Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β

Biochemical and Biophysical Research Communications

Volumn 418, Issue 4, 2012, Pages 759-764

  Choi, Cheol Hee ^a   Lee, Byung Hoon ^b   Ahn, Sang Gun ^a   Oh, Seon Hee ^a  

^a Chosun University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Autophagy; GSK3; MAPK; MG132; P70S6K

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LITHIUM; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCASPASE 3; PROTEIN BAX;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYSTEINE PROTEINASE INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LEUPEPTINS; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;

EID: 84862829824     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.095     Document Type: Article

References (37)

1. Crawford L.J., Walker B., Irvine A.E. Proteasome inhibitors in cancer therapy. J. Cell Commun. Signal. 2011, 5:101-110.
2. Meusser B., Hirsch C., Jarosch E., et al. ERAD: the long road to destruction. Nat. Cell Biol. 2005, 7:766-772.
3. Szokalska A., Makowski M., Nowis D. Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein response. Cancer Res. 2009, 69:4235-4243.
4. Hyun D.H., Lee M., Halliwell B., et al. Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins. J. Neurochem. 2003, 86:363-373.
5. Chen D., Dou Q.P. The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention. Curr. Protein Pept. Sci. 2010, 11:459-470.
6. Cheng Y., Yang J.M. Survival and death of endoplasmic-reticulum-stressed cells: role of autophagy. World J. Biol. Chem. 2011, 2:226-231.
7. Adams J. The development of proteasome inhibitors as anticancer drugs. Cancer Cell 2004, 5:417-421.
8. Perez-Galan P., Roué G., Villamor N., et al. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 2006, 107:257-264.
9. Park W.H. Mitogen-activated protein kinase inhibitors differently affect the growth inhibition and death of a proteasome inhibitor, carbobenzoxy-Leu-Leu-leucinal-treated human pulmonary fibroblast cells. Hum. Exp. Toxicol. 2011, 30:1945-1954.
10. Ko J.K., Choi C.H., Kim Y.K., et al. The proteasome inhibitor MG-132 induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway. Neurochem. Res. 2011, 36:722-731.
11. Stoll S.J., Pitt S.C., Chen H. Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132. J. Surg. Res. 2009, 156:39-44.
12. Richardson P.G., Barlogie B., Berenson J., et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N. Engl. J. Med. 2003, 348:2609-2617.
13. Hideshima T., Podar K., Chauhan D., et al. p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells. Oncogene 2004, 23:8766-8776.
14. Grimes C.A., Jope R.S. The multifaceted roles of glycogen synthase kinase 3β in cellular. Signaling Prog. Neurobiol. 2001, 65:391-426.
15. Chen G., Bower K.A., Ma C., et al. Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death. FASEB J. 2004, 18:1162-1164.
16. Brewster J.L., Linseman D.A., Bouchard R.J., et al. Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 and a caspase-9-dependent apoptosis in cerebellar granule neurons. Mol. Cell Neurosci. 2006, 32:242-253.
17. Huang W.C., Lin Y.S., Chen C.L., et al. Glycogen Synthase Kinase-3β mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia. J. Pharmacol. Exp. Therapeutics 2009, 329:524-531.
18. Takadera T., Fujibayashi M., Kaniyu H., et al. Caspase-dependent apoptosis induced by thapsigargin was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical neurons. Neurochem. Res. 2007, 32:1336-1342.
19. Meares G.P. Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells. Exp. Cell Res. 2011, 317:1621-1628.
20. Armanious H., Deschenes J., Gelebart P., et al. Clinical and biological significance of GSK-3β inactivation in breast cancer-an immunohistochemical study. Hum. Pathol. 2010, 41:1657-1663.
21. Choi C.H., Jung Y.K., Oh S.H. Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines. Free Radical Bio. Med. 2010, 49:245-257.
22. Cohen P., Frame S. The renaissance of GSK3. Nat. Rev. Mol. Cell Biol. 2001, 2:769-776.
23. Kawasome H., Papst P., Webb S., et al. Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity. Proc. Natl. Acad. Sci. USA 1998, 95:5033-5038.
24. Zhang L., Ebenezer P.J., Dasuri K., et al. Ebenezer Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival. J. Neurosci. Res. 2009, 87:3231-3238.
25. Ishizawa J., Yoshida S., Oya M., et al. Inhibition of the ubiquitin-proteasome pathway activates stress kinases and induces apoptosis in renal cancer cells. Int. J. Oncol. 2004, 25:697-702.
26. Stanciu M., DeFranco D.B. Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line. J. Biol. Chem. 2002, 277:4010-4017.
27. Shi Y.Y., Small G.W., Orlowski R.Z. Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer. Breast Cancer Res. Treat. 2006, 100:33-47.
28. Thornton T.M., Pedraza-Alva G., Deng B., et al. Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation. Science 2008, 320:667-670.
29. Ding Q., Xia W., Liu J.C., et al. Erk associates with and rimes GSK-3β for its inactivation resulting in upregulation of β-catenin. Mol. Cell 2005, 19:159-170.
30. Fenton T.R., Gout I.T. Functions and regulation of the 70kDa ribosomal S6 kinases. Int. J. Biochem. Cell Biol. 2011, 43:47-59.
31. Ragan T.J., Ross D.B., Keshwani M.M., et al. Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1). Protein Expres. Purif. 2008, 57:271-279.
32. Moser B.A., Dennis P.B., Pullen N., et al. Dual requirement for a newly identified phosphorylation site in p70s6k. Mol. Cell Biol. 1997, 17:5648-5655.
33. Musnier A., Heitzler D., Boulo T., et al. Developmental regulation of p70 S6 kinase by a G protein-coupled receptor dynamically modelized in primary cells. Cell. Mol. Life Sci. 2009, 66:3487-3503.
34. Duchêne S., Audouin E., Berri C., et al. Tissue-specific regulation of S6K1 by insulin in chickens divergently selected for growth. Gen. Comp. Endocrinol. 2008, 156:190-198.
35. Lehman J.H., Calvo V., Gomez-Cambronero J. Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SERr424 kinase and a rapamycin-sensitive, mTOR-related THR389 kinase. J. Biol. Chem. 2003, 278:28130-28138.
36. Li M., Dong X., Liu Y., et al. Inhibition of ubiquitin proteasome function suppresses proliferation of pulmonary artery smooth muscle cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 2011, 384:517-523.
37. s6k function is essential for G1 progression. Nature 1993, 363:170-172.