Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease

Cell Death and Differentiation

Volumn 21, Issue 3, 2014, Pages 369-380

  Tang, Y ^a   Li, T ^a   Li, J ^a   Yang, J ^a   Liu, H ^b   Zhang, X J ^a   Le, W ^a,b  

^a Chinese Academy of Sciences   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

aging; histone H3K27me3 demethylase; Jmjd3; microglia polarization; neuron degeneration; Parkinson's disease

Indexed keywords

HISTONE DEMETHYLASE; KDM6B PROTEIN, HUMAN; KDM6B PROTEIN, MOUSE;

AGE; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; ENZYMOLOGY; EPIGENETICS; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MICROGLIA; MOUSE; PARKINSON DISEASE; PATHOLOGY; PHENOTYPE;

AGE FACTORS; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EPIGENOMICS; GENE KNOCKDOWN TECHNIQUES; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; PARKINSON DISEASE; PHENOTYPE; TRANSFECTION;

EID: 84893857631     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.159     Document Type: Article

References (44)

1. Dauer W, Przedborski S. Parkinson's disease: Mechanisms and models. Neuron 2003; 39: 889-909
2. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 24: 197-211
3. Imamura K, Hishikawa N, Sawada M, Nagatsu T, Yoshida M, Hashizume Y. Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains. Acta Neuropathol 2003; 106: 518-526
4. Hanisch UK, Kettenmann H. Microglia: Active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 2007; 10: 1387-1394
5. Colton CA. Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 2009; 4: 399-418
6. Liu B, Gao HM, Wang JY, Jeohn GH, Cooper CL, Hong JS. Role of nitric oxide in inflammation-mediated neurodegeneration. Ann N Y Acad Sci 2002; 962: 318-331
7. Le W, Rowe D, Xie W, Ortiz I, He Y, Appel SH. Microglial activation and dopaminergic cell injury: An in vitro model relevant to Parkinson's disease. J Neurosci 2001; 21: 8447-8455
8. Li R, Huang YG, Fang D, Le WD. (-)-Epigallocatechin gallate inhibits lipopolysaccharideinduced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury. J Neurosci Res 2004; 78: 723-731
9. Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammationinduced death. Cell 2009; 137: 47-59
10. Mayo L, Stein R. Characterization of LPS and interferon-gamma triggered activationinduced cell death in N9 and primary microglial cells: Induction of the mitochondrial gateway by nitric oxide. Cell Death Differ 2007; 14: 183-186
11. Colton C, Wilcock DM. Assessing activation states in microglia. CNS Neurol Disord Drug Targets 2010; 9: 174-191
12. Giaume C, Kirchhoff F, Matute C, Reichenbach A, Verkhratsky A. Glia: The fulcrum of brain diseases. Cell Death Differ 2007; 14: 1324-1335
13. Block ML, Hong JS. Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism. Prog Neurobiol 2005; 76: 77-98
14. Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D et al. Pathogenic role of glial cells in Parkinson's disease. Mov Disord 2003; 18: 121-129
15. Magnus T, Chan A, Grauer O, Toyka KV, Gold R. Microglial phagocytosis of apoptotic inflammatory T cells leads to down-regulation of microglial immune activation. J Immunol 2001; 167: 5004-5010
16. Liu Y, Hao W, Letiembre M, Walter S, Kulanga M, Neumann H et al. Suppression of microglial inflammatory activity by myelin phagocytosis: Role of p47-PHOX-mediated generation of reactive oxygen species. J Neurosci 2006; 26: 12904-12913
17. Polazzi E, Contestabile A. Reciprocal interactions between microglia and neurons: From survival to neuropathology. Rev Neurosci 2002; 13: 221-242
18. Zhang Z, Zhang ZY, Schluesener HJ. Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with reduced side effects. J Immunol 2009; 183: 3081-3091
19. Berger SL. The complex language of chromatin regulation during transcription. Nature 2007; 447: 407-412
20. Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol 2010; 28: 1057-1068
21. Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 2007; 449: 731-734
22. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004; 25: 677-686
23. Vanden Berghe W, Ndlovu MN, Hoya-Arias R, Dijsselbloem N, Gerlo S, Haegeman G. Keeping up NF-kappaB appearances: Epigenetic control of immunity or inflammationtriggered epigenetics. Biochem Pharmacol 2006; 72: 1114-1131
24. Cho IH, Hong J, Suh EC, Kim JH, Lee H, Lee JE et al. Role of microglial IK Kbeta in kainic acid-induced hippocampal neuronal cell death. Brain 2008; 131: 3019-3033
25. Aoki E, Yano R, Yokoyama H, Kato H, Araki T. Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6- Tetrahyropyridine)-induced apoptosis in nigral neurons of mice. Exp Mol Pathol 2009; 86: 57-64
26. Bronte V, Zanovello P. Regulation of immune responses by L-Arginine metabolism. Nat Rev Immunol 2005; 5: 641-654
27. Lee J, Ryu H, Ferrante RJ, Morris SM Jr., Ratan RR. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci USA 2003; 100: 4843-4848
28. Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WG et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 1999; 5: 1403-1409
29. Kuzumaki N, Ikegami D, Tamura R, Sasaki T, Niikura K, Narita M et al. Hippocampal epigenetic modification at the doublecortin gene is involved in the impairment of neurogenesis with aging. Synapse 2010; 64: 611-616
30. Zeng Y, Tan M, Kohyama J, Sneddon M, Watson JB, Sun YE et al. Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J Neurosci 2011; 31: 17800-17810
31. De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 2007; 130: 1083-1094
32. Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim HJ, Glass CK et al. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 2007; 450: 415-419
33. Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol 2010; 11: 936-944
34. Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM et al. Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 2009; 114: 3244-3254
35. Guillemin GJ, Brew BJ. Microglia,macrophages, perivascular macrophages, and pericytes: A review of function and identification. J Leukoc Biol 2004; 75: 388-397
36. Wang XP, Chen YG, Qin WD, Zhang W, Wei SJ, Wang J et al. Arginase I attenuates inflammatory cytokine secretion induced by lipopolysaccharide in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2011; 31: 1853-1860
37. Xie WJ, Li XP, Li C, Zhu W, Jankovic J, Le WD. Proteasome inhibition modeling nigral neuron degeneration in Parkinson's disease. J Neurochem 2010; 115: 188-199
38. Levy G. The relationship of Parkinson disease with aging. Arch Neurol 2007; 64: 1242-1246
39. Ye SM, Johnson RW. Increased interleukin-6 expression by microglia from brain of aged mice. J Neuroimmunol 1999; 93: 139-148
40. Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 2007; 55: 412-424
41. Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nat Genet 2000; 25: 294-297
42. Sheng JG, Mrak RE, Griffin WS. Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol 1998; 95: 229-234
43. Sugama S, Yang L, Cho BP, DeGiorgio LA, Lorenzl S, Albers DS et al. Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6- Tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice. Brain Res 2003; 964: 288-294
44. West MJ. New stereological methods for counting neurons. Neurobiol Aging 1993; 14: 275-285