Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity

Toxicology

Volumn 314, Issue 1, 2013, Pages 22-29

  Shimizu, Ryo ^a   Yamaguchi, Masafumi ^a   Uramaru, Naoto ^b   Kuroki, Hiroaki ^c   Ohta, Shigeru ^d   Kitamura, Shigeyuki ^b   Sugihara, Kazumi ^a  

^a HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^b NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^c DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Food colorant; Halogenated phenolic compound; Iodotyrosine deiodinase; Polybrominated diphenyl ether; Polychlorinated biphenyl; Thyroid hormone metabolism

Indexed keywords

2 HYDROXY 3,3',4,4' TETRACHLOROBIPHENYL; 2,2',4,4' TETRACHLOROBIPHENYL; 3 HYDROXY 2,2',5,5' TETRACHLOROBIPHENYL; 3,3',4,4',5 PENTACHLOROBIPHENYL; 4 HYDROXY 2',3',4',5' TETRACHLOROBIPHENYL; 4 HYDROXY 2',3,4',5 TETRACHLOROBIPHENYL; 4 HYDROXY 2',3,4',5,6' PENTACHLOROBIPHENYL; 4 HYDROXY 2',3,4',5,6' TETRACHLOROBIPHENYL; 4 HYDROXY 2',3,4',6' TETRACHLOROBIPHENYL; 4 HYDROXY 2',3,4'5,5' PENTACHLOROBIPHENYL; 4 HYDROXY 2',3,4'5,6' PENTACHLOROBIPHENYL; 4 HYDROXY 2,2',2,5' TETRACHLOROBIPHENYL; 4 HYDROXY 2,2',3,4',5 PENTABROMODIPHENYL ETHER; 4 HYDROXY 2,2',3,4',5,5' HEXACHLOROPHENYL; 4 HYDROXY 2,3',3,4' TETRABROMODIPHENYL ETHER; 4 HYDROXY 2,3,3',4' TETRACHLOROBIPHENYL; 4 HYDROXY 3,3',4',5 TETRACHLOROBIPHENYL; 4 METHOXY 3,3',4',5 TETRACHLOROBIPHENYL; 4' HYDROXY 2,2',4 TRIBROMODIPHENYL ETHER; 4' HYDROXY 2,2',4,5' TETRABROMODIPHENYL ETHER; 4,4' DIHYDROXY 3,3',5,5' TETRACHLOROBIPHENYL; 4,4' DIMETHOXY 3,3',5,5' TETRACHLOROBIPHENYL; BENZBROMARONE; BROMOXYNIL; ERYTHROSINE; HALIDE; INORGANIC COMPOUND; IODIDE PEROXIDASE; PHLOXINE; ROSE BENGAL; UNCLASSIFIED DRUG; AGRICULTURAL CHEMICAL; ANTIPARASITIC AGENT; ENZYME INHIBITOR; FOOD DYE; HALOGENATED HYDROCARBON;

ARTICLE; ATOM; CONTROLLED STUDY; ENZYME INHIBITION; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; THYROID HORMONE METABOLISM; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; LIVER MICROSOME; METABOLISM; PLASMID; SYNTHESIS; WESTERN BLOTTING;

AGROCHEMICALS; ANTIPARASITIC AGENTS; BLOTTING, WESTERN; CELL LINE; ENZYME INHIBITORS; FOOD COLORING AGENTS; HEK293 CELLS; HUMANS; HYDROCARBONS, HALOGENATED; IODIDE PEROXIDASE; MICROSOMES; MICROSOMES, LIVER; PLASMIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84884916010     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.08.017     Document Type: Article

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