The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change

Journal of Biological Chemistry

Volumn 290, Issue 46, 2015, Pages 27533-27544

  Howe, Vicky ^a   Chua, Ngee Kiat ^a   Stevenson, Julian ^b   Brown, Andrew J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; CHEMICAL REACTIONS; CONFORMATIONS; TOPOLOGY;

CHEMICAL CHAPERONE; CHOLESTEROL SYNTHESIS; CONFORMATIONAL CHANGE; CRITICAL CONTROL POINTS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM MEMBRANES; NATIVE CONFORMATION; UBIQUITIN-PROTEASOME SYSTEM;

CHOLESTEROL;

CHOLESTEROL; GLYCEROL; GREEN FLUORESCENT PROTEIN; PROTEASOME; SQUALENE MONOOXYGENASE; UBIQUITIN; CYSTEINE; HYBRID PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHOLESTEROL REGULATORY DOMAIN; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM MEMBRANE; ENZYME DEGRADATION; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CHO CELL LINE; CRICETULUS; ENDOPLASMIC RETICULUM; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CHO CELLS; CHOLESTEROL; CRICETULUS; CYSTEINE; ENDOPLASMIC RETICULUM; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS; SQUALENE MONOOXYGENASE;

EID: 84946925425     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.675181     Document Type: Article

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