Probing the S2′ subsite of the anthrax toxin lethal factor using novel N-alkylated hydroxamates

Journal of Medicinal Chemistry

Volumn 58, Issue 21, 2015, Pages 8723-8733

  Kurbanov, Elbek K ^a   Chiu, Ting Lan ^a   Solberg, Jonathan ^b   Francis, Subhashree ^b   Maize, Kimberly M ^a   Fernandez, Jenna ^a   Johnson, Rodney L ^a   Hawkinson, Jon E ^b   Walters, Michael A ^b   Finzel, Barry C ^a   Amin, Elizabeth Ambrose ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; ASPARTIC ACID; DIOXANE; HYDROXAMIC ACID DERIVATIVE; SULFONAMIDE; BACTERIAL ANTIGEN; BACTERIAL TOXIN; ENZYME INHIBITOR; HYDROXAMIC ACID;

ALGORITHM; ALKYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; BACILLUS ANTHRACIS; BENZYLATION; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROGEN BOND; LETHAL GENE; LIGAND BINDING; MOLECULAR DOCKING; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; ANTHRAX; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ALKYLATION; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84947475182     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01446     Document Type: Article

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