메뉴 건너뛰기




Volumn 151, Issue 12, 2010, Pages 5961-5970

Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; DEETHYLAMIODARONE; IODOTHYRONINE DEIODINASE TYPE 2; THYROID PEROXIDASE; THYROTROPIN; UNCLASSIFIED DRUG;

EID: 78649890094     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0553     Document Type: Article
Times cited : (64)

References (39)
  • 5
    • 0020319067 scopus 로고
    • Decreased transport of thyroxine (T4), 3,3′,5-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (rT3) into rat hepatocytes in primary culture due to a decrease of cellular ATP content and various drugs
    • Krenning EP, Docter R, Bernard B, Visser T, Hennemann G 1982 Decreased transport of thyroxine (T4), 3,3′,5-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (rT3) into rat hepatocytes in primary culture due to a decrease of cellular ATP content and various drugs. FEBS Lett 140:229-233
    • (1982) FEBS Lett , vol.140 , pp. 229-233
    • Krenning, E.P.1    Docter, R.2    Bernard, B.3    Visser, T.4    Hennemann, G.5
  • 6
    • 0028180732 scopus 로고
    • Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein
    • Bakker O, van Beeren HC, Wiersinga WM 1994 Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein. Endocrinology 134:1665-1670
    • (1994) Endocrinology , vol.134 , pp. 1665-1670
    • Bakker, O.1    Van Beeren, H.C.2    Wiersinga, W.M.3
  • 7
    • 0029047556 scopus 로고
    • Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone alpha 1-receptor protein
    • van Beeren HC, Bakker O, Wiersinga WM 1995 Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone alpha 1-receptor protein. Mol Cell Endocrinol 112:15-19
    • (1995) Mol Cell Endocrinol , vol.112 , pp. 15-19
    • Van Beeren, H.C.1    Bakker, O.2    Wiersinga, W.M.3
  • 9
    • 25144509449 scopus 로고    scopus 로고
    • Regulation of type 1 iodothyronine deiodinase in health and disease
    • Koenig RJ 2005 Regulation of type 1 iodothyronine deiodinase in health and disease. Thyroid 15:835-840
    • (2005) Thyroid , vol.15 , pp. 835-840
    • Koenig, R.J.1
  • 11
    • 0021123286 scopus 로고
    • Amiodarone inhibits the conversion of thyroxine to triiodothyronine in isolated rat hepatocytes
    • Aanderud S, Sundsfjord J, Aarbakke J 1984 Amiodarone inhibits the conversion of thyroxine to triiodothyronine in isolated rat hepatocytes. Endocrinology 115:1605-1608
    • (1984) Endocrinology , vol.115 , pp. 1605-1608
    • Aanderud, S.1    Sundsfjord, J.2    Aarbakke, J.3
  • 13
    • 0024341183 scopus 로고
    • Rat heart thyroxine 5′-deiodinase is sensitively depressed by amiodarone
    • Gotzsche LS, Boye N, Laurberg P, Andreasen F 1989 Rat heart thyroxine 5′-deiodinase is sensitively depressed by amiodarone. J Cardiovasc Pharmacol 14:836-841
    • (1989) J Cardiovasc Pharmacol , vol.14 , pp. 836-841
    • Gotzsche, L.S.1    Boye, N.2    Laurberg, P.3    Andreasen, F.4
  • 14
    • 0024189191 scopus 로고
    • Effect of amiodarone on the conversion of thyroxine to triiodothyronine in the myocardium of rats in vivo and in vitro
    • B Aires
    • Ceppi JA, Gonzalez MR, Zaninovich AA 1988 [Effect of amiodarone on the conversion of thyroxine to triiodothyronine in the myocardium of rats in vivo and in vitro]. Medicina (B Aires) 48:29-32
    • (1988) Medicina , vol.48 , pp. 29-32
    • Ceppi, J.A.1    Gonzalez, M.R.2    Zaninovich, A.A.3
  • 15
    • 0018101621 scopus 로고
    • The influence of fasting, diabetes, and several pharmacological agents on the pathways of thyroxine metabolism in rat liver
    • Balsam A, Ingbar SH 1978 The influence of fasting, diabetes, and several pharmacological agents on the pathways of thyroxine metabolism in rat liver. J Clin Invest 62:415-424
    • (1978) J Clin Invest , vol.62 , pp. 415-424
    • Balsam, A.1    Ingbar, S.H.2
  • 16
    • 0020507470 scopus 로고
    • The effects of amiodarone on serum thyroid hormones and hepatic thyroxine 5′-monodeiodination in rats
    • Sogol PB, Hershman JM, Reed AW, Dillmann WH 1983 The effects of amiodarone on serum thyroid hormones and hepatic thyroxine 5′- monodeiodination in rats. Endocrinology 113:1464-1469
    • (1983) Endocrinology , vol.113 , pp. 1464-1469
    • Sogol, P.B.1    Hershman, J.M.2    Reed, A.W.3    Dillmann, W.H.4
  • 17
    • 0022560254 scopus 로고
    • Amiodarone inhibits T4 to T3 conversion and alpha-glycerophosphate dehydrogenase and malic enzyme levels in rat liver
    • Pekary AE, Hershman JM, Reed AW, Kannon R, Wang YS 1986 Amiodarone inhibits T4 to T3 conversion and alpha-glycerophosphate dehydrogenase and malic enzyme levels in rat liver. Horm Metab Res 18:114-118
    • (1986) Horm Metab Res , vol.18 , pp. 114-118
    • Pekary, A.E.1    Hershman, J.M.2    Reed, A.W.3    Kannon, R.4    Wang, Y.S.5
  • 18
    • 0024397281 scopus 로고
    • Effects of amiodarone on 5′-deiodination of thyroxine to tri-iodothyronine in rat myocardium
    • Ceppi JA, Zaninovich AA 1989 Effects of amiodarone on 5′-deiodination of thyroxine to tri-iodothyronine in rat myocardium. J Endocrinol 121:431-434
    • (1989) J Endocrinol , vol.121 , pp. 431-434
    • Ceppi, J.A.1    Zaninovich, A.A.2
  • 19
    • 0034038927 scopus 로고    scopus 로고
    • Structure-effect relationships of amiodarone analogues on the inhibition of thyroxine deiodination
    • Ha HR, Stieger B, Grassi G, Altorfer HR, Follath F 2000 Structure-effect relationships of amiodarone analogues on the inhibition of thyroxine deiodination. Eur J Clin Pharmacol 55:807-814
    • (2000) Eur J Clin Pharmacol , vol.55 , pp. 807-814
    • Ha, H.R.1    Stieger, B.2    Grassi, G.3    Altorfer, H.R.4    Follath, F.5
  • 20
    • 0028271579 scopus 로고
    • Amiodarone-induced hypercholesterolemia is associated with a decrease in liver LDL receptor mRNA
    • Hudig F, Bakker O, Wiersinga WM 1994 Amiodarone-induced hypercholesterolemia is associated with a decrease in liver LDL receptor mRNA. FEBS Lett 341:86-90
    • (1994) FEBS Lett , vol.341 , pp. 86-90
    • Hudig, F.1    Bakker, O.2    Wiersinga, W.M.3
  • 22
    • 34447123224 scopus 로고    scopus 로고
    • Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: Role of neuronal afferents and type 2 deiodinase
    • Fekete C, Lechan RM 2007 Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. Front Neuroendocrinol 28:97-114
    • (2007) Front Neuroendocrinol , vol.28 , pp. 97-114
    • Fekete, C.1    Lechan, R.M.2
  • 23
    • 24644436920 scopus 로고    scopus 로고
    • Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans
    • Maia AL, Kim BW, Huang SA, Harney JW, Larsen PR 2005 Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest 115:2524-2533
    • (2005) J Clin Invest , vol.115 , pp. 2524-2533
    • Maia, A.L.1    Kim, B.W.2    Huang, S.A.3    Harney, J.W.4    Larsen, P.R.5
  • 24
    • 0023924631 scopus 로고
    • Human epidermal keratinocytes in culture convert thyroxine to 3,5,3′-triiodothyronine by type II iodothyronine deiodination: A novel endocrine function of the skin
    • Kaplan MM, Pan CY, Gordon PR, Lee JK, Gilchrest BA 1988 Human epidermal keratinocytes in culture convert thyroxine to 3,5,3′-triiodothyronine by type II iodothyronine deiodination: a novel endocrine function of the skin. J Clin Endocrinol Metab 66:815-822
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 815-822
    • Kaplan, M.M.1    Pan, C.Y.2    Gordon, P.R.3    Lee, J.K.4    Gilchrest, B.A.5
  • 25
    • 0021693513 scopus 로고
    • Conversion of thyroxine to triiodothyronine in the anterior pituitary gland and the influence of this process on thyroid status
    • Kaplan MM, Breitbart R 1984 Conversion of thyroxine to triiodothyronine in the anterior pituitary gland and the influence of this process on thyroid status. Horm Metab Res Suppl 14:79-85
    • (1984) Horm Metab Res Suppl , vol.14 , pp. 79-85
    • Kaplan, M.M.1    Breitbart, R.2
  • 26
    • 0022921782 scopus 로고
    • Effects of amiodarone and desethylamiodarone on pituitary deiodinase activity and thyrotropin secretion in the rat
    • Safran M, Fang SL, Bambini G, Pinchera A, Martino E, Braverman LE 1986 Effects of amiodarone and desethylamiodarone on pituitary deiodinase activity and thyrotropin secretion in the rat. Am J Med Sci 292:136-141
    • (1986) Am J Med Sci , vol.292 , pp. 136-141
    • Safran, M.1    Fang, S.L.2    Bambini, G.3    Pinchera, A.4    Martino, E.5    Braverman, L.E.6
  • 27
    • 0017079456 scopus 로고
    • Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxin, and thyrotropin. A drug influencing peripheral metabolism of thyroid hormones
    • Burger A, Dinichert D, Nicod P, Jenny M, Lemarchand-Beraud T, Vallotton MB 1976 Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxin, and thyrotropin. A drug influencing peripheral metabolism of thyroid hormones. J Clin Invest 58:255-259
    • (1976) J Clin Invest , vol.58 , pp. 255-259
    • Burger, A.1    Dinichert, D.2    Nicod, P.3    Jenny, M.4    Lemarchand-Beraud, T.5    Vallotton, M.B.6
  • 29
    • 0019982356 scopus 로고
    • Pharmacokinetic significance of serum reverse T3 levels during amiodarone treatment: A potential method for monitoring chronic drug therapy
    • Nademanee K, Singh BN, Hendrickson JA, Reed AW, Melmed S, Hershman J 1982 Pharmacokinetic significance of serum reverse T3 levels during amiodarone treatment: a potential method for monitoring chronic drug therapy. Circulation 66:202-211
    • (1982) Circulation , vol.66 , pp. 202-211
    • Nademanee, K.1    Singh, B.N.2    Hendrickson, J.A.3    Reed, A.W.4    Melmed, S.5    Hershman, J.6
  • 30
    • 0035211984 scopus 로고    scopus 로고
    • Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4
    • Schneider MJ, Fiering SN, Pallud SE, Parlow AF, St Germain DL, Galton VA 2001 Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4. Mol Endocrinol 15:2137-2148
    • (2001) Mol Endocrinol , vol.15 , pp. 2137-2148
    • Schneider, M.J.1    Fiering, S.N.2    Pallud, S.E.3    Parlow, A.F.4    St Germain, D.L.5    Galton, V.A.6
  • 34
    • 0023624937 scopus 로고
    • Relationship of steady-state serum concentrations of amiodarone and desethylamiodarone to therapeutic efficacy and adverse effects
    • Falik R, Flores BT, Shaw L, Gibson GA, Josephson ME, Marchlinski FE 1987 Relationship of steady-state serum concentrations of amiodarone and desethylamiodarone to therapeutic efficacy and adverse effects. Am J Med 82:1102-1108
    • (1987) Am J Med , vol.82 , pp. 1102-1108
    • Falik, R.1    Flores, B.T.2    Shaw, L.3    Gibson, G.A.4    Josephson, M.E.5    Marchlinski, F.E.6
  • 35
    • 0031766069 scopus 로고    scopus 로고
    • The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells
    • Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL 1998 The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells. Endocrinology 139:4476-4482
    • (1998) Endocrinology , vol.139 , pp. 4476-4482
    • Yusta, B.1    Alarid, E.T.2    Gordon, D.F.3    Ridgway, E.C.4    Mellon, P.L.5
  • 36
    • 0030786397 scopus 로고    scopus 로고
    • Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone
    • Tu HM, Kim SW, Salvatore D, Bartha T, Legradi G, Larsen PR, Lechan RM 1997 Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology 138:3359-3368
    • (1997) Endocrinology , vol.138 , pp. 3359-3368
    • Tu, H.M.1    Kim, S.W.2    Salvatore, D.3    Bartha, T.4    Legradi, G.5    Larsen, P.R.6    Lechan, R.M.7
  • 37
    • 0018629220 scopus 로고
    • Effects of three-day oral cholecystography on serum iodothyronines and TSH concentrations: Comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitarythyroid axis
    • Copenh
    • Suzuki H, Kadena N, Takeuchi K, Nakagawa S 1979 Effects of three-day oral cholecystography on serum iodothyronines and TSH concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitarythyroid axis. Acta Endocrinol (Copenh) 92:477-488
    • (1979) Acta Endocrinol , vol.92 , pp. 477-488
    • Suzuki, H.1    Kadena, N.2    Takeuchi, K.3    Nakagawa, S.4
  • 39
    • 0025093836 scopus 로고
    • Thyroid hormone regulates type I deiodinase messenger RNA in rat liver
    • Berry MJ, Kates AL, Larsen PR 1990 Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Mol Endocrinol 4:743-748
    • (1990) Mol Endocrinol , vol.4 , pp. 743-748
    • Berry, M.J.1    Kates, A.L.2    Larsen, P.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.