P2Y1R-initiated, IP3R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouse

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 4, 2013, Pages 600-611

  Zheng, Wei ^a   Talley Watts, Lora ^a   Holstein, Deborah M ^a   Wewer, Jimmy ^b   Lechleiter, James D ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

calcium signaling; dendritic damage; IP3R type2 knockout; ischemic stroke; neuroprotection; purinergic receptor

Indexed keywords

2 METHYLTHIOLADENOSINE 5' DIPHOSPHATE; ADENOSINE DERIVATIVE; CALCIUM ION; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; MEMBRANE PROTEIN; PURINERGIC P2Y1 RECEPTOR; TETRAMETHYLRHODAMINE METHYL ESTER; THY1 PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN; ADENOSINE DIPHOSPHATE; DRUG DERIVATIVE; PURINERGIC P2Y RECEPTOR AGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFICACY; IN VIVO STUDY; INTRACELLULAR MEMBRANE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL; NERVE CELL LESION; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROPROTECTION; NONHUMAN; PHOTOTHROMBOSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CALCIUM SIGNALING; DENDRITE; DRUG EFFECT; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY; TRANSGENIC MOUSE;

ADENOSINE DIPHOSPHATE; ANIMALS; ASTROCYTES; BRAIN ISCHEMIA; CALCIUM SIGNALING; DENDRITES; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; PURINERGIC P2Y RECEPTOR AGONISTS; RECEPTORS, PURINERGIC P2Y1;

MLCS; MLOWN;

EID: 84876415041     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.214     Document Type: Article

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