Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells

Toxicological Sciences

Volumn 148, Issue 1, 2015, Pages 204-219

  Kwon, Hyuk Kwon ^a   Shin, Hyeon Jun ^a   Lee, Jae Hyeok ^a   Park, Seol Hee ^a   Kwon, Min Cheol ^a   Panneerselvam, Suresh ^a   Lee, Chan Gyu ^b   Kim, Sang Geon ^b   Kim, Jae Ho ^a   Choi, Sangdun ^a  

^a Ajou University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Antiapoptosis; Apoptosis; Etoposide; Necrosis; p53

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; CARBON NANOTUBE; CASPASE 3; CASPASE 7; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLOOXYGENASE 2; DOXORUBICIN; ETOPOSIDE; GAMMA HISTONE H2AX; HISTONE H2AX; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; P53 BINDING PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SERINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DNA LIGASE; GYRASE INHIBITOR;

APOPTOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; BIOGENESIS; CELL ADHESION; CELL CYCLE ARREST; CELL DEATH; CELL MEMBRANE; CELL SIZE; CELL SURVIVAL; CELL SWELLING; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IONIZING RADIATION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE NECROSIS; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; PHASE CONTRAST MICROSCOPY; PROTEIN EXPRESSION; ULTRAVIOLET RADIATION; UPREGULATION; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE; CELL LINE; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRIAL DYNAMICS; MOUSE; NECROSIS; ORGANELLE BIOGENESIS; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL ADHESION; CELL CYCLE; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR ENZYMES; ETOPOSIDE; GENE EXPRESSION REGULATION; HUMANS; KIDNEY TUBULES, PROXIMAL; MICE; MITOCHONDRIAL DYNAMICS; NECROSIS; ORGANELLE BIOGENESIS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TOPOISOMERASE II INHIBITORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84947709640     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv182     Document Type: Article

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