Dynamic reactive astrocytes after focal ischemia

Neural Regeneration Research

Volumn 9, Issue 23, 2014, Pages 2048-2052

  Ding, Shinghua ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Cell proliferation; Cell therapy; Dynamics; Glial scar; Ischemic stroke; Morphology; Reactive astrocytes

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

ALZHEIMER DISEASE; ASTROCYTE; ASTROCYTOSIS; BEHAVIOR DISORDER; BRAIN ISCHEMIA; BRAIN REGION; BRDU ASSAY; CELL PROLIFERATION; CELL STRUCTURE; CELL THERAPY; EXPERIMENTAL BEHAVIORAL TEST; GENE EXPRESSION; HUMAN; NONHUMAN; REVIEW; SCAR FORMATION; SIGNAL TRANSDUCTION;

EID: 84921747792     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.147929     Document Type: Review

References (52)

1. Addis RC, Hsu FC, Wright RL, Dichter MA, Coulter DA, Gearhart JD (2011) Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector. PLoS One 6: e28719.
2. Badan I, Buchhold B, Hamm A, Gratz M, Walker LC, Platt D, Kessler C, Popa-Wagner A (2003) Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery. J Cereb Blood Flow Metab 23: 845-854.
3. Bao Y, Qin L, Kim E, Bhosle S, Guo H, Febbraio M, Haskew-Layton RE, Ratan R, Cho S (2012) CD36 is involved in astrocyte activation and astroglial scar formation. J Cereb Blood Flow Metab 32: 1567-1577.
4. Barreto GE, Sun X, Xu L, Giffard RG (2011) Astrocyte proliferation following stroke in the mouse depends on distance from the Infarct. PLoS One 6: e27881.
5. Benesova J, Hock M, Butenko O, Prajerova I, Anderova M, Chvatal A (2009) Quantification of astrocyte volume changes during ischemia in situ reveals two populations of astrocytes in the cortex of GFAP/EGFP mice. J Neurosci Res 87: 96-111.
6. Berninger B, Costa MR, Koch U, Schroeder T, Sutor B, Grothe B, Gotz MM (2007) Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia. J Neurosci 27: 8654-8664.
7. Buffo A, Rite I, Tripathi P, Lepier A, Colak D, Horn AP, Mori T, Gotz M (2008) Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proc Natl Acad Sci U S A 105: 3581-3586.
8. Burda J, Sofroniew M (2014) Reactive gliosis and the multicellular response to CNS damage and disease. Neuron 81: 229-248.
9. Bushong EA, Martone ME, Jones YZ, Ellisman MH (2002) Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J Neurosci 22: 183-192.
10. Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, Thompson WJ, Barres BA (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28: 264-278.
11. Clarkson AN, Lopez-Valdes HE, Overman JJ, Charles AC, Brennan KC, Thomas Carmichael S (2013) Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model. J Cereb Blood Flow Metab 33: 716-723.
12. Dimou L, Gotz M (2014) Glial cells as progenitors and stem cells: new roles in the healthy and diseased brain. Physiol Rev 94: 709-737.
13. Ding S, Wang T, Cui W, Haydon PG (2009) Photothrombosis ischemia stimulates a sustained astrocytic Ca2+ signaling in vivo. Glia 57: 767-776.
14. Ding S (2013) In vivo astrocytic Ca2+ signaling in health and brain disorders. Future Neurol 8: 529-554.
15. Ding S (2014) Ca2+ signaling in astrocytes and its role in ischemic stroke. Adv Neurobiol 11: 189-211.
16. Escartin C, Bonvento G (2008) Targeted activation of astrocytes: a potential neuroprotective strategy. Mol Neurobiol 38: 231-241.
17. Guo Z, Zhang L, Wu Z, Chen Y, Wang F, Chen G (2014) In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimers disease model. Cell Stem Cell 14: 188-202.
18. Halassa MM, Fellin T, Takano H, Dong JH, Haydon PG (2007) Synaptic islands defined by the territory of a single astrocyte. J Neurosci 27: 6473-6477.
19. Haupt C, Witte OW, Frahm C (2007) Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injury. Mol Cell Neurosci 35: 89-99.
20. Hayakawa K, Nakano T, Irie K, Higuchi S, Fujioka M, Orito K, Iwasaki K, Jin G, Lo EH, Mishima K, Fujiwara M (2010) Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab 30: 871-882.
21. Heinrich C, Blum R, Gascon S, Masserdotti G, Tripathi P, Sanchez R, Tiedt S, Schroeder T, Gotz M, Berninger B (2010) Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biol 8: e1000373.
22. Li H, Zhang N, Lin H, Yu Y, Cai QM (2014) Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice. BMC Neurosci 15: 58.
23. Li H, Zhang N, Sun G, Ding S (2013) Inhibition of the group I mGluRs reduces acute brain damage and improves long-term histological outcomes after photothrombosis-induced ischaemia. ASN Neuro 5: 195-207.
24. Li X, Blizzard KK, Zeng Z, DeVries AC, Hurn PD, McCullough LD (2004) Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp Neurol 187: 94-104.
25. Mestriner RgG, Saur L, Bagatini PB, Baptista PP, Vaz SP, Ferreira K, Machado SA, Xavier Ld, Netto CA (2015) Astrocyte morphology after ischemic and hemorrhagic experimental stroke has no influence on the different recovery patterns. Behav Brain Res 278: 257-261.
26. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH (2014) Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature 509: 189-194.
27. Mori T, Tanaka K, Buffo A, Wurst W, Kuhn R, Gotz M (2006) Inducible gene deletion in astroglia and radial glia is valuable tool for functional and lineage analysis. Glia 54: 21-34.
28. Nowicka D, Rogozinska K, Aleksy M, Witte OW, Skangiel-Kramska J (2008) Spatiotemporal dynamics of astroglial and microglial responses after photothrombotic stroke in the rat brain. Acta Neurobiol Exp 68: 155-68.
29. Ohab JJ, Fleming S, Blesch A, Carmichael ST (2006) A Neurovascular Niche for Neurogenesis after Stroke. J Neurosci 26: 13007-13016.
30. Panickar KS, Norenberg MD (2005) Astrocytes in cerebral ischemic injury: morphological and general considerations. Glia 50: 287-298.
31. Robel S, Berninger B, Gotz M (2011) The stem cell potential of glia: lessons from reactive gliosis. Nat Rev Neurosci 12: 88-104.
32. Schroeter M, Jander S, Stoll G (2002) Non-invasive induction of focal cerebral ischemia in mice by photothrombosis of cortical microvessels: characterization of inflammatory responses. J Neurosci Methods 117: 43-49.
33. Shen J, Ishii Y, Xu G, Dang TC, Hamashima T, Matsushima T, Yamamoto S, Hattori Y, Takatsuru Y, Nabekura J, Sasahara M (2012) PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia. J Cereb Blood Flow Metab 32: 353-367.
34. Shimada IS, Borders A, Aronshtam A, Spees JL (2011) Proliferating reactive astrocytes are regulated by notch-1 in the peri-infarct area after stroke. Stroke 42: 3231-3237.
35. Shimada IS, LeComte MD, Granger JC, Quinlan NJ, Spees JL (2012) Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke. J Neurosci 32: 7926-7940.
36. Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai LH, Fischer A, Grobe K, Dimou L, et al. (2013) Reactive glia in the injured brain acquire stem cell properties in response to sonic Hedgehog. Cell Stem Cell 12: 426-439.
37. Sofroniew M, Vinters H (2010) Astrocytes: biology and pathology. Acta Neuropathol 119: 7-35.
38. Stapf C, Mohr JP (2002) Ischemic stroke therapy. Annu Rev Med 53: 453-475.
39. Stoll G, Jander S, Schroeter M (1998) Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56: 149-171.
40. Su Z, Niu W, Liu ML, Zou Y, Zhang CL (2014) In vivo conversion of astrocytes to neurons in the injured adult spinal cord. Nat Commun 5: 3338-3353.
41. Takata N, Hirase H (2008) Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo. PLoS One 3: e2525.
42. Tobin MK, Bonds JA, Minshall RD, Pelligrino DA, Testai FD, Lazarov O (2014) Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here. J Cereb Blood Flow Metab 10: 1573-1584.
43. Verkhratsky A, Sofroniew MV, Messing A, deLanerolle NC, Rempe D, Rodroguez JJ, Nedergaard M (2012) Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro 4.
44. Wagner DC, Scheibe J, Glocke I, Weise G, Deten A, Boltze J, Kranz A (2013) Object-based analysis of astroglial reaction and astrocyte subtype morphology after ischemic brain injury. Acta Neurobiol Exp (Wars) 73: 79-87.
45. Wanner IB, Anderson MA, Song B, Levine J, Fernandez A, Gray-Thompson Z, Ao Y, Sofroniew MV (2013) Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J Neurosci 33: 12870-12886.
46. Wilhelmsson U, Bushong EA, Price DL, Smarr BL, Phung V, Terada M, Ellisman MH, Pekny M (2006) Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury. Proc Natl Acad Sci U S A 103: 17513-17518.
47. Xie Y, Wang T, Sun GY, Ding S (2010) Specific disruption of astrocytic Ca2+ signaling pathway in vivo by adeno-associated viral transduction. Neuroscience 170: 992-1003.
48. Young CC, van der Harg JM, Lewis NJ, Brooks KJ, Buchan AM, Szele FG (2013) Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after stroke. Cereb Cortex 23: 647-659.
49. Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA (2012) Genomic analysis of reactive astrogliosis. J Neurosci 32: 6391-6410.
50. Zhang W, Xie Y, Wang T, Bi J, Li H, Zhang LQ, Ye SQ, Ding S (2010) Neuronal protective role of PBEF in a mouse model of cerebral ischemia. J Cereb Blood Flow Metab 30: 1962-1971.
51. Zhang Y, Barres BA (2010) Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr Opin Neurobiol 20: 588-594.
52. Zhou M, Kimelberg HK (2000) Freshly isolated astrocytes from rat hippocampus show two distinct current patterns and different [K+]ouptake capabilities. J Neurophysiol 84: 2746-2757.