A high-throughput screening approach to anthrax lethal factor inhibition

Bioorganic Chemistry

Volumn 35, Issue 4, 2007, Pages 306-312

  Johnson, Sherida L ^a   Chen, Li Hsing ^a   Pellecchia, Maurizio ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Anthrax; Botulinum Neurotoxin; High throughput screening; Lethal factor

Indexed keywords

BOTULINUM TOXIN; GELATINASE A; GELATINASE B; METALLOPROTEINASE INHIBITOR;

ANTHRAX; ARTICLE; CHEMICAL STRUCTURE; DIAGNOSTIC APPROACH ROUTE; ENZYME INHIBITION; FLUORESCENCE; IC 50; IN VITRO STUDY; LETHAL GENE; MOLECULAR MODEL; PRIORITY JOURNAL; SCREENING;

ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; METALLOPROTEASES; MOLECULAR STRUCTURE;

BACILLUS ANTHRACIS;

EID: 34250824029     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2006.12.005     Document Type: Article

References (21)

1. Smith H., and Keppie J. Nature 173 (1954) 869-870
2. Hanna P., et al. Proc. Natl. Acad. Sci. USA 90 (1993) 10198-10201
3. Petosa C., et al. Nature 385 (1997) 833-838
4. Scobie H.M., et al. Proc. Natl. Acad. Sci. USA 100 (2003) 5170-5174
5. Leppla S.H. Proc. Natl. Acad. Sci. USA 79 (1982) 3162-3166
6. Vitale G., et al. Biochem. Biopphys. Res. Commun. 248 (1998) 706-711
7. Duesbery N.S., et al. Science 280 (1998) 734-737
8. Park J.M., et al. Science 297 (2002) 2048-2051
9. Forino M., et al. Proc. Natl. Acad. Sci. USA 102 (2005) 9499-9504
10. Johnson S.L., et al. J. Med. Chem. 49 (2006) 27-30
11. Johnson S., and Pellecchia M. Curr. Top. Med. Chem. 6 (2006) 317-329
12. Houghten R.A., Dooley C.T., and Appel J.R. AAPS J. 8 (2006) 371-382
13. The Cambridge Crystallographic Data Centre 12 Union Road, Cambridge, CB2 1EZ, UK.
14. Jones G., et al. J. Mol. Biol. 267 (1997) 727-748
15. Eldridge M.D., et al. J. Comput.-Aid. Mol. Des. 11 (1997) 425-445
16. Schepetkin I.A., et al. J. Med. Chem. (2006) published on the web
17. McGovern S.L., et al. J. Med. Chem. 46 (2003) 4265-4272
18. Puerta D.T., Lewis J.A., and Cohen S. J. Am. Chem. Soc. 126 (2004) 8388
19. T. Akizawa, et al., Japan JP 2000226329, 2000.
20. U. Seipp, et al., Germany WO 200019989, 2000.
21. Jacobsen F.E., Lewis J.A., and Cohen S. J. Am. Chem. Soc. 128 (2006) 3156