-
1
-
-
79953236022
-
The role of LKB1 and AMPK in cellular responses to stress and damage
-
Alexander A, Walker CL. The role of LKB1 and AMPK in cellular responses to stress and damage. FEBS Lett 585: 952-957, 2011.
-
(2011)
FEBS Lett
, vol.585
, pp. 952-957
-
-
Alexander, A.1
Walker, C.L.2
-
2
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
Ballatore C, Lee VM, Trojanowski JQ. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 8: 663-672, 2007.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
3
-
-
0024824922
-
Patterns of gliosis in Alzheimer's disease and aging cerebrum
-
Beach TG, Walker R, McGeer EG. Patterns of gliosis in Alzheimer's disease and aging cerebrum. Glia 2: 420-436, 1989.
-
(1989)
Glia
, vol.2
, pp. 420-436
-
-
Beach, T.G.1
Walker, R.2
McGeer, E.G.3
-
4
-
-
42249107660
-
Obesity and central obesity as risk factors for incident dementia and its subtypes: A systematic review and meta-analysis
-
Beydoun MA, Beydoun HA, Wang Y. Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev 9: 204-218, 2008.
-
(2008)
Obes Rev
, vol.9
, pp. 204-218
-
-
Beydoun, M.A.1
Beydoun, H.A.2
Wang, Y.3
-
5
-
-
84881427415
-
Increased tau phosphorylation and impaired brain insulin/IGF signaling in mice fed a high fat/high cholesterol diet
-
Bhat NR, Thirumangalakudi L. Increased tau phosphorylation and impaired brain insulin/IGF signaling in mice fed a high fat/high cholesterol diet. J Alzheimer's Dis 36: 781-789, 2013.
-
(2013)
J Alzheimer's Dis
, vol.36
, pp. 781-789
-
-
Bhat, N.R.1
Thirumangalakudi, L.2
-
6
-
-
84857253827
-
Roles of AMP-activated protein kinase in Alzheimer's disease
-
Cai Z, Yan LJ, Li K, Quazi SH, Zhao B. Roles of AMP-activated protein kinase in Alzheimer's disease. Neuromolecular Med 14: 1-14, 2012.
-
(2012)
Neuromolecular Med
, vol.14
, pp. 1-14
-
-
Cai, Z.1
Yan, L.J.2
Li, K.3
Quazi, S.H.4
Zhao, B.5
-
7
-
-
0003616161
-
-
Canadian Council on Animal Care (2nd ed.). Ottawa, Canada: Canadian Council on Animal Care
-
Canadian Council on Animal Care. Guide to the Care and Use of Experimental Animals (2nd ed.). Ottawa, Canada: Canadian Council on Animal Care, 1993.
-
(1993)
Guide to the Care and Use of Experimental Animals
-
-
-
8
-
-
64549127790
-
PGC-1alpha SIRT1 and AMPK, an energy sensing network that controls energy expenditure
-
Canto C, Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 20: 98-105, 2009.
-
(2009)
Curr Opin Lipidol
, vol.20
, pp. 98-105
-
-
Canto, C.1
Auwerx, J.2
-
9
-
-
84901236201
-
Exercise training protects against an acute inflammatory insult in mouse epididymal adipose tissue
-
Castellani L, Root-Mccaig J, Frendo-Cumbo S, Beaudoin MS, Wright DC. Exercise training protects against an acute inflammatory insult in mouse epididymal adipose tissue. J Appl Physiol (1985) 116: 1272-1280, 2014.
-
(2014)
J Appl Physiol (1985)
, vol.116
, pp. 1272-1280
-
-
Castellani, L.1
Root-Mccaig, J.2
Frendo-Cumbo, S.3
Beaudoin, M.S.4
Wright, D.C.5
-
10
-
-
62649115914
-
Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via upregulating BACE1 transcription
-
Chen Y, Zhou K, Wang R, Liu Y, Kwak YD, Ma T, Thompson RC, Zhao Y, Smith L, Gasparini L, Luo Z, Xu H, Liao FF. Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via upregulating BACE1 transcription. Proc Natl Acad Sci USA 106: 3907-3912, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 3907-3912
-
-
Chen, Y.1
Zhou, K.2
Wang, R.3
Liu, Y.4
Kwak, Y.D.5
Ma, T.6
Thompson, R.C.7
Zhao, Y.8
Smith, L.9
Gasparini, L.10
Luo, Z.11
Xu, H.12
Liao, F.F.13
-
11
-
-
28844493414
-
Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3
-
Clodfelder-Miller B, De Sarno P, Zmijewska AA, Song L, Jope RS. Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3. J Biol Chem 280: 39723-39731, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 39723-39731
-
-
Clodfelder-Miller, B.1
De Sarno, P.2
Zmijewska, A.A.3
Song, L.4
Jope, R.S.5
-
12
-
-
16544362766
-
Neurocognitive aging and cardiovascular fitness: Recent findings and future directions
-
Colcombe SJ, Kramer AF, McAuley E, Erickson KI, Scalf P. Neurocognitive aging and cardiovascular fitness: recent findings and future directions. J Mol Neurosci 24: 9-14, 2004.
-
(2004)
J Mol Neurosci
, vol.24
, pp. 9-14
-
-
Colcombe, S.J.1
Kramer, A.F.2
McAuley, E.3
Erickson, K.I.4
Scalf, P.5
-
13
-
-
18244389436
-
The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease
-
Gandy S. The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest 115: 1121-1129, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 1121-1129
-
-
Gandy, S.1
-
14
-
-
78049339834
-
MAPK signalling in cellular metabolism: Stress or wellness?
-
Gehart H, Kumpf S, Ittner A, Ricci R. MAPK signalling in cellular metabolism: stress or wellness? EMBO Rep 11: 834-840, 2010.
-
(2010)
EMBO Rep
, vol.11
, pp. 834-840
-
-
Gehart, H.1
Kumpf, S.2
Ittner, A.3
Ricci, R.4
-
15
-
-
25144501662
-
Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease
-
Gouras GK, Almeida CG, Takahashi RH. Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging 26: 1235-1244, 2005.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 1235-1244
-
-
Gouras, G.K.1
Almeida, C.G.2
Takahashi, R.H.3
-
16
-
-
16244391770
-
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
-
Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O'Connor R, O'Neill C. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J Neurochem 93: 105-117, 2005.
-
(2005)
J Neurochem
, vol.93
, pp. 105-117
-
-
Griffin, R.J.1
Moloney, A.2
Kelliher, M.3
Johnston, J.A.4
Ravid, R.5
Dockery, P.6
O'Connor, R.7
O'Neill, C.8
-
17
-
-
61649114950
-
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease
-
Hampel H, Shen Y. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease. Scand J Clin Lab Invest 69: 8-12, 2009.
-
(2009)
Scand J Clin Lab Invest
, vol.69
, pp. 8-12
-
-
Hampel, H.1
Shen, Y.2
-
18
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 256: 184-185, 1992.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
19
-
-
0025093199
-
Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer's disease and aging
-
Hauw JJ, Verny M, Delaere P, Cervera P, He Y, Duyckaerts C. Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer's disease and aging. Neurosci Lett 119: 182-186, 1990.
-
(1990)
Neurosci Lett
, vol.119
, pp. 182-186
-
-
Hauw, J.J.1
Verny, M.2
Delaere, P.3
Cervera, P.4
He, Y.5
Duyckaerts, C.6
-
20
-
-
0033043939
-
P38 kinase is activated in the Alzheimer's disease brain
-
Hensley K, Floyd RA, Zheng NY, Nael R, Robinson KA, Nguyen X, Pye QN, Stewart CA, Geddes J, Markesbery WR, Patel E, Johnson GV, Bing G. p38 kinase is activated in the Alzheimer's disease brain. J Neurochem 72: 2053-2058, 1999.
-
(1999)
J Neurochem
, vol.72
, pp. 2053-2058
-
-
Hensley, K.1
Floyd, R.A.2
Zheng, N.Y.3
Nael, R.4
Robinson, K.A.5
Nguyen, X.6
Pye, Q.N.7
Stewart, C.A.8
Geddes, J.9
Markesbery, W.R.10
Patel, E.11
Johnson, G.V.12
Bing, G.13
-
21
-
-
4644286910
-
Dietinduced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
-
Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, Hof PR, Pasinetti GM. Dietinduced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J 18: 902-904, 2004.
-
(2004)
FASEB J
, vol.18
, pp. 902-904
-
-
Ho, L.1
Qin, W.2
Pompl, P.N.3
Xiang, Z.4
Wang, J.5
Zhao, Z.6
Peng, Y.7
Cambareri, G.8
Rocher, A.9
Mobbs, C.V.10
Hof, P.R.11
Pasinetti, G.M.12
-
22
-
-
79953854897
-
Alzheimer's disease: The challenge of the second century
-
Holtzman DM, Morris JC, Goate AM. Alzheimer's disease: the challenge of the second century. Sci Transl Med 3: 77sr71, 2011.
-
(2011)
Sci Transl Med
, vol.3
, pp. 77sr71
-
-
Holtzman, D.M.1
Morris, J.C.2
Goate, A.M.3
-
23
-
-
77953506502
-
Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's diseaselinked APPswe/PS1DeltaE9 mice
-
Hu YS, Xu P, Pigino G, Brady ST, Larson J, Lazarov O. Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's diseaselinked APPswe/PS1DeltaE9 mice. FASEB J 24: 1667-1681, 2010.
-
(2010)
FASEB J
, vol.24
, pp. 1667-1681
-
-
Hu, Y.S.1
Xu, P.2
Pigino, G.3
Brady, S.T.4
Larson, J.5
Lazarov, O.6
-
25
-
-
40449127705
-
Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia
-
Jellinger KA. Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia. Neurodegener Dis 5: 118-121, 2008.
-
(2008)
Neurodegener Dis
, vol.5
, pp. 118-121
-
-
Jellinger, K.A.1
-
26
-
-
0037323971
-
AMP-activated protein kinase, super metabolic regulator
-
Kemp BE, Stapleton D, Campbell DJ, Chen ZP, Murthy S, Walter M, Gupta A, Adams JJ, Katsis F, van Denderen B, Jennings IG, Iseli T, Michell BJ, Witters LA. AMP-activated protein kinase, super metabolic regulator. Biochem Soc Trans 31: 162-168, 2003.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 162-168
-
-
Kemp, B.E.1
Stapleton, D.2
Campbell, D.J.3
Chen, Z.P.4
Murthy, S.5
Walter, M.6
Gupta, A.7
Adams, J.J.8
Katsis, F.9
Van Denderen, B.10
Jennings, I.G.11
Iseli, T.12
Michell, B.J.13
Witters, L.A.14
-
27
-
-
78049510856
-
Exercise and physical activity: Clinical outcomes and applications
-
Kokkinos P, Myers J. Exercise and physical activity: clinical outcomes and applications. Circulation 122: 1637-1648, 2010.
-
(2010)
Circulation
, vol.122
, pp. 1637-1648
-
-
Kokkinos, P.1
Myers, J.2
-
28
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2[-delta delta C(T)] method
-
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2[-delta delta C(T)] method. Methods 25: 402-408, 2001.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
29
-
-
84906910072
-
Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid beta
-
Ma T, Chen Y, Vingtdeux V, Zhao H, Viollet B, Marambaud P, Klann E. Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid beta. J Neurosci 34: 12230-12238, 2014.
-
(2014)
J Neurosci
, vol.34
, pp. 12230-12238
-
-
Ma, T.1
Chen, Y.2
Vingtdeux, V.3
Zhao, H.4
Viollet, B.5
Marambaud, P.6
Klann, E.7
-
30
-
-
84941778684
-
Adipose tissue insulin action and IL-6 signaling following exercise in obese mice
-
MacPherson RE, Huber JS, Frendo-Cumbo S, Simpson JA, Wright DC. Adipose tissue insulin action and IL-6 signaling following exercise in obese mice. Med Sci Sports Exerc 47: 2034-2042, 2015.
-
(2015)
Med Sci Sports Exerc
, vol.47
, pp. 2034-2042
-
-
MacPherson, R.E.1
Huber, J.S.2
Frendo-Cumbo, S.3
Simpson, J.A.4
Wright, D.C.5
-
31
-
-
84883412703
-
Continuation of exercise is necessary to inhibit high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice
-
Maesako M, Uemura K, Iwata A, Kubota M, Watanabe K, Uemura M, Noda Y, Asada-Utsugi M, Kihara T, Takahashi R, Shimohama S, Kinoshita A. Continuation of exercise is necessary to inhibit high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. PLoS One 8: e72796, 2013.
-
(2013)
PLoS One
, vol.8
, pp. e72796
-
-
Maesako, M.1
Uemura, K.2
Iwata, A.3
Kubota, M.4
Watanabe, K.5
Uemura, M.6
Noda, Y.7
Asada-Utsugi, M.8
Kihara, T.9
Takahashi, R.10
Shimohama, S.11
Kinoshita, A.12
-
32
-
-
85058205901
-
Environmental enrichment ameliorated high-fat diet-induced Abeta deposition and memory deficit in APP transgenic mice
-
e1011-1023
-
Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, Shimohama S, Kihara T, Kinoshita A. Environmental enrichment ameliorated high-fat diet-induced Abeta deposition and memory deficit in APP transgenic mice. Neurobiol Aging 33: 1011 e1011-1023, 2012.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 1011
-
-
Maesako, M.1
Uemura, K.2
Kubota, M.3
Kuzuya, A.4
Sasaki, K.5
Asada, M.6
Watanabe, K.7
Hayashida, N.8
Ihara, M.9
Ito, H.10
Shimohama, S.11
Kihara, T.12
Kinoshita, A.13
-
33
-
-
84863310264
-
Exercise is more effective than diet control in preventing high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice
-
Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Hayashida N, Asada-Utsugi M, Watanabe K, Uemura M, Kihara T, Takahashi R, Shimohama S, Kinoshita A. Exercise is more effective than diet control in preventing high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. J Biol Chem 287: 23024-23033, 2012.
-
(2012)
J Biol Chem
, vol.287
, pp. 23024-23033
-
-
Maesako, M.1
Uemura, K.2
Kubota, M.3
Kuzuya, A.4
Sasaki, K.5
Hayashida, N.6
Asada-Utsugi, M.7
Watanabe, K.8
Uemura, M.9
Kihara, T.10
Takahashi, R.11
Shimohama, S.12
Kinoshita, A.13
-
34
-
-
1342333003
-
Fasting-induced activation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus
-
Morikawa Y, Ueyama E, Senba E. Fasting-induced activation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus. J Neuroendocrinol 16: 105-112, 2004.
-
(2004)
J Neuroendocrinol
, vol.16
, pp. 105-112
-
-
Morikawa, Y.1
Ueyama, E.2
Senba, E.3
-
35
-
-
0035478618
-
Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand
-
Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, Davis RJ, Shirasaki Y, Greenberg ME. Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J Neurosci 21: 7551-7560, 2001.
-
(2001)
J Neurosci
, vol.21
, pp. 7551-7560
-
-
Morishima, Y.1
Gotoh, Y.2
Zieg, J.3
Barrett, T.4
Takano, H.5
Flavell, R.6
Davis, R.J.7
Shirasaki, Y.8
Greenberg, M.E.9
-
36
-
-
41049117459
-
Different effect of high fat diet and physical exercise in the hippocampal signaling
-
Muller AP, Cammarota M, Dietrich MO, Rotta LN, Portela LV, Souza DO, Izquierdo I, Bevilaqua LR, Perry ML. Different effect of high fat diet and physical exercise in the hippocampal signaling. Neurochem Res 33: 880-885, 2008.
-
(2008)
Neurochem Res
, vol.33
, pp. 880-885
-
-
Muller, A.P.1
Cammarota, M.2
Dietrich, M.O.3
Rotta, L.N.4
Portela, L.V.5
Souza, D.O.6
Izquierdo, I.7
Bevilaqua, L.R.8
Perry, M.L.9
-
37
-
-
70349451730
-
Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus
-
O'Callaghan RM, Griffin EW, Kelly AM. Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus. Hippocampus 19: 1019-1029, 2009.
-
(2009)
Hippocampus
, vol.19
, pp. 1019-1029
-
-
O'Callaghan, R.M.1
Griffin, E.W.2
Kelly, A.M.3
-
38
-
-
84889636990
-
Acute exercise induces a phenotypic switch in adipose tissue macrophage polarization in dietinduced obese rats
-
Oliveira AG, Araujo TG, Carvalho BM, Guadagnini D, Rocha GZ, Bagarolli RA, Carvalheira JB, Saad MJ. Acute exercise induces a phenotypic switch in adipose tissue macrophage polarization in dietinduced obese rats. Obesity (Silver Spring) 21: 2545-2556, 2013.
-
(2013)
Obesity (Silver Spring)
, vol.21
, pp. 2545-2556
-
-
Oliveira, A.G.1
Araujo, T.G.2
Carvalho, B.M.3
Guadagnini, D.4
Rocha, G.Z.5
Bagarolli, R.A.6
Carvalheira, J.B.7
Saad, M.J.8
-
39
-
-
84877306949
-
Reactive glia show increased immunoproteasome activity in Alzheimer's disease
-
Orre M, Kamphuis W, Dooves S, Kooijman L, Chan ET, Kirk CJ, Dimayuga Smith V, Koot S, Mamber C, Jansen AH, Ovaa H, Hol EM. Reactive glia show increased immunoproteasome activity in Alzheimer's disease. Brain 136: 1415-1431, 2013.
-
(2013)
Brain
, vol.136
, pp. 1415-1431
-
-
Orre, M.1
Kamphuis, W.2
Dooves, S.3
Kooijman, L.4
Chan, E.T.5
Kirk, C.J.6
Dimayuga Smith, V.7
Koot, S.8
Mamber, C.9
Jansen, A.H.10
Ovaa, H.11
Hol, E.M.12
-
40
-
-
0037031840
-
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
-
Park H, Kaushik VK, Constant S, Prentki M, Przybytkowski E, Ruderman NB, Saha AK. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem 277: 32571-32577, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 32571-32577
-
-
Park, H.1
Kaushik, V.K.2
Constant, S.3
Prentki, M.4
Przybytkowski, E.5
Ruderman, N.B.6
Saha, A.K.7
-
41
-
-
0038100358
-
Role of protein kinase B in Alzheimer's neurofibrillary pathology
-
Pei JJ, Khatoon S, An WL, Nordlinder M, Tanaka T, Braak H, Tsujio I, Takeda M, Alafuzoff I, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K. Role of protein kinase B in Alzheimer's neurofibrillary pathology. Acta Neuropathol 105: 381-392, 2003.
-
(2003)
Acta Neuropathol
, vol.105
, pp. 381-392
-
-
Pei, J.J.1
Khatoon, S.2
An, W.L.3
Nordlinder, M.4
Tanaka, T.5
Braak, H.6
Tsujio, I.7
Takeda, M.8
Alafuzoff, I.9
Winblad, B.10
Cowburn, R.F.11
Grundke-Iqbal, I.12
Iqbal, K.13
-
42
-
-
0033516947
-
Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation
-
Perry G, Roder H, Nunomura A, Takeda A, Friedlich AL, Zhu X, Raina AK, Holbrook N, Siedlak SL, Harris PL, Smith MA. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport 10: 2411-2415, 1999.
-
(1999)
Neuroreport
, vol.10
, pp. 2411-2415
-
-
Perry, G.1
Roder, H.2
Nunomura, A.3
Takeda, A.4
Friedlich, A.L.5
Zhu, X.6
Raina, A.K.7
Holbrook, N.8
Siedlak, S.L.9
Harris, P.L.10
Smith, M.A.11
-
43
-
-
84871882957
-
Protection against the synaptic targeting and toxicity of Alzheimer's-associated Abeta oligomers by insulin mimetic chiro-inositols
-
Pitt J, Thorner M, Brautigan D, Larner J, Klein WL. Protection against the synaptic targeting and toxicity of Alzheimer's-associated Abeta oligomers by insulin mimetic chiro-inositols. FASEB J 27: 199-207, 2013.
-
(2013)
FASEB J
, vol.27
, pp. 199-207
-
-
Pitt, J.1
Thorner, M.2
Brautigan, D.3
Larner, J.4
Klein, W.L.5
-
44
-
-
76849101075
-
Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders
-
Profenno LA, Porsteinsson AP, Faraone SV. Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry 67: 505-512, 2010.
-
(2010)
Biol Psychiatry
, vol.67
, pp. 505-512
-
-
Profenno, L.A.1
Porsteinsson, A.P.2
Faraone, S.V.3
-
45
-
-
0034067992
-
Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
-
Reynolds CH, Betts JC, Blackstock WP, Nebreda AR, Anderton BH. Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta. J Neurochem 74: 1587-1595, 2000.
-
(2000)
J Neurochem
, vol.74
, pp. 1587-1595
-
-
Reynolds, C.H.1
Betts, J.C.2
Blackstock, W.P.3
Nebreda, A.R.4
Anderton, B.H.5
-
46
-
-
2342558065
-
Akt activity in Alzheimer's disease and other neurodegenerative disorders
-
Rickle A, Bogdanovic N, Volkman I, Winblad B, Ravid R, Cowburn RF. Akt activity in Alzheimer's disease and other neurodegenerative disorders. Neuroreport 15: 955-959, 2004.
-
(2004)
Neuroreport
, vol.15
, pp. 955-959
-
-
Rickle, A.1
Bogdanovic, N.2
Volkman, I.3
Winblad, B.4
Ravid, R.5
Cowburn, R.F.6
-
47
-
-
77952865658
-
Reversible Ponceau staining as a loading control alternative to actin in Western blots
-
Romero-Calvo I, Ocon B, Martinez-Moya P, Suarez MD, Zarzuelo A, Martinez-Augustin O, de Medina FS. Reversible Ponceau staining as a loading control alternative to actin in Western blots. Anal Biochem 401: 318-320, 2010.
-
(2010)
Anal Biochem
, vol.401
, pp. 318-320
-
-
Romero-Calvo, I.1
Ocon, B.2
Martinez-Moya, P.3
Suarez, M.D.4
Zarzuelo, A.5
Martinez-Augustin, O.6
De Medina, F.S.7
-
48
-
-
64349115078
-
AMPK in the brain: Its roles in energy balance and neuroprotection
-
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S. AMPK in the brain: its roles in energy balance and neuroprotection. J Neurochem 109, Suppl 1: 17-23, 2009.
-
(2009)
J Neurochem
, vol.109
, pp. 17-23
-
-
Ronnett, G.V.1
Ramamurthy, S.2
Kleman, A.M.3
Landree, L.E.4
Aja, S.5
-
49
-
-
79960566233
-
AMP-activated protein kinase: A potential player in Alzheimer's disease
-
Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. AMP-activated protein kinase: a potential player in Alzheimer's disease. J Neurochem 118: 460-474, 2011.
-
(2011)
J Neurochem
, vol.118
, pp. 460-474
-
-
Salminen, A.1
Kaarniranta, K.2
Haapasalo, A.3
Soininen, H.4
Hiltunen, M.5
-
50
-
-
0036580703
-
Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition
-
Savage MJ, Lin YG, Ciallella JR, Flood DG, Scott RW. Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition. J Neurosci 22: 3376-3385, 2002.
-
(2002)
J Neurosci
, vol.22
, pp. 3376-3385
-
-
Savage, M.J.1
Lin, Y.G.2
Ciallella, J.R.3
Flood, D.G.4
Scott, R.W.5
-
52
-
-
5644239087
-
Alzheimer disease: Mechanistic understanding predicts novel therapies
-
Selkoe DJ. Alzheimer disease: mechanistic understanding predicts novel therapies. Ann Intern Med 140: 627-638, 2004.
-
(2004)
Ann Intern Med
, vol.140
, pp. 627-638
-
-
Selkoe, D.J.1
-
53
-
-
0034727889
-
JNK activation is associated with intracellular beta-amyloid accumulation
-
Shoji M, Iwakami N, Takeuchi S, Waragai M, Suzuki M, Kanazawa I, Lippa CF, Ono S, Okazawa H. JNK activation is associated with intracellular beta-amyloid accumulation. Brain Res Mol Brain Res 85: 221-233, 2000.
-
(2000)
Brain Res Mol Brain Res
, vol.85
, pp. 221-233
-
-
Shoji, M.1
Iwakami, N.2
Takeuchi, S.3
Waragai, M.4
Suzuki, M.5
Kanazawa, I.6
Lippa, C.F.7
Ono, S.8
Okazawa, H.9
-
54
-
-
0030499745
-
Energy metabolism, oxidative stress and neuronal degeneration in Alzheimer's disease
-
Sims NR. Energy metabolism, oxidative stress and neuronal degeneration in Alzheimer's disease. Neurodegeneration 5: 435-440, 1996.
-
(1996)
Neurodegeneration
, vol.5
, pp. 435-440
-
-
Sims, N.R.1
-
55
-
-
0022186670
-
Measurement of protein using bicinchoninic acid
-
Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85, 1985.
-
(1985)
Anal Biochem
, vol.150
, pp. 76-85
-
-
Smith, P.K.1
Krohn, R.I.2
Hermanson, G.T.3
Mallia, A.K.4
Gartner, F.H.5
Provenzano, M.D.6
Fujimoto, E.K.7
Goeke, N.M.8
Olson, B.J.9
Klenk, D.C.10
-
56
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes?
-
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes? J Alzheimer's Dis 7: 63-80, 2005.
-
(2005)
J Alzheimer's Dis
, vol.7
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
De La Monte, S.M.9
-
57
-
-
2942589223
-
Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain
-
Swatton JE, Sellers LA, Faull RL, Holland A, Iritani S, Bahn S. Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain. Eur J Neurosci 19: 2711-2719, 2004.
-
(2004)
Eur J Neurosci
, vol.19
, pp. 2711-2719
-
-
Swatton, J.E.1
Sellers, L.A.2
Faull, R.L.3
Holland, A.4
Iritani, S.5
Bahn, S.6
-
58
-
-
79952135798
-
AMPactivated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure
-
Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D. AMPactivated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure. Biochem J 434: 503-512, 2011.
-
(2011)
Biochem J
, vol.434
, pp. 503-512
-
-
Thornton, C.1
Bright, N.J.2
Sastre, M.3
Muckett, P.J.4
Carling, D.5
-
59
-
-
79952135316
-
AMPK is abnormally activated in tangle-and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies
-
Vingtdeux V, Davies P, Dickson DW, Marambaud P. AMPK is abnormally activated in tangle-and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol 121: 337-349, 2011.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 337-349
-
-
Vingtdeux, V.1
Davies, P.2
Dickson, D.W.3
Marambaud, P.4
-
60
-
-
0030006438
-
Exercise-induced changes in local cerebral glucose utilization in the rat
-
Vissing J, Andersen M, Diemer NH. Exercise-induced changes in local cerebral glucose utilization in the rat. J Cereb Blood Flow Metab 16: 729-736, 1996.
-
(1996)
J Cereb Blood Flow Metab
, vol.16
, pp. 729-736
-
-
Vissing, J.1
Andersen, M.2
Diemer, N.H.3
-
61
-
-
84864210982
-
IL-6 indirectly modulates the induction of glyceroneogenic enzymes in adipose tissue during exercise
-
Wan Z, Ritchie I, Beaudoin MS, Castellani L, Chan CB, Wright DC. IL-6 indirectly modulates the induction of glyceroneogenic enzymes in adipose tissue during exercise. PLoS One 7: e41719, 2012.
-
(2012)
PLoS One
, vol.7
, pp. e41719
-
-
Wan, Z.1
Ritchie, I.2
Beaudoin, M.S.3
Castellani, L.4
Chan, C.B.5
Wright, D.C.6
-
62
-
-
84872551783
-
-
Wang JZ, Xia YY, Grundke-Iqbal I, Iqbal K. Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. J Alzheimer's Dis 33, Suppl 1: S123-139, 2013.
-
(2013)
Abnormal hyperphosphorylation of tau: Sites, regulation, and molecular mechanism of neurofibrillary degeneration. J Alzheimer's Dis
, vol.33
, pp. S123-139
-
-
Wang, J.Z.1
Xia, Y.Y.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
63
-
-
34548301663
-
Cellular energy sensing and signaling by AMP-activated protein kinase
-
Winder WW, Thomson DM. Cellular energy sensing and signaling by AMP-activated protein kinase. Cell Biochem Biophys 47: 332-347, 2007.
-
(2007)
Cell Biochem Biophys
, vol.47
, pp. 332-347
-
-
Winder, W.W.1
Thomson, D.M.2
|