Identification of small molecule inhibitors of anthrax lethal factor

Nature Structural and Molecular Biology

Volumn 11, Issue 1, 2004, Pages 67-72

  Panchal, Rekha G ^a   Hermone, Ann R ^a   Nguyen, Tam Luong ^a   Wong, Thiang Yian ^b   Schwarzenbacher, Robert ^b   Schmidt, James ^c   Lane, Douglas ^a   McGrath, Connor ^a   Turk, Benjamin E ^d   Burnett, James ^a   Aman, M Javad ^c   Little, Stephen ^c   Sausville, Edward A ^a   Zaharevitz, Daniel W ^a   Cantley, Lewis C ^d   Liddington, Robert C ^b   Gussio, Rick ^a   Bavari, Sina ^c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^d HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX LETHAL FACTOR; ANTHRAX TOXIN; BACTERIAL PROTEIN; EDEMA FACTOR; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL SPORE; BACTERIAL VIRULENCE; CELL DEATH; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DATA BASE; DRUG DESIGN; DRUG SCREENING; ENZYME ASSAY; ENZYME INHIBITION; LETHAL GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCREENING TEST; SPOROGENESIS; THREE DIMENSIONAL IMAGING; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CELL LINE; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HUMANS; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION;

ANIMALIA; ANTHRAX; BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 10744223044     PISSN: 15459993     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsmb711     Document Type: Article

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