Oxidant-induced corticosteroid unresponsiveness in human bronchial epithelial cells

Thorax

Volumn 69, Issue 1, 2014, Pages 5-13

  Heijink, Irene ^a   Van Oosterhout, Antoon ^a   Kliphuis, Nathalie ^a   Jonker, Marnix ^a   Hoffmann, Roland ^a   Telenga, Eef ^a   Klooster, Karin ^a   Slebos, Dirk Jan ^a   Ten Hacken, Nick ^a   Postma, Dirkje ^a   Van Den Berge, Maarten ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CIGARETTE SMOKE; EPIDERMAL GROWTH FACTOR RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYDROGEN PEROXIDE; INTERLEUKIN 8;

ADULT; AGED; ARTICLE; ASTHMA; CELL DEATH; CELL FUNCTION; CELL MEMBRANE RESISTANCE; CELL STIMULATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORTICOSTEROID UNRESPONSIVENESS; DRUG RESISTANCE; DRUG RESPONSE; DRUG SENSITIVITY; ELECTRIC RESISTANCE; EPITHELIAL BARRIER DYSFUNCTION; EPITHELIAL BARRIER FUNCTION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MIDDLE AGED; OXIDATIVE STRESS; PREMEDICATION; PRIMARY BRONCHIAL EPITHELIAL CELL; PRIORITY JOURNAL; SMOKING; YOUNG ADULT;

AIRWAY EPITHELIUM; ASTHMA; COPD PHARMACOLOGY; GM-CSF; OXIDATIVE STRESS;

ADULT; ASTHMA; BRONCHI; BUDESONIDE; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; GLUCOCORTICOIDS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; OXIDATIVE STRESS; PHOSPHORYLATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING;

EID: 84890290436     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2013-203520     Document Type: Article

References (35)

1. Broekema M, Ten Hacken NH, Volbeda F, et al. Airway epithelial changes in smokers but not in ex-smokers with asthma. Am J Respir Crit Care Med 2009;180:1170-8.
2. Godtfredsen NS, Lange P, Prescott E, et al. Changes in smoking habits and risk of asthma: a longitudinal population based study. Eur Respir J 2001;18:549-54.
3. Hackett TL, Singhera GK, Shaheen F, et al. Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to RSV and air pollution. Am J Respir Cell Mol Biol 2011;45:1090-100.
4. Heijink IH, Brandenburg SM, Postma DS, et al. Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery. Eur Respir J 2012;39:419-28.
5. Tam A, Wadsworth S, Dorscheid D, et al. The airway epithelium: more than just a structural barrier. Ther Adv Respir Dis 2011;5:255-73.
6. Nawijn MC, Hackett TL, Postma DS, et al. E-cadherin: gatekeeper of airway mucosa and allergic sensitization. Trends Immunol 2011;32:248-55.
7. Shaykhiev R, Otaki F, Bonsu P, et al. Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo. Cell Mol Life Sci 2011;68:877-92.
8. Xiao C, Puddicombe SM, Field S, et al. Defective epithelial barrier function in asthma. J Allergy Clin Immunol 2011;128:549-56.
9. van der TM, Rezayat D, Kauffman HF, et al. Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009;297:L109-14.
10. Calhoun WJ, Reed HE, Moest DR, et al. Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjects. Am Rev Respir Dis 1992;145:317-25.
11. Brussino L, Badiu I, Sciascia S, et al. Oxidative stress and airway inflammation after allergen challenge evaluated by exhaled breath condensate analysis. Clin Exp Allergy 2010;40:1642-7.
12. Postma DS, Renkema TE, Noordhoek JA, et al. Association between non-specific bronchial hyperreactivity and superoxide anion production by polymorphonuclear leukocytes in chronic air-flow obstruction. Am Rev Respir Dis 1988;137:57-61.
13. Chalmers GW, MacLeod KJ, Thomson L, et al. Smoking and airway inflammation in patients with mild asthma. Chest 2001;120:1917-22.
14. Barnes PJ, Ito K, Adcock IM. Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet 2004;363:731-3.
15. Thomson NC, Chaudhuri R, Livingston E. Asthma and cigarette smoking. Eur Respir J 2004;24:822-33.
16. Wadsworth SJ, Nijmeh HS, Hall IP. Glucocorticoids increase repair potential in a novel in vitro human airway epithelial wounding model. J Clin Immunol 2006;26:376-87.
17. Ma C, Martins-Green M. Second-hand cigarette smoke inhibits wound healing of the cornea by stimulating inflammation that delays corneal reepithelialization. Wound Repair Regen 2009;17:387-96.
18. Heijink IH, Kies PM, Kauffman HF, et al. Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity. J Immunol 2007;178:7678-85.
19. Heijink IH, Postma DS, Noordhoek JA, et al. House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium. Am J Respir Cell Mol Biol 2010;42:69-79.
20. Zijlstra GJ, Ten Hacken NH, Hoffmann RF, et al. Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells. Eur Respir J 2012;39:439-45.
21. Heijink IH, van OA, Kapus A. EGFR signaling contributes to house dust mite-induced epithelial barrier dysfunction. Eur Respir J 2010;36:1016-26.
22. Slebos DJ, Ryter SW, van der TM, et al. Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death. Am J Respir Cell Mol Biol 2007;36:409-17.
23. Konno S, Gonokami Y, Kurokawa M, et al. Cytokine concentrations in sputum of asthmatic patients. Int Arch Allergy Immunol 1996;109:73-8.
24. Thomas PS. Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma. Immunol Cell Biol 2001;79:132-40.
25. Keatings VM, Collins PD, Scott DM, et al. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996;153:530-4.
26. Heijink IH, Brandenburg SM, Noordhoek JA, et al. Characterisation of cell adhesion in airway epithelial cell types using electric cell-substrate impedance sensing. Eur Respir J 2010;35:894-903.
27. Heijink IH, Marcel KP, van Oosterhout AJ, et al. Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium. Am J Respir Cell Mol Biol 2007;36:351-9.
28. Ochs-Balcom HM, Grant BJ, Muti P, et al. Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD. Eur J Clin Nutr 2006;60:991-9.
29. Psarras S, Caramori G, Contoli M, et al. Oxidants in asthma and in chronic obstructive pulmonary disease (COPD). Curr Pharm Des 2005;11:2053-62.
30. Adcock IM, Chou PC, Durham A, et al. Overcoming steroid unresponsiveness in airways disease. Biochem Soc Trans 2009;37:824-9.
31. Chung KF, Marwick JA. Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease. Ann N Y Acad Sci 2010;1203:85-91.
32. Ito K. Impact of post-translational modifications of proteins on the inflammatory process. Biochem Soc Trans 2007;35:281-3.
33. Smith PJ, Cousins DJ, Jee YK, et al. Suppression of granulocyte- macrophage colony-stimulating factor expression by glucocorticoids involves inhibition of enhancer function by the glucocorticoid receptor binding to composite NF-AT/activator protein-1 elements. J Immunol 2001;167:2502-10.
34. Hew M, Bhavsar P, Torrego A, et al. Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med 2006;174:134-41.
35. Sekiyama A, Gon Y, Terakado M, et al. Glucocorticoids enhance airway epithelial barrier integrity. Int Immunopharmacol 2012;12:350-7.