Crystal structure of the anthrax lethal factor

Nature

Volumn 414, Issue 6860, 2001, Pages 229-233

  Pannifer, Andrew D ^a,b   Wong, Thiang Yian ^e   Schwarzenbacher, Robert ^e   Renatus, Martin ^e   Petosa, Carlo ^a,c   Bienkowska, Jadwiga ^d,f   Lacy, D Borden ^g   Collier, R John ^g   Park, Sukjoon ^h   Leppla, Stephen H ^h   Hanna, Philip ⁱ   Liddington, Robert C ^e  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^d BOSTON UNIVERSITY   (United States)

^e BURNHAM INSTITUTE   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

^h NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

ⁱ UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CRYSTAL STRUCTURE; MUTAGENESIS; PROTEINS;

GENE DUPLICATION;

DISEASES;

DISEASE;

ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; CRYSTAL STRUCTURE; GENE DUPLICATION; LETHAL GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CRYSTALLOGRAPHY, X-RAY; MACROMOLECULAR SUBSTANCES; MAP KINASE KINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; ZINC;

ANTHRAX; BACILLUS ANTHRACIS; BACILLUS CEREUS; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 0035829518     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/n35101998     Document Type: Article

References (32)

1. Medical progress: Anthrax
2. Contribution of individual toxin components to virulence of Bacillus anthracis
3. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
4. Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/ threonine phosphorylation of MAPKs in cultured macropahges
5. Susceptibility of mitogenactivated protein kinase kinase family members to proteolysis by anthrax lethal factor
6. Anthraxas a biological weapon: Medical and public health management. Working group on civilian biodefense
7. Crystal structure of the anthrax toxin protective antigen
8. Identification of residues lining the anthrax protective antigen channel
9. Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
10. Suppression of ras-mediated transformation and inhibition of turnout growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways
11. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process
12. On the role of macrophages in anthrax
13. Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNγ-induced release of NO and TNFα
14. Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo
15. Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp 120-anthrax toxin fusion protein
16. Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis
17. Involvement of residues 147VYYEIGK153 in binding of lethal factor to protective antigen of Bacillus anthracis
18. Dali/FSSP classification of three-dimensional protein folds
19. NAD binding site of diphtheria toxin: Identification ofa residue within the nicotinamide subsite by photochemical modification with NAD
20. Arazoformyl dipeptide substrates for thermolysin. Confirmation of a reverse protonation catalytic mechanism
21. Optimized production and purification of Bacillus anthracis lethal factor
22. Processing of X-ray diffraction data collected in oscillation mode
23. The CCP4 suite: Programs for protein crystallography
24. Automated MAD and MIR structure solution
25. Crystallography & NMR system: A new software suite for macromolecular structure determination
26. Secondary structure of anthrax lethal toxin proteins and their interaction with large unilamellar vesicles (LUV): A Fourier-transform infrared spectroscopy approach
27. A fast algorithm for rendering space-filling molecule pictures
28. Molscript-a program to produce both detailed and schematic plots of protein structures
29. Raster 3D version 2.0. A program for photorealistic molecular graphics