Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: Substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil

Endocrinology

Volumn 147, Issue 7, 2006, Pages 3519-3529

  Kuiper, George G J M ^a   Klootwijk, Willem ^a   Dubois, Ghislaine Morvan ^d   Destree, Olivier ^c   Darras, Veerle M ^b   Van Der Geyten, Serge ^b   Demeneix, Barbara ^d   Visser, Theo J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c HUBRECHT INSTITUTE   (Netherlands)

^d MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AUROTHIOGLUCOSE; COMPLEMENTARY DNA; IODOACETIC ACID; IODOTHYRONINE DEIODINASE; LIOTHYRONINE; PROLINE; PROPYLTHIOURACIL; SELENOCYSTEINE; SERINE; THYROXINE DEIODINASE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN TISSUE; CATALYSIS; CONTROLLED STUDY; DNA TRANSFECTION; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE INSERTION SEQUENCE; HOMOGENATE; IC 50; INTESTINE; KIDNEY; LIVER; METAMORPHOSIS; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; SEQUENCE HOMOLOGY; STATISTICAL SIGNIFICANCE; TADPOLE; XENOPUS LAEVIS;

3' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; IODIDE PEROXIDASE; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; PROLINE; PROPYLTHIOURACIL; RATS; SELENOCYSTEINE; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; XENOPUS LAEVIS;

EID: 33745139184     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-0711     Document Type: Article

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