The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase

Endocrinology

Volumn 138, Issue 12, 1997, Pages 5452-5458

  Sun, Ben C ^a   Harney, John W ^a   Berry, Marla J ^a   Larsen, P Reed ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DITHIOTHREITOL; SELENOCYSTEINE; THYROXINE DEIODINASE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEIODINATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; FROG; HUMAN; HUMAN CELL; LIOTHYRONINE SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0030724860     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.12.5623     Document Type: Article

References (37)

1. Larsen PR, Berry MJ 1995 Nutritional and hormonal regulation of thyroid hormone deiodinases. Annu Rev Nutr 15:323-352
2. Berry MJ, Banu L, Larsen PR 1991 Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 349:438-440
3. Mandel SJ, Berry MJ, Kieffer JD, Harney JW, Warne RL, Larsen PR 1992 Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab 75:1133-1139
4. Toyoda N, Harney JW, Berry MJ, Larsen PR 1994 Identification of critical amino acids for 3,5′,3′-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes. J Biol Chem 269:20329-20334
5. Maia AL, Berry MJ, Sabbag R, Harney JW, Larsen PR 1995 Structural and functional differences in the Diol gene in mice with inherited Type 1 deiodinase deficiency. Mol Endocrinol 9:969-980
6. Davey JC, Becker KB, Schneider MJ, St Germain DL, Galton VA 1995 Cloning of a cDNA for the type II iodothyronine deiodinase. J Biol Chem 270:26786-26789
7. Salvatore D, Bartha T, Harney JW, Larsen PR 1996 Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology 137:3308-3315
8. Croteau W, Whittemore SL, Schneider MJ, St Germain DL 1995 Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase. J Biol Chem 270:16569-16575
9. Salvatore D, Low SC, Berry MJ, Maia AL, Harney JW, Croteau W, St Germain DL, Larsen PR 1995 Type 3 iodothyronine deiodinase: cloning, in vitro expression and functional analysis of the placental selenoenzyme. J Clin Invest 95:2421-2430
10. Becker KB, Schneider MJ, Davey JC, Galton VA 1995 The type III 5-deiodinase in Rana catesbeiana tadpoles is encoded by a thyroid hormone-responsive gene. Endocrinology 136:4424-4431
11. Moreno M, Berry MJ, Horst C, Thoma R, Goglia F, Harney JW, Larsen PR, Visser TJ 1994 Activation and inactivation of thyroid hormone by type 1 iodothyronine deiodinase. FEBS Lett 344:143-146
12. Leonard JL, Visser TJ 1986 Biochemistry of deiodination. In: Hennemann G (ed) Thyroid Hormone Metabolism. Marcel Dekker, New York, pp 189-229
13. Berry MJ, Kieffer JD, Harney JW, Larsen PR 1991 Selenocysteine confers the biochemical properties of the type I iodothyronine deiodinase. J Biol Chem 266:14155-14158
14. Toyoda N, Kaptein E, Berry MJ, Harney JW, Larsen PR, Visser TJ 1997 Structure-activity relationships for thyroid hormone deiodination by mammalian type 1 iodothyronine deiodinases. Endocrinology 138:213-219
15. Berry MJ 1992 Identification of essential histidine residues in rat type I iodothyronine deiodinase. J Biol Chem 267:18055-18059
16. Berry MJ, Maia AL, Kieffer JD, Harney JW, Larsen PR 1992 Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation. Endocrinology 131:1848-1852
17. Devereux J, Haeberli P, Smithies O 1984 A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12:387-395
18. Berry MJ, Harney JW, Ohama T, Hatfield DL 1994 Selenocysteine insertion or termination: factors affecting UGA codon fate and complementary anticodon:codon mutations. Nucleic Acids Res 22:3753-3759
19. Higuchi R 1990 Recombinant PCR. In: Inms MA, Gelfland DH, Shinsky JJ, White TJ (eds) PCR Protocols: A Guide to Methods, and Applications. Academic Press, San Diego, pp 177-188
20. Brent GA, Larsen PR, Harney JW, Koenig RJ, Moore DD 1989 Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J Biol Chem 264:178-182
21. Mol JA, Docter R, Kaptein E, Jansen G, Hennemann G, Visser TJ 1984 Inactivation and affinity-labeling of rat liver iodothyronine deiodinase with N-bromoacetyl-3,3′,5-triiodothyronine. Biochem Biophys Res Commun 124:475-483
22. Mol JA, Visser TJ 1985 Synthesis and some properties of sulfate esters and sulfamates of iodothyronines. Endocrinology 117:1-7
23. Visser TJ, Mol JA, Otten MH 1983 Rapid deiodination of triiodothyronine sulfate by rat liver microsomal fraction. Endocrinology 112:1547
24. Kohrle J, Rasmussen UB, Ekenbarger DM, Alex S, Rokos H, Hesch RD, Leonard JL 1990 Affinity labeling of rat liver and kidney type I 5′-deiodinase. Identification of the 27-kDa substrate binding subunit. J Biol Chem 265:6155-6163
25. Larsen PR, Berry MJ 1994 Type I iodothyronine deiodinase: unexpected complexities in a simple deiodination reaction. Thyroid 4:357-362
26. Fersht A 1985 Enzyme Structure Mechanism, ed. 2. Freeman, New York, pp 98-120
27. Leonard JL, Rosenberg IN 1980 Iodothyronine 5′-deiodinase from rat kidney: substrate specificity and the 5′-deiodination of reverse triiodothyronine. Endocrinology 107:1376-1383
28. Cleland W 1970 Steady state kinetics. In: Boyer P (ed) The Enzymes. Academic Press, New York, vol 2:1-65
29. Leonard JL, Rosenberg IN 1978 Thyroxine 5′-deiodinase activity of rat kidney: observations on activation by thiols and inhibition by propylthiouracil. Endocrinology 103:2137-2144
30. Leonard JL, Rosenberg IN 1980 Characterization of essential enzyme sulfhydryl groups on thyroxine 5′-deiodinase from rat kidney. Endocrinology 106:444-451
31. Goswami A, Rosenberg IN 1983 Stimulation of iodothyronine outer ring monodeiodinase by dihydrolipoamide. Endocrinology 112:1180-1187
32. Chopra IJ 1978 Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine. Science 199:904-905
33. Goswami A, Rosenberg IN 1988 Effects of glutathione on iodothyronine 5′-deiodinase activity. Endocrinology 123:192-202
34. Sato K, Mimura H, Wakai K, Tomori N, Tsushima T, Shizume K 1983 Modulating effect of glutathione disulfide on thyroxine-5′-deiodination by rat hepatocytes in primary culture: effect of glucose. Endocrinology 113:878-886
35. Muller S, Senn H, Gsell B, Vetter W, Baron C, Bock A 1994 The formation of diselenide bridges in proteins by incorporation of selenocysteine residues: biosynthesis and characterization of (Se)2-thioredoxin. Biochemistry 33:3404-3412
36. Trotman-Dickenson A, Kerr J 1997 Strengths of chemical bonds. In: Weast R (ed) Handbook of Chemistry and Physics. Chemical Rubber Co., Cleveland, pp F158-F161
37. Sharifi J, St Germain DL 1992 The cDNA for the type I iodothyronine 5′-deiodinase encodes an enzyme manifesting both high Km and low Km activity. J Biol Chem 267:12539-12544