메뉴 건너뛰기




Volumn 309, Issue 10, 2015, Pages 627-638

Microenvironment in metastasis: Roadblocks and supportive niches

Author keywords

Cancer; Metastasis; Microenvironment; Niche; Stem cells

Indexed keywords

ARTICLE; CANCER CELL; HOST; HUMAN; INFLAMMATORY CELL; METASTASIS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STROMA CELL; TUMOR MICROENVIRONMENT; ANIMAL; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; NEOPLASM; PATHOPHYSIOLOGY; PHYSIOLOGY;

EID: 84947274381     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00145.2015     Document Type: Article
Times cited : (45)

References (151)
  • 2
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 7: 834-846, 2007.
    • (2007) Nat Rev Cancer , vol.7 , pp. 834-846
    • Aguirre-Ghiso, J.A.1
  • 3
    • 0037379794 scopus 로고    scopus 로고
    • ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)
    • Aguirre-Ghiso JA, Estrada Y, Liu D, Ossowski L. ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). Cancer Res 63: 1684-1695, 2003.
    • (2003) Cancer Res , vol.63 , pp. 1684-1695
    • Aguirre-Ghiso, J.A.1    Estrada, Y.2    Liu, D.3    Ossowski, L.4
  • 4
    • 5644222639 scopus 로고    scopus 로고
    • Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth
    • Aguirre-Ghiso JA, Ossowski L, Rosenbaum SK. Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res 64: 7336-7345, 2004.
    • (2004) Cancer Res , vol.64 , pp. 7336-7345
    • Aguirre-Ghiso, J.A.1    Ossowski, L.2    Rosenbaum, S.K.3
  • 5
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R, Kasimir-Bauer S. Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res 11: R46, 2009.
    • (2009) Breast Cancer Res , vol.11
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 8
    • 84881112672 scopus 로고    scopus 로고
    • The evolution of the cancer niche during multistage carcinogenesis
    • Barcellos-Hoff MH, Lyden D, Wang TC. The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer 13: 511-518, 2013.
    • (2013) Nat Rev Cancer , vol.13 , pp. 511-518
    • Barcellos-Hoff, M.H.1    Lyden, D.2    Wang, T.C.3
  • 11
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40: 499-507, 2008.
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6    Weinberg, R.A.7
  • 12
    • 79951854922 scopus 로고    scopus 로고
    • Inhibition of stromal cell-derived factor-1alpha further impairs diabetic wound healing
    • Bermudez DM, Xu J, Herdrich BJ, Radu A, Mitchell ME, Liechty KW. Inhibition of stromal cell-derived factor-1alpha further impairs diabetic wound healing. J Vasc Surg 53: 774-784, 2011.
    • (2011) J Vasc Surg , vol.53 , pp. 774-784
    • Bermudez, D.M.1    Xu, J.2    Herdrich, B.J.3    Radu, A.4    Mitchell, M.E.5    Liechty, K.W.6
  • 14
    • 84930179858 scopus 로고    scopus 로고
    • The relevance of EMT in breast cancer metastasis: Correlation or causality?
    • Bill R, Christofori G. The relevance of EMT in breast cancer metastasis: correlation or causality? FEBS Lett 589: 1577-1587, 2015.
    • (2015) FEBS Lett , vol.589 , pp. 1577-1587
    • Bill, R.1    Christofori, G.2
  • 15
    • 79952392467 scopus 로고    scopus 로고
    • Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    • Bissell MJ, Hines WC. Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 17: 320-329, 2011.
    • (2011) Nat Med , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 16
    • 84862823626 scopus 로고    scopus 로고
    • Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
    • Bonde AK, Tischler V, Kumar S, Soltermann A, Schwendener RA. Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors. BMC Cancer 12: 35, 2012.
    • (2012) BMC Cancer , vol.12 , pp. 35
    • Bonde, A.K.1    Tischler, V.2    Kumar, S.3    Soltermann, A.4    Schwendener, R.A.5
  • 17
    • 84922333220 scopus 로고    scopus 로고
    • Remodelling the extracellular matrix in development and disease
    • Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol 15: 786-801, 2014.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 786-801
    • Bonnans, C.1    Chou, J.2    Werb, Z.3
  • 18
    • 0026778310 scopus 로고
    • Transforming growth factor-beta in disease: The dark side of tissue repair
    • Border WA, Ruoslahti E. Transforming growth factor-beta in disease: the dark side of tissue repair. J Clin Invest 90: 1-7, 1992.
    • (1992) J Clin Invest , vol.90 , pp. 1-7
    • Border, W.A.1    Ruoslahti, E.2
  • 23
    • 84892741034 scopus 로고    scopus 로고
    • Reactive gliosis and the multicellular response to CNS damage and disease
    • Burda JE, Sofroniew MV. Reactive gliosis and the multicellular response to CNS damage and disease. Neuron 81: 229-248, 2014.
    • (2014) Neuron , vol.81 , pp. 229-248
    • Burda, J.E.1    Sofroniew, M.V.2
  • 28
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 331: 1559-1564, 2011.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 29
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2: 563-572, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    Macdonald, I.C.3
  • 31
    • 77956803700 scopus 로고    scopus 로고
    • The perivascular niche microenvironment in brain tumor progression
    • Charles N, Holland EC. The perivascular niche microenvironment in brain tumor progression. Cell Cycle 9: 3012-3021, 2010.
    • (2010) Cell Cycle , vol.9 , pp. 3012-3021
    • Charles, N.1    Holland, E.C.2
  • 32
    • 80054725681 scopus 로고    scopus 로고
    • Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs
    • Chen Q, Zhang XH, Massague J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20: 538-549, 2011.
    • (2011) Cancer Cell , vol.20 , pp. 538-549
    • Chen, Q.1    Zhang, X.H.2    Massague, J.3
  • 33
    • 58149102321 scopus 로고    scopus 로고
    • Molecular basis of metastasis
    • Chiang AC, Massague J. Molecular basis of metastasis. N Engl J Med 359: 2814-2823, 2008.
    • (2008) N Engl J Med , vol.359 , pp. 2814-2823
    • Chiang, A.C.1    Massague, J.2
  • 36
    • 0015852146 scopus 로고
    • Breast cancer: Induction of differentiation by embryonic tissue
    • DeCosse JJ, Gossens CL, Kuzma JF, Unsworth BR. Breast cancer: induction of differentiation by embryonic tissue. Science 181: 1057-1058, 1973.
    • (1973) Science , vol.181 , pp. 1057-1058
    • Decosse, J.J.1    Gossens, C.L.2    Kuzma, J.F.3    Unsworth, B.R.4
  • 38
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315: 1650-1659, 1986.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 39
    • 57849100048 scopus 로고    scopus 로고
    • Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
    • Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 15: 35-44, 2009.
    • (2009) Cancer Cell , vol.15 , pp. 35-44
    • Erler, J.T.1    Bennewith, K.L.2    Cox, T.R.3    Lang, G.4    Bird, D.5    Koong, A.6    Le, Q.T.7    Giaccia, A.J.8
  • 40
    • 0037437371 scopus 로고    scopus 로고
    • TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins
    • Evans RA, Tian YC, Steadman R, Phillips AO. TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins. Exp Cell Res 282: 90-100, 2003.
    • (2003) Exp Cell Res , vol.282 , pp. 90-100
    • Evans, R.A.1    Tian, Y.C.2    Steadman, R.3    Phillips, A.O.4
  • 41
    • 84906053870 scopus 로고    scopus 로고
    • Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma
    • Fan QM, Jing YY, Yu GF, Kou XR, Ye F, Gao L, Li R, Zhao QD, Yang Y, Lu ZH, Wei LX. Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Cancer Lett 352: 160-168, 2014.
    • (2014) Cancer Lett , vol.352 , pp. 160-168
    • Fan, Q.M.1    Jing, Y.Y.2    Yu, G.F.3    Kou, X.R.4    Ye, F.5    Gao, L.6    Li, R.7    Zhao, Q.D.8    Yang, Y.9    Lu, Z.H.10    Wei, L.X.11
  • 42
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The ‘seed and soil’ hypothesis revisited
    • Fidler IJ. The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer 3: 453-458, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 47
    • 38149006909 scopus 로고    scopus 로고
    • Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
    • Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 319: 195-198, 2008.
    • (2008) Science , vol.319 , pp. 195-198
    • Gao, D.1    Nolan, D.J.2    Mellick, A.S.3    Bambino, K.4    McDonnell, K.5    Mittal, V.6
  • 49
    • 84925669716 scopus 로고    scopus 로고
    • Metastasis prevention by targeting the dormant niche
    • Ghajar CM. Metastasis prevention by targeting the dormant niche. Nat Rev Cancer 15: 238-247, 2015.
    • (2015) Nat Rev Cancer , vol.15 , pp. 238-247
    • Ghajar, C.M.1
  • 51
    • 77956280130 scopus 로고    scopus 로고
    • Reciprocal activation of prostate cancer cells and cancerassociated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
    • Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L, Chiarugi P. Reciprocal activation of prostate cancer cells and cancerassociated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res 70: 6945-6956, 2010.
    • (2010) Cancer Res , vol.70 , pp. 6945-6956
    • Giannoni, E.1    Bianchini, F.2    Masieri, L.3    Serni, S.4    Torre, E.5    Calorini, L.6    Chiarugi, P.7
  • 52
    • 10144241022 scopus 로고    scopus 로고
    • Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancermediated osteolysis
    • Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, Boyce BF, Yoneda T, Mundy GR. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancermediated osteolysis. J Clin Invest 98: 1544-1549, 1996.
    • (1996) J Clin Invest , vol.98 , pp. 1544-1549
    • Guise, T.A.1    Yin, J.J.2    Taylor, S.D.3    Kumagai, Y.4    Dallas, M.5    Boyce, B.F.6    Yoneda, T.7    Mundy, G.R.8
  • 54
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, Lander ES. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146: 633-644, 2011.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 55
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364, 1996.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 61
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer 9: 239-252, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 65
    • 84869225491 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue
    • Karagiannis GS, Poutahidis T, Erdman SE, Kirsch R, Riddell RH, Diamandis EP. Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol Cancer Res 10: 1403-1418, 2012.
    • (2012) Mol Cancer Res , vol.10 , pp. 1403-1418
    • Karagiannis, G.S.1    Poutahidis, T.2    Erdman, S.E.3    Kirsch, R.4    Riddell, R.H.5    Diamandis, E.P.6
  • 68
    • 76249097588 scopus 로고    scopus 로고
    • Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture
    • Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N, Kudo A. Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem 285: 2028-2039, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 2028-2039
    • Kii, I.1    Nishiyama, T.2    Li, M.3    Matsumoto, K.4    Saito, M.5    Amizuka, N.6    Kudo, A.7
  • 73
    • 79551643707 scopus 로고    scopus 로고
    • Framework models of tumor dormancy from patient-derived observations
    • Klein CA. Framework models of tumor dormancy from patient-derived observations. Curr Opin Genet Dev 21: 42-49, 2011.
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 42-49
    • Klein, C.A.1
  • 75
    • 81255205399 scopus 로고    scopus 로고
    • Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    • Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20: 576-590, 2011.
    • (2011) Cancer Cell , vol.20 , pp. 576-590
    • Labelle, M.1    Begum, S.2    Hynes, R.O.3
  • 78
    • 77956855574 scopus 로고    scopus 로고
    • Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels
    • Lin Q, Balasubramanian K, Fan D, Kim SJ, Guo L, Wang H, Bar-Eli M, Aldape KD, Fidler IJ. Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels. Neoplasia 12: 748-754, 2010.
    • (2010) Neoplasia , vol.12 , pp. 748-754
    • Lin, Q.1    Balasubramanian, K.2    Fan, D.3    Kim, S.J.4    Guo, L.5    Wang, H.6    Bar-Eli, M.7    Aldape, K.D.8    Fidler, I.J.9
  • 79
    • 0026806148 scopus 로고
    • Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients
    • Lindemann F, Schlimok G, Dirschedl P, Witte J, Riethmuller G. Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet 340: 685-689, 1992.
    • (1992) Lancet , vol.340 , pp. 685-689
    • Lindemann, F.1    Schlimok, G.2    Dirschedl, P.3    Witte, J.4    Riethmuller, G.5
  • 84
    • 69249228553 scopus 로고    scopus 로고
    • ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
    • Lu X, Wang Q, Hu G, Van Poznak C, Fleisher M, Reiss M, Massague J, Kang Y. ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev 23: 1882-1894, 2009.
    • (2009) Genes Dev , vol.23 , pp. 1882-1894
    • Lu, X.1    Wang, Q.2    Hu, G.3    Van Poznak, C.4    Fleisher, M.5    Reiss, M.6    Massague, J.7    Kang, Y.8
  • 85
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases
    • Luzzi KJ, MacDonald IC, Schmidt EE, Kerkvliet N, Morris VL, Chambers AF, Groom AC. Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol 153: 865-873, 1998.
    • (1998) Am J Pathol , vol.153 , pp. 865-873
    • Luzzi, K.J.1    Macdonald, I.C.2    Schmidt, E.E.3    Kerkvliet, N.4    Morris, V.L.5    Chambers, A.F.6    Groom, A.C.7
  • 91
    • 0345366593 scopus 로고
    • Normal genetically mosaic mice produced from malignant teratocarcinoma cells
    • Mintz B, Illmensee K. Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci USA 72: 3585-3589, 1975.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 3585-3589
    • Mintz, B.1    Illmensee, K.2
  • 93
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-284, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 94
    • 33746807641 scopus 로고    scopus 로고
    • Is cancer a disease of self-seeding?
    • Norton L, Massague J. Is cancer a disease of self-seeding? Nat Med 12: 875-878, 2006.
    • (2006) Nat Med , vol.12 , pp. 875-878
    • Norton, L.1    Massague, J.2
  • 97
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 59: 5002-5011, 1999.
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 99
  • 100
    • 84884709908 scopus 로고    scopus 로고
    • Extracellular matrix components in breast cancer progression and metastasis
    • Oskarsson T. Extracellular matrix components in breast cancer progression and metastasis. Breast 22, Suppl 2: S66-S72, 2013.
    • (2013) Breast , vol.22 , pp. S66-S72
    • Oskarsson, T.1
  • 102
    • 84896113460 scopus 로고    scopus 로고
    • Metastatic stem cells: Sources, niches, and vital pathways
    • Oskarsson T, Batlle E, Massague J. Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell 14: 306-321, 2014.
    • (2014) Cell Stem Cell , vol.14 , pp. 306-321
    • Oskarsson, T.1    Batlle, E.2    Massague, J.3
  • 103
    • 84857189202 scopus 로고    scopus 로고
    • Extracellular matrix players in metastatic niches
    • Oskarsson T, Massague J. Extracellular matrix players in metastatic niches. EMBO J 31: 254-256, 2012.
    • (2012) EMBO J , vol.31 , pp. 254-256
    • Oskarsson, T.1    Massague, J.2
  • 104
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    • Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massague J. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133: 66-77, 2008.
    • (2008) Cell , vol.133 , pp. 66-77
    • Padua, D.1    Zhang, X.H.2    Wang, Q.3    Nadal, C.4    Gerald, W.L.5    Gomis, R.R.6    Massague, J.7
  • 105
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. Lancet 133: 571-573, 1889.
    • (1889) Lancet , vol.133 , pp. 571-573
    • Paget, S.1
  • 107
    • 0029867674 scopus 로고    scopus 로고
    • Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases
    • Pantel K, Izbicki J, Passlick B, Angstwurm M, Haussinger K, Thetter O, Riethmuller G. Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases. Lancet 347: 649-653, 1996.
    • (1996) Lancet , vol.347 , pp. 649-653
    • Pantel, K.1    Izbicki, J.2    Passlick, B.3    Angstwurm, M.4    Haussinger, K.5    Thetter, O.6    Riethmuller, G.7
  • 111
    • 84870052886 scopus 로고    scopus 로고
    • Convergent multi-miRNA targeting of ApoE drives LRP1/ LRP8-dependent melanoma metastasis and angiogenesis
    • Pencheva N, Tran H, Buss C, Huh D, Drobnjak M, Busam K, Tavazoie SF. Convergent multi-miRNA targeting of ApoE drives LRP1/ LRP8-dependent melanoma metastasis and angiogenesis. Cell 151: 1068-1082, 2012.
    • (2012) Cell , vol.151 , pp. 1068-1082
    • Pencheva, N.1    Tran, H.2    Buss, C.3    Huh, D.4    Drobnjak, M.5    Busam, K.6    Tavazoie, S.F.7
  • 112
    • 84924249260 scopus 로고    scopus 로고
    • The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells?
    • Plaks V, Kong N, Werb Z. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell 16: 225-238, 2015.
    • (2015) Cell Stem Cell , vol.16 , pp. 225-238
    • Plaks, V.1    Kong, N.2    Werb, Z.3
  • 113
    • 84855813448 scopus 로고    scopus 로고
    • A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
    • Png KJ, Halberg N, Yoshida M, Tavazoie SF. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature 481: 190-194, 2012.
    • (2012) Nature , vol.481 , pp. 190-194
    • Png, K.J.1    Halberg, N.2    Yoshida, M.3    Tavazoie, S.F.4
  • 114
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4: 71-78, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 115
    • 63049121364 scopus 로고    scopus 로고
    • The metastatic niche: Adapting the foreign soil
    • Psaila B, Lyden D. The metastatic niche: adapting the foreign soil. Nat Rev Cancer 9: 285-293, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 285-293
    • Psaila, B.1    Lyden, D.2
  • 116
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J, Lang RA, Pollard JW. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLos One 4: e6562, 2009.
    • (2009) Plos One , vol.4
    • Qian, B.1    Deng, Y.2    Im, J.H.3    Muschel, R.J.4    Zou, Y.5    Li, J.6    Lang, R.A.7    Pollard, J.W.8
  • 119
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Roodman GD. Mechanisms of bone metastasis. N Engl J Med 350: 1655-1664, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 1655-1664
    • Roodman, G.D.1
  • 120
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: An old hypothesis revisited
    • Schafer M, Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol 9: 628-638, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 628-638
    • Schafer, M.1    Werner, S.2
  • 123
    • 79951672873 scopus 로고    scopus 로고
    • Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis
    • Seike T, Fujita K, Yamakawa Y, Kido MA, Takiguchi S, Teramoto N, Iguchi H, Noda M. Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis. Clin Exp Metastasis 28: 13-25, 2011.
    • (2011) Clin Exp Metastasis , vol.28 , pp. 13-25
    • Seike, T.1    Fujita, K.2    Yamakawa, Y.3    Kido, M.A.4    Takiguchi, S.5    Teramoto, N.6    Iguchi, H.7    Noda, M.8
  • 124
    • 79751472667 scopus 로고    scopus 로고
    • Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
    • Sethi N, Dai X, Winter CG, Kang Y. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 19: 192-205, 2011.
    • (2011) Cancer Cell , vol.19 , pp. 192-205
    • Sethi, N.1    Dai, X.2    Winter, C.G.3    Kang, Y.4
  • 125
    • 67649849871 scopus 로고    scopus 로고
    • Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs
    • Shibue T, Weinberg RA. Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci USA 106: 10290-10295, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 10290-10295
    • Shibue, T.1    Weinberg, R.A.2
  • 128
    • 84867924331 scopus 로고    scopus 로고
    • The metastatic niche and stromal progression
    • Sleeman JP. The metastatic niche and stromal progression. Cancer Metastasis Rev 31: 429-440, 2012.
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 429-440
    • Sleeman, J.P.1
  • 130
    • 84906937205 scopus 로고    scopus 로고
    • Mechanisms of disseminated cancer cell dormancy: An awakening field
    • Sosa MS, Bragado P, Aguirre-Ghiso JA. Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat Rev Cancer 14: 611-622, 2014.
    • (2014) Nat Rev Cancer , vol.14 , pp. 611-622
    • Sosa, M.S.1    Bragado, P.2    Aguirre-Ghiso, J.A.3
  • 131
    • 0025336260 scopus 로고
    • The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia
    • Stoker AW, Hatier C, Bissell MJ. The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia. J Cell Biol 111: 217-228, 1990.
    • (1990) J Cell Biol , vol.111 , pp. 217-228
    • Stoker, A.W.1    Hatier, C.2    Bissell, M.J.3
  • 132
    • 33746620430 scopus 로고    scopus 로고
    • Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency
    • Suzuki M, Mose ES, Montel V, Tarin D. Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency. Am J Pathol 169: 673-681, 2006.
    • (2006) Am J Pathol , vol.169 , pp. 673-681
    • Suzuki, M.1    Mose, E.S.2    Montel, V.3    Tarin, D.4
  • 133
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 134
    • 0029761679 scopus 로고    scopus 로고
    • Immunocytochemical detection of disseminated tumor cells in the bone marrow of patients with esophageal carcinoma
    • Thorban S, Roder JD, Nekarda H, Funk A, Siewert JR, Pantel K. Immunocytochemical detection of disseminated tumor cells in the bone marrow of patients with esophageal carcinoma. J Natl Cancer Inst 88: 1222-1227, 1996.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1222-1227
    • Thorban, S.1    Roder, J.D.2    Nekarda, H.3    Funk, A.4    Siewert, J.R.5    Pantel, K.6
  • 136
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22: 725-736, 2012.
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 137
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 147: 275-292, 2011.
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 139
    • 84885352426 scopus 로고    scopus 로고
    • Origins of metastatic traits
    • Vanharanta S, Massague J. Origins of metastatic traits. Cancer Cell 24: 410-421, 2013.
    • (2013) Cancer Cell , vol.24 , pp. 410-421
    • Vanharanta, S.1    Massague, J.2
  • 142
    • 81155127516 scopus 로고    scopus 로고
    • Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
    • Victor BC, Anbalagan A, Mohamed MM, Sloane BF, Cavallo-Medved D. Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion. Breast Cancer Res 13: R115, 2011.
    • (2011) Breast Cancer Res , vol.13
    • Victor, B.C.1    Anbalagan, A.2    Mohamed, M.M.3    Sloane, B.F.4    Cavallo-Medved, D.5
  • 147
    • 84055216938 scopus 로고    scopus 로고
    • Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation
    • Yao D, Dai C, Peng S. Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation. Mol Cancer Res 9: 1608-1620, 2011.
    • (2011) Mol Cancer Res , vol.9 , pp. 1608-1620
    • Yao, D.1    Dai, C.2    Peng, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.