New insights into the structure and mechanism of iodothyronine deiodinases

Journal of Molecular Endocrinology

Volumn 55, Issue 3, 2015, Pages T37-T52

  Schweizerulrich, Ulrich ^a   Steegborn, Clemens ^b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Dehalogenation; Metabolism; Structure; Thyroid hormone

Indexed keywords

IODOTHYRONINE; IODOTHYRONINE DEIODINASE; MONOMER; PROTON; UNCLASSIFIED DRUG; IODIDE PEROXIDASE; PROTEIN BINDING; THYROID HORMONE;

BINDING SITE; CATALYSIS; CATALYST; CELLULAR DISTRIBUTION; CRYSTAL STRUCTURE; DEHALOGENATION; DEIODINATION; DENSITY FUNCTIONAL THEORY; DIMERIZATION; DRUG MECHANISM; DRUG STRUCTURE; ELECTRON; ENZYMATIC DEGRADATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; ENZYME ACTIVATION; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SKIN;

ANIMALS; CATALYSIS; CATALYTIC DOMAIN; DRUG DISCOVERY; ENZYME ACTIVATION; HUMANS; IODIDE PEROXIDASE; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SKIN; SUBSTRATE SPECIFICITY; THYROID HORMONES;

EID: 84947734242     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-15-0156     Document Type: Review

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