Halogenated phenolic contaminants inhibit the in vitro activity of the thyroid-regulating deiodinases in human liver

Toxicological Sciences

Volumn 124, Issue 2, 2011, Pages 339-347

  Butt, Craig M ^a   Wang, Dongli ^a   Stapleton, Heather M ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Brominated flame retardants; Deiodinase enzymes; Halogenated phenolics; Human liver microsomes; Metabolites; Thyroid hormones

Indexed keywords

3,3' DIIODOTHYRONINE; 3,3',5' TRIIODOTHYRONINE; DEIODINASE; FLAME RETARDANT; IODIDE PEROXIDASE; IODINE; LIOTHYRONINE; TETRABROMOBISPHENOL A; THYROID HORMONE; THYROXINE; TRICLOSAN; UNCLASSIFIED DRUG;

ARTICLE; DEIODINATION; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; HUMAN CELL; IC 50; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; DIIODOTHYRONINES; ENDOCRINE DISRUPTORS; HALOGENATED DIPHENYL ETHERS; HUMANS; IODIDE PEROXIDASE; MICROSOMES, LIVER; POLYBROMINATED BIPHENYLS; TANDEM MASS SPECTROMETRY; THYROID GLAND; THYROXINE; TRIIODOTHYRONINE, REVERSE;

EID: 80051702431     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr117     Document Type: Article

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