Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 42, 2005, Pages 15075-15080

  Karginov, Vladimir A ^a   Mestorovich, Ekaterina M ^b   Moayeri, Mahtab ^c   Leppla, Stephen H ^c   Bezrukov, Sergey M ^b  

^a Innovative Biologics Inc   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Infectious diseases; Membrane transport; Modified cyclodextrins

Indexed keywords

6 (3 AMINOPROPYLTHIO) BETA CYCLODEXTRIN; ANTHRAX TOXIN; BACTERIAL ANTIGEN; BETA CYCLODEXTRIN DERIVATIVE; POLYPEPTIDE; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG;

ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL INFECTION; CYTOTOXICITY; LIPID BILAYER; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; BETA-CYCLODEXTRINS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ELECTROPHYSIOLOGY; HUMANS; MACROPHAGES; MALE; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; RATS; RATS, INBRED F344;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 27244439667     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0507488102     Document Type: Article

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