Exercise and physical activity: Clinical outcomes and applications

Circulation

Volumn 122, Issue 16, 2010, Pages 1637-1648

  Kokkinos, Peter ^a,b   Myers, Jonathan ^c,d  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; BLOOD CLOTTING FACTOR 8; C REACTIVE PROTEIN; CHOLESTEROL; GLUCOSE TRANSPORTER 4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; VON WILLEBRAND FACTOR;

AEROBIC EXERCISE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; DIABETES MELLITUS; ENERGY EXPENDITURE; ESSENTIAL HYPERTENSION; EXERCISE; EXERCISE INTENSITY; FITNESS; FOLLOW UP; HEART LEFT VENTRICLE HYPERTROPHY; HEART REHABILITATION; HEREDITY; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; LEISURE; LIFESTYLE MODIFICATION; METABOLIC SYNDROME X; MORTALITY; OBESITY; PHYSICAL ACTIVITY; PRESCRIPTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESISTANCE TRAINING; REVIEW; SURVIVAL; THROMBOSIS; TREADMILL EXERCISE; TREATMENT OUTCOME; WEIGHT LIFTING; WEIGHT REDUCTION; CARDIOVASCULAR DISEASE; FEMALE; MALE; MOTOR ACTIVITY; PHYSIOLOGY; RISK FACTOR; UNITED STATES;

CARDIOVASCULAR DISEASES; EXERCISE; FEMALE; HUMANS; LEISURE ACTIVITIES; MALE; MOTOR ACTIVITY; PHYSICAL FITNESS; RISK FACTORS; UNITED STATES;

EID: 78049510856     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.948349     Document Type: Review

References (136)

1. Morris JN, Heady JA, Raffle PA, Roberts CG, Parks JW. Coronary heartdisease and physical activity of work. Lancet. 1953;265:1111-1120.
2. Kokkinos P, Myers J, Kokkinos JP, Pittaras A, Narayan P, Manolis A, Karasik P, Greenberg M, Papademetriou V, Singh S. Exercise capacity and mortality in black and white men. Circulation. 2008;117:614-622.
3. Blair SN, Kohl HW III, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality: a prospective study of healthy men and women. JAMA. 1989;262:2395-2401.
4. Blair SN, Kampert JB, Kohl HW III, Barlow CE, Macera CA, Paffenbarger RS Jr, Gibbons LW. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA. 1996;276:205-210.
5. Blair SN, Kohl HW III, Barlow CE, Paffenbarger RS Jr, Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality: a prospective study of healthy and unhealthy men. JAMA. 1995;273:1093-1098.
6. Manson JE, Greenland P, LaCroix AZ, Stefanick ML, Mouton CP, Oberman A, Perri MG, Sheps DS, Pettinger MB, Siscovick DS. Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med. 2002;347:716-725.
7. Manson JE, Hu FB, Rich-Edwards JW, Stefanick ML, Mouton CP, Oberman A, Perri MG, Sheps DS, Pettinger MB, Siscovick DS. A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. N Engl J Med. 1999;341:650-658.
8. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793-801.
9. Paffenbarger RS Jr, Hyde RT, Wing AL, Lee IM, Jung DL, Kampert JB. The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med. 1993;328:538-545.
10. Mora S, Cook N, Buring JE, Ridker PM, Lee IM. Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms. Circulation. 2007;116:2110-2118.
11. Kujala UM, Kaprio J, Sarna S, Koskenvuo M. Relationship of leisure-time physical activity and mortality: the Finnish twin cohort. JAMA. 1998;279:440-444.
12. Myers JN, Kaykha A, George S, Abella J, Zaheer N, Lear S, Yamazaki T, Froelicher VF. Fitness versus physical activity patterns in predicting mortality in men. Am J Med. 2004;117:912-918.
13. Mora S, Redberg RF, Cui Y, Whiteman MK, Flaws JA, Sharrett AR, Blumenthal RS. Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: a 20-year follow-up of the lipid research clinics prevalence study. JAMA. 2003;290:1600-1607.
14. Gulati M, Pandey DK, Arnsdorf MF, Arnsdorf MF, Lauderdale DS, Thisted RA, Wicklund RH, Al-Hani AJ, Black HR. Exercise capacity and the risk of death in women: the St James Women Take Heart Project. Circulation. 2003;108:1554-1259.
15. Kushi LH, Fee RM, Folsom AR, Mink PJ, Anderson KE, Sellers TA. Physical activity and mortality in postmenopausal women. JAMA. 1997;277:1287-1292.
16. Manson JE, Greenland P, La Croix AZ, Stefanick ML, Mouton CP, Oberman A, Perri MG, Sheps DS, Pettinger MB, Siscovick DS. Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med. 2002;347:716-725.
17. Gregg EW, Cauley JA, Stone K, Thompson TJ, Bauer DC, Cummings SR, Ensrud KE. Relationship of changes in physical activity and mortality among older women. JAMA. 2003;289:2379-2386.
18. Balady GJ, Larson MG, Vasan RS, Leip EP, O'Donnell CJ, Levy D. Usefulness of exercise testing in the prediction of coronary disease risk among asymptomatic persons as a function of the Framingham risk score. Circulation. 2004;110:1920-1925.
19. Dorn J, Naujton J, Imamura D, Trevisan M. Results of a multicenter randomized clinical trial of exercise and long-term survival in myocardial infarction patients: the National Exercise and Heart Disease Project (NEHDP). Circulation. 1999;100:1764-1769.
20. Goraya TY, Pellikka PA, Miller TD, Khan A, Weston SA, Gersh BJ, Roger VL. Prognostic value of treadmill exercise testing in elderly persons. Ann Intern Med. 2000;132:862-870.
21. Paffenbarger RS Jr, Wing AL, Hyde RT. Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol. 1978;108:161-175.
22. Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med. 1986;314:605-613.
23. Tanasescu M. Leitzmann MF, Rimm EB, Willett WC, Stampfer MJ, Hu FB. Exercise type and intensity in relation to coronary heart disease in men. JAMA. 2002;288:1994-2000.
24. Powell KE, Thompson PD, Caspersen CJ, Kendrick JS. Physical activity and the incidence of coronary heart disease. Annu Rev Public Health. 1987;8:253-287.
25. Lee IM, Skerrett PJ. Physical activity and all-cause mortality: what is the dose-response relation? Med Sci Sports Exerc. 2001;33:S459-S471.
26. Myers JN. Exercise and fitness. In: Perk J, Mathes P, eds. Cardiovascular Prevention and Rehabilitation. London, UK: Springer; 2007:77-87.
27. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116:1081-1093.
28. Morris JN. Exercise in the prevention of coronary heart disease: today's best buy in public health. Med Sci Sports Exerc. 1994;26:807-814.
29. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 Report. Hypertension. 2003;42:1206-1252.
30. Vasan RS, Larson MG, Leip EP, Kannel WB, Levy D. Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet. 2001;358:1682-1686.
31. World Health Organization. World Health Report 2002: reducing risks, promoting healthy life. World Health Organization; 2002:57.
32. Grimm RH Jr, Grandits GA, Cutler JA, Stewart AL, McDonald RH, Svendsen K, Prineas RJ, Liebson PR. Relationships of quality-of-life measures to long-term lifestyle and drug treatment in the Treatment of Mild Hypertension Study. Arch Intern Med. 1997;157:638-648.
33. Fagard RH. Exercise characteristics and the blood pressure response to dynamic physical training. Med Sci Sports Exerc. 2001;33:S484-S492.
34. Cornelissen VA, Fagard RH. Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension. 2005;46:667-675.
35. Pescatello LS, Franklin B, Fagard R, Farquhar WB, Kelley GA, Ray CA. American College of Sports Medicine position stand: exercise and hypertension. Med Sci Sports Exerc. 2004;36:533-553.
36. Kokkinos P, Narayan P, Papademetriou V. Exercise as hypertension therapy. Cardiol Clin. 2001;19:507-516.
37. Motoyama M, Sunami Y, Kinoshita F, Kiyonaga A, Tanaka H, Shindo M, Irie T, Urata H, Sasaki J, Arakawa K. Blood pressure lowering effect of low intensity aerobic training in elderly hypertensive patients. Med Sci Sports Exerc. 1998;30:818-823.
38. Ishikawa K, Ohta T, Zhang J, Hashimoto S, Tanaka H. Influence of age and gender on exercise training-induced blood pressure reduction in systemic hypertension. Am J Cardiol. 1999;84:192-196.
39. Kokkinos PF, Narayan P, Colleran J, Pittaras A, Notargiacomo A, Reda D, Papademetriou V. Effects of regular exercise on blood pressure and left ventricular hypertrophy in African-American men with severe hypertension. N Engl J Med. 1995;333:1462-1467.
40. Kokkinos P, Pittaras A, Manolis A, Panagiotakos D, Narayan P, Manjoros D, Amdur RL, Singh S. Exercise capacity and 24-hr blood pressure in pre-hypertensive men and women. Am J Hypertens. 2006;19:251-258.
41. Guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2007;28:1462-1536.
42. Hagberg JM, Montain SJ, Martin WH, Ehsani AA. Effect of exercise training in 60-to 69-year-old persons with essential hypertension. Am J Cardiol. 1989;64:348-353.
43. Rogers MW, Probst MM, Gruber JJ, Berger R, Boone JB. Differential effects of exercise training intensity on blood pressure and cardiovascular responses to stress in borderline hypertensive humans. J Hypertens. 1996;14:1399-1375.
44. Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med. 2002;136:493-502.
45. Kokkinos P, Pittaras A, Narayan P, Faselis C, Singh S, Manolis A. Exercise capacity and blood pressure associations with left ventricular mass in prehypertensive individuals. Hypertension. 2007;49:55-61.
46. Kokkinos PF, Narayan P, Fletcher RD, Tsagadopoulos D, Papademetriou V. Effects of aerobic training on exaggerated blood pressure response to exercise in African-Americans with hypertension treated with indapamide, verapamil and enalapril. Am J Cardiol. 1997;79:1424-1426.
47. Palatini P, Mos L, Munari L, Valle F, Del Torre M, Rossi A, Varotto L, Macor F, Martina S, Pessina AC. Blood pressure changes during heavyresistance exercise. J Hypertens. 1989;7:S72-S73.
48. Hurley BF, Roth SM. Strength training in elderly: effects on risk factors for age-related diseases. Sports Med. 2000;4:249-268.
49. Kelly GA, Kelly KS. Progressive resistance exercise and resting blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2000;35:838-843.
50. Nelson ME, Rejeski WJ, Blair SN, Duncan PW, Judge JO, King AC, Macera CA, Castaneda-Sceppa C. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116:1094-1105.
51. Williams MA, Haskell WL, Ades PA, Amsterdam EA, Bittner V, Franklin BA, Gulanick M, Laing ST, Stewart KJ. Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a Scientific Statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2007;116:572-584.
52. Blair SN, Kohl HW, Barlow CE, Gibbons LW. Physical fitness and all-cause mortality in hypertensive men. Ann Med. 1991;23:307-312.
53. Kokkinos P, Manolis A, Pittaras A, Doumas M, Giannelou A, Panagiotakos DB, Faselis C, Narayan P, Singh S, Myers J. Exercise capacity and mortality in hypertensive men with and without additional risk factors. Hypertension. 2009;53:494-499.
54. Kokkinos P, Myers J, Doumas M, Faselis C, Manolis A, Pittaras A, Kokkinos JP, Singh S, Fletcher RD. Exercise capacity and all-cause mortality in prehypertensive men. Am J Hypertens. 2009;22:735-741.
55. Shepherd PR, Kahn BB. Glucose transporters and insulin action: implications for insulin resistance and diabetes mellitus. N Engl J Med. 1999;341:248-257.
56. Smutok MA, Reece C, Kokkinos PF, Farmer C, Dawson P, Shulman R, DeVane-Bell J, Patterson J, Charabogos C, Goldberg AP, Hurley BF. Aerobic versus strength training for risk factor intervention in middle-aged men at high risk for coronary heart disease. Metabolism. 1993;42:177-184.
57. Miller JP, Pratley RE, Goldberg AP, Rubin M, Treuth MS, Ryan AS, Hurley BF. Strength training increases insulin action in healthy 50-to 65-yr-old men. J Appl Physiol. 1994;77:1122-1127.
58. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med. 1991;325:147-152.
59. Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, Hennekens CH. A prospective study of exercise and incidence of diabetes among US male physicians. JAMA. 1992;268:63-67.
60. Hu FB, Sigal RJ, Rich-Edwards JW, Colditz GA, Solomon CG, Willett WC, Speizer FE, Manson JE. Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA. 1999;282:1433-1439.
61. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344:1343-1350.
62. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403.
63. Wei M, Gibbons LW, Kampert JB, Nichaman NZ, Blair SN. Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann Intern Med. 2000;132:605-611.
64. Hu FB, Stampfer MJ, Solomon C, Colditz GA, Speizer FE, Willett WC, Manson JE. Physical activity and risk for cardiovascular events in diabetic women. Ann Intern Med. 2001;134:96-105.
65. Church TS, LaMonte MJ, Barlow CE, Blair SN. Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. Arch Intern Med. 2005;165:2114-2120.
66. Ness J, Nassimiha D, Feria MI, Aronow WS. Diabetes in older African-Americans, Hispanics, and whites in an academic hospital-based geriatrics practice. Coronary Artery Dis. 1999;10:343-346.
67. National Center for Health Statistics. Health, United States, 2006 with chart book on trends in the health of Americans. Hyattsville, Md: US Department of Health and Human Services, CDC, National Center for Health Statistics; 2006. Available at: http://www.cdc.gov/nchs/data/hus/hus06.pdf. Accessed March 12, 2010.
68. Kokkinos P, Myers J, Nylen E, Panagiotakos D, Manolis A, Pittaras A, Blackman M, Jocob-Issac R, Faselis C, Abella J, Singh S. Exercise capacity and all-cause mortality in African American and Caucasian men with type 2 diabetes. Diabetes Care. 2009;32:623-628.
69. Kokkinos PF, Fernhall B. Physical activity and high density lipoprotein cholesterol levels: what is the relationship? Sports Med. 1999;28:307-314.
70. Durstine JL, Haskell WL. Effects of exercise training on plasma lipids and lipoproteins. In: Holloszy JO, ed. Exercise and Sports Science Reviews. Baltimore, Md: Williams & Wilkins; 1994;22:477-521.
71. Leon AS, Sanchez OA. Response of blood lipids to exercise training alone or combined with dietary intervention. Med Sci Sports Exerc. 2001;33:S502-S515.
72. Stefanick ML, Mackey S, Sheehan M, Ellsworth N, Haskell WL, Wood PD. Effects of diet and exercise in men and postmenopausal women with low levels of HDL cholesterol and high levels of LDL cholesterol. N Engl J Med. 1998;339:12-20.
73. Wood PD, Stefanick ML, Williams PT, Haskell WL. The effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women. N Engl J Med. 1991;325:461-466.
74. Mattson FH, Grundy SM. Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J Lipid Res. 1985;26:194-202.
75. Brinton EA, Eisenberg S, Breslow JL. A low-fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates. J Clin Invest. 1990;85:144-151.
76. Leon AS, Rice T, Mandel S, Despres JP, Bergeron J, Gagnon J, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Blood lipid response to 20 weeks of supervised exercise in a large biracial population: the HERITAGE Family Study. Metabolism. 2000;49:513-520.
77. Kokkinos PF, Holland JC, Pittaras AE, Narayan P, Dotson CO, Papademetriou V. Cardiorespiratory fitness and coronary heart disease risk factor association in women. J Am Coll Cardiol. 1995;26:358-364.
78. Lindheim SR, Notelovitz M, Feldman EB, Larsen S, Khan FY, Lobo RA. The independent effects of exercise and estrogen on lipids and lipoproteins in postmenopausal women. Obstet Gynecol. 1994;83:167-172.
79. Binder EF, Birge SJ, Kohrt WM. Effects of endurance exercise and hormone replacement therapy on serum lipids in older women. J Am Geriatr Soc. 1996;44:231-236.
80. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, Bales CW, Henes S, Samsa GP, Otvos JD, Kulkarni KR, Slentz CA. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med. 2002;347:1483-1492.
81. Drygas W, Jegler A, Kunski H. Study on threshold dose of physical activity in coronary heart disease prevention, part I: relationship between leisure time physical activity and coronary risk factors. Int J Sports Med. 1988;9:275-278.
82. Kokkinos PF, Holland JC, Narayan P, Colleran JA, Dotson CO, Papademetriou V. Miles run per week and high-density lipoprotein cholesterol levels in healthy, middle-aged men: a dose-response relationship. Arch Intern Med. 1995;155:414-420.
83. Wood PD, Haskell WL, Blair SN, Williams PT, Krauss RM, Lindgren FT, Albers JJ, Ho PH, Farquhar JW. Increased exercise level and plasma lipoprotein concentrations: a one-year, randomized, controlled study in sedentary, middle-aged men. Metabolism. 1983;32:31-39.
84. Williams PT, Wood PD, Haskell WL, Vranizan K. The effects of running mileage and duration on plasma lipoprotein levels. JAMA. 1982;247:2674-2679.
85. Williams PT. Interactive effects of exercise, alcohol, and vegetarian diet on coronary artery disease risk factors in 9242 runners: the National Runners' Health Study. Am J Clin Nutr. 1997;66:1197-1206.
86. Williams PT. High density lipoprotein cholesterol and other risk factors for coronary heart disease in female runners. N Engl J Med. 1996;334:1298-1303.
87. King GA, Fitzhugh EC, Bassett DR, McLaughlin JE, Strath SJ, Swartz AM, Thompson DL. Relationship of leisure-time physical activity and occupational activity to the prevalence of obesity. Int J Obes Relat Metab Disord. 2001;25:606-612.
88. Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger RS Jr, Blair SN. Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA. 1999;282:1547-1553.
89. Sui X, LaMonte MJ, Laditka JN, Hardin JW, Chase N, Hooker SP, Blair SN. Cardiorespiratory fitness and adiposity as mortality predictors in older adults. JAMA. 2007;298:2507-2516.
90. Hu FB, Willett CW, Li T, Stampfer MJ, Colditz GA, Manson JE. Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med. 2004;351:2694-2703.
91. Li TY, Rana JS, Manson JE, Willett WC, Stamfer MJ, Colditz GA, Rexrode KM, Hu FB. Obesity as compared with physical inactivity in predicting risk of coronary heart disease risk in women. Circulation. 2006;113:499-506.
92. LaMonte M, Blair SN. Physical activity, cardiorespiratory fitness, and adiposity: contributions to disease risk. Curr Opin Clin Nutr Metabolic Care. 2006;9:540-546.
93. Katzmarzyk PT, Janssen I, Ardern CI. Physical inactivity, excess adiposity, and premature mortality. Obes Rev. 2003;4:257-290.
94. Audelin MC, Savage PD, Ades PA. Changing clinical profile of patients entering cardiac rehabilitation/secondary prevention programs: 1996 to 2006. J Cardiopulm Rehabil Prev. 2008;28:299-306.
95. Ades PA, Savage PD, Toth MJ, Harvey-Berino J, Schneider DJ, Bunn JY, Audelin MC, Ludlow M. High calorie-expenditure exercise: a new approach to cardiac rehabilitation for overweight coronary patients. Circulation. 2009;119:2671-2678.
96. Oreopoulos A, Padwal R, Kalanter-Zadeh K, Fonarow GC, Norris CM, McAlister FA. Body mass index and mortality in heart failure: a metaanalysis. Am Heart J. 2008;156:13-22.
97. Ades PA. The obesity paradox: perception vs knowledge. Mayo Clin Proc. 2010;85:112-114.
98. McAuley PA, Kokkinos PF, Oliveira RB, Emerson BT, Myers JN. Obesity paradox and cardiorespiratory fitness in 12, 417 male veteran patients aged 40 to 70. Mayo Clin Proc. 2010;85:115-121.
99. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KJ, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies, part I. Circulation. 2003;108:1664-1672.
100. Yeh ET, Willerson JT. Coming of age of C-reactive protein: using inflammation markers in cardiology. Circulation. 2003;107:370-371.
101. Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003;107:363-369.
102. Ridker PM, Glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation. 1998;97:2007-2011.
103. Albert CM, Ma J, Rifai N, Stampfer MJ, Ridker PM. Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation. 2002;105:2595-2599.
104. Aronson D, Sella R, Sheikh-Ahmad M, Kerner A, Avizohar O, Rispler S, Bartha P, Markiewicz W, Levy Y, Brook GJ. The association between cardiorespiratory fitness and C-reactive protein in subjects with the metabolic syndrome. J Am Coll Cardiol. 2004;44:2003-2007.
105. McGavock JM, Mandic S, Vonder Muhll I, Lewanczuk RZ, Quinney HA, Taylor DA, Welsh RC, Haykowsky M. Low cardiorespiratory fitness is associated with elevated C-reactive protein levels in women with type 2 diabetes. Diabetes Care. 2004;7:320-325.
106. Church TS, Barlow CE, Earnest CP, Kampert JB, Priest EL, Blair SN. Associations between cardiorespiratory fitness and C-reactive protein in men. Arterioscler Thromb Vasc Biol. 2002;22:1869-1876.
107. Ichihara Y, Ohno J, Suzuki M, Anno T, Sugino M, Nagata K. Higher C-reactive protein concentration and white blood cell count in subjects with more coronary risk factors and/or lower physical fitness among apparently healthy Japanese. Circ J. 2002;66:677-684.
108. Mark DB, Lauer MS. Exercise capacity: the prognostic variable that doesn't get enough respect. Circulation. 2003;108:1534-1536.
109. Mattusch F, Dufaux B, Heine O, Mertens I, Rost R. Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int J Sports Med. 2000;21:21-24.
110. Abramson JL, Vaccarino V. Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults. Arch Intern Med. 2002;162:1286-1292.
111. Ford ES. Does exercise reduce inflammation? Physical activity and C-reactive protein among US adults. Epidemiology. 2002;13:561-568.
112. Milani RV, Lavie CJ, Mehra MR. Reduction in C-reactive protein through cardiac rehabilitation and exercise training. J Am Coll Cardiol. 2004;43:1056-1061.
113. King DE, Carek P, Mainous AG III, Pearson WS. Inflammatory markers and exercise: differences related to exercise type. Med Sci Sports Exerc. 2003;35:575-581.
114. Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, Pahor M, Taaffe DR, Brach J, Rubin S, Harris TB. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2004;52:1098-1104.
115. Barinas-Mitchell E, Cushman M, Meilahn EN, Tracy RP, Kuller LH. Serum levels of C-reactive protein are associated with obesity, weight gain, and hormone replacement therapy in healthy postmenopausal women. Am J Epidemiol. 2001;153:1094-1101.
116. Festa A, D'Agostino R Jr, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 2000;102:42-47.
117. Verma S, Buchanan MR, Anderson TJ. Endothelial function testing as a biomarker of vascular disease. Circulation. 2003;108:2054-2059.
118. El-Sayed MS, Ali N, El-Sayed Ali Z. Aggregation and activation of blood platelets in exercise and training. Sports Med. 2005;35:11-22.
119. Womack CJ, Nagelkirk PR, Coughlin AM. Exercise-induced changes in coagulation and fibrinolysis in healthy populations and patients with cardiovascular disease. Sports Med. 2003;33:795-807.
120. Hyers TM, Martin BJ, Pratt DS, Dreisin RB, Franks JJ. Enhanced thrombin and plasmin activity with exercise in man. J Appl Physiol. 1980;48:821-825.
121. Prisco D, Francalanci I, Filippini M, Hagi MI. Physical exercise and hemostasis. Int J Clin Lab Res. 1994;24:125-131.
122. Prisco D, Paniccia R, Bandinelli B, Fedi S, Cellai AP, Liotta AA, Gatteschi L, Giusti B, Colella A, Abbate R, Gensini GF. Evaluation of clotting and fibrinolytic activation after protracted physical exercise. Thromb Res. 1998;89:73-78.
123. Connelly JB, Cooper JA, Meade TW. Strenuous exercise, plasma fibrinogen, and factor VII activity. Br Heart J. 1992;67:351-354.
124. Wang JS, Li YS, Chen JC, Chen YW. Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men. Arterioscler Thromb Vasc Biol. 2005;25:454-560.
125. Wang JS, Jen CJ, Chen HI. Effects of exercise training and deconditioning on platelet function in men. Arterioscler Thromb Vasc Biol. 1995;15:1668-1674.
126. Wang JS, Jen CJ, Chen HI. Effects of chronic exercise and deconditioning on platelet function in women. J Appl Physiol. 1997;83:2080-2085.
127. Lockard MM, Gopinathannair R, Paton CM, Phares DA, Hagberg JM. Exercise training-induced changes in coagulation factors in older adults. Med Sci Sports Exerc. 2007;39:587-592.
128. Rauramaa R, Salonen JT, Seppänen K, Salonen R, Venäläinen JM, Ihanainen M, Rissanen V. Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men. Circulation. 1986;74:939-944.
129. Wannamethee SG, Lowe GD, Whincup PH, Rumley A, Walker M, Lennon L. Physical activity and hemostatic and inflammatory variables in elderly men. Circulation. 2002;105:1785-1790.
130. Rankinen T, Rauramaa R, Vaisanen S, Penttila IM, Uusitupa M. Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors. Thromb Haemost. 1994;71:180-183.
131. Rauramaa R, Vaisanen SB, Kuhanen R, Penttila I, Bouchard C. The Rsal polymorphism in the alpha-fibrinogen gene and response of plasma fibrinogen to physical training: a controlled randomized clinical trial in men. Thromb Haeost. 2000;83:803-806.
132. Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol. 2007;102:1439-1447.
133. Nemoto K, Gen-no H, Masuki S, Okazaki K, Nose H. Effects of highintensity interval walking training on physical fitness and blood pressure in middle-aged and older people. Mayo Clin Proc. 2007;82:803-811.
134. Haram PM, Kemi OJ, Lee SJ, Bendheim MO, Al-Share QY, Waldum HL, Gilligan LJ, Koch LG, Britton SL, Najjar SM, Wisloff U. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovasc Res. 2009;81:723-732.
135. Gibala MJ, Little JP, van Essen M, Wilkin GP, Burgomaster KA, Safdar A, Raha S, Tarnopolsky MA. Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. J Physiol. 2006;575:901-911.
136. Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, Tjonna AE, Helgerud J, Slordahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen O, Skjaerpe T. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115:3086-3094.