Acad Sci USA 105(9):3581-3586. (Pubitemid 351723595)
14. 2+ oscillations in astrocytes. J Neurosci 27(33):8957-8966.
15. Mashimo M, et al. (2010) Inositol 1,4,5-trisphosphate signaling maintains the activity of glutamate uptake in Bergmann glia. Eur J Neurosci 32(10):1668-1677.
16. Hanisch UK, Kettenmann H (2007) Microglia: Active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10(11):1387-1394.
17. White EK, Moore-Jarrett T, Ruley HE (2001) PUM2, a novel murine puf protein, and its consensus RNA-binding site. RNA 7(12):1855-1866. (Pubitemid 34042298)
18. Wickens M, Bernstein DS, Kimble J, Parker R (2002) A PUF family portrait: 3′ UTR regulation as a way of life. Trends Genet 18(3):150-157. (Pubitemid 34164641)
19. Vázquez-Chona F, Geisert EE, Jr. (1999) N-cadherin at the glial scar in the rat. Brain Res 838(1-2):45-50. (Pubitemid 29389817)
20. Tran MD, Wanner IB, Neary JT (2008) Purinergic receptor signaling regulates N-cadherin expression in primary astrocyte cultures. J Neurochem 105(1):272-286. (Pubitemid 351441644)
21. Kostetskii I, et al. (2005) Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res 96(3):346-354. (Pubitemid 40279909)
22. Mori T, et al. (2006) Inducible gene deletion in astroglia and radial glia - a valuable tool for functional and lineage analysis. Glia 54(1):21-34. (Pubitemid 43980031)
23. Etienne-Manneville S, Hall A (2001) Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell 106(4):489-498. (Pubitemid 32786992)
24. Liang CC, Park AY, Guan JL (2007) In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2(2):329-333. (Pubitemid 47040047)
25. Okada S, et al. (2006) Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med 12(7):829-834. (Pubitemid 44050074)
26. Cavallaro U, Dejana E (2011) Adhesion molecule signalling: Not always a sticky business. Nat Rev Mol Cell Biol 12(3):189-197.
27. Harris TJ, Tepass U (2010) Adherens junctions: From molecules to morphogenesis. Nat Rev Mol Cell Biol 11(7):502-514.
28. Takeichi M (2007) The cadherin superfamily in neuronal connections and interactions. Nat Rev Neurosci 8(1):11-20.
29. Fiore R, et al. (2009) Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J 28(6):697-710.
30. Maragakis NJ, Rothstein JD (2006) Mechanisms of disease: Astrocytes in neurodegenerative disease. Nat Clin Pract Neurol 2(12):679-689. (Pubitemid 44782682)
31. Dupin I, Camand E, Etienne-Manneville S (2009) Classical cadherins control nucleus and centrosome position and cell polarity. J Cell Biol 185(5):779-786.
32. Suyama K, Shapiro I, Guttman M, Hazan RB (2002) A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell 2(4):301-314. (Pubitemid 41043964)
33. Narayanan R, Dougherty KJ, Johnston D (2010) Calcium store depletion induces persistent perisomatic increases in the functional density of h channels in hippocampal pyramidal neurons. Neuron 68(5):921-935.
34. Schmidt S, Ehrlich BE (2010) Unloading intracellular calcium stores reveals regionally specific functions. Neuron 68(5):806-808.
35. Koizumi S, et al. (2007) UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446(7139):1091-1095. (Pubitemid 46676051)
36. Buffo A, et al. (2005) Expression pattern of the transcription factor Olig2 in response to brain injuries: Implications for neuronal repair. Proc Natl Acad Sci USA 102(50):18183-18188. (Pubitemid 41798522)