Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis

Molecular Brain

Volumn 6, Issue 1, 2013, Pages

  Paquet, Maryse ^a   Ribeiro, Fabiola M ^b   Guadagno, Jennifer ^a   Esseltine, Jessica L ^a   Ferguson, Stephen S G ^a   Cregan, Sean P ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Astrocyte; Cell death; Homer; Inositol phosphate; Metabotropic glutamate receptor; Oxygen glucose deprivation

Indexed keywords

GLUCOSE; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; OXYGEN; PHOSPHOLIPASE C; PROTEIN HOMER;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL DEATH; ENZYME ACTIVATION; INVESTIGATIVE PROCEDURES; MOUSE; NONHUMAN; OXYGEN GLUCOSE DEPRIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; ASTROCYTES; CARRIER PROTEINS; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; INOSITOL PHOSPHATES; MICE; NECROSIS; OXYGEN; PHOSPHORYLATION; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION;

MUS;

EID: 84873588919     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-6-9     Document Type: Article

References (50)

1. Pharmacology and functions of metabotropic glutamate receptors. Conn PJ, Pin JP, Annu Rev Pharmacol Toxicol 1997 37 205 237 10.1146/annurev.pharmtox.37. 1.205 9131252 (Pubitemid 27238875)
2. Phosphorylation-independent attenuation of GPCR signaling. Ferguson SSG, Trends Pharmacol Sci 2007 28 173 179 10.1016/j.tips.2007.02.008 17350109 (Pubitemid 46483720)
3. Group I metabotropic glutamate receptor signaling and its implication in Neurological disease processes. Ribeiro FM, Paquet M, Cregan SP, Ferguson SSG, CNS Neurol Disord Drug Targets 2010 9 574 595 10.2174/187152710793361612 20632969
4. Metabotropic glutamate receptor desensitization. Dhami GK, Ferguson SSG, Pharmacol Ther 2006 111 260 271 10.1016/j.pharmthera.2005.01.008 16574233 (Pubitemid 43765534)
5. Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. Biber K, Laurie DJ, Berthele A, Sommer B, Tolle TR, Gebicke-Harter PJ, van Calker D, Boddeke HW, J Neurochem 1999 72 1671 1680 10098876 (Pubitemid 29140843)
6. Metabotropic glutamate receptors in acutely isolated hippocampal astrocytes: developmental changes of mGluR5 mRNA and functional expression. Cai Z, Schools GP, Kimelberg HK, Glia 2000 29 70 80 10.1002/(SICI)1098- 1136(20000101)29:1<70::AID-GLIA7>3.0.CO;2-V 10594924 (Pubitemid 30031135)
7. Group I and II metabotropic glutamate receptor expression in cultured rat spinal cord astrocytes. Silva GA, Theriault E, Mills LR, Pennefather PS, Feeney CJ, Neurosci Lett 1999 263 117 120 10.1016/S0304-3940(99)00145-7 10213149 (Pubitemid 29158942)
8. mGluR5 stimulates gliotransmission in the nucleus accumbens. D'Ascenzo M, Fellin T, Terunuma M, Revilla-Sanchez R, Meaney DF, Auberson YP, Moss SJ, Haydon PG, Proc Natl Acad Sci U S A 2007 104 1995 2000 10.1073/pnas.0609408104 17259307 (Pubitemid 46239892)
9. Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis. Vermeiren C, Hemptinne I, Vanhoutte N, Tilleux S, Maloteaux JM, Hermans E, J Neurochem 2006 96 7197 7131
10. Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. Shi Y, Liu X, Gebremedhin D, Falck JR, Harder DR, Koehler RC, J Cereb Blood Flow Metab 2008 28 111 125 10.1038/sj.jcbfm.9600511 17519974
11. Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection. Nicoletti F, Bruno V, Catania MV, Battaglia G, Copani A, Barbagallo G, Cena V, Sanchez-Prieto J, Spano PF, Pizzi M, Neuropharmacology 1999 38 1477 1484 10.1016/S0028-3908(99)00102-1 10530809 (Pubitemid 29457729)
12. Exacerbation of neuronal cell death by activation of group I metabotropic glutamate receptors: role of NMDA receptors and arachidonic acid release. Allen JW, Vicini S, Faden AI, Exp Neurol 2001 169 449 460 10.1006/exnr.2001.7672 11358458 (Pubitemid 32524439)
13. An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors. Bruno V, Battaglia G, Copani A, Cespedes VM, Galindo MF, Cena V, Sanchez-Prieto J, Gasparini F, Kuhn R, Flor PJ, Nicoletti F, Eur J Neurosci 2001 13 1469 1478 10.1046/j.0953-816x.2001.01541.x 11328342 (Pubitemid 32423335)
14. Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis. Baskys A, Bayazitov I, Fang L, Blaabjerg M, Poulsen FR, Zimmer J, Neuropharmacology 2005 49 146 156 16023152 (Pubitemid 41115901)
15. The distinct role of mGlu1 receptors in post-ischemic neuronal death. Pellegrini-Giampietro DE, Trends Pharmacol Sci 2003 24 461 470 10.1016/S0165-6147(03)00231-1 12967771 (Pubitemid 37088171)
16. PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K, Nat Neurosci 2003 6 1153 1161 10.1038/nn1134 14528310 (Pubitemid 37346035)
17. Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo. Szydlowska K, Kaminska B, Baude A, Parsons CG, Danysz W, Eur J Pharmacol 2007 554 18 29 10.1016/j.ejphar.2006.09.061 17109843 (Pubitemid 44820044)
18. Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR-induced release of Ca++ from intracellular stores and is prevented by estradiol. Hilton GD, Nunez JL, Bambrick L, Thompson SM, McCarthy MM, Eur J Neurosci 2006 24 3008 3016 10.1111/j.1460-9568.2006.05189.x 17156362 (Pubitemid 44952633)
19. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. Mao L, Yang L, Tang Q, Samdani S, Zhang G, Wang JQ, J Neurosci 2005 25 2741 2752 10.1523/JNEUROSCI.4360-04.2005 15758184 (Pubitemid 40365185)
20. Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease. Ribeiro FM, Paquet M, Ferreira LT, Cregan T, Swan P, Cregan SP, Ferguson SS, J Neurosci 2010 30 316 324 10.1523/JNEUROSCI.4974-09.2010 20053912
21. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF, Neuron 1998 21 717 726 10.1016/S0896-6273(00)80589-9 9808459 (Pubitemid 28498781)
22. Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in taylor-type focal cortical dysplasia. Aronica E, Gorter JA, Jansen GH, van Veelen CW, van Rijen PC, Ramkema M, Troost D, Epilepsia 2003 44 785 795 10.1046/j.1528-1157.2003.54802.x 12790891 (Pubitemid 36754003)
23. Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5. Ferraguti F, Corti C, Valerio E, Mion S, Xuereb J, Exp Brain Res 2001 137 1 11 10.1007/s002210000633 11310162 (Pubitemid 32186610)
24. Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis. Anneser JM, Chahli C, Ince PG, Borasio GD, Shaw PJ, J Neuropathol Exp Neurol 2004 63 831 840 15330338 (Pubitemid 39038505)
25. Glutamate receptor expression in multiple sclerosis lesions. Newcombe J, Uddin A, Dove R, Patel B, Turski L, Nishizawa Y, Smith T, Brain Pathol 2008 18 52 61 10.1111/j.1750-3639.2007.00101.x 17924980
26. Astrocytic demise in the developing rat and human brain after hypoxic-ischemic damage. Gelot A, Villapol S, Billette de Villemeur T, Renolleau S, Charriaut-Marlangue C, Dev Neurosci 2009 31 459 470 10.1159/000232564 19672074
27. Apoptosis and activation of Erkl/2 and Akt in astrocytes postischemia. Jiang Z, Zhang Y, Chen XQ, Lam PY, Yang H, Xu Q, Yu AC, Neurochem Res 2003 28 831 837 10.1023/A:1023206906164 12718435 (Pubitemid 36438399)
28. Astrocyte apoptosis: implications for neuroprotection. Takuma K, Baba A, Matsuda T, Prog Neurobiol 2004 72 1111 1127
29. Ischemia-induced apoptosis in primary cultures of astrocytes. Yu AC, Wong HK, Yung HW, Lau LT, Glia 2001 35 121 130 10.1002/glia.1077 11460268 (Pubitemid 32773781)
30. Astrocytes are more resistant to focal cerebral ischemia than neurons and die by a delayed necrosis. Gurer G, Gursoy-Ozdemir Y, Erdemli E, Can A, Dalkara T, Brain Pathol 2009 19 630 641 10.1111/j.1750-3639.2008.00226.x 18947334
31. Up-regulation of metabotropic glutamate receptor subtypes 3 and 5 in spinal cord in a clinical model of persistent inflammation and hyperalgesia. Dolan S, Kelly JG, Monteiro AM, Nolan AM, Pain 2003 106 501 512 10.1016/j.pain.2003.09.017 14659534 (Pubitemid 37505899)
32. Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis. Geurts JJ, Wolswijk G, Bo L, van der Valk P, Polman CH, Troost D, Aronica E, Brain 2003 126 1755 1766 10.1093/brain/awg179 12805104 (Pubitemid 36917335)
33. Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures. Ulas J, Satou T, Ivins KJ, Kesslak JP, Cotman CW, Balazs R, Glia 2000 30 352 361 10.1002/(SICI)1098- 1136(200006)30:4<352::AID-GLIA40>3.0.CO;2-6 10797615 (Pubitemid 30334336)
34. Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity. Prezeau L, Gomeza J, Ahern S, Mary S, Galvez T, Bockaert J, Pin JP, Mol Pharmacol 1996 49 422 429 8643081
35. Astrocyte metabolism and signaling during brain ischemia. Rossi DJ, Brady JD, Mohr C, Nat Neurosci 2007 10 1377 1386 10.1038/nn2004 17965658 (Pubitemid 350014689)
36. Astroglial phosphoinositide hydrolysis during combined glucose-oxygen deprivation: role of the metabotropic glutamate receptor. Segeleon JE, Lipscomb DC, Haun SE, Trapp VL, Horrocks LA, J Neurochem 1995 65 1115 1123 7643089
37. Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor. Peavy RD, Chang MS, Sanders-Bush E, Conn PJ, J Neurosci 2001 21 9619 9628 11739572 (Pubitemid 34184049)
38. Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation. Nicodemo AA, Pampillo M, Ferreira LT, Dale LB, Cregan T, Ribeiro FM, Ferguson SS, Mol Brain 2010 3 4 10.1186/1756-6606-3-4 20180987
39. Activation of Erk1/2 and Akt in astrocytes under ischemia. Jiang Z, Zhang Y, Chen X, Lam PY, Yang H, Xu Q, Yu AC, Biochem Biophys Res Commun 2002 294 726 733 10.1016/S0006-291X(02)00540-5 12056831 (Pubitemid 34694073)
40. Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes. Ciccarelli R, D'Alimonte I, Ballerini P, D'Auro M, Nargi E, Buccella S, Di Iorio P, Bruno V, Nicoletti F, Caciagli F, Mol Pharmacol 2007 71 1369 1380 10.1124/mol.106.031617 17293559 (Pubitemid 46658690)
41. Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective. Bruno V, Ksiazek I, Battaglia G, Lukic S, Leonhardt T, Sauer D, Gasparini F, Kuhn R, Nicoletti F, Flor PJ, Neuropharmacology 2000 39 2223 2230 10.1016/S0028-3908(00)00079-4 10974306 (Pubitemid 30642765)
42. Focal degeneration of astrocytes in amyotrophic lateral sclerosis. Rossi D, Brambilla L, Valori CF, Roncoroni C, Crugnola A, Yokota T, Bredesen DE, Volterra A, Cell Death Differ 2008 15 1691 1700 10.1038/cdd.2008.99 18617894
43. Cell signalling: IP3 receptors channel calcium into cell death. Hanson CJ, Bootman MD, Roderick HL, Curr Biol 2004 14 933 R935 10.1016/j.cub.2004.10. 019 15530388 (Pubitemid 39464810)
44. Integrated genomic analyses of ovarian carcinoma. Cancer Genome Atlas Research Network, Nature 2011 474 609 615 10.1038/nature10166 21720365
45. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Cancer Genome Atlas Research Network, Nature 2008 455 1061 1068 10.1038/nature07385 18772890
46. Somatic mutations in GRM1 in cancer alter metabotropic glutamate receptor 1 intracellular localization and signaling. Esseltine JL, Willard ML, Wulur IH, Lajiness ME, Barber TD, Ferguson SSG, Mo Pharmacol 2013 [Epub ahead of print]
47. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM, Roder JC, J Neurosci 1997 17 5196 5205 9185557 (Pubitemid 27263833)
48. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. McCarthy KD, de Vellis J, J Cell Biol 1980 85 890 902 10.1083/jcb.85.3.890 6248568 (Pubitemid 10007455)
49. Puma is a dominant regulator of oxidative stress induced bax activation and neuronal apoptosis. Steckley D, Karajgikar M, Dale LB, Swan P, Fuerth B, Drummond-Main C, Poulter MO, Ferguson SSG, Strasser A, Cregan SP, J Neurosci 2007 27 12989 12999 10.1523/JNEUROSCI.3400-07.2007 18032672 (Pubitemid 350159577)
50. p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death. Cregan SP, Arbour NA, Maclaurin JG, Callaghan SM, Fortin A, Cheung EC, Guberman DS, Park DS, Slack RS, J Neurosci 2004 24 10003 10012 10.1523/JNEUROSCI.2114-04.2004 15525786 (Pubitemid 39463582)