Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells

Endocrinology

Volumn 151, Issue 2, 2010, Pages 821-829

  Goemann, Iuri Martin ^a   Gereben, Balázs ^b   Harney, John W ^c   Zhu, Bo ^c   Maia, Ana Luiza ^a   Larsen, P Reed ^c  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DITHIOTHREITOL; ENZYME; GLUTATHIONE; IODOTHYRONINE DEIODINASE 2; LIOTHYRONINE; PROLINE; PROPYLTHIOURACIL; SERINE; THYROXINE; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; BIOTRANSFORMATION; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; CYTOSOL; DEIODINATION; EMBRYO; ENZYME KINETICS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PREDICTION; PRIORITY JOURNAL; SUBSTITUTION REACTION;

AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; CELL LINE; DITHIOTHREITOL; GLUTATHIONE; HUMANS; IODIDE PEROXIDASE; KIDNEY; KINETICS; LIVER; PROLINE; PROPYLTHIOURACIL; SERINE; THYROXINE; TRANSFECTION;

EID: 74949099519     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0980     Document Type: Article

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