Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation

Current Opinion in Pharmacology

Volumn 26, Issue , 2016, Pages 96-101

  Matt, Stephanie M ^a   Johnson, Rodney W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MICRORNA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; BRAIN CORTEX; BRAIN REGION; CELL ACTIVITY; CELL POPULATION; CELL PROLIFERATION; CELL RENEWAL; CYTOKINE PRODUCTION; DISEASE COURSE; ENCEPHALITIS; ENDOTHELIUM CELL; EPIGENETICS; IMMUNE DYSREGULATION; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; MACROPHAGE; MICROGLIA; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; REVIEW; SYNAPSE; UPREGULATION; ANIMAL; BRAIN; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION;

AGING; ANIMALS; BRAIN; EPIGENOMICS; HUMANS; INFLAMMATION; MICROGLIA;

EID: 84947080762     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2015.10.009     Document Type: Review

References (57)

1. H.A. Jurgens, and R.W. Johnson Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation Exp Neurol 233 2012 40 48
2. D.M. Norden, and J.P. Godbout Review: microglia of the aged brain: primed to be activated and resistant to regulation Neuropathol Appl Neurobiol 39 2013 19 34
3. R. Dantzer, J.C. O'Connor, G.G. Freund, R.W. Johnson, and K.W. Kelley From inflammation to sickness and depression: when the immune system subjugates the brain Nat Rev Neurosci 9 2008 46 56
4. N. Quan, and W.A. Banks Brain-immune communication pathways Brain Behav Immun 21 2007 727 735
5. A. Louveau, I. Smirnov, T.J. Keyes, J.D. Eccles, S.J. Rouhani, J.D. Peske, N.C. Derecki, D. Castle, J.W. Mandell, K.S. Lee, and et al. Structural and functional features of central nervous system lymphatic vessels Nature 523 2015 337 341
6. A. Aspelund, S. Antila, S.T. Proulx, T.V. Karlsen, S. Karaman, M. Detmar, H. Wiig, and K. Alitalo A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules J Exp Med 212 2015 991 999
7. J.J. Iliff, M. Wang, Y. Liao, B.A. Plogg, W. Peng, G.A. Gundersen, H. Benveniste, G.E. Vates, R. Deane, S.A. Goldman, and et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta Sci Transl Med 4 2012 147ra111
8. R.N. Dilger, and R.W. Johnson Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system J Leukoc Biol 84 2008 932 939
9. D. Nayak, T.L. Roth, and D.B. McGavern Microglia development and function Annu Rev Immunol 32 2014 367 402
10. F. Ginhoux, M. Greter, M. Leboeuf, S. Nandi, P. See, S. Gokhan, M.F. Mehler, S.J. Conway, L.G. Ng, E.R. Stanley, and et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages Science 330 2010 841 845
11. C. Schulz, E. Gomez Perdiguero, L. Chorro, H. Szabo-Rogers, N. Cagnard, K. Kierdorf, M. Prinz, B. Wu, S.E. Jacobsen, J.W. Pollard, and et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells Science 336 2012 86 90
12. K. Kierdorf, D. Erny, T. Goldmann, V. Sander, C. Schulz, E.G. Perdiguero, P. Wieghofer, A. Heinrich, P. Riemke, C. Holscher, and et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways Nat Neurosci 16 2013 273 280
13. M.R. Elmore, A.R. Najafi, M.A. Koike, N.N. Dagher, E.E. Spangenberg, R.A. Rice, M. Kitazawa, B. Matusow, H. Nguyen, B.L. West, and et al. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain Neuron 82 2014 380 397
14. C.L. Cunningham, V. Martínez-Cerdeño, and S.C. Noctor Microglia regulate the number of neural precursor cells in the developing cerebral cortex J Neurosci 33 2013 4216 4233
15. D.P. Schafer, E.K. Lehrman, A.G. Kautzman, R. Koyama, A.R. Mardinly, R. Yamasaki, R.M. Ransohoff, M.E. Greenberg, B.A. Barres, and B. Stevens Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner Neuron 74 2012 691 705
16. A. Nimmerjahn, F. Kirchhoff, and F. Helmchen Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308 2005 1314 1318
17. H. Wake, A.J. Moorhouse, S. Jinno, S. Kohsaka, and J. Nabekura Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals J Neurosci 29 2009 3974 3980
18. P. Thériault, A. ElAli, and S. Rivest The dynamics of monocytes and microglia in Alzheimer's disease Alzheimers Res Ther 7 2015 41
19. N.L. Sparkman, and R.W. Johnson Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress Neuroimmunomodulation 15 2008 323 330
20. C.J. Henry, Y. Huang, A.M. Wynne, and J.P. Godbout Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines Brain Behav Immun 23 2009 309 317
21. A.M. Fenn, C.J. Henry, Y. Huang, A. Dugan, and J.P. Godbout Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice Brain Behav Immun 26 2012 766 777
22. A. Sierra, A.C. Gottfried-Blackmore, B.S. McEwen, and K. Bulloch Microglia derived from aging mice exhibit an altered inflammatory profile Glia 55 2007 412 424
23. S.M. Ye, and R.W. Johnson Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor kappaB J Neuroimmunol 117 2001 87 96
24. J.P. Godbout, J. Chen, J. Abraham, A.F. Richwine, B.M. Berg, K.W. Kelley, and R.W. Johnson Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system FASEB J 2005
25. J.O. Ojo, P. Rezaie, P.L. Gabbott, and M.G. Stewart Impact of age-related neuroglial cell responses on hippocampal deterioration Front Aging Neurosci 7 2015 57
26. Y. Tang, S. Purkayastha, and D. Cai Hypothalamic microinflammation: a common basis of metabolic syndrome and aging Trends Neurosci 38 2015 36 44
27. M. Prinz, and J. Priller Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease Nat Rev Neurosci 15 2014 300 312
28. S.E. Hickman, N.D. Kingery, T.K. Ohsumi, M.L. Borowsky, L.C. Wang, T.K. Means, and J. El Khoury The microglial sensome revealed by direct RNA sequencing Nat Neurosci 16 2013 1896 1905
29. M. Orre, W. Kamphuis, L.M. Osborn, J. Melief, L. Kooijman, I. Huitinga, J. Klooster, K. Bossers, and E.M. Hol Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice Neurobiol Aging 35 2014 1 14
30. W. Ma, R. Cojocaru, N. Gotoh, L. Gieser, R. Villasmil, T. Cogliati, A. Swaroop, and W.T. Wong Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation Neurobiol Aging 34 2013 2310 2321
31. P.D. Wes, I.R. Holtman, E.W. Boddeke, T. Moller, and B.J. Eggen Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease Glia 2015
32. E.L. Goldberg, and V.D. Dixit Drivers of age-related inflammation and strategies for healthspan extension Immunol Rev 265 2015 63 74
33. Y.H. Youm, R.W. Grant, L.R. McCabe, D.C. Albarado, K.Y. Nguyen, A. Ravussin, P. Pistell, S. Newman, R. Carter, A. Laque, and et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging Cell Metab 18 2013 519 532
34. M.G. Frank, R.M. Barrientos, J.C. Biedenkapp, J.W. Rudy, L.R. Watkins, and S.F. Maier mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging Neurobiol Aging 27 2006 717 722
35. A.M. Wynne, C.J. Henry, Y. Huang, A. Cleland, and J.P. Godbout Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge Brain Behav Immun 24 2010 1190 1201
36. R.M. Hoek, S.R. Ruuls, C.A. Murphy, G.J. Wright, R. Goddard, S.M. Zurawski, B. Blom, M.E. Homola, W.J. Streit, M.H. Brown, and et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200) Science 290 2000 1768 1771
37. A.E. Cardona, E.P. Pioro, M.E. Sasse, V. Kostenko, S.M. Cardona, I.M. Dijkstra, D. Huang, G. Kidd, S. Dombrowski, R. Dutta, and et al. Control of microglial neurotoxicity by the fractalkine receptor Nat Neurosci 9 2006 917 924
38. P.L. Poliani, Y. Wang, E. Fontana, M.L. Robinette, Y. Yamanishi, S. Gilfillan, and M. Colonna TREM2 sustains microglial expansion during aging and response to demyelination J Clin Invest 125 2015 2161 2170
39. O. Butovsky, M.P. Jedrychowski, C.S. Moore, R. Cialic, A.J. Lanser, G. Gabriely, T. Koeglsperger, B. Dake, P.M. Wu, C.E. Doykan, and et al. Identification of a unique TGF-beta-dependent molecular and functional signature in microglia Nat Neurosci 17 2014 131 143
40. T. Koeglsperger, S. Li, C. Brenneis, J.L. Saulnier, L. Mayo, Y. Carrier, D.J. Selkoe, and H.L. Weiner Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-beta1 in the CNS Glia 61 2013 985 1002
41. D.M. Norden, A.M. Fenn, A. Dugan, and J.P. Godbout TGFbeta produced by IL-10 redirected astrocytes attenuates microglial activation Glia 62 2014 881 895
42. S. Yona, K.W. Kim, Y. Wolf, A. Mildner, D. Varol, M. Breker, D. Strauss-Ayali, S. Viukov, M. Guilliams, A. Misharin, and et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis Immunity 38 2013 79 91
43. T. Goldmann, P. Wieghofer, P.F. Muller, Y. Wolf, D. Varol, S. Yona, S.M. Brendecke, K. Kierdorf, O. Staszewski, M. Datta, and et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation Nat Neurosci 16 2013 1618 1626
44. C.N. Parkhurst, G. Yang, I. Ninan, J.N. Savas, J.R. Yates 3rd, J.J. Lafaille, B.L. Hempstead, D.R. Littman, and W.B. Gan Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor Cell 155 2013 1596 1609
45. C. Beutner, V. Lepperhof, A. Dann, B. Linnartz-Gerlach, S. Litwak, I. Napoli, M. Prinz, and H. Neumann Engineered stem cell-derived microglia as therapeutic vehicle for experimental autoimmune encephalomyelitis Gene Ther 20 2013 797 806
46. D. Gosselin, V.M. Link, C.E. Romanoski, G.J. Fonseca, D.Z. Eichenfield, N.J. Spann, J.D. Stender, H.B. Chun, H. Garner, F. Geissmann, and et al. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities Cell 159 2014 1327 1340
47. Y. Lavin, D. Winter, R. Blecher-Gonen, E. David, H. Keren-Shaul, M. Merad, S. Jung, and I. Amit Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment Cell 159 2014 1312 1326
48. A. Satoh, C.S. Brace, N. Rensing, P. Cliften, D.F. Wozniak, E.D. Herzog, K.A. Yamada, and S. Imai Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH Cell Metab 18 2013 416 430
49. S.H. Cho, J.A. Chen, F. Sayed, M.E. Ward, F. Gao, T.A. Nguyen, G. Krabbe, P.D. Sohn, I. Lo, S. Minami, and et al. SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1beta J Neurosci 35 2015 807 818
50. K.E. Sullivan, A.B.M. Reddy, K. Dietzmann, A.R. Suriano, V.P. Kocieda, M. Stewart, and M. Bhatia Epigenetic regulation of tumor necrosis factor alpha Mol Cell Biol 27 2007 5147 5160
51. J.L. Eddy, K. Krukowski, L. Janusek, and H.L. Mathews Glucocorticoids regulate natural killer cell function epigenetically Cell Immunol 290 2014 120 130
52. Y. Tang, T. Li, J. Li, J. Yang, H. Liu, X.J. Zhang, and W. Le Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease Cell Death Differ 21 2014 369 380
53. F. Sato, S. Tsuchiya, S.J. Meltzer, and K. Shimizu MicroRNAs and epigenetics FEBS J 278 2011 1598 1609
54. A.L. Cardoso, J.R. Guedes, L. Pereira de Almeida, and M.C. Pedroso de Lima miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production Immunology 135 2012 73 88
55. A.M. Fenn, K.M. Smith, A.E. Lovett-Racke, M. Guerau-de-Arellano, C.C. Whitacre, and J.P. Godbout Increased miR-29b in the aged brain correlates with the reduction of IGF-1 and CX(3)CL1 Neurobiol Aging 34 2013 2748 2758
56. R.W. Johnson Feeding the beast: can microglia in the senescent brain be regulated by diet? Brain Behav Immun 43 2015 1 8
57. K.S. vel Szic, K. Declerck, M. Vidaković, and W. Vanden Berghe From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? Clin Epigenetics 7 2015 33