An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases

Thyroid

Volumn 25, Issue 8, 2015, Pages 962-968

  Renko, Kostja ^a   Schäche, Sonja ^a   Hoefig, Carolin S ^b   Welsink, Tim ^a   Schwiebert, Christian ^a   Braun, Doreen ^c   Becker, Niels Peter ^a   Köhrle, Josef ^a   Schomburg, Lutz ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3,3',5' TRIIODOTHYRONINE; AUROTHIOGLUCOSE; GENISTEIN; IODIDE PEROXIDASE; IODOTHYRONINE DEIODINASE 1; IODOTHYRONINE DEIODINASE 2; IODOTHYRONINE DEIODINASE 3; IOPANOIC ACID; LIOTHYRONINE; OXIDOREDUCTASE INHIBITOR; PROPYLTHIOURACIL; THYROXINE; UNCLASSIFIED DRUG; XANTHOHUMOL; DIDO1 PROTEIN, HUMAN; DNA BINDING PROTEIN; ENZYME; FLAVONOID; IODOTHYRONINE DEIODINASE TYPE II; IODOTHYRONINE DEIODINASE TYPE III; ISOENZYME; PROPIOPHENONE DERIVATIVE; RECOMBINANT PROTEIN; SELENODEIODINASE TYPE 1, MOUSE; THYROID HORMONE;

ARTICLE; CONTROLLED STUDY; DEIODINATION; DRUG IDENTIFICATION; DRUG SCREENING; HEK293 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY; ANIMAL; ANTAGONISTS AND INHIBITORS; CATALYSIS; CELL DIFFERENTIATION; CHEMISTRY; IC50; MASS SPECTROMETRY; MOUSE; OPEN READING FRAME; PRECLINICAL STUDY;

ANIMALS; CATALYSIS; CELL DIFFERENTIATION; CHROMATOGRAPHY, LIQUID; DNA-BINDING PROTEINS; DRUG EVALUATION, PRECLINICAL; ENZYMES; FLAVONOIDS; GENISTEIN; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; IODIDE PEROXIDASE; IOPANOIC ACID; ISOENZYMES; MASS SPECTROMETRY; MICE; OPEN READING FRAMES; PROPIOPHENONES; RECOMBINANT PROTEINS; THYROID HORMONES;

EID: 84938834269     PISSN: 10507256     EISSN: 15579077     Source Type: Journal    
DOI: 10.1089/thy.2015.0058     Document Type: Article

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