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Volumn 14, Issue 6, 2007, Pages 503-510

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; PROTEIN CRK; PROTEIN CRKI; PRTOEIN CRKII; UNCLASSIFIED DRUG;

EID: 34249902061     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb1241     Document Type: Article
Times cited : (107)

References (37)
  • 1
    • 0032825266 scopus 로고    scopus 로고
    • Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
    • Cheresh, D.A., Leng, J. & Klemke, R.L. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. J. Cell Biol. 146, 1107-1116 (1999).
    • (1999) J. Cell Biol , vol.146 , pp. 1107-1116
    • Cheresh, D.A.1    Leng, J.2    Klemke, R.L.3
  • 2
    • 0031004266 scopus 로고    scopus 로고
    • Downstream of Crk: Activation of JNK by v-Crk through the guanine nucleotide exchange protein C3G
    • Tanaka, S., Ouchi, T. & Hanafusa, H. Downstream of Crk: activation of JNK by v-Crk through the guanine nucleotide exchange protein C3G. Proc. Natl. Acad. Sci. USA 94, 2356-2361 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2356-2361
    • Tanaka, S.1    Ouchi, T.2    Hanafusa, H.3
  • 3
    • 0027245610 scopus 로고
    • Both the SH2 and SH3 domains of human Crk protein are required for neuronal differentiation of PC12 cells
    • Tanaka, S. et al. Both the SH2 and SH3 domains of human Crk protein are required for neuronal differentiation of PC12 cells. Mol. Cell. Biol. 13, 4409-4415 (1993).
    • (1993) Mol. Cell. Biol , vol.13 , pp. 4409-4415
    • Tanaka, S.1
  • 4
    • 0032213110 scopus 로고    scopus 로고
    • Activation of Rac1 by a Crk SH3-binding protein, DOCK180
    • Kiyokawa, E. et al. Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev. 12, 3331-3336 (1998).
    • (1998) Genes Dev , vol.12 , pp. 3331-3336
    • Kiyokawa, E.1
  • 5
    • 0033612572 scopus 로고    scopus 로고
    • Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle
    • Oktay, M., Wary, K.K., Dans, M., Birge, R.B. & Giancotti, F.G. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J. Cell Biol. 145, 1461-1469 (1999).
    • (1999) J. Cell Biol , vol.145 , pp. 1461-1469
    • Oktay, M.1    Wary, K.K.2    Dans, M.3    Birge, R.B.4    Giancotti, F.G.5
  • 6
    • 0035475308 scopus 로고    scopus 로고
    • Crk family adaptors - signalling complex formation and biological roles
    • Feller, S.M. Crk family adaptors - signalling complex formation and biological roles. Oncogene 20, 6348-6371 (2001).
    • (2001) Oncogene , vol.20 , pp. 6348-6371
    • Feller, S.M.1
  • 7
    • 33745135776 scopus 로고    scopus 로고
    • Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS
    • Linghu, H. et al. Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS. Oncogene 25, 3547-3556 (2006).
    • (2006) Oncogene , vol.25 , pp. 3547-3556
    • Linghu, H.1
  • 8
    • 18344372171 scopus 로고    scopus 로고
    • Molecular and immunohistochemical analysis of adaptor protein Crk in human cancers
    • Nishihara, H. et al. Molecular and immunohistochemical analysis of adaptor protein Crk in human cancers. Cancer Lett. 180, 55-61 (2002).
    • (2002) Cancer Lett , vol.180 , pp. 55-61
    • Nishihara, H.1
  • 9
    • 18544365698 scopus 로고    scopus 로고
    • Gene-expression profiles predict survival of patients with lung adenocarcinoma
    • Beer, D.G. et al. Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat. Med. 8, 816-824 (2002).
    • (2002) Nat. Med , vol.8 , pp. 816-824
    • Beer, D.G.1
  • 10
    • 0344255674 scopus 로고    scopus 로고
    • Increased C-Crk proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas
    • Miller, C.T. et al. Increased C-Crk proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas. Oncogene 22, 7950-7957 (2003).
    • (2003) Oncogene , vol.22 , pp. 7950-7957
    • Miller, C.T.1
  • 11
    • 0037699007 scopus 로고    scopus 로고
    • CrkI adapter protein modulates cell migration and invasion in glioblastoma
    • Takino, T. et al. CrkI adapter protein modulates cell migration and invasion in glioblastoma. Cancer Res. 63, 2335-2337 (2003).
    • (2003) Cancer Res , vol.63 , pp. 2335-2337
    • Takino, T.1
  • 12
    • 0037468572 scopus 로고    scopus 로고
    • Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer
    • Konishi, H. et al. Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer. Oncogene 22, 1892-1905 (2003).
    • (2003) Oncogene , vol.22 , pp. 1892-1905
    • Konishi, H.1
  • 13
    • 33746888255 scopus 로고    scopus 로고
    • Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines
    • Watanabe, T. et al. Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines. Mol. Cancer Res. 4, 499-510 (2006).
    • (2006) Mol. Cancer Res , vol.4 , pp. 499-510
    • Watanabe, T.1
  • 14
    • 0026686182 scopus 로고
    • Two species of human Crk cDNA encode proteins with distinct biological activities
    • Matsuda, M. et al. Two species of human Crk cDNA encode proteins with distinct biological activities. Mol. Cell. Biol. 12, 3482-3489 (1992).
    • (1992) Mol. Cell. Biol , vol.12 , pp. 3482-3489
    • Matsuda, M.1
  • 15
    • 0028243505 scopus 로고
    • c-Abl kinase regulates the protein binding activity of c-Crk
    • Feller, S.M., Knudsen, B. & Hanafusa, H. c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J. 13, 2341-2351 (1994).
    • (1994) EMBO J , vol.13 , pp. 2341-2351
    • Feller, S.M.1    Knudsen, B.2    Hanafusa, H.3
  • 16
    • 0028916892 scopus 로고
    • Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein
    • Rosen, M.K. et al. Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein. Nature 374, 477-479 (1995).
    • (1995) Nature , vol.374 , pp. 477-479
    • Rosen, M.K.1
  • 18
    • 0035903217 scopus 로고    scopus 로고
    • A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo
    • Kurokawa, K. et al. A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo. J. Biol. Chem. 276, 31305-31310 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 31305-31310
    • Kurokawa, K.1
  • 19
    • 0034177596 scopus 로고    scopus 로고
    • Generation of a dual-labeled fluorescence biosensor for Crk-II phosphorylation using solid-phase expressed protein ligation
    • Cotton, G.J. & Muir, T.W. Generation of a dual-labeled fluorescence biosensor for Crk-II phosphorylation using solid-phase expressed protein ligation. Chem. Biol. 7, 253-261 (2000).
    • (2000) Chem. Biol , vol.7 , pp. 253-261
    • Cotton, G.J.1    Muir, T.W.2
  • 20
    • 0035936696 scopus 로고    scopus 로고
    • Solution structure of Grb2 reveals extensive flexibility necessary for target recognition
    • Yuzawa, S. et al. Solution structure of Grb2 reveals extensive flexibility necessary for target recognition. J. Mol. Biol. 306, 527-537 (2001).
    • (2001) J. Mol. Biol , vol.306 , pp. 527-537
    • Yuzawa, S.1
  • 21
    • 0037195067 scopus 로고    scopus 로고
    • Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide
    • Donaldson, L.W., Gish, G., Pawson, T., Kay, L.E. & Forman-Kay, J.D. Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. Proc. Natl. Acad. Sci. USA 99, 14053-14058 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14053-14058
    • Donaldson, L.W.1    Gish, G.2    Pawson, T.3    Kay, L.E.4    Forman-Kay, J.D.5
  • 22
    • 4644340524 scopus 로고    scopus 로고
    • Automated NMR structure calculation with CYANA
    • Guntert, P. Automated NMR structure calculation with CYANA. Methods Mol. Biol. 278, 353-378 (2004).
    • (2004) Methods Mol. Biol , vol.278 , pp. 353-378
    • Guntert, P.1
  • 23
    • 3543012707 scopus 로고    scopus 로고
    • Crystallography & NMR system: A new software suite for macromolecular structure determination
    • Brunger, A.T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54, 905-921 (1998).
    • (1998) Acta Crystallogr. D Biol. Crystallogr , vol.54 , pp. 905-921
    • Brunger, A.T.1
  • 24
    • 0029813117 scopus 로고    scopus 로고
    • A potential SH3 domain-binding site in the Crk SH2 domain
    • Anafi, M., Rosen, M.K., Gish, G.D., Kay, L.E. & Pawson, T. A potential SH3 domain-binding site in the Crk SH2 domain. J. Biol. Chem. 271, 21365-21374 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 21365-21374
    • Anafi, M.1    Rosen, M.K.2    Gish, G.D.3    Kay, L.E.4    Pawson, T.5
  • 25
    • 0029643950 scopus 로고
    • Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk
    • Wu, X. et al. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure 3, 215-226 (1995).
    • (1995) Structure , vol.3 , pp. 215-226
    • Wu, X.1
  • 26
    • 0035018366 scopus 로고    scopus 로고
    • Crk family adaptor proteins trans-activate c-Abl kinase
    • Shishido, T. et al. Crk family adaptor proteins trans-activate c-Abl kinase. Genes Cells 6, 431-440 (2001).
    • (2001) Genes Cells , vol.6 , pp. 431-440
    • Shishido, T.1
  • 27
    • 0028335709 scopus 로고
    • The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells
    • Ogawa, S. et al. The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells. Oncogene 9, 1669-1678 (1994).
    • (1994) Oncogene , vol.9 , pp. 1669-1678
    • Ogawa, S.1
  • 28
    • 20144372827 scopus 로고    scopus 로고
    • C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF
    • Akakura, S. et al. C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF. J. Cell. Physiol. 204, 344-351 (2005).
    • (2005) J. Cell. Physiol , vol.204 , pp. 344-351
    • Akakura, S.1
  • 29
    • 0035931912 scopus 로고    scopus 로고
    • Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II
    • Zvara, A. et al. Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II. Oncogene 20, 951-961 (2001).
    • (2001) Oncogene , vol.20 , pp. 951-961
    • Zvara, A.1
  • 30
    • 33746220057 scopus 로고    scopus 로고
    • Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II
    • Muralidharan, V. et al. Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II. Biochemistry 45, 8874-8884 (2006).
    • (2006) Biochemistry , vol.45 , pp. 8874-8884
    • Muralidharan, V.1
  • 31
    • 0026648707 scopus 로고
    • Activation of c-Src in cells bearing v-Crk and its suppression by Csk
    • Sabe, H., Okada, M., Nakagawa, H. & Hanafusa, H. Activation of c-Src in cells bearing v-Crk and its suppression by Csk. Mol. Cell. Biol. 12, 4706-4713 (1992).
    • (1992) Mol. Cell. Biol , vol.12 , pp. 4706-4713
    • Sabe, H.1    Okada, M.2    Nakagawa, H.3    Hanafusa, H.4
  • 32
    • 33846688095 scopus 로고    scopus 로고
    • Proline cis-trans isomerization controls autoinhibition of a signaling protein
    • Sarkar, P., Reichman, C., Saleh, T., Birge, R.B. & Kalodimos, C.G. Proline cis-trans isomerization controls autoinhibition of a signaling protein. Mol. Cell 25, 413-426 (2007).
    • (2007) Mol. Cell , vol.25 , pp. 413-426
    • Sarkar, P.1    Reichman, C.2    Saleh, T.3    Birge, R.B.4    Kalodimos, C.G.5
  • 34
    • 0343459675 scopus 로고
    • The program XEASY for computer-supported NMR spectral analysis of biological macromolecules
    • Bartels, C., Xia, T.-H., Billeter, M., Güntert, P. & Wüthrich, K. The program XEASY for computer-supported NMR spectral analysis of biological macromolecules. J. Biomol. NMR 6, 1-10 (1995).
    • (1995) J. Biomol. NMR , vol.6 , pp. 1-10
    • Bartels, C.1    Xia, T.-H.2    Billeter, M.3    Güntert, P.4    Wüthrich, K.5
  • 35
    • 0033003335 scopus 로고    scopus 로고
    • Protein backbone angle restraints from searching a database for chemical shift and sequence homology
    • Cornilescu, G., Delaglio, F. & Bax, A. Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J. Biomol. NMR 13, 289-302 (1999).
    • (1999) J. Biomol. NMR , vol.13 , pp. 289-302
    • Cornilescu, G.1    Delaglio, F.2    Bax, A.3
  • 36
    • 3142732260 scopus 로고    scopus 로고
    • Solution structure of the tandem Src homology 3 domains of p47phox in an autoinhibited form
    • Yuzawa, S. et al. Solution structure of the tandem Src homology 3 domains of p47phox in an autoinhibited form. J. Biol. Chem. 279, 29752-29760 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 29752-29760
    • Yuzawa, S.1
  • 37
    • 0344823945 scopus 로고    scopus 로고
    • Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation
    • Akagi, T., Sasai, K. & Hanafusa, H. Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation. Proc. Natl. Acad. Sci. USA, 100, 13567-13572 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 13567-13572
    • Akagi, T.1    Sasai, K.2    Hanafusa, H.3


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