Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes

Cell

Volumn 163, Issue 5, 2015, Pages 1124-1137

  Yeap, Leng Siew ^a   Hwang, Joyce K ^a   Du, Zhou ^a   Meyers, Robin M ^a   Meng, Fei Long ^a   Jakubauskaite, Agne ^a   Liu, Mengyuan ^a   Mani, Vinidhra ^a   Neuberg, Donna ^b   Kepler, Thomas B ^c   Wang, Jing H ^a   Alt, Frederick W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; HEMOGLOBIN BETA CHAIN; PUROMYCIN; SIGNAL PEPTIDE; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE;

ALLELE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CHIMERA; CODON; COMPARATIVE STUDY; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; EMBRYONIC STEM CELL; EXON; HIGH THROUGHPUT SEQUENCING; IN VIVO STUDY; KINETICS; MOUSE; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROMOTER REGION; SOMATIC HYPERMUTATION; ANIMAL; GENE REARRANGEMENT; GENETICS; HUMAN; METABOLISM; MUTATION; VDJ RECOMBINATION;

ANIMALS; B-LYMPHOCYTES; BETA-GLOBINS; CYTIDINE DEAMINASE; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; MICE; MUTATION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; V(D)J RECOMBINATION;

EID: 84947728969     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.10.042     Document Type: Article

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