Role of Exosomal Noncoding RNAs in Lung Carcinogenesis

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Sun, Tao ^a   Kalionis, Bill ^b   Lv, Guoying ^c   Xia, Shijin ^a   Gao, Wen ^a  

^a FUDAN UNIVERSITY   (China)

^b ROYAL WOMEN'S HOSPITAL   (Australia)

^c HUBEI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; UNTRANSLATED RNA;

BIOLOGY; EXOSOME; HUMAN; LUNG CANCER; LUNG CARCINOGENESIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN TARGETING; REVIEW; BIOSYNTHESIS; CARCINOGENESIS; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; PATHOLOGY;

CARCINOGENESIS; EXOSOMES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICRORNAS; RNA, UNTRANSLATED;

EID: 84947460728     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/125807     Document Type: Review

References (114)

1. R. Siegel, D. Naishadham, andA. Jemal, "Cancer statistics, 2013, " CA: Cancer Journal for Clinicians, vol. 63, no. 1, pp. 11-30, 2013.
2. M. Esteller, "Non-coding RNAs in human disease, " Nature Reviews Genetics, vol. 12, no. 12, pp. 861-874, 2011.
3. E. A. Gibb, C. J. Brown, and W. L. Lam, "The functional role of long non-coding RNA in human carcinomas, " Molecular Cancer, vol. 10, article 38, 2011.
4. B. Ricciuti, C. Mecca, L. Crino et al., "Non-coding RNAs in lung cancer, " Oncoscience, vol. 1, no. 11, pp. 674-705, 2014.
5. H. Valadi, K. Ekström, A. Bossios, M. Sjöstrand, J. J. Lee, and J. O. Lötvall, "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, " Nature Cell Biology, vol. 9, no. 6, pp. 654-659, 2007.
6. M. Lagos-Quintana, R. Rauhut, W. Lendeckel, and T. Tuschl, "Identification of novel genes coding for small expressedRNAs, " Science, vol. 294, no. 5543, pp. 853-858, 2001.
7. G. Hu, K. M. Drescher, and X.-M. Chen, "Exosomal miRNAs: biological properties and therapeutic potential, " Frontiers in Genetics, vol. 3, article 56, 2012.
8. J. Ratajczak, K. Miekus, M. Kucia et al., "Embryonic stem cellderived microvesicles reprogram hematopoietic progenitors: Evidence for horizontal transfer ofmRNAand protein delivery, " Leukemia, vol. 20, no. 5, pp. 847-856, 2006.
9. M. Fabbri, A. Paone, F. Calore et al., "MicroRNAs bind to Tolllike receptors to induce prometastatic inflammatory response, " Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 31, pp. E2110-E2116, 2012.
10. K. Ohshima, K. Inoue, A. Fujiwara et al., "Let-7 microRNA family Is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line, " PLoS ONE, vol. 5, no. 10, Article ID e13247, 2010.
11. J. Lu, G. Getz, E. A. Miska et al., "MicroRNA expression profiles classify human cancers, " Nature, vol. 435, no. 7043, pp. 834-838, 2005.
12. S. Volinia, G. A. Calin, C.-G. Liu et al., "A microRNA expression signature of human solid tumors defines cancer gene targets, " Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 7, pp. 2257-2261, 2006.
13. R. J. Webster, K. M. Giles, K. J. Price, P. M. Zhang, J. S. Mattick, and P. J. Leedman, "Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7, " The Journal of Biological Chemistry, vol. 284, no. 9, pp. 5731-5741, 2009.
14. M. W. Nasser, J. Datta, G. Nuovo et al., "Down-regulation of micro-RNA-1 (miR-1) in lung cancer: suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1, " The Journal of Biological Chemistry, vol. 283, no. 48, pp. 33394-33405, 2008.
15. M. Garofalo, C. Quintavalle, G. Di Leva et al., "MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer, " Oncogene, vol. 27, no. 27, pp. 3845-3855, 2008.
16. Y. Hayashita, H. Osada, Y. Tatematsu et al., "A polycistronic MicroRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation, " Cancer Research, vol. 65, no. 21, pp. 9628-9632, 2005.
17. Y. Fujita, F. Takeshita, K. Kuwano, and T. Ochiya, "RNAi therapeutic platforms for lung diseases, " Pharmaceuticals, vol. 6, no. 2, pp. 223-250, 2013.
18. S.-L. Yu, H.-Y. Chen, G.-C. Chang et al., "microRNA signature predicts survival and relapse in lung cancer, " Cancer Cell, vol. 13, no. 1, pp. 48-57, 2008.
19. M. Redova, J. Sana, and O. Slaby, "Circulating miRNAs as new blood-based biomarkers for solid cancers, " Future Oncology, vol. 9, no. 3, pp. 387-402, 2013.
20. K. Zen and C.-Y. Zhang, "Circulating microRNAs: a novel class of biomarkers to diagnose and monitor human cancers, " Medicinal Research Reviews, vol. 32, no. 2, pp. 326-348, 2012.
21. J. D. Arroyo, J. R. Chevillet, E. M. Kroh et al., "Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma, " Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 12, pp. 5003-5008, 2011.
22. Y. Fujita, Y. Yoshioka, S. Ito, J. Araya, K. Kuwano, andT. Ochiya, "Intercellular communication by extracellular vesicles and their microRNAs in Asthma, " Clinical Therapeutics, vol. 36, no. 6, pp. 873-881, 2014.
23. C. Théry, M. Ostrowski, and E. Segura, "Membrane vesicles as conveyors of immune responses, " Nature Reviews Immunology, vol. 9, no. 8, pp. 581-593, 2009.
24. G. Rabinowits, C. Gerçel-Taylor, J. M. Day, D. D. Taylor, and G. H. Kloecker, "Exosomal microRNA: a diagnostic marker for lung cancer, " Clinical Lung Cancer, vol. 10, no. 1, pp. 42-46, 2009.
25. D. J. Gibbings, C. Ciaudo, M. Erhardt, and O. Voinnet, "Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity, " Nature Cell Biology, vol. 11, no. 9, pp. 1143-1149, 2009.
26. C. Villarroya-Beltri, C. Gutiérrez-Vázquez, F. Sánchez-Cabo et al., "Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs, " Nature Communications, vol. 4, article 2980, 2013.
27. D. Koppers-Lalic, M. Hackenberg, I. V. Bijnsdorp et al., "Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes, " Cell Reports, vol. 8, no. 6, pp. 1649-1658, 2014.
28. N. Kosaka, H. Iguchi, K. Hagiwara, Y. Yoshioka, F. Takeshita, and T. Ochiya, "Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic micrornas regulate cancer cell metastasis, "The Journal of Biological Chemistry, vol. 288, no. 15, pp. 10849-10859, 2013.
29. H. F. G. Heijnen, A. E. Schiel, R. Fijnheer, H. J. Geuze, and J. J. Sixma, "Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules, " Blood, vol. 94, no. 11, pp. 3791-3799, 1999.
30. M. Yanez-Mo, P. R. Siljander, Z. Andreu et al., "Biological properties of extracellular vesicles and their physiological functions, " Journal of Extracellular Vesicles, vol. 4, Article ID27066, 2015.
31. H. C. Christianson, K. J. Svensson, T. H. Van Kuppevelt, J.-P. Li, and M. Belting, "Cancer cell exosomes depend on cellsurface heparan sulfate proteoglycans for their internalization and functional activity, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 43, pp. 17380-17385, 2013.
32. R. Cazzoli, F. Buttitta, M. Di Nicola et al., "microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer, " Journal of Thoracic Oncology, vol. 8, no. 9, pp. 1156-1162, 2013.
33. J. Takamizawa, H. Konishi, K. Yanagisawa et al., "Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival, " Cancer Research, vol. 64, no. 11, pp. 3753-3756, 2004.
34. S. M. Johnson, H. Grosshans, J. Shingara et al., "RAS is regulated by the let-7 microRNA family, " Cell, vol. 120, no. 5, pp. 635-647, 2005.
35. Y. S. Lee and A. Dutta, "The tumor suppressor microRNA let-7 represses the HMGA2 oncogene, " Genes and Development, vol. 21, no. 9, pp. 1025-1030, 2007.
36. B. Meyer, S. Loeschke, A. Schultze et al., "HMGA2 overexpression in non-small cell lung cancer, " Molecular Carcinogenesis, vol. 46, no. 7, pp. 503-511, 2007.
37. M. S. Kumar, J. Lu, K. L. Mercer, T. R. Golub, and T. Jacks, "Impaired microRNA processing enhances cellular transformation and tumorigenesis, " Nature Genetics, vol. 39, no. 5, pp. 673-677, 2007.
38. E. Koscianska, V. Baev, K. Skreka, K. Oikonomaki, V. Rusinov, and K. Kalantidis, "Prediction and preliminary validation of oncogene regulation by miRNAs, " BMC Molecular Biology, vol. 8, article 79, 2007.
39. C. D. Johnson, A. Esquela-Kerscher, G. Stefani et al., "The let-7 microRNA represses cell proliferation pathways in human cells, " Cancer Research, vol. 67, no. 16, pp. 7713-7722, 2007.
40. A. Ota, H. Tagawa, S. Karnan et al., "Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma, " Cancer Research, vol. 64, no. 9, pp. 3087-3095, 2004.
41. M. R. Davidson, J. E. Larsen, I. A. Yang et al., "microRNA-218 is deleted and downregulated in lung squamous cell carcinoma, " PLoS ONE, vol. 5, no. 9, Article ID e12560, 2010.
42. M. E. Hatley, D. M. Patrick, M. R. Garcia et al., "Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21, " Cancer Cell, vol. 18, no. 3, pp. 282-293, 2010.
43. A. Mogi and H. Kuwano, "TP53 mutations in nonsmall cell lung cancer, " Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 583929, 9 pages, 2011.
44. L. He, X. He, L. P. Lim et al., "A microRNA component of the p53 tumour suppressor network, " Nature, vol. 447, no. 7148, pp. 1130-1134, 2007.
45. H. Hermeking, "The miR-34 family in cancer and apoptosis, " Cell Death & Differentiation, vol. 17, no. 2, pp. 193-199, 2010.
46. M. Yamakuchi and C. J. Lowenstein, "MiR-34, SIRT1 and p53: the feedback loop, " Cell Cycle, vol. 8, no. 5, pp. 712-715, 2009.
47. A. L. Kasinski and F. J. Slack, "miRNA-34 prevents cancer initiation and progression in a therapeutically resistant Kras and p53-induced mouse model of lung adenocarcinoma, " Cancer Research, vol. 72, no. 21, pp. 5576-5587, 2012.
48. B. Liu, X.-C. Peng, X.-L. Zheng, J. Wang, and Y.-W. Qin, "miR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo, " Lung Cancer, vol. 66, no. 2, pp. 169-175, 2009.
49. M. Crawford, E. Brawner, K. Batte et al., "MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines, " Biochemical and Biophysical Research Communications, vol. 373, no. 4, pp. 607-612, 2008.
50. S. M. Feller, "CrKfamily adaptors-signalling complex formation and biological roles, " Oncogene, vol. 20, no. 44, pp. 6348-6371, 2001.
51. Y. Kobashigawa, M. Sakai, M. Naito et al., "Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK, " Nature Structural & Molecular Biology, vol. 14, no. 6, pp. 503-510, 2007.
52. D. L. Gibbons, W. Lin, C. J. Creighton et al., "Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression, " Genes & Development, vol. 23, no. 18, pp. 2140-2151, 2009.
53. L. Jiang, Q. Huang, S. Zhang et al., "Hsa-miR-125a-3p and hsamiR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells, " BMC Cancer, vol. 10, article 318, 2010.
54. J.-G. Zhang, J.-J. Wang, F. Zhao, Q. Liu, K. Jiang, and G.-H. Yang, "MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC), " Clinica Chimica Acta, vol. 411, no. 11-12, pp. 846-852, 2010.
55. U. Savita and D. Karunagaran, "MicroRNA-106b-25 cluster targets α-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (non small cell lung cancer) cells, " Biochemical and Biophysical Research Communications, vol. 434, no. 4, pp. 841-847, 2013.
56. N. M. White, C. R. Cabanski, J. M. Silva-Fisher, H. X. Dang, R. Govindan, and C. A. Maher, "Transcriptome sequencing reveals altered long intergenic non-coding RNAs in lung cancer, " Genome Biology, vol. 15, no. 8, article 429, 2014.
57. Y.-R. Yang, S.-Z. Zang, C.-L. Zhong, Y.-X. Li, S.-S. Zhao, and X.-J. Feng, "Increased expression of the lncRNA PVT1 promotes tumorigenesis in non-small cell lung cancer, " International Journal of Clinical and Experimental Pathology, vol. 7, no. 10, pp. 6929-6935, 2014.
58. J. Silva, V. Garć?a, A. Zaballos et al., "Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival, " European Respiratory Journal, vol. 37, no. 3, pp. 617-623, 2011.
59. M. Rodŕguez, J. Silva, A. López-Alfonso et al., "Different exosome cargo from plasma/bronchoalveolar lavage in nonsmall-cell lung cancer, " Genes Chromosomes and Cancer, vol. 53, no. 9, pp. 713-724, 2014.
60. L. Lu, X. Zhang, B. Zhang, X. Zhang, and J. Wu, "Synaptic acetylcholinesterase targeted by microRNA-212 functions as a tumor suppressor in non-small cell lung cancer, " International Journal of Biochemistry and Cell Biology, vol. 45, no. 11, pp. 2530-2540, 2013.
61. H. Ebi, T. Sato, N. Sugito et al., "Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species andDNA damage induction in lung cancers, " Oncogene, vol. 28, no. 38, pp. 3371-3379, 2009.
62. M. Garofalo, G. Di Leva, G. Romano et al., "miR-221-222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation, " Cancer Cell, vol. 16, no. 6, pp. 498-509, 2009.
63. L. Du, J. J. Schageman, M. C. Subauste et al., "miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1, " Molecular Cancer Research, vol. 7, no. 8, pp. 1234-1243, 2009.
64. H. Zhao, L. Zhu, Y. Jin, H. Ji, X. Yan, and X. Zhu, "miR-375 is highly expressed and possibly transactivated by achaetescute complex homolog 1 in small-cell lung cancer cells, " Acta Biochimica et Biophysica Sinica, vol. 44, no. 2, pp. 177-182, 2012.
65. H. Matsubara, T. Takeuchi, E. Nishikawa et al., "Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92, " Oncogene, vol. 26, no. 41, pp. 6099-6105, 2007.
66. S. Arora, A. R. Ranade, N. L. Tran et al., "microRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis andmediates NSCLC migration, " International Journal of Cancer, vol. 129, no. 11, pp. 2621-2631, 2011.
67. P.-Y. Wang, Y.-J. Li, S. Zhang et al., "Regulating A549 cells growth by ASO inhibiting miRNA expression, " Molecular and Cellular Biochemistry, vol. 339, no. 1-2, pp. 163-171, 2010.
68. S. Jiang, H.-W. Zhang, M.-H. Lu et al., "MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene, " Cancer Research, vol. 70, no. 8, pp. 3119-3127, 2010.
69. Y. Yamanaka, H. Tagawa, N. Takahashi et al., "Aberrant overexpression of microRNAs activate AKT signaling via downregulation of tumor suppressors in natural killer-cell lymphoma/leukemia, " Blood, vol. 114, no. 15, pp. 3265-3275, 2009.
70. W. Kong, H. Yang, L. He et al., "MicroRNA-155 is regulated by the transforming growth factor/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA, " Molecular and Cellular Biology, vol. 28, no. 22, pp. 6773-6784, 2008.
71. M. Zhan, Q. Qu, G. Wang et al., "Let-7c inhibits NSCLC cell proliferation by targeting HOXA1, " Asian Pacific Journal of Cancer Prevention, vol. 14, no. 1, pp. 387-392, 2013.
72. E. Miko, Z. Margitai, Z. Czimmerer et al., "MiR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5, " FEBS Letters, vol. 585, no. 8, pp. 1191-1196, 2011.
73. X. Dang, A. Ma, L. Yang et al., "MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells, " Cancer Genetics, vol. 205, no. 3, pp. 113-123, 2012.
74. S. Xiong, Y. Zheng, P. Jiang, R. Liu, X. Liu, and Y. Chu, "microRNA-7 inhibits the growth of human non-small cell lung cancer A549 cells through targeting BCL-2, " International Journal of Biological Sciences, vol. 7, no. 6, pp. 805-814, 2011.
75. H. Wang, M. Li, R. Zhang et al., "Effect of miR-335 upregulation on the apoptosis and invasion of lung cancer cell A549 and H1299, " Tumor Biology, vol. 34, no. 5, pp. 3101-3109, 2013.
76. W. C. S. Cho, A. S. C. Chow, and J. S. K. Au, "MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1, " RNA Biology, vol. 8, no. 1, pp. 125-131, 2011.
77. Z. Chen, H. Zeng, Y. Guo et al., "miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc, " Journal of Experimental & Clinical Cancer Research, vol. 29, article 151, 2010.
78. R. Yin, S. Zhang, Y. Wu et al., "microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4, " Oncology Reports, vol. 25, no. 6, pp. 1747-1754, 2011.
79. N. Zhang, Y. Su, and L. Xu, "Targeting PKC by miR-143 regulates cell apoptosis in lung cancer, " FEBS Letters, vol. 587, no. 22, pp. 3661-3667, 2013.
80. S. Feng, S. Cong, X. Zhang et al., "MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells, " Nucleic Acids Research, vol. 39, no. 15, pp. 6669-6678, 2011.
81. M. Lizé, A. Klimke, and M. Dobbelstein, "MicroRNA-449 in cell fate determination, " Cell Cycle, vol. 10, no. 17, pp. 2874-2882, 2011.
82. G. Mudduluru, P. Ceppi, R. Kumarswamy, G. V. Scagliotti, M. Papotti, and H. Allgayer, "Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer, " Oncogene, vol. 30, no. 25, pp. 2888-2899, 2011.
83. N. H. Kim, H. S. Kim, X.-Y. Li et al., "A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition, "The Journal of Cell Biology, vol. 195, no. 3, pp. 417-433, 2011.
84. X. Wang, C. Ling, Y. Bai, and J. Zhao, "MicroRNA-206 is associated with invasion and metastasis of lung cancer, " Anatomical Record, vol. 294, no. 1, pp. 88-92, 2011.
85. G. Chen, I. A. Umelo, S. Lv et al., "miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells, " PLoS ONE, vol. 8, no. 3, Article ID e60317, 2013.
86. C. Wang, X. Wang, H. Liang et al., "miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKC, " PLoS ONE, vol. 8, no. 9, Article ID e73985, 2013.
87. P. A. Gregory, A. G. Bert, E. L. Paterson et al., "The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1, " Nature Cell Biology, vol. 10, no. 5, pp. 593-601, 2008.
88. Y.-S. Wang, Y.-H. Wang, H.-P. Xia, S.-W. Zhou, G. Schmid-Bindert, and C.-C. Zhou, "MicroRNA-214 regulates the acquired resistance to gefitinib via the PTEN/AKT pathway in EGFR-mutant cell lines, " Asian Pacific Journal of Cancer Prevention, vol. 13, no. 1, pp. 255-260, 2012.
89. F.-Q. Nie, Q. Zhu, T.-P. Xu et al., "Long non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion, " Tumour Biology, vol. 35, no. 8, pp. 7587-7594, 2014.
90. W. Chen, W. Böcker, J. Brosius, and H. Tiedge, "Expression of neural BC200 RNA in human tumours, " Journal of Pathology, vol. 183, no. 3, pp. 345-351, 1997.
91. L. Gao, A. Mai, X. Li et al., "LncRNA-DQ786227-mediated cell malignant transformation induced by benzo(a)pyrene, " Toxicology Letters, vol. 223, no. 2, pp. 205-210, 2013.
92. L. H. Schmidt, T. Spieker, S. Koschmieder et al., "The long noncoding MALAT-1 RNA indicates a poor prognosis in nonsmall cell lung cancer and induces migration and tumor growth, " Journal of Thoracic Oncology, vol. 6, no. 12, pp. 1984-1992, 2011.
93. Y. Yang, H. Li, S. Hou, B. Hu, J. Liu, andJ. Wang, "Thenoncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell, " PLoS ONE, vol. 8, no. 5, Article ID e65309, 2013.
94. P. Thai, S. Statt, C. H. Chen, E. Liang, C. Campbell, and R. Wu, "Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines, " The American Journal of Respiratory Cell and Molecular Biology, vol. 49, no. 2, pp. 204-211, 2013.
95. Y. Zhuang, X. Wang, H. T. Nguyen et al., "Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen, " Journal of Hematology and Oncology, vol. 6, no. 1, article 35, 2013.
96. Z. Liu, M. Sun, K. Lu et al., "The long noncoding RNAHOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p211/1 expression, " PLoS ONE, vol. 8, no. 10, Article IDe77293, 2013.
97. H. Ono, N. Motoi, H. Nagano et al., "Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer, " Cancer Medicine, vol. 3, no. 3, pp. 632-642, 2014.
98. M. Sun, X.-H. Liu, K.-M. Wang et al., "Downregulation of BRAF activated non-coding RNAis associatedwith poor prognosis for non-small cell lung cancer and promotesmetastasis by affecting epithelial-mesenchymal transition, " Molecular Cancer, vol. 13, no. 1, article 68, 2014.
99. K.-H. Lu, W. Li, X.-H. Liu et al., "Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression, " BMC Cancer, vol. 13, article 461, 2013.
100. M. Sun, X.-H. Liu, K.-H. Lu et al., "EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition, " Cell Death and Disease, vol. 5, no. 6, Article ID e1298, 2014.
101. E.-B. Zhang, D.-D. Yin, M. Sun et al., "P53-regulated long noncoding RNA TUG1 affects cell proliferation in human nonsmall cell lung cancer, partly through epigenetically regulating HOXB7 expression, " Cell Death & Disease, vol. 5, Article ID e1243, 2014.
102. S. RoushandF. J. Slack, "The let-7 family ofmicroRNAs, " Trends in Cell Biology, vol. 18, no. 10, pp. 505-516, 2008.
103. P. Leidinger, A. Keller, and E. Meese, "Micrornas-important molecules in lung cancer research, " Frontiers in Genetics, vol. 2, article 104, 2012.
104. L. J. Chin, E. Ratner, S. Leng et al., "A SNP in a let-7 microRNA complementary site in the KRAS 3 untranslated region increases non-small cell lung cancer risk, " Cancer Research, vol. 68, no. 20, pp. 8535-8540, 2008.
105. X. He, C. Duan, J. Chen et al., "Let-7a elevates p21WAF1 levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells, " FEBS Letters, vol. 583, no. 21, pp. 3501-3507, 2009.
106. M. Unoki, T. Nishidate, and Y. Nakamura, "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain, " Oncogene, vol. 23, no. 46, pp. 7601-7610, 2004.
107. B. Zhao, H. Han, J. Chen et al., "microRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3, " Cancer Letters, vol. 342, no. 1, pp. 43-51, 2014.
108. W. Gao, Y. Yu, H. Cao et al., "Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis, " Biomedicine and Pharmacotherapy, vol. 64, no. 6, pp. 399-408, 2010.
109. M. Seike, A. Goto, T. Okano et al., "MiR-21 is anEGFR-regulated anti-apoptotic factor in lung cancer in never-smokers, " Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 29, pp. 12085-12090, 2009.
110. D. Frezzetti, M. De Menna, P. Zoppoli et al., "Upregulation of miR-21 by Ras in vivo and its role in tumor growth, " Oncogene, vol. 30, no. 3, pp. 275-286, 2011.
111. X. Pan, Z.-X. Wang, and R. Wang, "MicroRNA-21: a novel therapeutic target in human cancer, " Cancer Biology and Therapy, vol. 10, no. 12, pp. 1224-1232, 2010.
112. M. Chiba, M. Kimura, and S. Asari, "Exosomes secreted from human colorectal cancer cell lines containmRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines, " Oncology Reports, vol. 28, no. 5, pp. 1551-1558, 2012.
113. Y. Sun, Y. Bai, F. Zhang, Y. Wang, Y. Guo, and L. Guo, "miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7, " Biochemical and Biophysical Research Communications, vol. 391, no. 3, pp. 1483-1489, 2010.
114. G. Ren and Y. Kang, "A one-two punch of miR-126/126 against metastasis, " Nature Cell Biology, vol. 15, no. 3, pp. 231-233, 2013.